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      • KCI등재

        비만 및 대사성증후군 위험인자에 대한 천연물 식품의 인체 및 동물 효능연구

        문근아(Geun-Ah Moon),최선미(Sun-Mi Choi),김선형(Sun-Hyung Kim),김성수(Sung-Su Kim),강지연(Ji-Yeon Kang),윤유식(Yoosik Yoon) 한국식품영양과학회 2003 한국식품영양과학회지 Vol.32 No.8

        본 연구에서는 비만 및 대사성증후군 위험인자를 개선하기 위하여 한방원리를 활용한 조성물 KSH28을 구성하고 동물실험과 인체실험을 통한 효능 평가를 수행하였다. 동물실험에서는 4주령의 수컷 C57BL/6 마우스에게 30%고지방식이를 급여하면서 4주간 KSH28을 경구투여하였다. 4주후 체중과 복부의 부고환 및 신장후 지방조직은 KSH28에 의해 용량의존적으로 의미있게 감소하였다. 또한 지방조직내의 지방세포 평균단면적이 KSH28에 의해 용량의존적으로 감소하여 지방조직 억제 효과가 뚜렷함이 발견되었다. 공복시혈당과 혈중 중성지방 농도는 KSH28에 의해 유의적으로 감소하였다. 인체실험에서는 40명(남성 8명, 여성 32명)의 피험자들이 KSH28을 포함한 생식제품(30 g)을 하루 2포 4주간 복용하였다. 체중은 4주간 평균적으로 1.91 kg(남 2.05 kg,여 1.87 kg) 감소하여 주당 약 0.5 kg의 감소를 나타내었고 체성분 분석에서는 체지방이 1.77 kg(남 2.69 kg, 여 1.56 kg) 감소하여 체중감량 부분의 대부분을 차지하였다. 수분과 단백질, 근육, 무기질은 변화가 없었다. 여성에서 수축기 혈압, 확장기혈압과 혈중 총콜레스테롤, LDL콜레스테롤이 모두 의미있게 감소하여 대사성증후군을 개선시킴이 관찰되었다. 간기능의 지표로 이용되는 GPT 수치에는 변화가 없었고 기타의 특별한 부작용은 발견되지 아니하였다. In this study, a natural composition containing oriental herbs, KSH28, for reducing obesity and metabolic syndrome was constructed and its efficacy was evaluated in animal and human. To investigate the anti-obesity effect of KSH28, animal study was conducted using high fat diet-induced obese mice. KSH28 significantly decreased body weight and adipose tissue in high fat diet-fed obese mice. The mean size of fat cells in adipose tissue was significantly reduced. Glucose and triglyceride levels were also significantly decreased. To elucidate its efficacy in human, a natural food containing KSH28 with grains, vegetables, vitamins, minerals and dietary fibers was constructed and 40 subjects (8 male and 32 female) were tested for the change of body composition, blood pressure and blood lipid profile. All subjects had 2 pack (30 g each) of natural food per day for 4 weeks. Compared to the baseline value, body fat was significantly reduced, however, water, protein and mineral contents in the body were not changed, suggesting selective reduction of fat tissue. Blood pressure and serum lipid profile were significantly decreased to reduce risk for metabolic syndrome. Serum GPT, a liver function indicator, was not changed and no significant side effects were detected. Therefore, it was shown that the KSH28 is a safe and effective composition for reducing obesity and metabolic syndrome.

