지도모양 혀와 균열 혀를 동반한 전신성 농포성 건선 2예

김병국,윤재일 ( Byoung Kook Kim,Jai Il Youn ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.2

Generalized pustular psoriasis is a rare disease, even psoriasis involving oral mucosa is very rare. There are many reports of tongue lesions in patients with psoriasis that are clinically and histologically indistinguishable from geographic tongue, and there are many reports of fissured tongue in association with psoriasis. It has been debated whether oral psoriasis exists or not, or occurs as part of generalized pustular psoriasis. We experienced two cases of combined geographic tongue and fissured tongue in patient with generalized pustular psoriasis, and report these cases with review of the literature about the oral lesions in psoriasis, geographic tongue, and fissured tongue. (Kor J Dermatol 1997;35(2): 383-387)

UVB 에 의한 홍반반응 및 색소반응의 Dose - response Angle과 피부의 자외선 감수성 지표들과의 상관관계에 관한 연구

김병국,박석범,윤재일 ( Byoung Kook Kim,Seok Beom Park,Jai Il Youn ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.6

Background: There are many predictors of sensitivity to UVR, but controversies exist about their objectivity, correlation bet,ween them, and applicability to various races. Objective : In 42 healthy volunteers, we assessed the validaty of dose response angle of erythe ma(DRAE) and delayed tanning(DRADT) after UVB irradiation, and also evaluated the correlation hetween dose-response angb s and other predictors of UV sensitivity. Methods : We measured erythema and melanin index using reflectance spectrophotometer aft,er irradiation of UVB on the back of 42 males. When the erythema index and melanin index were plotted against UV doses for each patient, a dose response curve was obtained. Linear regression analysis was used to calculate the slope of those curves for erythema and delayed tanning, which were called DRAE and DRADl respectively. Also we checked predictots of UV sensitivity such as skin type, MED, MMD, consiitutional and facult,ative skin color, then analyzed the relation be tween dose response angles and other predictors. Results : Statistically significa it linear regression lines were obtained from 41 subjects regar d- ing to erythema and frorn 31 subjects regarding to delayed tanning. As for the relationship he tween the pvedictors of UV senitivity, only the MED correlated well with DRAE. Conclusion : We found that dose response angles, especially DRAE, were an objective and adequate predictor of cutaneous LJV sensitivity, but could not find validity of skin type and skin color in Koreans. A more organized study with a larger number of subjects is needed to clarify the usefulness of the predictors. (Korean J Dermatol 1997;35(6): 1177-1183)

동종 골수이식에 의한 만성 골수성 백혈병의 치료

김병국(Byoung Kook Kim),이진학(Jin Hak Lee),박선양(Seon Yang Park),이제환(Je Hwan Lee),양성현(Sung Hyun Yang),서철원(Cheol Won Suh),이재훈(Jae Hoon Lee),김승택(Seung Taik Kim),김은실(Eun Shil Kim),최강원(Kang Won Choe),오명돈(Myung D 대한내과학회 1994 대한내과학회지 Vol.47 No.2

Objectives: We report the results of 11 patients with chronic myelogenous leukemia treated with allogeneic bone marrow transplantation using marrow cells from HLA-identical sibling donors, Methods: Patients with chronic myelogenous leukemia less than 40 years of age were eligible for study entry. Bone marrow donors were HLA-identical siblings. The conditioning regimens consisted of busulfan plus cyclophosphamide or cyclophosphamide plus total body irradiation, and cyclosporin-A was given to pre- vent graft-versus-host disease. Patients were managed in reverse isolation and received oral gut decontamination. Supportive cares such as transfusion and empirical antibiotics were done. Results: Seven patients were male, and four female. Median age was 27 years (range 18-36 years), and nine patients were in chronic phase at the time of transplantation, and two patients in accelerated phase. Donors had a median age of 35 years (range 15-42 years): two were male, and nine female. Median interval from diagnosis to transplantation was 13 months (range 3-26 months). Median duration of severe neutropenia (neutrophil < 0.5 x 10/L) was 20 days (range 16-42 days). Six patients developed grade I-II acute graft-versus- host-disease, mainly involving the skin. Four patients developed chronic graft-versus-host-disease, which mainly involved oral mucosa and skin. Four patients relapsed cytogenetically within 12 months posttransplant. Five patients developed infections within 30 days posttransplant, three had pneumocystis carinii pneumonia after 100 days posttransplant. Six patients were alive after median follow-up of 25 months, and the median leukemia-free survival of all patients was 6 months (range 3.5-75 months). Three patients died from relapse, and two from interstitial pneumonitis. Conclusion: This report confirms high probability of the cure of chronic myelogenous leukemia with allogeneic bone marrow transplantation, especially in chronic phase, and showed milder complications associated with transplantation than previous reports.

