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한국인 조현병 환자에서CNR1 유전자의 (AAT)n 삼핵산 반복 다형성과 안구추적운동 이상에 대한 연합 연구
김민재,김채리,박진완,백두현,신형두,최인근,한상우,황재욱,이연정,우성일,Kim, Min Jae,Kim, Chae-Ri,Park, Jin Wan,Pak, Doo Hyun,Shin, Hyoung Doo,Choi, Ihn-Geun,Hahn, Sang Woo,Hwang, Jaeuk,Lee, Yeon Jung,Woo, Sung-Il 대한생물정신의학회 2016 생물정신의학 Vol.23 No.4
Objectives According to previous studies, the cannabinoid receptor 1 (CNR1) gene could be an important candidate gene for schizophrenia. Some studies have linked the (AAT)n trinucleotide repeat polymorphism in CNR1 gene with the risk of schizophrenia. Meanwhile, smooth pursuit eye movement (SPEM) has been regarded as one of the most consistent endophenotypes of schizophrenia. In this study, we investigated the association between the (AAT)n trinucleotide repeats in CNR1 gene and SPEM abnormality in Korean patients with schizophrenia. Methods We measured SPEM function in 167 Korean patients with schizophrenia (84 male, 83 female) and they were divided according to SPEM function into two groups, good and poor SPEM function groups. We also investigated allele frequencies of (AAT)n repeat polymorphisms on CNR1 gene in each group. A logistic regression analysis was performed to find the association between SPEM abnormality and the number of (AAT)n trinucleotide repeats. Results The natural logarithm value of signal/noise ratio (Ln S/N ratio) of the good SPEM function group was $4.34{\pm}0.29$ and that of the poor SPEM function group was $3.21{\pm}0.70$. In total, 7 types of trinucleotide repeats were identified, each containing 7, 10, 11, 12, 13, 14, and 15 repeats, respectively. In the patients with $(AAT)7$ allele, the distributions of the good and poor SPEM function groups were 18 (11.1%) and 19 (11.0%) respectively. In the patients with $(AAT)_{10}$ allele, $(AAT)_{11}$ allele, $(AAT)_{12}$ allele, $(AAT)_{13}$ allele, $(AAT)_{14}$ allele and $(AAT)_{15}$ allele, the distributions of good and poor SPEM function groups were 13 (8.0%) and 12 (7.0%), 4 (2.5%) and 6 (3.5%), 31 (19.8%) and 35 (20.3%), 51 (31.5%) and 51 (29.7%), 36 (22.2%) and 45 (26.2%), 9 (5.6%) and 4 (2.3%) respectively. As the number of (AAT) n repeat increased, there was no aggravation of abnormality of SPEM function. Conclusions There was no significant aggravation of SPEM abnormality along with the increase of number of (AAT)n trinucleotide repeats in the CNR1 gene in Korean patients with schizophrenia.
기저부를 갖는 축대칭 수중운동체의 저항예측에 관한 수치적 연구
김민재,Kim, Min-Jae 한국군사과학기술학회 2010 한국군사과학기술학회지 Vol.13 No.3
The objective of this study is to predict the drag of an axisymmetric underwater vehicle with bluff afterbody using CFD. FLUENT, commercial CFD code, is used to simulate high Reynolds number turbulent flows around the vehicle. The computed drag coefficients are compared to available experimental data at various Reynolds numbers. Four widely used two-equation turbulence models are investigated to evaluate their performance of predicting the anisotropic turbulence in a recirculating flow region, which is caused by flow separation arising from the base of the vehicle. The simulations with Realizable ${\kappa}-{\varepsilon}$ and ${\kappa}-{\omega}$ SST turbulence models predict the anisotropic turbulent flows comparatively well and the drag prediction results with those models show good agreements with the experimental data.
