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- 저자 : 김선목 ( Sun Mok Kim ) (검색결과 4 건)
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증례 : 완전 관해를 얻은 결합조직형성 소원형세포종양 1예
김선목 ( Sun Mok Kim ),박지현 ( Ji Hyun Park ),김정석 ( Jung Seok Kim ),김민수 ( Min Soo Kim ),장정은 ( Jung Eun Jang ),황희상 ( Hee Sang Hwang ),서철원 ( Cheol Won Suh ) 대한내과학회 2012 대한내과학회지 Vol.83 No.3
결합조직형성 소원형세포종양은 주로 소아나 젊은 연령의 남성에서 발생하는 드문 종양으로 비교적 최근에 독립된 질환으로 분류되었으며, 아직 표준화된 치료법이 없는 예후가 나쁜 암이다. 저자들은 고용량의 복합항암화학 요법 외에도 방사선치료 그리고 두 차례의 수술의 적극적인 국소 요법을 병행하여 만 23개월째 무질병 상태로 생존한 환자 1예를 경험하였으며, 처음부터 완전한 근치적 절제가 불가능한 경우라도 고용량의 항암화학 요법에 반응이 있는 경우 적극적인 국소 치료의 병행이 환자의 생존을 연장시키는 중요한 치료 전략임을 강조하고자 문헌고찰과 함께 보고하는 바이다. A desmoplastic small-round-cell tumor (DSRCT) is a rare, aggressive neoplasm that develops mostly in the abdominal cavity in children and young adults. We present a case of a 19-year-old male with right upper quadrant discomfort for 3 months. On abdominal computerized tomography, multiple huge and demarcated masses were found in the liver, retroperitoneal lymph nodes, and peritoneal and retroperitoneal cavities. Fine needle aspiration biopsy of the hepatic mass was performed and DSRCT was diagnosed by hematoxylin and eosin staining and immunohistochemical analysis. He was treated initially with high-dose systemic chemotherapy (alternating schedules of cyclophosphamide, vincristine, doxorubicin, ifosfamide, and etoposide), underwent two debulking surgeries and pelvic irradiation between systemic chemotherapy schedules, and achieved complete remission after the 15 months of treatment duration. We report this case to emphasize the importance of aggressive local treatment modalities as well as high-dose systemic chemotherapy for treatment of DSRCT even with initially unresectable or extensively metastatic presentation.
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혈액종양 : Anthracycline 기반 항암화학요법에 반응을 한 염증성 근섬유모세포종
김달용 ( Dal Yong Kim ),박한승 ( Han Seung Park ),김선목 ( Sun Mok Kim ),박지현 ( Ji Hyun Park ),홍용상 ( Yong Sang Hong ),이재련 ( Jae Lyun Lee ),서철원 ( Cheok Won Suh ) 대한내과학회 2012 대한내과학회지 Vol.82 No.6
염증성 근섬유모세포종에 대한 정립된 치료 방침은 없다. 수술이 완치를 위한 치료로 알려져 있으나 조직 검사상 염증세포의 침윤이 있고 기존에 보고된 증례들을 바탕으로 하여 스테로이드 또는 비스테로이드성 염증약물도 하나의 치료 방침이 될 수 있겠다. 본 증례와 같이 급속히 진행하는 종양의 경우 연부 조직 육종에 준한 anthracycline 기반 항암 화학요법을 시행하는 것이 질병을 조절하고 생존기간의 연장하는 데에 적절한 선택이 될 수 있을 것으로 보이며 이것을 뒷받침하기 위한 추가 연구가 필요하겠다. An inflammatory myofibroblastic tumor (IMT) is a rare disease entity, and the clinical characteristics range from indolent to aggressive forms. No established management for patients with unresectable or aggressive IMT is available. We report on a 62-year-old patient with aggressive IMT who achieved a durable partial response lasting 12 months after anthracycline-containing cytotoxic chemotherapy without corticosteroids. The patient was admitted for an evaluation of progressive weight loss and lower abdominal pain lasting for 2 weeks. Abdominopelvic computed tomography revealed a 10 cm sized heterogeneous mass in the mesentery that encased the superior mesenteric artery and a liver metastasis. The diagnosis of IMT was confirmed by percutaneous core needle biopsy of the mesenteric mass. Systemic chemotherapy was performed after confirming disease progression during a 1 month observation period. A partial response was obtained after two cycles of chemotherapy. Anthracycline-containing cytotoxic chemotherapy could be a treatment option for patients with aggressive IMT.
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오세운(Se-woon Oh),이창현(Chang-hyun Lee),김선목(Sun-mok Kim),임덕진(Deok-jin Lim),이기백(Ki-beak Lee) 대한전기학회 2021 전기학회논문지 Vol.70 No.1
In this paper, we propose a novel multi-object distinction method with class-agnostic object detection and class retreival. Multi-object distinction is usually divided into the processes of detecting and classifying an object. Since it is common for industrial applications to add new kinds of objects to be recognized, it is inefficient to re-train the system every time the new object is added. Thus, the propose method employs two deep learning models to solve this problem. 1) Class agnostic object detection model to predict the bounding boxes regardless of the classes of objects and 2) Class retrieval model to determine the classes of the objects. The experimental results show that the proposed method successfully detects and classifies the both experienced and inexperienced objects: the final classification accuracy for 15 learned objects was 98.0%, and for the other 30 new objects that had not been learned. the accuracy was 87.7% on average.
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애디슨병 환자에게 리팜핀 투여 후 발생한 급성 부신피질기능 저하증 1예
강종식,고광범,이재준,김민수,전성진,최광현,김선목,이우제 영남대학교 의과대학 2012 Yeungnam University Journal of Medicine Vol.29 No.1
Adrenal insufficiency during the treatment of pulmonary tuberculosis is a troublesome condition and can at times be lifethreatening if untreated. Rifampin is one of the most widely prescribed anti-tuberculosis agents. Further- more, rifampin has been known to be capable of affecting the metabolism of various medications, including glucocorticoids. In this paper, a case of recurrent adrenal insufficiency induced by rifampin during the treat- ment of pulmonary tuberculosis is reported. The patient was a 63-year-old man who was diagnosed with Addison’s disease 17 years earlier and had been undergoing glucocorticoid replacement therapy. Five months before, the patient manifested pulmonary tuberculosis and was immediately given anti-tuberculosis medication that included rifampin. After one week of medication, general weakness and hyponatremia occurred. Despite the increased dose of the glucocorticoid medication, the adrenal insufficiency recurred many times. Since the substitution of levofloxacin for rifampin, the episodes of adrenal insufficiency have not recurred so far.
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