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닭고기와 잘 어울리는 췌장라이페이즈 억제능을 가진 한약재의 비교평가
신미래 ( Mi-rae Shin ),안효진 ( Hyo-jin An ),이영철 ( Young Cheol Lee ),서부일 ( Bu-il Seo ),노성수 ( Seong-soo Roh ) 대한본초학회 2017 大韓本草學會誌 Vol.32 No.4
Objectives:In this study, the inhibitory activities of Korean Medicine against pancreatic lipase in vitro and biochemical analyses in vivo were measured to determine its possibility as a well-matched sauce material with chicken. Methods:The inhibitory activity on pancreatic lipase enzyme of 11 samples were evaluated in vitro and then 5 samples were selected. The activity of pancreatic lipase was investigated using orlistat as a positive control. Animals were divided into eight groups (n =7). The experimental groups except for normal group were fed 60% high-fat diet for 7 days. 5 samples were orally administered at a dose of 200 ㎎/㎏ body weight and orlistat were orally administrated at a dose of 60 ㎎/㎏ body weight for 7 days. Biochemical anaylses of 5 samples were executed based on lipid parameters analysis. Results:Korean Medicines with an IC50 of below 1 ㎎/㎏ were Scutellariae Radix, Gardeniae Fructus, Theae Folium Coptidis Radix, and Mori Cortex Radicis. Body weight change of Mori Cortex Radicis reduced significantly, however fecal triglyceride couldn`t regulate effectively. The most excellent inhibitory effect of pancreatic lipase showed in Scutellariae Radix treatment and also regulated significantly serum triglyceride and total cholesterol. Moreover, the supplementation of Coptidis Radix excreted meaningfully triglyceride to fece. Conclusions:In conclusion, Coptidis Radix may exert anti-obesity effect by directly inhibiting pancreatic lipase, which would prevent the absorption of lipid from the small intestine. Besides, Mori Cortex Radicis may led to the decrease of the body weight via the different pathway.
Bowen모양 구진증의 임상, 병리조직학적 소견 및 추적관찰
서기석 ( Kee Suck Suh ),노효진 ( Hyo Jin Roh ),전영승 ( Yeong Seung Jeon ),류현열 ( Hyun Yul Rhew ),김상태 ( Sang Tae Kim ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.11
Background: Bowenoid papulosis occurs primarily on the genitalia of young adults and this is characterized by multiple, apparently benign maculopapular lesions. Bowenoid papulosis shows the histopathological findings of a squamous cell carcinoma in situ, but it follows a largely benign clinical course. If it is misdiagnosed as malignant tumor, unnecessary excessive therapy may be performed. Therefore, exact recognition of this entity is important. Objective: The purpose of this study is to examine the clinical and histopathologic features and outcomes of Bowenoid papulosis. Methods: Twelve patients who had been diagnosed with Bowenoid papulosis between June 1996 and September 2007 were reviewed clinicopathologically. Results: The mean age of the patients was 34.8 years (range: 23∼57 years), and the mean duration of Bowenoid papulosis until presentation was 6.3 months (range: 5∼48 months). Nine patients were males and 3 patients were females. Eleven patients (92%) had multiple lesions. The average size of the individual lesions was 1.4×0.6 cm in diameter. The colors of the papules were red to black. Seven of 9 male patients had lesions on the penile shaft, with 6 of those occurring at the proximal shaft. The other 2 male patients had lesions on the scrotum and perianal area, respectively. Three female patients had lesions on the labium major, labium major and clitoris, and perianal area respectively. Nine patients (75%) presented without symptom and 3 (25%) presented with mild pruritus. The histopathologic features were as follows: a rete ridge of approximately equal length and breadth throughout the entire lesion (100%), skipped areas of normal keratinocytes between zones of atypical keratinocytes (100%). necrotic keratinocytes (92%), parakeratosis (83%), mitotic figures (83%), vacuolated cells resembling owl`s eyes (83%), multinucleated cells (67%), residual changes of typical condyloma acuminatum (17%), involvement of acrotrichia (100%) and involvement of acrosyringia (100%). Eleven patients were effectively treated with surgical excision (8 patients), CO2 laser (2 patients), diphenylcyclopropenone (DPCP) and immunotherapy (1 patient) and 1 patient underwent biopsy only. We followed 12 patients for an average 78.1 months (from 24 to 137 months). During this period, no recurrence or malignant transformation was observed. Conclusion: Bowenoid papulosis shows a form of squmaous cell carcinoma in situ for its histopathology, but it hardly ever progresses to squmaous cell carcinoma. On our long term follow-up, there was no malignant transformation. Thus, excessive treatment of Bowenoid papulosis by amputation of the external genitalia is not necessary. Therefore, a through understanding of the clinical and histopathologic features of this entity is necessary for making the diagnosis, the treatment planning and determining the prognosis. (Korean J Dermatol 2008; 46 (11): 1463∼1469)
