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원지에 의한 뇌 성상세포로부터 염증성 세포활성물질 분필의 억제 효과에 관한 연구
강형원,류영수(Yeoung Su Lyu),황시영(Si Young Hwang) 대한한방신경정신과학회 1999 동의신경정신과학회지 Vol.10 No.1
We investigated whether an aqueous extract of Polygala tenuifolia root (PTAE) inhibits secretion of inflammatory cytokines from primary cultures of mouse astrocytes. PTAE dose-dependently inhibited the Tumor necrosis factor-α (TNF-α) secretion by astrocytes stimulated with substance p (SP) and lipopolysaccharide (LPS). Interleukin-1 (IL-1) has been shown to elevate TNF-α secretion from LPS-stimulated astrocytes while having no effect on astrocytes in the absence of LPS. We therefore also investigated whether IL-1 mediated inhibition of TNF-α secretion from primary astrocytes by PTAE. Treatment of PTAE to astrocytes stimulated with both LPS and SP decreased IL-1 secretion to the level observed with LPS alone. Moreover, incubation of astrocytes with IL-1 antibody abolished the synergistic cooperative effect of LPS and SP. Reverse transcriptase-polymerase chain reaction analysis demonstrated the significantly reduced level of the Tnf-α mRNA was expressed in astrocytes treated with PTAE. These results suggest that PTAE has an antiinflammatory activity on the central nervous system curing some pathological disease states.
전신체열촬영(全身體熱撮影)에 의한 화병환자(火病患者)의 임상적(臨床的) 연구(硏究)
김태헌,류영수,Kim Tae-Heon,Lyu Yeoung-Su 대한한방신경정신과학회 1999 동의신경정신과학회지 Vol.10 No.1
First I chose a patient group and a comparative group composed of 23 members each. Then the body temperature differences in these groups was taken with D.I.T.I. The results are as follows. 1. Average body temperature of the Hwa-Byung patient group is $36.6^{\circ}C$ and that of the comparative group is $36.4^{\circ}C$. So there is no meaningful body temperature difference. 2. The hwa-Byung patient group has higher temperature than the comparative group by ${\triangle}T>1.0^{\circ}C$ at the following acupunture points in these body parts upper and lower, left and right, anterior and posterior, trunk and limb. Especially, the body temperature difference was clear in the CV-17 (jun-Joong) and the GV-4(Myung-moon). 3. When the body temperature was compared in the upper and lower part of the back, it had meaningful differences at the upper and lower acupunture points of the back in the Hwa-Byung patient group but not in the comparative group. 4. When the body temperature was compared in the left and right part of the body, its average difference was ${\triangle}T>1.0^{\circ}C$ in the two groups and the result were meaningless. 5. When body temperature was compared in the anterior and posterior part of the body, its average difference was ${\triangle}T>1.0^{\circ}C$ in the two groups and the result were meaningless. 6. When body temperature was compared in the trunk and limb part of the body, its difference in the patient group was meaningful compared with the non-patient group. From the above results, I think that D.I.T.I. could be used to objectively visualize heat sensation of the Hwa-Byung patients and make an objective concept of Han Yul in oriental medicine.
뇌신경교 성상세포로부터 종양괴사인자 알파의 생성에 있어서 총명탕의 효과
강형원,류영수(Yeoung Su Lyu),이종길(Jong Gil Lee) 대한한방신경정신과학회 1999 동의신경정신과학회지 Vol.10 No.1
We investigated whether an aqueous extract of Chong-Myung-Tang inhibits secretion of tumor necrosis factor-a (TNF-α) from primary cultures of mouse astrocytes. Chong-Myung-Tang dosedependently inhibited the TNF-α secretion by astrocytes stimulated with substance P (SP) and lipopolysaccharide (LPS). Interleukin-1 (IL-1) has been shown to elevate TNF-α secretion from LPS-stimulated astrocytes while having no effect on astrocytes in the absence of LPS. We therefore investigated whether IL-1 mediated inhibition of TNF-α secretion from astrocytes by Chong-Myung-Tang. Treatment of Chong-Myung-Tang to astrocytes stimulated with both LPS and SP decreased IL-1 secretion. Moreover, incubation of astrocytes with IL-1 amtobody abolished the synergistic cooperative effect of LPS and SP. These results suggest that Chong-Myung-Tang may inhibits TNF-α secretion by inhibiting IL-1 secretion and that Chong-Myung-Tang has a antiinflammatory activity in the central nervous system.