볼엔드밀 가공에서 런아웃 측정을 통한 가공성 평가에 관한 연구

김병국(Byoung-Kook Kim),박희범(Hee-Bum Park),이득우(Deug-Woo Lee),김정석(Jeong-Suk Kim),정융호(Yoong-Ho Jung) Korean Society for Precision Engineering 1999 한국정밀공학회지 Vol.16 No.10

윤상 농포성 건선 4예

김병국 ( Byoung Kook Kim ),윤재일 ( Jai Il Youn ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.1

Annular pustular psoriasis is a rare variant of the generalized pustular psoriasis characterized by subacute onset of annular lesions with pustules on the advancing edge. Compared with the Zumbusch type, annular type is less severe and has a more benign course, and it is known to respond more rapidly to therapy. Histologically, spongiform pustules are seen in the epidermis and discrimination from subcorneal pustular dermatosis may be difficult. We report four cases of annular pustular psoriasis. Two cases were adult female patients who had been given long-term systemic corticosteroid therapy. In the other two patients who were a 9-year-old female and a 10-year-old male respectively, we could not find any provocating factor of pustular psoriasis. There was a past history of psoriasis vulgaris in three cases, although none had any family history of psoriasis. (Kor J Dermatol 1996;34(1): 155-159)

장티브스 및 각종 감염성 질환에서 말초혈청 중성구의 Nitroblue Tetrazolium 색소 환원에 관한 연구

김병국 ( Byoung Kook Kim ) 대한내과학회 1973 대한내과학회지 Vol.16 No.1

This present study was performed to evaluate the linical usefulness of the NBT test and to take any preliminary information abut the mechanism of neutrophilic phagocytosis through this test, in 150 cases with healthy normal population and various infectiou

Retinoid - 변형 Ingram 법에 의한 건선의 치료효과 및 호전기간

김병국 ( Byoung Kook Kim ),윤재일 ( Jai Il Youn ),장승호 ( Seung Ho Chang ) 대한피부과학회 1996 大韓皮膚科學會誌 Vol.34 No.2

Background: Although treatment with etretinate or modified Ingram method is effective for psoriasis, both regimens have limitations beeause of the risk of long-term toxicity. Objective : We performed retinoid-modified Ingram combination therapy expecting greater therapeutic efficacy and less side effect. Methods : Thirty three plaque-form psoriasis patients were included. Pretreatment with etretinate for 1 to 2 weeks was followed by modified Ingram therapy in combination with etretinate. Results : l. Among 33 patients, clearing was shown in 26 patients(78.8%), 4 patients(12.1%) was improved, and 3 patients(9.1%) showed failure. The number of cleared patient was 13/15 (86.7% ) in moderate group, and 13/18 (72.2%) in severe group. 2. In cleared patients, the mean numbers, duration, and total dose of UVB therapy reaching grade 4 were 11.9, 24.5 days, 1348.5 mJ/cm in trunk, and 13.5, 29.1 days, 1733.3 mJ/cm in extremities. Their differences between trunk and extremities were not statistically significant (p>0.05). 3. In cleared patients, the mean numbers, duration, total dose of phototherapy, and total close of etretinate reaching grade 4 in severe group were not significantly higher than them in moderate group (p>0.05). 4. There were some side effects of etretinate such as cheilitis, dry mouth, and side effects of modified Ingram therapy such as erythema, pruritus. But there was no discontinuation of therapy due to side effect. 5. In 22 patients who were followed up at least,one year, the mean remission time was 14.9 months in moderate group and 6.9 months in severe group. Conclusion : Our study suggests that retinoid-modified Ingram regimen is effective and tolerable in the treatment of psoriasis, especially in severe group. (Kor J Dermatol 1996;34(2): 240-247)

