온도 차이에 따른 수영훈련이 결핵균 감염정도에 미치는 영향

곽이섭,Kwak Yi-Sub 한국생명과학회 2005 생명과학회지 Vol.15 No.4

본 연구를 통하여 규칙적인 수영 트레이닝이 체중의 감소를 일으켰으며(온수 및 냉수), 특히 냉수 훈련이 큰 감소를 나타내었다. 온수 훈련군에서는 $INF-\gamma$의 감소를 유발하여 림프구의 증식을 Th0에서 Th2 쪽으로 유도한다는 사실을 알 수 있었으며, 이로 인해 결핵균을 감염시켰을 경우 오히려 폐와 비장에서 결핵균의 수가 현저히 증가하는 사실을 알 수 있어, 수영 훈련군에게서의 결핵균 감염 시 대조군에 비해 균수가 현저히 증가함을 알 수 있었다. 하지만 냉수 훈련군에서는 통제군에 비해 $INF-\gamma$의 현저한 증가를 보여, 결핵균 감염 시 폐에서 결핵균 수가 감소함을 확인 할 수 있었다. Tuberculosis is the leading infectious disease in the world. It is urgent to develop new vaccine and treating drugs. Besides vaccines, we want to know the effects of regular swim training on TB infection in the mouse model. This study was designed to examine the effects of regular swim training on lung and spleen TB counts and $INF-\gamma$ activity in the trained mice at different temperature. The trained mice underwent a 10-wk endurance swim training (5 times/wk) in water at $29\~33^{\circ}C$ (WWG) and $21\~23^{\circ}C$(CWG) for 60 min. And they were divided into 3 groups according to the regular swim training (CG; control, WWG; warm water group, and CWG; cold water group). Mice were challenged by aerosol infection with M. tuberculosis H37Rv using an inhalation device (Glas-Col, Terre Haute, Ind.) calibrated to deliver bacteria into lungs. Three weeks after immunization, the mice were challenged. Four weeks after challenge, the mice were sacrificed and the numbers of viable bacteria in lung and spleen were determined by plating serial dilution of whole organ homogenates on nutrient Middlebrook 7H11 agar (Difco, Detroit, MI). Colonies were counted after four weeks incubation at $37^{\circ}C$. All data were expressed as mean, standard deviation by using SPSS package program (win 10.0). The result through the statistical analysis of this data were summarized as follows; In the weight changes, there were significant differences among CG, WWG, and CWG following the swim training at different temperature, and CWG was the lowest. In the change of $INF-\gamma$ following the swim training, there were significant differences (p<.05) among CG, WWG, and CWG after stimulated with media and CFP. In MTB counts, there were significant differences (p<.05) between CG and WWG in the lung. And also there were significant differences (p<.05) among CG, WWG, and CWG. These results suggest that regular swim training suppress Th1 immune response caused by decreased $INF-\gamma$ level in the WWG, Also For the WWG, highly increased level of TB counts appear in the lung and spleen compare to CG.

규칙적인 수영훈련이 마우스 비장세포의 ROS생성과 림프구 증식에 미치는 영향

곽이섭,박전한,김세종,장윤수,이봉기,Kwak, Yi-Sub,Park, Jeon-Han,Kim, Se-Jong,Jang, Yun-Soo,Lee, Bong-Ki 대한면역학회 2002 Immune Network Vol.2 No.2

