산전진찰로 진단이 가능했던 Beckwith-Wiedemann 증후군 1례

김수곤 ( Su Kon Kim ),김정아 ( Jung A Kim ),장영표 ( Young Pyo Chang ),박진완 ( Jin Wan Park ),허의종 ( Eui Jung Hur ) 대한주산의학회 2002 大韓周産醫學會雜誌 Vol.13 No.1

Beckwith-Wiedemann 증후군은 1963년 Beckwith와 1964년 Wiedemann에 의해 처음 기술된 증후군으로서 대설증, 제대기형, 거대증, 화염상모반, 신생아 저혈당증, 적혈구 과다증, 부신피질세포 거대증, 신수질 이형성, 췌장의 소포나 섬세포의 이상증식 등의 임상적, 병리학적 이상이 다양하게 나타나는 질환이다. 현재 전세계적으로 200례 정도 보고되고 있으며, 국내에서도 몇례가 보고되고 있다. 본 저자들은 최근 본 병원에서 출생한 신생아로서 35주 5일에 3,505gm의 거대증, 거설증, 구개순열, 제류, 오른쪽 이개의 주름을 동반한 Beckwith-Wiedemann 증후군 한 예를 경험 하였기에 문헌 고찰과 함께 보고 하는 바이다. Beckwith-Wiedemann syndrome(BWS) is a group of disorders having in common coexistence of a macrosomia, macroglossia, abdominal wall defects, visceromegaly, hypoglycemia in the neonatal period and embryonal cancers of infancy and early childhood. Beckwith-Wiedemann first reported this distinct clinical entity, and about 200cases have subsequently been reported. Etiology is usually sporadic. BWS is a multigenic disorder with dysregulation of the expression of imprinted genes involved in growth and cell cycle control in the 11p15.5 chromosomal region. Placental endocrine dysfunction leading to increased levels of growth hormone and insulin-like growth factors would causes the visceromegaly. Early visceromegaly may pedispose to omphalocele, malrotation anomalies, and diaphragmatic herniation. Detection and treatment of hypoglycemia in any neonate with features of this syndrome are critical. The frequency of hypoglycemia in this population is between 30 and 50%. The majority of infants with hypoglycemia will be asymptomatic and have resolution of the hypoglycemia within the first 3 days of life. Less than 5% of infoots will have hypoglycemia beyond neonatal period one requive either continous feeding or a partial pancreatectomy. We have experienced and case of Beckwith-Wiedemann syndrome so that we report with brief review of the concerned literature.

인간난관상피세포 및 Vero 세포가 생쥐배아의 발생에 미치는 영향에 대한 연구

김수곤(Su Kon Kim),박진완(Jin Wan Park),허의종(Eui Jong Hur) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.6

Objective : The purpose of the study was to determine the effects of co-culture with oviductal epithelial cells and Vero cells on mouse embryo. Method : For the control group, mouse embryos were cultured alone in Ham`s F-10 with 10% FBS. Subcultured oviductal epithelial cell and Vero cell were cocultured in Ham`s F-10 with 10% FBS with the mouse embryo and used as the treatment group. Development of mouse embryos were observed. Result : The development rate and hatching rate of embryos that cocultured with oviductal epithelial cell and Vero cell was significantly higher (p<0.05) than control group. When subcultured oviductal epithelial cells were co-cultured with mouse embryo, there was no significant difference in development rate and hatching rate among subculture step. When oviductal epithelial cells that have been frozen-thawed were co-cultured with mouse embryo, there was no significant difference in development rate and hatching rate among subculture step. No statistical significance was seen in the development rate and hatching rate between subcultured oviductal epithelial cells and frozen-thawed oviductal epithelial cells when cocultured with mouse embryo, Vero cells and frozen-thawed when cocultured with mouse embryo, and Vero cells and oviductal epithelial cells when cocultured with mouse embryo. Conclusion : Oviductal epithelial cells and Vero cell may have a stimulatory role in early mouse embryonal development compared to control in vitro. As well, there is no significant difference in development rate and hatching rate among subculture step, when early mouse embryo was cocultured with cells that subcultured and frozen-thawed.

