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전이성 대장암 환자에서 동시성 및 이시성 간전이 종양의 Cyclooxygenase (COX)-1과 Cyclooxygenase (COX)-2 및 E-cadherin 발현의 의의
주선형(Sun Hyung Joo),김범수(Bum Soo Kim),최성일(Sung Il Choi),송정윤(Jeong Yoon Song),이길연(Kil Yeon Lee),김윤화(Yun Wha Kim),김교영(Gyo Young Kim),이석환(Suk Hwan Lee),이상목(Sang Mok Lee),홍성화(Sung Wha Hong) 대한외과학회 2010 Annals of Surgical Treatment and Research(ASRT) Vol.78 No.3
Purpose: Recent studies have shown that cyclooxygenase (COX)-2 may be involved in colorectal carcinogenesis. In this study, we evaluate the differences of COX-2 expression in patients with synchronous and metachronous hepatic metastasis of colorectal cancer. In addition, the expression of COX-1 and E-cadherin were also evaluated. Methods: Paraffin embedded blocks were obtained from 41 patients who underwent surgery for colorectal cancer with hepatic metastasis. Samples from primary colorectal cancer, synchronous and metachronous hepatic lesions were stained by immunohistochemistry for monoclonal antibody against COX-1, COX-2, and E-cadherin. Results: In colonic COX-1 expression, there was no significant difference in the degree of COX-1 expression between primary colorectal cancer with synchronous hepatic metastasis and that of metachronous hepatic metastasis (P=0.507). In colonic COX-2 and E-cadherin expression, the degree of COX-2 expression was not different between the two groups. But, the patient survival rate in the positive group of COX-1 and COX-2 expression was lower than in the negative group, respectively (P=0.023, P=0.006). Conclusion: The degree of colonic COX-1 and COX-2 expression has an impact on prognosis in synchronous and metachronous hepatic metastasis. Further large-scale study is necessary to determine the meaning of COX-2 expression in colorectal cancer.
가토 간내 선택적 담관결찰후 간부피의 변화에 대한 실험적 연구
이혜원,윤엽,고영태,최우석,임주원,오주형,임형택,김윤화,이석환,Lee, Hye Won,Yoon, Yup,Ko, Young Tae,Choi, Woo Suk,Lim, Joo Won,Oh, Joo Hyeong,Rim, Heyong Teck,Kim, Youn Wha,Lee, Seok Hwan 대한영상의학회 1998 대한영상의학회지 Vol.39 No.6
Purpose : To evaluate the role of bile duct obstuction in the development of atrophy of the liver, using ananimal model. Materials and Methods : Seven rabbits were divided into two groups : group 1(n=5), in which therewas selective bile duct ligation, and group 2(n=2), which underwent a sham operation. Each group was evaluatedusing CT for changes in hepatic volume after selective bile duct ligation or a sham operation. In group I, thediameter of dilated bile duct was measured 2, 4, 8, 12 and 16 weeks after bile duct ligation, while gross andhistologic change were evaluated in all cases. Results : In group 1, bile duct dilatation was seen on CT two weeksafter selective bile duct ligation, and did not change significantly during follow-up. In four of five cases, CTrevealed no evidence of significant atrophy of the involved segment. Pathologic specimens, however, revealeddilatation of the bile duct, periductal fibrosis, infiltration of chronic inflammatory cells, and periportalfibrosis. One of five cases showed segmental liver atrophy after selective bile duct ligation. In addion to theabove pathologic findings, there was obstruction of the portal vein by foreign body reaction. In group 2, noevidence of dilated bile duct or liver atrophy was revealed by CT or pathologic specimen after a sham operation.Conclusion : During long-term follow-up of 16 weeks, obstruction of the bile duct did not play a major role in thedevelopment of lobar atrophy in the rabbit.