Streptozotocin으로 유도된 당뇨 랫드에서 황칠나무 잎 열수추출물의 항당뇨 효과
김민재,강예진,이동언,김석,임세훈,이후장,Kim, Min-Jae,Kang, Ye-Jin,Lee, Dong-Eon,Kim, Suk,Lim, Se-Hun,Lee, Hu-Jang 대한수의학회 2021 大韓獸醫學會誌 Vol.61 No.4
This study examined the anti-diabetic effects of aqueous extracts of Dendropanax morbifera leaves (DMWEs) in streptozotocin-induced diabetic Sprague-Dawley (SD) rats. Thirty male SD rats (body weight [BW], 250.4 ± 19.7 g) were divided into the following six groups: normal control rats (NC), diabetic control rats (DC), diabetic rats treated with metformin HCl 100 mg/kg BW (DT), diabetic rats treated with DMWEs 50 mg/kg BW (DM-50), diabetic rats treated with DMWEs 100 mg/kg BW (DM-100), and diabetic rats treated with DMWEs 200 mg/kg BW (DM-200). From two weeks of administration of DMWEs, the BW of all groups treated with DMWEs increased significantly compared to DC (p < 0.05). At four weeks after treatment, the blood glucose levels in DT, DM-100, and DM-200 decreased below 200 mg/dL, while the glycated hemoglobin concentrations in all groups administered DMWEs were similar to those of NC and DT. Regarding the blood biochemical parameters, the levels of aspartate transaminase, alanine transaminase, blood urea nitrogen, and creatinine in DM-100 and DM-200 were similar to those in NC and DT. Overall, these results highlight the effectiveness of DM-100 in the treatment of diabetes.
김민재,강수경,전양현,홍정표,어규식,Kim, Min-Jae,Kang, Soo-Kyung,Chun, Yang-Hyun,Hong, Jung-Pyo,Auh, Q-Schick 대한안면통증구강내과학회 2013 Journal of Oral Medicine and Pain Vol.38 No.2
하행성 억제계란 중뇌, 연수, 뇌교에 존재하는 해부학적 유해수용 조절성 기전을 일컫는 용어이다. 이들 부위를 전기적으로 자극을 하면 진통효과가 나타나며, 하행성 억제계의 실패시 지속적인 통증이 야기된다는 것을 알 수 있다. 또한 우울불안 같은 질환은 만성 신경병성 통증 상태로 쉽게 진행됨이 밝혀졌다. 이러한 요인들이 만성 신경병성 통증에 영향을 주는 경로는 아마도 하행성 억제계일 가능성이 있다. 흥미롭게도, 광범위하게 하행성 억제계가 작동하지 않을 경우 과민성 대장증상이 호발하는 것으로 보인다. 또한 이러한 환자들은 높은 불안, 우울 지수가 관찰되기도 한다. 다양한 연구에서, 하행성 억제계에 관여하는 ${\alpha}2$ 아드레날린성 약물, 아편유사약물들이 만성 통증에 사용될 수 있음을 동물에서 평가 중이다. 아직 신체내에서 얼마나 하행성 억제계가 일어나고 있는가에 대해서는 임상적으로 증명하기 힘든 감이 있지만, 여러 감각 신경기전의 수정에 중요한 구실을 하고 있는 것으로 믿어진다. 즉 중추신경계는 대상을 인식하기 위해 말초정보를 받아들이는 기능만 있는 것이 아니라 여러 방법으로 정보의 홍수를 조절하고 선택하는 기능을 동시에 갖추고 있는 것으로 생각된다. The descending control system is composed of a group of structures in the midbrain, medulla oblongata and pons that form a network of descending inhibitory projections. In the clinical setting, it has been shown that the application of a electrical counterirritant to these structures and diminishes the pain in patients. Thus, depression and anxiety have been shown to predict the development of chronic neuropathic pain state. These factors could influence pain might also involve descending controls. Interestingly, reduced descending controls are seen in patients with irritable bowel syndrome and theses patients had greater anxiety, depression compared to controls. And, the influence of anxiety on the chronicity of pain and on the descending control pathways should be tested in animal models, using modern techniques. Given this Knowledge, it is no wonder that pain is a highly personal experience that is susceptible to a variety of biologic, pharmacologic, and environmental influences.