악성 난소 섬유난포막종

김수곤 ( Su Kon Kim ),박진완 ( Jin Wan Park ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.3

Fibrothecomas are mesenchymal tumors deriving from the ovarian stromal and consisting of theca-like elements and fibrous tissue. They are common, but their malignant counterpart is extraordinarily rare. Classical malignant fibrothecomas are said to show four or more mitotic figures per 10 high power fields. We have experienced a rare case of malignant ovarian fibrothecoma in a 72-year-old postmenopausal woman. We report a case with brief review of literature.

성폭력 피해자에 대한 분석: 충남 원스톱지원센터 내원자를 중심으로

김수곤 ( Su Kon Kim ),박예규 ( Ye Kyu Park ),강윤단 ( Yun Dan Kang ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.10

Objective The aim of this study was to identify characteristics of female victims of sexual assault. Methods The subjects were 207 female patients who visited Chungcheongnam-do One-stop Service Center as victims of sexual assault from January 13th, 2010 to January 12th, 2012. The medical records of victims of sexual assault were analyzed retrospectively. Results Of 207 sexual assault victims, 48.3% were under 19 years of age. Summer was relatively vulnerable season for sexual assaults, vulnerable time was between 14 to 18 o`clock for victims younger than 13 years and between 22 to 2 o`clock for victims older than 13 years. Most frequent place was hotel for victims older than 13 years and was victim`s house victims younger than 13 years. 50.7% of assailants were strangers to the victims. The detection rate of sperm was 22.4% and the follow up rate was 30.7%. 27.5% of victims were injured and 2% of victims were pregnant. Conclusion There were several differences between sexual assaults committed by strangers and those committed by acquaintances. Sexual assaults committed by acquaintances lasted for a longer period of time than those committed by strangers. All victims of sexual assault need some sort of urgent intervention. This study provides more accurate information about epidemiology of sexual assaults.

복강경수술로 치료된 거대난소종양

김수곤 ( Su Kon Kim ),김종수 ( Jong Soo Kim ),박충학 ( Choong Hak Park ),박진완 ( Jin Wan Park ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.7

Mucinous ovarian tumors account for 15% all ovarian neoplasms, of which giant variants rarely occur. Recently huge ovarian cysts (more than 12 kg) are now rarely seen because of the development in health care systems and education. The patient is 26-yearold nulligravida female who presented with abdominal distension. A laparoscopic left salpingo-oophorectomy was performed. Laparoscopic approach to giant ovarian cyst may be difficult regarding the risk of cyst rupture and limited working space. To reduce the limitations of the laparoscopy, we performed laparoscopy after aspirating the cystic contents. During laparoscopy, abdominal cavity was explored by the scope. Cyst contained about 53 L of fluid. The histopathologic examination revealed a borderline mucinous tumor of the left ovary. Laparoscopic excision of giant ovarian cyst seems to be safe and applicable treatment modality.

Inductively Coupled Plasma를 이용한 SnO 박막의 식각 특성 연구

김수곤(Su-Kon Kim),박병옥(Byung-Ok Park),이준형(Joon-Hyung Lee),김정주(Jeong-Joo Kim),허영우(Young-Woo Heo) 한국표면공학회 2016 한국표면공학회지 Vol.49 No.1

The dry etching characteristics of SnO thin films were investigated using inductively coupled plasma (ICP) in Ar, CF₄, Cl₂ chemistries. the SnO thin films were deposited by reactive rf magnetron sputtering with Sn metal target. In order to study the etching rates of SnO, the processing factors of processing pressure, source power, bias power, and etching gas were controlled. The etching behavior of SnO films under various conditions was obtained and discussed by comparing to that of SiO₂ films. In our results, the etch rate of SnO film was obtained as 94nm/min. The etch rates were mainly affected by physical etching and the contribution of chemical etching to SnO films appeared relatively week.