Background: Aerobic training can be defined as any physical exercise that increases the heart rate and enhances the body's intake of oxygen long enough to benefit the condition of body. Running, cycling, and swimming are examples of aerobic activities. This type of exercise optimises immune functions. Recently several experimental findings suggested that the regular swimming training increase immune response, but there have been very few reports which compare warm water exercise with cold water exercise in spleen lymphocytes. Methods: This study was designed to examine the effects of regular swimming training on Index, the number of lymphocytes, proliferative activity and production of reactive oxygen species (ROS) by splenocytes in BALB/c mice. Thirty six mice (6 week old) were performed 10 weeks of regular swimming training and they were divided into 6 groups according to the regular swimming training (CRG: control resting group, CEG: control exercise group, WRG: warm water trained resting group, WEG: warm water trained exercise group, CORG: cold water trained resting group, COEG: cold water exercise group). Analytical items were weight change, spleen index, the number of lymphocytes, proliferative activity and production of ROS. All data were expressed as mean and standard deviation by using SPSS package program (ver. 10.0). Results: The swimming training significantly decreased body weight, and increased spleen index, the number of lymphocytes and proliferative activity in the presence or absence of Con A and LPS added conditions. For the WRG and CORG, the quantity of ROS from splenocytes was higher than CRG, whereas, ROS by spleen lymphocytes was lower following 90 min acute exercise stress. Conclusion: These results suggested that the swimming training not only increases the number of lymphocytes but also increases proliferative activity by splenocytes in vitro.

1년간의 복합 운동프로그램이 남성 치매환자의 운동능력과 인지기능에 미치는 영향

곽이섭,엄상용,Kwak Yi-Sub,Um Sang-Yong 한국생명과학회 2005 생명과학회지 Vol.15 No.2

1년간의 운동이 남성 치매환자의 운동능력과 인지기능에 미치는 영향을 연구한 결과, 운동군의 경우 심폐지구력, 근력, 근지구력 및 MMSE는 운동전에 비해 운동중과 운동후 유의하게 증가하였고, 평형성과 민철성은 운동후 유의하게 증가하였으나 유연성은 유의한 차이가 없었다. 반면, 통제군은 모든 시기에서 유의한 차이가 나타나지 않았다. 이상의 결과를 볼 때, 1년간의 운동은 남성 치매환자의 운동능력과 인지기능을 향상시켜 환자들에게 자신감과 성취감을 얻을 수 있는 기회를 주었고, 나아가 독립적인 일상생활을 영위하고 삶의 질을 높이는데 크게 이바지 할 것으로 기대된다. The purpose of the present study is to investigate the effects of long-term exercise program on exercise capacity and cognitive function (MMSE) in male patients with dementia. 24 male patients were divided into two experimental groups : the exercise group (n=12) and the control group (n=12). The exercise group participated in regular exercise program for 12 months, and their exercise capacity (cardiopulmonary function, muscle strength, muscular endurance, flexibility, balance, agility) and MMSE (Mini-mental state examination) levels were evaluated at baseline (pre), after 6 months (mid) and after 12 months (post). The subjects carried on group-exercise of $VO_{2}max\;30\~60\%$, $30\~60$ minute a day, $2\~3$ times per week. Statistical techniques for data analysis was paired samples t-test. The level of statistical significance was ${\le}.05.$ The results of this study were summarized as follows: In the exercise group, there were significant differences in cardiopulmonary function, muscle strength, muscular endurance and MMSE at the times of pre & mid and pre & post, there were significant differences in balance and agility at the time of pre & post only, whereas there was no significant difference in flexibility following the long-term exercise. In the control group, there were no significant differences in all the times. Based on the results of this particular study, one year exercise program increases on the cognitive function & exercise capacity in male patients with dementia.

운동과 면역반응에 대한 고찰

곽이섭,김철우,백영호,Kwak, Yi-Sub,Kim, Chul-Woo,Paik, Young-Ho 한국생명과학회 2007 생명과학회지 Vol.17 No.8