비타민 D 결핍이 동반된 다발성 연속적 골단판 손상

김병국(Byoung-Kook Kim),김용근(Yong-Gun Kim),이호재(Ho-Jae Lee),최대성(Dae-Sung Choi),단진명(Jinmyoung Dan) 대한정형외과학회 2018 대한정형외과학회지 Vol.53 No.6

최근 신체의 다양한 조직과 세포에서 면역과 증식, 분화를 조절하는 기능이 알려진 비타민 D는 정형외과 영역에서는 칼슘과 인 대사에 관여하여 뼈 발육과 성장, 건강한 골격 유지에 필수적인 역할을 하며, 특히 청소년기 비타민 D의 부족은 뼈의 무기질화에 영향을 주어 구조적인 결함을 야기하여 골절의 위험의 증가와 골절 치유에 부정적인 영향을 미친다. 저자들은 여러 부위의 성장판에 연쇄적인 골절이 발생한 13세 소아 환자에서 비타민 D 결핍이 다발 부위의 연쇄적 골절의 가능한 원인으로 확인하였다. 비타민 D 결핍이 골절 발생에 중요한 원인이므로 비타민 D의 투여가 부상에서 성공적으로 회복하고 추가적인 골절을 방지하는 데 중요함을 보고한다. Vitamin D plays a major role in bone metabolism, and its deficiency has an impact on fracture risk and healing. Low vitamin D levels are a cause of poor bone mineralization and have been associated with a significantly higher risk of physeal injury in children. This paper presents a case of a 13-year-old boy with a vitamin D deficiency, who sustained multiple sequential epiphyseal injuries at various areas. This report suggests that vitamin D deficiency is not only a significant cause of the clinical disease itself, but also an important factor affecting the successful recovery of injuries.

치과 임플란트 분야의 특허분석을 통한 정량적 기술수준평가

김병국(Byoung-Kook Kim),김광만(Kwang-Mahn Kim),김영진(Young Jin Kim) 대한치과재료학회 2015 대한치과재료학회지 Vol.42 No.1

The rapid advancement of technology has changed the business environment to a great extent. Recognizing technological leadership as the mainstay of competitive strength, most companies make an increasing investment in research and development activities. Along this line, this study outlines the evaluation of technology levels for different countries by analyzing an extensive amount of patent information in dental implant systems. Dividing technologies relevant to dental implant into three categories (i.e, fixture, abutment and surface treatment), extracted and analyzed are 2,873 patents registered in Patent Cooperation Treaty (PCT), the United States, EU, Japan and Korea for the last 20 years from 1994 to 2013. The patent trend analysis revealed that Korea came to the second place after the United States in terms of the number of patent applications. In particular, the ratio of patent applications by technology category indicated that a relatively large portion of research has been directed to the category of surface treatment in Korea. On the other hand, Korea is placed last in terms of overall technology level mainly due to the lack of cites per patent. The results of this study may provide valuable information for developing strategies for ensuring the sustained growth and market leadership in the future.

