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RISS 인기검색어
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- 저자 : 권오주(Oh-Joo Kwon) (검색결과 4 건)
- 무료
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권오주,Kwon, Oh-Joo 대한생물정신의학회 2001 생물정신의학 Vol.8 No.2
The completion of the rough draft of the human genome is a remarkable achievement. It provides the overall structures of huge DNA molecules that constitute the genome and an outline of the information needed to create a human being. This paper reviewed new ideas, projects, and scientific advances made by the Human Genome Project. We also discussed the future of medicine and biomedical research in postgenomic era.
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채동욱,권오주,이은정,김병철,Chae, Dong Wook,Kwon, Oh Joo,Lee, Eun Jeoung,Kim, Byoung Chul The Korean Fiber Society 2016 한국섬유공학회지 Vol.53 No.5
Dynamic rheological properties of polyacrylonitrile (PAN)/dimethylformamide (DMF) solutions were measured at several different temperatures ($25-55^{\circ}C$), and their electrospinning was conducted at corresponding temperatures to prepare PAN precursor fibers. The electrospun fibers were subsequently converted to carbon nanofibers through a carbonization process and their physical properties such as electrical conductivity, morphology and crystal structure were examined with regard to the electrospinning temperature. The dynamic viscosity of PAN/DMF solutions decreased with increasing temperature, exhibiting a lower Newtonian flow region followed by shear thinning. In the Cole-Cole plot, the initial slope decreased with decreasing temperature but a single master curve of constant slope above the inflection point was observed regardless of the temperature. FESEM images showed that the diameter of the PAN precursor fibers and resulting carbon nanofibers decreased as the electrospinning temperature increased. The diffraction peak of carbon nanofiber in the WAXD pattern was shifted from 22 to $24^{\circ}$. Further, Raman spectroscopy showed that the graphitic carbon peak at $1600cm^{-1}$ increased with increasing electrospinning temperature. In addition, the electrical conductivity of the carbon nanofiber increased considerably from 2.95 to 6.15 S/cm with increasing electrospinning temperature from 25 to $55^{\circ}C$.
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고지방식 사료를 섭취한 어린 쥐에서 Topiramate가 체중 증가 및 혈중 인슐린과 렙틴 농도에 미치는 영향
조경순(Kyoung Soon Cho),권오주(Oh Joo Kwon),김영훈(Young Hoon Kim),이인구(In Goo Lee) 대한소아신경학회 2010 대한소아신경학회지 Vol.18 No.2
Purpose : Topiramate is an antiepileptic drug used widely in the treatment of epil- epsy. It has also been reported to reduce body weight in humans and is currently used for eating disorders and obesity; little is known about the mechanism by which this drug induces weight loss. This study was carried out to investigate the effects of topiramate on weight and serum levels of insulin and leptin in young rats fed high fat diet (HFD). Methods : Forty male Wistar rats (4 weeks old) were randomly divided into four groups (diet, regular diet and high fat diet, treatment, topiramate and placebo). Topi- ramate (50 mg/kg/day) was orally administered via gastric gavage twice a day for 4 weeks. Food intake and body weight were monitored throughout the study. After 4 weeks, the plasma levels of glucose, triglycerides, free fatty acids, leptin, and insulin were determined. Results :We found significant reduction in body weight gain after topiramate admi- nistration in the HFD group (topiramate, 351.6 ± 28.6g; placebo, 397.6 ± 28.4g) (P < 0.05). Topiramate was able to reduce food intake in both diet groups (P <0.05). Fur- ture, fasting glucose levels were significantly lower in both topiramate groups than placebo groups (P <0.05), and serum leptin levels in the HFD group were decreased (P <0.05). Additionally, there was no significant difference in serum levels of triglycerides, free fatty acids, or insulin between the four groups. Conclusion : Topiramate significantly inhibited body weight gain by reducing food intake, especially in the HFD group and reduced serum levels of glucose in both diet groups and of leptin in the HFD group.
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유문간(Mun-Gan Rhyu),김진(Jin Kim),이원철(Won Chul Lee),주천기(Choun-Ki Joo),박조현(Cho-Hyun Park),권오주(Oh-Joo Kwon),김명석(Myung-Suk Kim) 한국의학교육학회 1999 Korean journal of medical education Vol.11 No.2
Over the past years, university administrators have known how hard it is to transform into the modern university. Rigid in-bred research system, narrow interest, unworkable graduate programs are complicatedly woven into a network of academic fraction. Cronyism and protectionism flood various laboratories and research institutes affiliated with the university. Until recently, the department structure of medical school has steadfastly guarded its territory and refused to allow non-medical undergraduate students to apply for the graduate schools of medical science. The graduate schools in medical science are considered just extra appendages because most of graduate students should be engaged in hard work position such as junior faculty or residentship training course of university hospital. In the present environment of graduate program, medical schools are consequently not able to bring in full-time young researchers, but only recently has its door been open for others. It should be time to reorganize the medical school graduate course into large multidisciplinary research group by expanding graduate programs.
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