면역학이 발점함에 따라서 인간의 면역체계에 영향을 미치는 많은 요인들에 대한 수많은 연구들이 진행되고 있다. 연령, 영야상태, 스트레스, 질병, 비만, 고지혈증, 장애 등 무수히 많은 변인들이 면역방응에 직접적인 영향을 주고 있으나 운동 또한 상당한 영향력이 있어, 운동시 나타나는 면역 반응에 대하여 고찰하게 되었다. 규칙적인 운동은 초기면역과 그 이후의 적응면역을 증진시키며 특히 적응면역 중 세포 매개 면역반응과 항체매개 면역반응에 영향을 미치는 것으로 알려져 있다. 하지만 이러한 운동도 몸의 상태가 건강하거나 몸에 맞는 운동을 규칙적으로 실시해야 효과적이며, 운동의 경험이 없거나 스트레스나 질병이 있는 상태에서의 운 동은 오히려 신체에 부담을 주어 면역력을 악화하는 결과를 초래하게 된다. 또한 일회성의 운동도 체력수준에 맞게 수행되어야 하는데, 장시간 너무 무리하게 수행하면 에너지 고갈과 함께 면역력의 감소를 초래하여 상기도 감염과 같은 질환을 야기하게 된다. 따라서 무리한 운동 후 'open window' 시기에 적절한 이온음료의 섭취, 영양분 공급 및 휴식은 건강 관리에 필수적이라 할 수 있다. 또한 수행한 운동이 규칙적이라 할지라도 운동은 운동 환경이나 선천적인 요소에 따라 운동 유발성 천식을 포함하는 운동 유발성 알레르기 질환을 야기하는 환경을 조성할 수 있으므로 본론에서 제시한 지식을 바탕으로 마라톤과 같은 장기간 운동 시 특히 주의해야 할 것으로 여겨진다. Exercise is the strongest stress to which the body is ever exposed. The body responds to this stress through a set of physiological changes in its metabolic, hormonal, and immunological systems. In this study, responses of the immune system to the long-term aerobic and anaerobic exercises have been investigated. Regular moderate exercise is associated with a reduced incidence of infection compared with a sedentary groups. Aerobic training increases the heart rate and enhances the body's intake of oxygen long enough to benefit the condition of the body. In recent years, the importance of exercise in everyday life has been rapidly increasing. Moderate exercise appears to stimulate the immune system. And also, Exercise elicits an increase in the numbers of circulating lymphocytes and lymphocyte subsets (including NK cells) which is followed by a decrease in the numbers of cells during recovery from exercise. However, prolonged bouts of strenuous exercise cause a temporary depression of various aspects of immune functions (e.g. lymphocyte proliferation, monocyte antigen presentation, open window periods, exercise induced asthma, exercise induced anaphylaxis) that usually lasts 2-24 hr after exercise depending on the intensity and duration of the exercise bout. Exercise-induced bronchoconstriction (EIB) was defined as a decrease of at least 15% in pre exercise forced expiratory volume in one second at any time point after exercise. This includes elevation of cortisol and cathecholamines in plasma. On the other hand, highly trained athletes exhibit a chronic mild hypercortisolism at baseline that maybe an adaptive change to chronic exercise. And, Consuming carbohydrate during prolonged strenuous exercise attenuates rises in stress hormones and appears to limit the degree of exercise-induced immune depression. Recent evidence suggests that antioxidant vitamin supplementation may also reduce exercise stress and impairment of leukocyte functions.

서로 다른 형태의 지방산 투여가 훈련된 흰쥐의 지구성 운동수행력, 안정시기와 운동스트레스 시기의 에너지 기질, Insulin 호르몬과 Lipase 활성에 미치는 영향

