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Bowen모양 구진증의 임상, 병리조직학적 소견 및 추적관찰
서기석 ( Kee Suck Suh ),노효진 ( Hyo Jin Roh ),전영승 ( Yeong Seung Jeon ),류현열 ( Hyun Yul Rhew ),김상태 ( Sang Tae Kim ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.11
Background: Bowenoid papulosis occurs primarily on the genitalia of young adults and this is characterized by multiple, apparently benign maculopapular lesions. Bowenoid papulosis shows the histopathological findings of a squamous cell carcinoma in situ, but it follows a largely benign clinical course. If it is misdiagnosed as malignant tumor, unnecessary excessive therapy may be performed. Therefore, exact recognition of this entity is important. Objective: The purpose of this study is to examine the clinical and histopathologic features and outcomes of Bowenoid papulosis. Methods: Twelve patients who had been diagnosed with Bowenoid papulosis between June 1996 and September 2007 were reviewed clinicopathologically. Results: The mean age of the patients was 34.8 years (range: 23∼57 years), and the mean duration of Bowenoid papulosis until presentation was 6.3 months (range: 5∼48 months). Nine patients were males and 3 patients were females. Eleven patients (92%) had multiple lesions. The average size of the individual lesions was 1.4×0.6 cm in diameter. The colors of the papules were red to black. Seven of 9 male patients had lesions on the penile shaft, with 6 of those occurring at the proximal shaft. The other 2 male patients had lesions on the scrotum and perianal area, respectively. Three female patients had lesions on the labium major, labium major and clitoris, and perianal area respectively. Nine patients (75%) presented without symptom and 3 (25%) presented with mild pruritus. The histopathologic features were as follows: a rete ridge of approximately equal length and breadth throughout the entire lesion (100%), skipped areas of normal keratinocytes between zones of atypical keratinocytes (100%). necrotic keratinocytes (92%), parakeratosis (83%), mitotic figures (83%), vacuolated cells resembling owl`s eyes (83%), multinucleated cells (67%), residual changes of typical condyloma acuminatum (17%), involvement of acrotrichia (100%) and involvement of acrosyringia (100%). Eleven patients were effectively treated with surgical excision (8 patients), CO2 laser (2 patients), diphenylcyclopropenone (DPCP) and immunotherapy (1 patient) and 1 patient underwent biopsy only. We followed 12 patients for an average 78.1 months (from 24 to 137 months). During this period, no recurrence or malignant transformation was observed. Conclusion: Bowenoid papulosis shows a form of squmaous cell carcinoma in situ for its histopathology, but it hardly ever progresses to squmaous cell carcinoma. On our long term follow-up, there was no malignant transformation. Thus, excessive treatment of Bowenoid papulosis by amputation of the external genitalia is not necessary. Therefore, a through understanding of the clinical and histopathologic features of this entity is necessary for making the diagnosis, the treatment planning and determining the prognosis. (Korean J Dermatol 2008; 46 (11): 1463∼1469)
김택상(Taek Sang Kim),강수환(Su Hwan Kang),오정현(Jung Hyun Oh),류현열(Hyun Yul Rhew) 대한비뇨기종양학회 2010 대한비뇨기종양학회지 Vol.8 No.3
Purpose: For appropriate treatment strategies in renal cell carcinoma (RCC) with bone metastasis, information about survival and prognosis of these patients were required. However, the reports about prognosis of RCC patients with bone metastasis are rare in the literature. We reviewed the records of RCC patients with bone metastasis, analysed about survival and prognostic factors. Materials and Methods: From January 2000 to December 2009, 73 patients presented with metastasis to bone secondary to RCC. We retrospectively reviewed their medical, radiologic, and nuclear medical records. As prognostic factor, we analysed age, sex, pathologic type and stage of primary RCC, metastasis to other organ, the interval between the diagnosis of RCC and bone metastasis, and orthopedic treatment of bone metastasis. The relationship between survival and each factors were analysed and we categorized all patient into two different groups for analyse the difference in survival duration. Results: The median survival time from bone metastasis was 12 month, 34 survival rate at 1, 2 and 5 year were 39.7%, 23.3%, and 2.7%. In the multivariate analysis, prognostic factors correlated with longer survival were the absence of metastasis to other organ and orthopedic surgery of bony lesion. Conclusions: As prognostic factors predicting survival, the absence of metastasis to other organ and orthopedic surgery of bony lesion were identified. These would offer the useful tools for predicting survival and prognosis, and making the treatment plan.
