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      • KCI등재후보

        성인 백혈병에서 경과에 따른 혈청 Ferritin 치의 동태

        구본환(Bon Hwan Koo),손상균(Sang Kyun Shon),하승우(Sung Woo Ha),이규보(Kyu Bo Lee),황기석(Kee Suk Whang) 대한내과학회 1988 대한내과학회지 Vol.34 No.5

        N/A Serum ferritin concentrations in adult patients with various types of leukemia were studied in order to evaluate the relation between changes in serum ferritin level and the clinical course of leukemia. The subjects were composed of 103 cases of various types of leukemia in which 52 cases were AML, 30 cases ALL, and 21 cases CML. The determination of serum ferritin concentration was made by using a GammaDab®[125I] ) Ferritin Radioimmunoassay Kit. The mean values of serum ferritin concentration in normal control were 89.6±15.3(M±S.E.)ng/ml in male and 5S.18.2ng/ml in female. The mean values of serum ferritin concentration in leukemia at presentation were 607.0±88.1ng/ml in AML, 507.5±124.2ng/ml in ALL, and 233.5±49.8ng/ml in CML. There was no significant changes in the mean serum ferritin concentration during the clinical course of acute leukemia, The mean serum ferritin concentration was conspicuously increased in the blastic phase of CML, whereas that of the chronic phase was within the normal range. In acute leukemia, the increased serum ferritin concentration was not correlated with total white blood cell count, peripheral blood blast count, serum iron, TIBC, transferrin concentration, serum transaminase level, or the number of units of blood transfused. There was, however, a positive significant correlation between serum ferritin concentration and serum iron concentration in the chronic phase of CML.

      • 방사성동위원소 심혈관촬영술에서 얻은 측정치의 분석

        이규보,구본환,손혜경,황기석 慶北大學校 醫科大學 1987 慶北醫大誌 Vol.28 No.3

        저자들은 ECG gated cardiac chamber scan에서 LVEF를 계측하는데 정도관리면에서 재현성을 검토하고자 26례의 표본을 무작위로 선택하여 변이도와 상관성을 검토하였다. 수동계측방법으로 LVEF를 산출하는데 일인의 반복관찰치의 변이계수 범위는 0.012∼0.146, 변화도 범위는 0.090∼0.817, 분산지수 범위는 0.008∼0.619이었다. 이인의 관찰자가 각기 계측한 변이계수의 범위는 0.000∼0.173, 변화도 범위는 0.000∼1.212, 분산지수 범위는 0.000∼1.471이었다. 일인의 반복계측치들 사이의 상관성(r=0.94)이나, 이인 관찰자의 계측치들 사이의 상관성(r=0.93)은 매우 유의한(P<0.0001) 정상관관계가 있으므로 가치 있는 검사치라고 말할 수 있다. Authors assessed quality control by evaluating intrainterpreter and interinterpreter variations and correlations in calculation of LVEF by ECG gated cardiac chamber scans in 26 random samples from March 1987 to December 1987. Intrainterpreter variations showed 0.012∼0.146 in the range of the variation coefficient, 0.090∼0.817 in the variability, and 0.008∼0.619 in the index of dispersion. Interinterpreter variations revealed 0.000∼0.173 in the range of the variation coefficient, 0.000∼1.212 in the variability, and 0.000∼1.471 in the index of dispersion. Correlation coefficients were 0.94 in intrainterpreter variations and 0.93 in interinterpreter variations, suggesting highly significant cardiac parameters derived from ECG gated cardiac chamber scans (P<0.0001).

      • SCOPUSKCI등재

        방사성동위원소를 이용한 Gastric Emptying Time 의 연구

        하승우,이재태,이규보,구본환,손상균,황기석 대한핵의학회 1988 핵의학 분자영상 Vol.22 No.2

        A gamma camera coupled to a computer was used in 20 normal volunteers after ingestion of the mixture of Tc-99m-DTPA and milk in order to determine gastric emptyng time (GET) and to evaluate the effect of metoclopramide, a dopamine antagonist that stimulates gastric motility, to gastric emptying. The normal value for biological gastric emptying half time was found to be 63±7 minutes, and the gastric emptying was monoexponential fashion, at least for the first 60 minutes. Among the 20 volunteers, nine were repeated the test after injection of metoclopramide, which has significant1y reduced the value of GET to 31±3 minutes (p〈0.01). GET test using Tc-99m-DTPA is very useful in gastric function evaluation, especially in follow-up check of the functional change

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