동의보감(東醫寶鑑)에 나타난 경계(驚悸) 정충(怔忡)에 관한 고찰
이효경,김태헌,류영수,강형원,Lee, Hyo-Gyung,Kim, Tae-Heon,Lyu, Yeoung-Su,Kang, Hyung-Won 대한한방신경정신과학회 2009 동의신경정신과학회지 Vol.20 No.1
Objectives : The aim of this study was to help treatment of Anxiety disorder patients through the study on Keongke(驚悸) and Cheongchung(怔忡) in "Donguibogam" Methods : Author searched the contents of Keongke(驚悸) and Cheongchung(怔忡) in "Donguibogam" and classfied them by concept, pathogenesis and treatment. Results : 1. Concepts of Keongke(驚悸) and Cheongchung(怔忡) are to leap up, be nervous and fear something. Keongke(驚悸) and Cheongchung(怔忡) are same kinds of disease but they are only distinguished as their seriousness. 2. There are four main causes of Keongke(驚悸) and Cheongchung(怔忡) such as phlegm and fluid retention(痰飮), insufficiency of the heart(心虛), being blocked of qi(氣鬱) and Hwa(火). Additionally the diseases are caused by astonishment(驚) excessive thought(思慮過度), insufficiency of the liver(肝虛), excessive perspiration and dirarrhea (汗,下過多) insufficiency of qi(氣鬱) 3. the number of herbal medicines which treat Keongke(驚悸) and Cheongchung(怔忡) are 68. In result of analyzing them, the number of herbal medicines to treat phlegm(痰) are 22 and the number of herbal medicines to treat deficiency of the heart blood(血心虛) are 18. 4. The number of herbs which treat Keongke(驚悸) and Cheongchung(怔忡) are 25. They stabilize Hon-Baek(魂魄), spirit(精神) and mind(心神), supplement the heart blood, and treat Damhwa(淡火) and Hwa(火). Poria(茯神) take a rule of leading to the causes of Keongke(驚悸) and Cheongchung(怔忡).
류승준,강형원,류영수,Lyu, Seung-jun,Kang, Hyung-won,Lyu, Yeoung-su 대한침구의학회 2003 대한침구의학회지 Vol.20 No.4
Objective: Dopamine activity in thenucleus accumbens is an important neuropharmacological component of morphine reinforcement. In this nucleus a shell and core have been distinguished on the basis of anatomical and neurochemical criteria. Although acupuncture has been standard intervention in many detoxication programs worldwide, the central mechanism by which morphine acts to reinforce behavior remain elusive. The present in vivo microdialysis study was conducted, in freely moving rats, to detect the effects of acupuncture on extracellular dopamine release in the nucleus accumbens. Methods: Male Sprague-Dawley rats received acupuncture for 1 min after injection of morphine hydrochloride (5mg/kg, s.c.). The employed acupuncture needle points corresponded to bilateral Neiguan(PC6) on the pericardium channel, which has been used to treat mental and psychosomatic disorders. Extracellular dopamine and its metabolites were measured every 20 mins for 3 hrs following the subcutaneous morphine injection. Results: Results showed that acupuncture at PC6 significantly attenuated increases in dopamine levels induced by a single acute morphine injection in the nucleus accumbens shell and core, respectively. Conclusions: These results provided strong evidence for acupuncture-mediated reduction in morphine-induced dopamine release in the rat nucleus accumbens.
몰핀에 민감화된 흰쥐의 내관부위 자침이 행동과 측핵의 도파민 유리에 미치는 효과
김상호,류승준,김태헌,강형원,류영수,Kim, Sang-Ho,Lyu, Seung-Jun,Kim, Tae-Heon,Kang, Hyung-Won,Lyu, Yeoung-Su 대한동의생리학회 2005 동의생리병리학회지 Vol.19 No.3
Acupuncture as a therapeutic intervention is widely used for the treatment of many functional disorders such as substance abuse and mental dysfunction. Clinical trials are currently underway to determine the effectiveness of acupuncture in the treatment of drug addiction. Yet, there are still many unanswered questions about the basic mechanism of acupuncture. Studies have shown that both the psychomotor stimulant effects and rewarding properties of addictive drugs, including morphine, are sensitized by repeated drug administration and raised the possibility that both of these effects may De linked to the same or closely overlapping the mesolimbic dopamine systems. Neiguan (PC6) point on the pericardium channel which is associated with the brain and its mental function, has been used to treat mental, psychosomatic disorders and gastroenterological disorders. The present study was designed to investigate the effect of acupuncture on repeated morphine-induced changes in extracellular dopamine levels using in vivo microdialysis and to measure the effect of acupuncture on repeated morphine-induced behavioral changes. Male Sprague-Dawley rats were treated twice a day for three days with increasing doses of morphine (10, 20 and 40 mg/kg, s.c.) or with saline. After 15 days of withdrawal, rats were challenged with morphine hydrochloride (5 mg/kg, s.c.). Acupuncture was applied at bilateral Neiguan (PC6) points for 1min after the morphine challenge. Results showed that acupuncture at the specific acupoint PC6, but not at control points (tail and HE8) significantly decreased both dopamine release, behavior induced by a systemic morphine challenge or a single s.c. morphine injection in the morphine-repeated animals. These results suggest that reduction in sensitization may be one mechanism whereby acupuncture alleviates morphine craving in addicts. Moreover, in a more general sense these results suggest that acupuncture can be used as a therapeutic intervention for correcting reversible malfunction of the body by direction of brain pathway and thus acupuncture can contribute to the biochemical balance in the central nervous system by regulating neurotransmitters.