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Characteristics of Appendicular Tissue Components in Patients with Rheumatoid Arthritis
구본산,윤병호 대한골대사학회 2020 대한골대사학회지 Vol.27 No.1
Background: The purpose of this study was to identify the characteristics of appendicular lean mass (ALM) associated with rheumatoid arthritis (RA) and to analyze appendicular tissue components in patients with RA. Methods: We prospectively reviewed of patients with RA who underwent dual energy X-ray absorptiometry in a single center. From data of 28 patients, ALM was calculated. Regression analysis was used to investigate the association between ALM and RA. Using propensity score matching, patients with RA were compared to the control group from 18,698 patients of Korea National Health and Nutrition Examination Surveys data. RA and control group were matched in a 1: 5, respectively. Results: In regression model, there was significantly negative association between disease activity score and ALM index in patients with RA in unadjusted (β=-0.387, 95% confidence interval [CI], -0.729 to -0.045) and model adjusted for age, sex, and body mass index (β=-0.227, 95% CI, -0.451 to -0.003). In matching with age and sex, the arms fat mass and fat fraction of RA group were significantly lower than that of control group. In matching with age, sex, and body mass index, the ALM index and legs lean mass of RA group were significantly higher than control group. Conclusions: Patients with RA have a lower ALM with higher disease activity. In addition, we found that patients with RA had different tissue component in arms and legs compared to general population.
초광대역 응용 시스템을 위한 L밴드 전압제어발진기 설계
구본산,신금식,장병준,류근관,이문규,Koo Bonsan,Shin Guem-Sik,Jang Byung-Jun,Ryu Keun-Kwan,Lee Moon-Que 한국전자파학회 2004 한국전자파학회논문지 Vol.15 No.9
본 논문에서는 TV set-top tuner용으로 사용할 수 있는 옥타브 밴드를 갖는 전압제어 발진기를 설계하였다. 측정 결과, 주파수 튜닝 범위는 0.9 GHz~2.2 GHz로써 1.3 GHz의 발진 대역을 갖는다. 광대역 튜닝과 선형성, 그리고 일정한 위상 잡음 성능을 유지하기 위해 트랜지스터의 베이스와 에미터부에 모두 4개의 배랙터 다이오드를 사용한 것이 특징이다. 개발된 전압제어발진기는 0 V~20 V의 제어 전압과 10 V, 15 mA의 공급 전력을 필요로 한다. 출력 전력은 5.3 dBm을 중심으로 약 $\pm$1.1 dB의 편차를 갖고, 위상 잡음은 전 발진 대역에서 -94.8 dBc/Hz @ 10 kHz offset 이하의 값을 보인다. 선형성은 평균적으로 65 MHz/V이고 $\pm$10 MHz의 편차를 보인다. In this paper an octave tuning voltage controlled oscillator which is used in set-top TV tuner was designed. Oscillation frequency range is 0.9 GHz~2.2 GHz with 1.3 GHz bandwidth. By using 4 varactor diodes in base and emitter of transistor, wide-band tuning, sweep linearity and low phase noise could be achieved. Designed VCO requires a tuning voltage of 0 V ~ 20 V and DC consumption of 10 V and 15 mA. Designed VCO exhibits an output power of 5.3 dBm $\pm$1.1 dB and a phase noise below -94.8 dBc/Hz @ 10 kHz over the entire frequency range. The sweep linearity shows 65 MHz/V with a deviation of $\pm$10 MHz.
구본산,Yoonah Song,Seunghun Lee,Yoon-Kyoung Sung,Kyoung-Jin Shin,Nam H. Cho,전재범 대한류마티스학회 2020 대한류마티스학회지 Vol.27 No.3
Objective. We investigated Asian mitochondrial DNA (mtDNA) haplogroups associated with knee osteoarthritis (OA) progression in a prospective community-based cohort comprised of Koreans. Methods. Epidemiologic data and Kellgren-Lawrence (K/L) scores of knee radiographs were obtained from the second (2005∼2006) and sixth (2013∼2014) follow-up, and patient DNA was analyzed. The mtDNA haplogroup frequencies (M, G, D, D4, D5, M7, M8, M9, M10, N, A, N9, R, F, and B) were compared between the progression (K/L score change on either knee ≥2 or arthroplasty) and non-progression (K/L score change on both knee ≤1) groups at the sixth follow-up. Multiple logistic regression was performed to determine relative risk (RRs) of mtDNA haplogroups for OA. Results. In total, 1,115 participants were included, 405 of whom had early OA (higher K/L score on both knees of 1 or 2). Among them, 143 and 166 patients were classified in non-progression and progression groups, respectively, at the sixth follow-up. The most frequent haplogroups, B and D4, in Koreans also showed a high frequency in our study. There were no significantly different haplogroups between the non-progression and progression groups. However, the frequency of haplogroup D4 was likely higher in the non-progression group than in the progression group, although not significantly (13.3% vs. 7.2%, RR=0.51, p=0.081 in the unadjusted model and RR=0.56, p=0.149 in the adjusted model). Conclusion. No significant haplogroups are related to OA progression. Large-scaled studies are needed to reveal the association between mtDNA haplogroups and OA.