      • KCI등재

        ‘제3의 공간’으로서 카페의 공간연출 전략에 관한 연구

        문근이(Moon, Geun-Yi),류호창(Lyu, Ho-Chang) 한국실내디자인학회 2013 한국실내디자인학회논문집 Vol.22 No.5

        The Third space,’ which is the concept that embraces sociological, spatial, and marketing concepts, refers to the place which is other than the home and the workplace and which is a comfortable frequented place where meditation, psychological relaxation, and social needs can be satisfied. ‘The Third space’ has the characteristics of comfort, openness, interactivity, playfulness, and diversity. In modern times, most of consumption spaces play the role of ‘the Third space,’ and the typical example is cafe. Cafe began from its origin with the characteristics of ‘the Third space,’ and recently it has become the complex cultural space of urban dwellers. Cafe as ‘the Third space’ has the characteristics of a healing space, communication space, personalized space, value-expressive space, culture and consumption space, nomad space. Such characteristics of cafe are well represented in the cafes around the regions where ‘street culture’ has recently been formed. As examined through the examples, cafe as ‘the Third space’ can be more strategically produced by establishing themes through storytelling, giving spatial identity through style creation, diversifying the sequence through complex space organization, and establishing interaction devices through experience elements.

      • 가미홍화탕의 방사선 부작용 억제 효능연구

        문근,송낙근,박성진,윤유식,Moon, Geun-Ah,Song, Nak-Geun,Park, Seong-Jin,Yoon, Yoo-Sik 한국한의학연구원 2003 한국한의학연구원논문집 Vol.9 No.2

        In this study, Kami-honghwa-tang (KH-19) was designed and animal study was conducted to evaluate its efficacy on the reduction of the side effect of radiotherapy. Bone marrow toxicity is one of the major side effect of radiotherapy which cause the reduction of blood cells, and KH-19 was designed to protect and enforce blood. C57BL/6 mice were irradiated with 4 Gy of gamma ray, and divided into control group which was treated with water and KH-19 group which was treated with 1.5g/Kg of KH-19 up to 4 weeks. KH-19 group showed significantly increased white blood cells, lymphocytes and platelet count compared with control group (p<0.05). When bone marrows were examined, KH-19 group showed higher cell densities than control group (p=0.06). KH-19 may increase blood cell count after radiation by its protective effects on bone marrow.

      • 가미홍화탕의 단회 경구 투여 독성 연구

        성현제,문근,유충렬,윤유식,Sung, Hyun-Jea,Moon, Geun-Ah,Ryoo, Choong-Ryeol,Yoon, Yoo-Sik 한국한의학연구원 2003 한국한의학연구원논문집 Vol.9 No.2

        Kami-honghwa-tang(KH-19) is a prescription for reducing the side effect of radiotherapy. In this study, safety of KH-19 was evaluated by GLP guideline of Korea Food and Drug Administration. In acute oral toxicity study on rat, transient inhibition of weight increase was shown, but change in general symptom was not detected. No dead animal was observed up to 5,000 mg/kg in both male and female animals. In acute oral toxicity study on Beagle dog, transient vomiting, diarrhea, anorexia, and weight reduction was observed. However, no dead animal was observed up to 2,000 mg/kg in both male and female animals.

      • KCI등재
      • KCI등재

        부정교합 환자에 있어 Facial axis 와 상악치아의 위치관계에 관한 연구

        이동주,문근 朝鮮大學校 口腔生物學硏究所 1989 口腔生物學硏究 Vol.13 No.-

        This study was undertaken to examine the relationship between the facial axis and maxillary teeth and to offer aids to diagnosis and treatment planning of malocclusion.Cephelometric headplates of 60 persons were traced and divided into three groups of Angle's Class Ⅰ, Class Ⅱ, Class Ⅲ. Mean, standard deviation, t-test, and simple correlation coefficient were used to compare three groups. The following results were obtained. 1. Facial axis angle was smallest in ClassⅢ malocclusion and great in Class Ⅰ and Class Ⅱmalocclusion, but there was no significant difference statistcally. 2. Horizontal position of maxillary first molar did not show the significant difference among the malocclusions. 3. In Class Ⅰ and Class Ⅱ malocclusion, when the facial axis angle was more increased the maxillary first molar was positioned more posterioly. 4. Distance between the facial axis and upper incisor was shortest in Class Ⅲ malocclusion. 5. Facial convexity was greatest in Class Ⅱ malocclusion and smallest in Class Ⅲ molocclusion, and there was significant difference among the each groups.

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