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유행성 이하선염성 고환염 환자의 불임에 대한 Interferon ${\alpha}$-2B의 예방 효과
구자현,임용순,이창호,김영호,송윤섭,전윤수,김민의,이남규,박영호,Ku, Ja-Hyeon,Yim, Yong-Soon,Lee, Chang-Ho,Kim, Young-Ho,Song, Yun-Seob,Jeon, Youn-Soo,Kim, Min-Eui,Lee, Nam-Kyu,Park, Young-Ho 대한생식의학회 1999 Clinical and Experimental Reproductive Medicine Vol.26 No.1
Postpubertal mumps may result in ochitis and permanent testicular atrophy may develop following infection. This present study was initiated to evaluate the preventive effect of interferon-${\alpha}2B$ on infertilty after mumps orchitis. There were 21 patients with mumps orchitis between May 1990 and June 1997. Patients were randomly distributed into 2 groups: group 1 patients (n=13) maintained therapy with interferon-${\alpha}2B$ ($3{\times}10^6$ IU per day) and group 2 were managed by conservatively. All of the patients were evaluated with testis size measurement, mumps virus titer, hormone level, and if possible semen analysis. For group 1 patients symptoms disappeared within 2 to 3 days and the volume of testis returned to normal within 11 days and testis atrophy was not observed in all patients in follow up. But asthenospermia was continued in 4 patients (unilateral 2, bilateral 2). For group 2 patients symptoms disappeared within 5 to 6 days and the volume of testis returned to normal within 10 days and testis atrophy was observed in 3 patients (unilateral 2, bilateral 1) in floow up. Asthenospermia was continued in 4 patients (unilateral 2, bilateral 2). Sperm count and morphology were recovered all the recover in group 1, 4 patients had persistent reduced sperm count and morphology in group 2, respectively. These observations suggest that systemic interferon-${\alpha}2B$ treatment is highly effective in preventing infertilty as well as testicular atrophy after mumps orchitis.
윤형도,이한영,구자현,장진현,박종훈,이경식,Yoon, Hyung-Do,Lee, Han-Young,Ku, Ja-Hyon,Chang, Jin-Hyeon,Park, Jong-Hoon,Lee, Kyung-Shik 대한전자공학회 1999 電子工學會論文誌, D Vol.d36 No.11
온도보상용 광섬유격자필터를 실현하기 위하여 서로다른 열팽창계수를 갖는 두물질을 이용하여 패키징을 한 후 -10도부터 70도 사이에서 온도변화실험을 하였다. 그결과 003nm이하의 파장변화율을 보여 상기온도 범위내에서 일반의 온도보상되지 않는 광섬유 격자에 비하여 약 30배의 온도보상 효과를 보였다. To temperature-compensate the Bragg wavelength of fiber grating filters two materials with different thermal expansion coefficients were depolyed for packaging. After temperature-compensation packaging the maximum difference of the Bragg wavelength in the temperature range of $-10^{\circ}C$ to $70^{\circ}C$ was 0.03nm, which is only about one thirtiety of the Bragg wavelength shift of the temperature-uncompensated fiber grating filter.
김명(Myong Kim),구자현(Ja Hyeon Ku) 대한비뇨기종양학회 2013 대한비뇨기종양학회지 Vol.11 No.3
Peri-operative intravesical instillation of chemotherapy in non-muscle invasive bladder cancer (NMIBC) is one of the options for adjuvant therapy after the transurethral resection of bladder tumor (TURBT). Early instillation is known tosuppress the implantation of tumor cells. Meta-analysis of postoperative immediate instillation of chemotherapy showed that treatment reduced the risk of recurrence up to 39%. Most guidelines recommended the routine application of postoperative immediate instillation within 24 hours after the TURBT in the low- to intermediate-risk NMIBC. However, efficacy of postoperative immediate instillation of chemotherapy in the high-risk NMIBC has not been well established. Although numerous researches implied that postoperative immediate instillation maybe effective, recent randomized controlled trials could not prove it. Therefore, the role of postoperative immediate instillation in the high-risk NMIBC has not been confirmed, although some guidelines also recommend that procedure in this group. The well-designed, large-sized randomized controlled trials are needed to verify this issue.
