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자궁경부 상피내종양에서 p16(INK4a)와 pRb의 이상 발현과 고위험 군 인유두종바이러스 감염 및 재발의 상관성에 관한 연구
남은지 ( Eun Ji Nam ),김혜연 ( Hye Yeon Kim ),김상운 ( Sang Woon Kim ),윤보성 ( Bo Sung Yoon ),김재훈 ( Jae Hoon Kim ),김영태 ( Young Tae Kim ),김재욱 ( Jae Wook Kim ),조남훈 ( Nam Hoon Cho ),김성훈 ( Sung Hoon Kim ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.7
Objective: The purpose of this study was to identify the abnormal expressions of p16(INK4a) and pRb in cervical intraepithelial neoplasia (CIN), and then to determine the relationship between the levels of p16(INK4a) and pRb and high risk HPV infection and recurrence. Methods: The study group was composed of 265 formalin-fixed, paraffin-embedded tissue array sections of the uterine cervix collected from women who had underwent biopsy, conization or hysterectomy at our hospital from January 2001 to December 2003. Immunohistochemical stainings for p16(INK4a) and pRb were performed and the association of pRb and p16(INK4a) expressions with clinical features was analyzed retrospectively. Results: There was positive correlation between p16(INK4a) expression rate and grade of cervical lesion. Meanwhile, there was reverse correlation between pRb expression rate and grade of cervical lesion. The expression rate of p16(INK4a) was higher (33%) in CIN I with high risk HPV infection, than in CIN I without high risk HPV infection (19%). In all CIN lesions, the mean expression rate of p16(INK4a) was lower in recurred group than in those which did not recur. In CIN(II) and CIN(III), the mean expression rate of pRb was higher in recurred group than in those which did not recur. Conclusion: With increasing CIN grade, abnormal expression of p16(INK4a) was increased, but pRb expression was decreased. Relatively decreased p16(INK4a) expressions and increased pRb expressions significantly cooperate to predict a recurrence of the CIN lesions.
난소의 성숙낭성기형종에서 기원한 편평상피세포암의 임상병리학적 고찰
김민경 ( Min Kyoung Kim ),남은지 ( Eun Ji Nam ),김재욱 ( Jae Wook Kim ),김영태 ( Young Tae Kim ),김재훈 ( Jae Hoon Kim ),김상운 ( Sang Wun Kim ),윤보성 ( Bo Sung Yoon ),김혜연 ( Hye Yeon Kim ),곽동욱 ( Dong Wook Kwak ),김성훈 ( Su 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.7
Objective: The aim of this study was to evaluate clinicopathologic characteristics of squamous cell carcinoma arising from ovarian mature cystic teratoma and to determine whether SCC Ag and CA 125 are useful serum markers for diagnosing this tumor. Methods: From January 1990 to December 2005, 1266 patients diagnosed with ovarian mature cystic teratoma were reviewed. Of the 1266 patients, 8 patients which had squamous cell carcinoma arising from mature cystic teratoma were evaluated in this study. A retrospective analysis of clinicopathologic characteristics and disease-free survival rate was performed. Results: The incidence of squamous cell carcinoma arising from ovarian mature cystic teratoma was 0.7% (8/1266). The mean age of the patients was 47.3 years (range, 32-72 years). Five patients (62.5%) had clinical FIGO stage I disease and three patients (37.5%) had stage III disease. The mean tumor diameter was 13.3㎝. The mean SCC Ag level was 0.3 ng/mL which was normal and the mean CA 125 was slightly increased to 68.5 U/mL. The mean disease free survival was 58.4 months and 2-year disease-free survival was 62.5% (5/8). Out of 8 patients, one patient died and one out of 7 patients who survived had recurrence. Age, clinical FIGO stage, grade, residual tumor, postoperative treatment were not significant prognostic factor for disease- free survival. Conclusion: The incidence of squamous cell carcinoma arising from ovarian mature cystic teratoma in our institute was lower and survival rate was relatively higher compared to previous studies. SCC Ag and CA 125 were not helpful tumor markers in diagnosing squamous cell carcinoma arising from ovarian mature cystic teratoma. Age, grade, residual tumor, postoperative treatment were not significant prognostic factor for disease-free survival.
