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곽현성 ( Hyun Sung Kwack ),박호정 ( Ho Jung Park ),임선옥 ( Sun Ok Im ),류기성 ( Ki Sung Ryu ),한구택 ( Ku Taek Han ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.1
Myxoid neurofibroma is a benign tumor of perineural cell origin, which is demonstrated with a positive immunohistochemical stainig for S-100. The most common locations of the myxoid neurofibroma are face, shoulder, arm, periungual and foot. We experienced an unusual case of myxoid neurofibroma which originated from labia majora area then reported it. To our knowledge, this is the first time that a labia majora location is reported.
DES (Diethyl stilbestrol)에 노출된 경험이 없는 27세 여성에서 발생한 자궁경부 투명세포암 및 근치적자궁경부절제술 (Radical Trachelectomy)
곽현성 ( Hyun Sung Kwack ),문영주 ( Young Joo Mun ),하재은 ( Jae Eun Ha ),황선정 ( Sun Jung Hwang ),김수미 ( Su Mi Kim ),한구택 ( Ku Taek Han ),류기성 ( Ki Sung Ryu ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.9
Clear cell adenocarcinoma (CCAC) is a rare cancer that comprises less than 9% of the cervical adenocarcinoma cases. We experienced a case of fertility-sparing radical abdominal trachelectomy for cervical clear cell adenocarcinoma (CCAC). Thus, reported it. A 27 year old female was diagnosed with clinical stage Ib cervical CCAC. She had no history of maternal exposure to diethylstilbestrol and had negative PAP cytology and HPV tests. She was treated with neoadjuvant chemotherapy followed by radical abdominal trachelectomy. After 2 cycles of postoperative adjuvant chemotherapy, the lesion disappeared completely in an imaging study, and potential fertility was preserved. Radical abdominal trachelectomy with chemotherapy may be a valuable approach for treating stage Ib cervical CCAC in women that wish to preserve potential fertility.
항암제를 투여한 세포주의 배양액에서 M30을 이용한 고사의 측정
박상호 ( Sang Ho Park ),곽현성 ( Hyun Sung Kwack ),류기성 ( Ki Sung Ryu ),이영 ( Young Lee ),한구택 ( Ku Taek Han ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.5
Objective: We investigated a possible use of the induced apoptosis as a biomarker in the cells and their media treated with commonly used anti-cancer agents in gynecologic malignancies. Methods: After treatments with low and high concentrations of paclitaxel, cisplatin, and camptothecin in HeLa and OVCAR-3 cells, the levels of M30 antigen were detected in the cells and their media by immunofluorescence staining and ELISA methods, respectively. Results: The percentages of M30-fluoresein isothiocyanate (FITC) positive cells in HeLa and OVCAR-3 cells treated with paclitaxel, cisplatin, and camptothecin were 4.3% vs 18.1% vs 34.87% and 4.07% vs 18.6% vs 32.63%, 4.3% vs 17.87% vs 32.38% and 4.07% vs 16.83% vs 32%, and 4.3% vs 16.75% vs 31.3% and 4.07% vs 15.18% vs 29.9% in control, low dose, and hight dose groups, respectively (P<0.001). M30 antigen levels (U/L) measured in culture media of HeLa and OVCAR-3 cells treated with paclitaxel, cisplatin, and camptothecin were 53.03 vs 101.53 vs 355.59 and 86 vs 114.41 vs 412.04, 53.03 vs 79.84 vs 327.64 and 86 vs 125.44 vs 385.09, and 53.03 vs 88.41 vs 295.005 and 86 vs 108.42 vs 263.1 in control, low dose, and hight dose groups, respectively (P<0.001). Conclusion: Our results obtained in this preclinical study suggests that measurement of the levels of M30 antigen may help to predict the clinical responses and to select the effective anti-cancer agents in clinical settings, rapidly and quantitatively.
항암제를 투여한 HeLa와 OVCAR-3 세포주에서 Cytokeratin 18-Asp(396) (M30) 항체를 이용한 항암제 감수성의 측정
송민경 ( Min Kyung Song ),박상호 ( Sang Ho Park ),곽현성 ( Hyun Sung Kwack ),류기성 ( Ki Sung Ryu ),한구택 ( Ku Taek Han ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.1
Objective: The aim of this study was to detect the levels of M30-antigens as a biomarker of apoptosis in cells and their culture media after treatments with anticancer drugs as a preclinical study. Methods: After HeLa and OVCAR-3 cells were treated respectively with paclitaxel, cisplatin, and camptothecin, the harvested cells were stained sequentially with M30 monoclonal antibodies and propidium iodide (PI). Afterwards, they were analyzed using a FACScan flow cytometer and observed under an immunofluorescence microscope for M30-FITC immunofluorescences. Levels of M30 antigens were also detected in their culture media using M30-Apoptosense ELISA kit. Results: The levels of M30-FITC immunofluorescences were elevated in both cell lines after each drug treatments compared with those of control cells. The levels of M30 antigens detected by ELISA in media culturing each cell line treated with each of drugs were elevated compared with those of control cells. Conclusion: This study suggests that M30-antigens representing chemotherapy induced apoptosis may be a useful biomarker for predicting and monitoring the response of neoadjuvant chemotherapy in patients with gynecologic cancers.