조혈모세포 이식 후 발생한 급성 신부전의 원인과 급성 신부전이 예후에 미치는 영향

김세중(Se Joong Kim),김성균(Seong Gyun Kim),오윤규(Yoon Kyu Oh),김현리(Hyun Lee Kim),김연수(Yon Su Kim),안규리(Cu Rie Ahn),한진석(Jin Suk Han),박선양(Seon Yang Park),김성권(Shung Gwon Kim),김병국(Byoung Kook Kim),이정상(Jung Sang Lee 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.3

배 경 : 조혈모세포 이식(hematopoietic stem cell transplantation; HCT) 후 합병증으로 패혈증(sepsis), 이식편대숙주반응(graft versus host disease; GVHD), 정맥폐색성 질환(venoocclusive disease; VOD), 약물에 의한 부작용(drug induced nephrotoxicity; DT), 급성 신부전(acute renal failure; ARF) 등이 있다. HCT 후 발생하는 ARF는 환자의 생존율에 영향을 미치는 것으로 알려져 있으나 우리나라에서의 연구는 미흡한 실정이다. 저자들은 HCT 후 ARF의 발생빈도, 위험인자를 살펴보고, ARF의 발생이 HCT 후 환자의 예후에 미치는 영향을 알아보고자 본 연구를 시행하였다. 방 법 : 1985년부터 2000년까지 서울대학교병원에서 HCT를 받은 환자 163명 중 분석이 가능하였던 107명을 대상으로 하였다. 결 과: HCT 후 ARF는 총 107명의 환자 중 52명(48.6%)에서 발생하였다. VOD, sepsis, GVHD 중 VOD가 ARF의 위험도를 4.4(1.13-17.2)배 증가시켰다(p<0.05). ARF의 원인은 시기에 따라 차이가 있었으나, cyclosporin 신독성이 전 기간에 걸쳐 ARF의 주된 원인이었다. ARF 발생군에서 전체 생존율은 60%였으며, ARF 비발생군(NARF)에서는 73%로, ARF 발생군에서 생존율이 낮았다(p<0.05). ARF 발생군을 최고 혈청 크레아티닌 3.0 ㎎/dL을 기준으로 경증과 중증 ARF로 나누어, NARF 군, 경증 ARF 발생군, 중증 ARF 발생군을 비교하였을 때, 중증 ARF 발생군에서 생존율이 낮았다(p<0.01). 결 론 : HCT 후 VOD, sepsis, GVHD 등이 ARF의 위험도를 증가시켰으나, ARF의 주된 원인은 cyclosporin 신독성이었다. ARF는 중증인 경우 HCT를 받은 환자의 예후를 결정하는 인자였다. Background : Common complications after hematopoietic stem cell transplantation(HCT) include sepsis, graft versus host disease(GVHD), veno-occlusive disease(VOD), drug-induced nephrotoxicity, and acute renal failure(ARF). Prior studies report that the presence of ARF affects prognosis. However, we are unaware of such reports on the incidence of ARF after HCT in Koreans, and whether or not the development of ARF is related to prognosis. The purpose of our study was to investigate the cause of ARF after HCT and its relation to prognosis. Methods : 163 patients received HCT at Seoul National University Hospital since 1985, of which, 107 were available for review. Results : ARF after HCT developed in 52 patients (48.6%). In the three clinical causes, VOD, sepsis, and GVHD, risk factor related to the development of ARF was preexisting VOD. Logistic regression confirmed this association(odds ratio 4.4). The causes of ARF were different according to the periods it developed, and cyclosporin nephrotoxicity was the main cause through the whole period after HCT. The overall survival was worse in the ARF group(60 vs 73 %; p<0.05). ARF group was split into two groups : patients whose peak serum creatinine levels were below 3.0 ㎎/dL(mild ARF group) and those who were above 3.0 ㎎/dL(severe ARF group). Severe ARF group had worse survival than mild ARF group and patients without ARF(p<0.01). Conclusion : VOD, sepsis, GVHD after HCT increase the risk of the deveolopment of ARF, but cyclosprin nephrotoxicity is the main cause of ARF. Severe ARF is a factor influencing the prognosis of patients who received HCT.