Hyuk-Dal Jung(정혁달),Hyeong Dong Yuk(육형동),Ulanbek Balpukov,Ja Hyeon Ku(구자현),Cheol Kwak(곽철),Hyeon Hoe Kim(김현회),Chang Wook Jeong(정창욱) 대한비뇨기종양학회 2020 대한비뇨기종양학회지 Vol.18 No.3
Purpose: To evaluate the clinical usefulness of the Seoul National University Prostate Cancer Risk Calculator (SNU-PCRC) to reduce unnecessary prostate biopsy and to increase the detection rate of high-risk cancer. Materials and Methods: We retrospectively analyzed 546 patients who underwent prostate biopsy between 2014 and 2016. The subjects were divided into 2 groups based on the type of risk calculator used: conventional and SNU-PCRC group. In the SNU-PCRC group, prostate biopsy was recommended when the probability of SNU-PCRC was more than 30%. Results: The SNU-PCRC group had significantly smaller prostate volume (p=0.010) and significantly more digital rectal examination and transrectal ultrasonography (TRUS) abnormalities (p=0.011 and p=0.010, respectively). Overall detection (71.9% vs. 32.1%) and high-risk cancer detection rates (40.6% vs. 19.3%) were significantly higher in the gray zone (prostate-specific antigen=4-10 ng/mL) (p<0.001 and p=0.006). The group with prostate cancer risk ≥30% on the SNU-PCRC compared to <30% group, overall detection rate of 72.3% versus 30.2% and high-risk detection rate of 60.6% versus 18.3% were significantly different (p<0.001 and p<0.001). Applying the SNU-PCRC to the conventional group could avoid unnecessary prostate biopsy in 50.6%. Conclusions: SNU-PCRC is clinically useful to reduce unnecessary prostate biopsy and increase overall detection rate and high-risk cancer detection rate.
Minhyun Cho(조민현),Sangjun Yoo(유상준),Juhyun Park(박주현),Chang Wook Jeong(정창욱),Ja Hyeon Ku(구자현),Cheol Kwak(곽철),Hyeon Hoe Kim(김현회),Min Chul Cho(조민철),Hyeon Jeong(정현) 대한비뇨기종양학회 2018 대한비뇨기종양학회지 Vol.16 No.2
Purpose: We evaluated the prognostic value of the 5-tiered grade group in Korean patients who underwent radical prostatectomy. Materials and Methods: Between 1996 and 2016, a number of 2,883 consecutive patients who underwent radical prostatectomy were included for the analysis. The impacts of biopsy and pathologic grade group on predicting biochemical recurrence (BCR) were assessed using multivariate analysis. Median follow-up duration was 49.0 months. Results: Mean age was 66.5 years and prostate-specific antigen (PSA) was 11.8 ng/mL. Prostate cancer was locally advanced on magnetic resonance imaging in 13.4%. Biopsy grade group was as follows: 1 (46.8%), 2(19.8%), 3 (14.2%), 4 (14.1%), and 5 (5.1%). Pathology stage was ≤T2 in 63.6%, T3a in 26.0%, and T3b/T4 in 10.4% patients. Pathologic grade was as follows: 1 (31.3%), 2 (37.9%), 3 (20.2%), 4 (4.7%), and 5 (5.1%). In multivariate analysis using biopsy-related variables, biopsy grade group (1, reference; 2, hazard ratio [HR], 1.771; p=0.001; 3, HR, 2.736; p<0.001; 4, HR, 2.966; p<0.001; 5, HR, 3.707; p<0.001) was associated with BCR-free survival, PSA level and % positive core. In multivariate analysis using pathologic outcomes, pathologic grade group(1, reference; 2, HR, 1.882; p<0.001; 3, HR, 3.352; p<0.001; 4, HR, 3.890; p<0.001; 5, HR: 3.118, p<0.001) was associated with BCR-free survival in addition to pathologic stage and positive surgical margin. Conclusions: New 5-tiered grading system could be useful for predicting oncological outcomes in Korean patients although its role for distinguishing outcomes between patients with grade groups 3.5 need to be validated before wide application of this grade system in Korea.
Genestone 190 체외충격파쇄석기를 이용한 요로결석 치료의 초기 경험
김민의,송윤섭,박영호,구자현 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2
Shock wave lithotripsy monotherapy was performed in 180 patients with urinary calculi using Genestone 190 lithotriptor between January 1996 and April 1998. Age range of the patients was 17 to 71 years (mean of 44.7 years)and male to female ratio was 2.3:1. There were 54 cases(30%) with renal calculi and 126 cases (70%) with ureteral calculi. NO regional or general anesthesia was required, but parenteral analgesics were required in some patients. The spark voltage was from 16 to 22Kv and average numbers were 2.04 sessions and the mean number of shock per session was 2230±350. The success rates of urinary calculi below 5㎜, 6-10㎜, 11-15㎜, 16-20㎜ and over 21㎜ were 95%, 94%, 91%,75% and 50%, respectively. The success rates of renal, midureter and lower ureter calculi were 85%, 98% and 73%, respectively. There were no significant complications. We think that SWL monotherapy using Genestone 190 lithotriptor is effective and safe procedure for calculi of kidney and upper ureter and calculi below 15㎜.