신이식 100예에서 이식신의 예후에 영향을 미치는 인자
편도철(Do Chul Pyun),정인권(In Kweon Jung),임창범(Chang Bum Lim),양영란(Young Ran Yang),임정식(Jeong Sik Lim),김종진(Jong Jin Kim),하봉준(Bong Jun Ha),김홍기(Hong Khee Kim),이시래(Si Rhae Lee),이승도(Sung Do Lee),류현열(Hyun Yul Rhew 대한내과학회 1989 대한내과학회지 Vol.37 No.5
N/A It has been reported that many factors other than HLA and the mode of immunosuppression influence the results of renal transplantation. The factors are constantly changing with the advances in surgical techniques and introduction of Cyclosporin-A s-A), etc. We analyzed the possible prognostic factors in 100 cases of renal allograft which were performed by the transplantation team of Kosin Medical College from Dec. 1984 to Aug. 1988. Detailed results are presented for the several factors as follows: 1) HLA and the mode of immunosuppression. Excluding 9cases of graft failure due to non-immunological causes, the actuarial graft survival in 3 years was 100% in the E3LA-II) group, 95.1% in the HLA-HID group and 84.6% in the LUR group. In the HLA-HID group, the 3 year graft survival (3YGS) was 96.8% in the Cs A+P treated group and 93.3% in the Aza+P treated group, and the difference in these 2 groups was not significant statistically (p>0.1). Numbers of patients with serum creatinine equal or above 2 mg/dl were 5 of 17cases (29.4%) in the Aza+P treated HLA-HID group, and 8 of 47cases (17.1%) in the Cs-A+P treated HLA-HID group, but the difference was not significant statistically (p>0.1). 2) Pretransplant transfusions. Twenty-seven cases which were transfused with more than 10 units of packed red cells were 100% in 3YGS and the other cases were 97.8% in 3YGS, And there was no significant difference between Aza+P and Cs A+P treated HLA-HID groups in relation to transfusion (p>0.1), 3) Donor and recipient age. The 3YGS in donors older than 50 years and in those 50 years old and under were 93.796 and 94.895, respectively, The percentages of cases with serum creatinine equal or above 2mg/dl were 26. 5% in the older than 50 years group and 12.3% in the other group, but the difference was not significant statistically (p>0.1). Thirteen cases older than 60 years were 10096 in 3YGS. Recipient age had no significant effect on 3YGS between the older than 50 years group and the other group (p>0.1). 4) Donor and recipient sex. The 3YGS was highest (100%) in the male to male group and lowest (87.5%) in the male to female group, but the difference was not significant in these 2 groups (p>0.1). 5) Minor ABO incompatibility. Seventeen cases with minor ABO incompatibility were 100% in 3YGS, and in remaining compatible 74 cases, the 3YGS was 93.4% and there was no significant difference (p>0.1). In summary, the 3YGS was higherst in the HLA-ID group, and there was no signifcant difference in 3YGS between Aza+P and Cs A+P treated HLA-HID groups. And the elder (more than 50 years or 60 years) donor group did not show lower 3YGS than the younger age group despite somewhat worse graft function. There appears to be a minimal effect with mismatch of sex and minor ABO incompatibility. And the fact that there is no significant relation between pretransplant transfusion and 3YGS seems to be due to DST, which was done in all cases except HLA-ID and 2cases of the HLA-HID group.
류현열,이창규,최재호 고신대학교 의학부 2000 高神大學校 醫學部 論文集 Vol.15 No.1
Background Tumor growth and metastasis require angiogenesis. Microvessel density (MVD), a measure of tumor angiogenesis, correlates with metastasis in man cancers, but its importance has not been evaluated in renal cell carcinoma with varying clinical behavior and prognosis. Methods To evaluate the prognostic significance of MVD in renal cell carcinoma, the relationship of MVD to tumor stage, histologic type, tumor grade and metastasis was studied in a retrospective review of 57 patients with renal cell carcinoma from January 1990 to December 1994. MVD was evaluated immunohistochemically using the labeled streptavidin-biotin-peroxidase method with monoclonal antibody directed against factor Ⅷ-related antigen. The area of highest MVD within the tumor was selected for review without knowledge of the patient's clinical parameters, and the number of vessels in an x400 field (0.1855mm^(2)) was counted. Results Mean was 597±173 vessels/mm^(2) and mean follow-up was 3.5 years. The mean MVD in 20 patients (35%) with metastasis was 635±202 vessels/mm^(2) and mean MVD in 37 patients (65%) without metastasis was significantly lower, 500±128 vessels/mm^(2) (P=0.024). MVD increased with increasing tumor grade, but no statistically significant differences. Conclusions MVD in renal cell carcinoma was significantly correlated with metastasis and MVD has a clinically practical and significant value in prognosis.