이중에너지 방사선 흡수법을 이용한 골밀도 측정 시 기기 간의 골밀도 값 비교와 표준화
정인철 ( In Cheul Jeung ),박윤경 ( Youn Kyung Park ),강영화 ( Young Hwa Kang ),곽현성 ( Hyun Sung Kwack ),김현정 ( Hyun Jung Kim ),최세경 ( Sae Kyung Choi ),조현희 ( Hyun Hee Jo ),김민정 ( Min Jung Kim ),황성진 ( Sung Jin Hwang 대한폐경학회 2007 대한폐경학회지 Vol.13 No.3
연구목적: 현재 골다공증의 진단은 주로 이중에너지 방사선 흡수법 (Dual energy X-ray densitometry, DXA)에 의존하고 있으며, 제조회사와 기종, 측정부위에 따라 결과가 상이하게 나타날 수 있다. 본 연구는 한국 여성을 대상으로 GE Lunar Prodigy와 Hologic QDR-4500을 사용하여 골밀도를 측정하여 두 기종간의 골밀도의 차이를 평가하고, 현재 이용되고 있는 변환공식의 검증과 그 유용성을 평가해 보고자 하였다. 연구재료 및 방법: 연구 대상은 한국 여성 100예의 지원자를 대상으로 GE Lunar Prodigy와 Hologic QDR-4500 두 가지 기종을 이용하여 각각 요추(L1-L4), 양측 대퇴골에서 골밀도를 평가했다. T-score, Z-score, Bone Mineral Density (BMD)를 통해 두 기기값의 관련성을 평가하고, WHO 진단 기준에 따른 골다공증, 골감소증, 정상으로 진단되는 비율을 비교해 GE Lunar Prodigy와 Hologic QDR-4500 기기간의 표준화 골밀도 값 (standardized Bone Mineral Density, sBMD)을 구하여 보고, 이를 한국 여성에서 적용할 수 있는지 검증을 시행, 새 변환식을 구하였다. 결과: 요추 및 대퇴골 경부의 평균 골밀도 및 T-score 값은 GE Lunar Prodigy로 측정한 경우 Hologic QDR- 4500로 측정한 경우보다 모두 유의하게 높게 나타났다 (P<0.001). 두 기기로 측정 된 T-score값으로 WHO 진단기준에 따라 분류되는 환자의 수를 비교한 결과 요추의 경우 P<0.001, 대퇴골 경부의 경우 P<0.0001로 유의한 차이를 보여, Hologic으로 측정한 경우 중증의 진단을 받는 것으로 나타났다. Lunar 값과 Hologic 값 사이의 상관계수는 요추의 경우 0.97, 대퇴골 경부의 경우는 0.95로 통계적으로 유의한 상관관계를 보였다 (P<0.01). 표준화 골밀도값을 통해 비교 분석한 결과, 요추의 계산값과 측정값이 paired t-test 결과 유의한 차이가 있었으며(P<0.01), 대퇴골 경부의 계산값과 측정값 사이에는 유의한 차이가 없었다. 본 연구를 통해 얻은 한국인을 대상으로 한 두 기기간의 변환식은 다음과 같다. 요추: Hologic=(0.844×Lunar)+0.006, 대퇴골 경부: Hologic=(0.886×Lunar) 0.05. DXA. 결론: 다른 기종의 DXA 기기로 환자의 골밀도 평가 및 추적 관찰 시에는 두 기기기간의 표준화를 거친 값을 사용하거나, 환자를 대상으로 두 기기를 측정하여 새로운 변환식을 만들어내 사용함으로서 이러한 진단의 불일치를 줄여 볼 수 있을 것으로 사료된다. Objectives: The Dual energy X-ray absorptiometry (DXA) has different results in reported bone mineral density (BMD) among manufactures, system and measurement site, so called T-score discrepancy. In this study, the comparision and standardization between DXA systems was obtained. Consequently evaluation of the cross calibration formaula and Korean reference database was also obtained. Methods: A total of 100 Korean women were recruited and studied between September 2006 and February 2007 in Kangnam St. Mary`s Hospital, the Catholic University of Korea. The BMD was measured in the lumbar vertebrae (L1-4) and the both femoral neck one the same day using a GE Lunar Prodigy and Hologic QDR-4500. We compared the BMD values, T-scores, Z-scores and patients` diagnoses based on WHO criteria between two systems. We calculated standardized BMD (sBMD) and compared Lunar to Hologic. This study evaluate and calculate new conversion formula between Lunar and Hologic DXA for Korean women. Results: Both the L-spine and the femur neck, the Lunar yielded consistently higher results than the Hologic (P<0.001). The BMD values measured by the two instruments were highly correlated (lumbar spine r=0.97, femur neck r=0.95 , P<0.01). The sBMD values by the conversion formula which were compared with BMD measured, had significant differnces in lumbar spine (P<0.01, paired t-test). New conversion formulas between two systems for Korean women are calculated. For the lumbar spine: Hologic=(0.844×Lunar)+0.006, for the femur neck: Hologic=(0.886×Lunar)-0.05. Conclusion: For correcting the discrepancy of different DXA systems, we can use sBMD, cross calibration, and furthermore calculate new conversion formula for the reference population.