Platinum 제제가 포함된 항암화학요법을 받은 부인암 환자에서의 당뇨병 발생 위험
손가현 ( Ga Hyun Son ),남은지 ( Eun Ji Nam ),김상운 ( Sang Wun Kim ),김재훈 ( Jae Hoon Kim ),김영태 ( Young Tae Kim ),김성훈 ( Sung Hoon Kim ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.2
Objective: To assess the association between platinum-based chemotherapy for gynecologic malignancy and the risk of diabetes mellitus. Material and Methods: We analyzed retrospectively the association between platinum-based chemotherapy and diabetes mellitus. Out of the 449 patients who received the chemotherapy in Severance Hospital from January 2002 to December 2005, 169 patients with serial measurements of fasting blood glucose throughout the chemotherapy period were enrolled in this study. The parameters that were analyzed included age, past history, family history, body mass index (BMI), serum glucose, type of cancer, chemotherapy regimen, dose cycle, time after cycle. We performed binomial test to compare the incidence in our patients with that of general population. Results: In 8 patients (4.8%) diabetes mellitus developed during the treatment period. The median age of patients was 57 years, and the mean BMI was 27.0 kg/m2. All patients received platinum-based chemotherapy and seven of them received cisplatin based regimen and two patient was given carboplatin based regimen. Median cisplatin cumulative dose up until the diabetes mellitus occurred was 252 mg/m2 and that of carboplatin was 812 mg/m2. Median time until the diagnosis of diabetes mellitus after administration of the first chemotherapy cycle was 7 months. The overall incidence of hyperglycemia (4.8%) in patients treated with platinum-based chemotherapy is higher than the incidence of diabetes mellitus in the general population (2.1%). Conclusion: We suggest that regular monitoring of serum glucose levels which is not generally included in the pre-chemo lab values in patients receiving chemotherapy with platinum based regimen should be considered.
유방암이 진단된 젊은 한국 여성에서 발견한 크루켄버그종양
권하얀 ( Ha Yan Kwon ),남은지 ( Eun Ji Nam ),김상운 ( Sang Wun Kim ),김영태 ( Young Tae Kim ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.10
Metastasis of breast cancer to lung, bone and liver is common, but metastasis to ovaries is rare in Korea. A 31-year-old woman diagnosed with breast cancer was referred to our department due to a newly detected adnexal mass via abdomen sonography during regular check-up. Imaging studies revealed solid mass on left ovary and enlarged lymph nodes. She underwent a laparotomy including hysterectomy, bilateral salpingo-oophorectomy, lymphadenectomy, with a suspected impression of primary ovarian neoplasms or Krukenberg tumors. Pathologic findings revealed metastatic adenocarcinoma from breast cancer involving left ovary and paraaortic lymph nodes. To our knowledge, this is the youngest Korean patient with Krukenberg tumors from the breast. In Korea, since the average age affected by breast cancer is younger than in the West, and the incidence and the mortality of breast cancer has increased, possible ovarian metastasis should be kept in mind when Korean patient with breast cancer visits for follow-up.
이재욱 ( Jae Wook Lee ),남은지 ( Eun Ji Nam ),윤보성 ( Bo Sung Yoon ),김상운 ( Sang Wun Kim ),김재훈 ( Jae Hoon Kim ),김영태 ( Young Tae Kim ),김재욱 ( Jae Wook Kim ),김호근 ( Ho Keun Kim ),김성훈 ( Sung Hoon Kim ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.11
Ovarian fibromas originating primarily from the ovarian stroma are rare, accounting for approximately 4% of all ovarian neoplasm. The ovarian fibromas are mostly benign tumors, but infrequently they have histologically malignant appearances such as hypercellularity, high mitotic rate, marked nuclear pleomorphism. Malignant fibromatous tumor can be categorized on the basis of prognosis into two separate types of tumors, one of which is cellular fibroma (one to three miotic counts per 10 high power fields) and the other of which is fibrosarcoma (over four miotic counts per 10 high power fields) that has extremely poor prognosis. We report a case of large ovarian fibrosarcoma accompanied with pregnancy and have a brief review of literatures.
이마리아 ( Maria Lee ),정용욱 ( Yong Wook Jung ),이산희 ( San Hui Lee ),백지흠 ( Ji Heum Paek ),남은지 ( Eun Ji Nam ),김영태 ( Young Tae Kim ),김상운 ( Sang Wun Kim ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.9
Laparoscopic hysterectomy is currently considered the standard procedure in many patients who need hysterectomy. To reduce incisional morbidity and improve cosmetic outcomes we performed transumbilical single-port total laparoscopic hysterectomy using a special single three-channel port and standard laparoscopic tools with virtually no scar. We used an Alexis wound retractor (Applied Medical, CA, USA) and a surgical glove as the single three-channel port. In this paper, we report four cases of total laparoscopic hysterectomy performed exclusively through an umbilical incision using a single three-channel port.