구본산,황수빈,박서영,신지희,김태환 대한류마티스학회 2023 대한류마티스학회지 Vol.30 No.2
Objective: Although nonsteroidal anti-inflammatory drugs (NSAIDs) are the first-line treatment for ankylosing spondylitis (AS), their effect on kidney function remains unclear. This longitudinal study investigated the correlation between long-term NSAID use and kidney function in patients with AS using electronic medical records. Methods: The electronic medical records of 1,280 patients with AS collected from a single center between January 2001 and December 2018 were reviewed. The Assessment of Spondyloarthritis International Society (ASAS) NSAID Intake Score was used to determine the cumulative dose of all NSAIDs prescribed for a different time intervals. Each ASAS NSAID Intake Score was obtained for intervals of 6 months, 1 year, 2 years, 3 years, 5 years, and 10 years. The correlation between the ASAS NSAID Intake Score and final estimated glomerular filtration rate (eGFR) for each interval was investigated. Results: The mean ASAS Intake Scores for 6-month, 1-year, 2-year, 3-year, 5-year, and 10-year intervals were 55.30, 49.28, 44.84, 44.14, 44.61, and 41.17, respectively. At each interval, the pearson correlation coefficients were −0.018 (95% CI: −0.031 to −0.006, p=0.004), −0.021 (95% CI: −0.039 to −0.004, p=0.018), −0.045 (95% CI: −0.071 to −0.019, p=0.001), −0.069 (95% CI: −0.102 to −0.037, p<0.001), −0.070 (95% CI: −0.114 to −0.026, p=0.002), −0.019 (95% CI: −0.099 to 0.062, p=0.645), respectively. There was a very weak negative relationship between ASAS Intake Score and eGFR at each interval. Conclusion: Long-term NSAID use did not correlate with kidney function based on real-world data in patients with AS.
류마티스관절염에 동반된 ANCA 관련 불충분-면역성 사구체신염 2예
구본산 ( Bon San Koo ),김용길 ( Young Gil Kim ),최종기 ( Jong Gi Choi ),안용철 ( Yong Chul Ahn ),이성근 ( Seung Geun Lee ),이창근 ( Chang Keun Lee ),유빈 ( Bin Yoo ) 대한류마티스학회 2010 대한류마티스학회지 Vol.17 No.3
Renal involvement is one of the extra-articular manifestations found in patients with rheumatoid arthritis (RA). Membranous glomerulonephopathy, membranoproliferative glomeruonophritis, secondary amyloidosis, and focal segmental glomerulosclerosis are reported as pathologic diagnoses of renal involvement. However, reports of renal involvement in patients with RA and antineutrophil cytoplasmic autoantibody (ANCA)-associated pauci-immune glomerulonephritis are rare. Recently, we experienced two patients with RA who developed azotemia and were finally diagnosed with ANCA-associated pauci-immune glomerulonephritis. Because of the rarity of these cases, we report two cases in patients with RA with a literature review.
구본산 ( Bon San Koo ),송윤아 ( Yoonah Song ),이승훈 ( Seunghun Lee ),김태환 ( Tae-hwan Kim ),전재범 ( Jae-bum Jun ) 대한내과학회 2018 대한내과학회지 Vol.93 No.5
Systemic sclerosis (SSc) is a chronic autoimmune disorder characterized by endothelial and fibroblast dysfunction, resulting in progressive fibrosis of the skin and internal organs. Ankylosing spondylitis (AS) is an arthritic condition affecting the axial skeleton and peripheral joints. An association between SSc and AS is relatively rare, as the two diseases share few characteristics. Here, we present a case of limited SSc in a 44-year-old man who exhibited low-grade AS, and discuss several cases of coexisting SSc and AS in the literature. Patients with both diseases showed several common features, including male predominance, middle age, and combined interstitial lung disease. However, unlike our case, the patients reported in the literature had advanced ankylosis and diffuse SSc. (Korean J Med 2018;93:492-496)