Granulocyte Colony-Stimulating Factor (G-CSF) 투여 후 비정형 골수세포와 혈관염을 보인 약진
서기석 ( Kee Suck Suh ),이진우 ( Jin Woo Lee ),노효진 ( Hyo Jin Roh ),최수영 ( Soo Young Choi ),도기승 ( Ki Seung Doh ),김상태 ( Sang Tae Kim ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.10
Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic growth factor (HGF) with many applications in cancer therapy. Many cutaneous adverse reactions associated with G-CSF have been reported in recent years, including injection site reactions, pyoderma gangrenosum, Sweet`s syndrome, cutaneous leukocytoclastic vasculitis, and widespread folliculitis. We report a case of vasculitis with atypical myeloid cell induced by G-CSF on the lower extremities (Korean J Dermatol 2007;45(10):1078∼1082)
서기석 ( Kee Suck Suh ),이진우 ( Jin Woo Lee ),노효진 ( Hyo Jin Roh ),최수영 ( Soo Young Choi ),도기승 ( Ki Seung Doh ),김상태 ( Sang Tae Kim ) 대한피부과학회 2007 大韓皮膚科學會誌 Vol.45 No.8
Palmoplantar lichen planus is a rare, localized variant of the disease that may create difficulty in diagnosis if it is present as an isolated finding. As palmoplantar lichen planus do not usually have the classically clinical features of lichen planus, a biopsy is very useful. Histopathologic findings are identical to classic lichen planus. According to literature, similar lichen planus may be found elsewhere on the body in palmoplantar lichen planus. We report a case of lichen planus limited to the soles in a 50 year-old female, who presents with erythematous hyperkeratotic crusted pruritic plaques on both soles. (Korean J Dermatol 2007;45(8):855∼857)
서기석 ( Kee Suck Suh ),이진우 ( Jin Woo Lee ),노효진 ( Hyo Jin Roh ),최수영 ( Soo Young Choi ),도기승 ( Ki Seung Doh ),김상태 ( Sang Tae Kim ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.1
Morphea is a rare, sclerotic connective tissue disorder and is thought to be caused by a decreased collagenase activity. Numerous treatment modalities have been tried, such as infiltration with glucocorticosteroid, D-penicillamine, antimalarial agents and cyclosporine. However, all have shown only limited success. We report a case of a 21 year-old female with localized scleroderma, who showed a marked improvement after localized therapy with high dose UVA-1. (Korean J Dermatol 2007;45(1):76~78)
김상태 ( Sang Tae Kim ),백재우 ( Jae Woo Baek ),김태권 ( Tae Kwon Kim ),이진우 ( Jin Woo Lee ),노효진 ( Hyo Jin Roh ),서기석 ( Kee Suck Suh ),전영승 ( Young Seung Jeon ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.1
We report here on a case of a patient who experienced fever, skin eruption and lymphadenopathy 1 month after the beginning of vancomycin treatment. Generalized mild pruritic erythematous pin-head to rice-grain sized confluent scaly papules and plaques appeared on the whole body. Skin biopy showed the characteristic findings of pseudolymphoma mimicking mycosis fungoides. The skin lesions and general symptoms improved after discontinuation of vancomycin and starting steroid therapy. The patient was diagnosed with pseudolymphoma syndrome due to vancomycin. Pseudolymphoma syndrome shows clinical features that are different from those of usual drug eruptions, and the histologic findings are similar to mycosis fungoides. Thus, a thorough understanding of the clinical and histologic features of this entity may aid making a diagnosis, establishing treatment plans and determining the prognosis. (Korean J Dermatol 2009;47(1):71~74)
기저세포암, 피부전이암과 유사한 조직소견을 보인 안검 외 피지선암 1예
김상태,노효진,서기석 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.1
Backgroud : Extraocular sebaceous carcinoma is a malignant tumor derived from the adnexal epithelium of sebaceous glands. A poorly differentiated sebaceous carcinoma shows variable histopathologic findings and mimics other primary tumor and cutaneous metastases mostly composed of clear cells. Case : Our patient consultation was requested for a 53 year?old female with solitary mild painful tumor on the scalp. The first histopathlogic impression of this case was basal cell carcinoma on the other hospital. After reevaluation, our diagnosis is not basal cell carcinoma but extraocular sebaceous carcinoma. Conclusion : A thorough exact recognition of characteristic histopathologic features of extraocular sebaceous carcinoma is necessary for making diagnosis, treatment plan and determining the prognosis.