알칼리 전해액의 상호작용에 의한 Stainless Steel 주성분의 변화 분석

변창섭,임수곤,김수곤,최호상,신훈규,Byun, Chang-Sub,Lim, Soo-Gon,Kim, Su-Kon,Choi, Ho-Sang,Shin, Hoon-Kyu 한국전기전자재료학회 2013 전기전자재료학회논문지 Vol.26 No.7

In this paper, We studied the change of surface and variation of elements on both electrodes of hydrogen generator of alkaline electrolysis in use of FE-SEM and SIMS. We used the stainless steel 316(600 ${\mu}m$) as electrode in condition of 25%KOH, $60^{\circ}C$ Temperature. The results show that the intensity of elements (C, Si, P, S, Ti, Cr, Mn, Fe, Ni, Mo) of Positive Electrode are decreased as much as about $10^1{\sim}10^3 $than the original electrode. Thickness of Positive Electrode is decreased about 40 ${\mu}m$ after chemical reaction. The negative electrode, however, shows a slight variation in the intensity of elements (C, Si, P, Fe, Ni, Mn, Mo) but Change of thickness and surface' shape of electrode show nothing after chemical reaction. The change in thickness and variation of Stainless Steel 316 cause the lifetime of electrode to be shorted. We also observed hydrogen, oxygen, potassium in both electrodes. Especially, The potassium is increased in proportional with depth of positive electrode. this means the concentration of alkali solutions is changed. and so we have to supply alkaline solution to generator in order to produce same quantity of hydrogen gas continuously. we hope that this study gives a foundation to develop the electrode for hydrogen generator of alkaline electrolysis.

알칼리 수전해 수소제조의 이온 교환막 변화 분석

변창섭,임수곤,김수곤,신훈규,Byun, Chang-Sub,Lim, Soo-Gon,Kim, Su-Kon,Shin, Hoon-Kyu 한국전기전자재료학회 2013 전기전자재료학회논문지 Vol.26 No.7

We investigated the variation of anion exchange membrane of hydrogen generator of alkaline electrolysis. We detected the variation of elements and change of anion exchange membrane using EDS and FE-SEM. We detected two different sites of membrane because of different structure of membrane. $Sp_1$ shows that the distribution ratio of C, O, Al is 98% very higher than $Sp_2$ of 78%. Especially, the main elements of STS316 which is P, S, Fe, Ni were more detected at $Sp_2$ than $Sp_1$. We think that this result depends on the structure of membrane. This also affect the resistance, lifetime of membrane and decrease the efficiency of hydrogen production. We hope that this article is a foundation of developing of hydrogen production technology.

임신 중 발생된 심상성 천포창

김종수 ( Jong Soo Kim ),김수곤 ( Su Kon Kim ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.12

Pemphigus vulgaris is an uncommon, autoimmune disease characterized by acantholysis and blister formation in the skin and mucosa. Pemphigus vulgaris during pregnancy is exceedingly rare. The disease may be associated with adverse neonatal outcome, including prematurity and fetal death. The clinical features of this patient were similar to those of pemphigoid gestationis. Circulating antibodies directed at desmosomal proteins may cross the placenta and place children at risk for neonatal pemphigus. Transient skin lesions may occasionally appear in the neonate. We report a case of pemphigus vulgaris in a 32-yearold pregnant woman who showed erythematous bullae, erosions and crusts on the whole body. She was diagnosed by clinical and histopathological findings, direct immunofluorescent test. This patient was treated with high dose of corticosteroids to control the disease.

선천성 처녀막 폐쇄증에 의한 질 및 자궁유혈종 2 예

진건(Keon Jin),김수곤(Su Kon Kim),최재호(Jae Ho Choi) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.10

Imperforate hymen is a rare congenital malformation. Two cases of imperforate hymen regarded to congenital origin, and formed hematocolpometra. In most instances definite finding is noticed after menarche as retention of menstrual flow results in abdominal pain, distension of the lower abdomen and often in acute urinary retention. Two cases of imperforate hymen associated with hematocolpora, hematometra and abdominal distension at age of 14 and 16 were treated satisfactorily by simple crucial incision of hymen, and drained of about 800 cc and 600 cc of tarry blood respectively. We present two cases of imperforate hymen with review of the literatures.