곽이섭,Kwak, Yi-Sub 한국생명과학회 2007 생명과학회지 Vol.17 No.3

본 연구는 장기간의 수영훈련을 마친 통제 훈련군, MCT 투여 훈련군 및 LCT 투여 훈련군에서 지구력 운동수행력과 장기간의 훈련 안정시기 및 운동스트레스 부여시기(실험동물이 상당한 스트레스를 느끼는 160분간의 강제수영)에서 에너지 기질의 변화, 인슐린 호르몬, 및 Lipase 효소의 활성화를 함께 비교하여, 만약 투여 훈련군에서 높은 운동수행력이 나왔다면 이것이 어느 에너지 기질 및 피로물질과 연관되는지 혹은 인슐린 호르몬과 지방분해 효소인 Lipase 효소와는 어떠한 연관이 있는지를 규명하여 지구성 운동수행력에 훈련과 투여효과를 과학적으로 검증하는 데에 연구목적이 있었다. 본 연구에서 사용된 실험동물은 평균체중 140-155 g의 Sprague-Dawley계 횐쥐 수컷으로(7 wk), SPF (Specific Pathogen Free: 특정병원체 부재동물)를 대한바이오링크에서 분양 받은 후에 D대학교 실험동물 사육실에서 사육하였다. 실험동물은 총 54마리를 환경적응과 적응훈련을 포함하는 총 9주간의 훈련을 거친 후 크게 세 그룹으로 나누어 비 투여 그룹 18마리, MCT 투여그룹 18마리, LCT 투여그룹 18마리로 구분하였고 각 그룹에서 안정 시기 6마리와 160분간의 운동 스트레스 시기 6마리 및 지구력 운동수행력시기(survival test) 6마리로 세분화 하여 분석하였다. 본 연구의 결과로 일반적인 지방 형태인 LCT의 투여는 추가적인 체중증가를 일으켰고, 운동수행력의 증가도 가져왔다. 하지만 같은 강도의 운동 부하에 대해서 운동 시 활용되는 지방의 형태인 지방산의 동원이 상대적으로 적었고, 운동증료시기에도 많은 양이 TG의 형태로 존재함을 알 수 있었다. 그리고 운동종료 시 피로물질인 젖산의 축적량이 증가하였고, 지방산화 효소인 Lipase 활성도도 크게 증가하지 않으면서 오히려 인슐린 호르몬을 증가시켜 많은 양의 에너지를 제공하여 지구력 운동 수행에는 도움을 주지만 효율성이 떨어짐을 알 수 있었다. 하지만 MCT의 투여는 인슐린 호르몬의 증가를 일으키지 않으면서 lipase 효소의 활성도를 증가시키고, 젖산 축적을 적게 하면서 유리지방산의 동원을 원활하게 하여 운동 지속시간을 상당히 연장했음을 알 수 있었다. 그리고 TG의 축적을 적게 일으키면서 체중의 감소도 나타났다. 이러한 결과를 통하여 장기간 지구성 운동시 추가적인 에너지 공급을 위해 MCT를 투여하는 것이 운동 수행력의 증가는 물론, 에너지 기질의 활성화를 도모하고 피로물질의 축적을 적게 일으켜, 효율적인 에르고게닉에이드로 권장된다. 뿐만 아니라 에너지 효율성을 증가하여 추가적인 지방축적을 일으키지 않기 때문에, 체중증가를 우려할 필요가 없으며, 오히려 많은 지방을 에너지로 사용하기 때문에 에너지 효율성의 면에서 운동만 한다면 다이어트에도 도움이 되리라 생각한다. The purpose of this study was to investigate the effects of different type of triglycerides (MCT & LCT) on weight, survival time, energy substrate (FFA, TG, pyruvate, lactate), insulin and lipase in the trained rats. Fifty-four Sprague-Dawley rats were divided into 3 groups: control group (CG, n=18), MCT supplement group (MG, n=18), and LCT supplement group (LG, n=18). They also were divided into 3 periods: trained resting (R, n=6) and trained & exercise load (E, n=6), and survival time test was performed to know the supplemented effects. Body weight of all animals was checked every week, MCT group and LCT group received supplementary MCT and LCT orally and preliminary swimming training for 6 days before the start of main experiment. All animals received 15-minute swimming training 5 times during first week of experiment, and swimming training time was increased 15 minutes every week until it reached 90 minutes at last 9th week. After last swimming training, animals were fasted for 12 hours and blood samples were taken from abdominal aorta in the Department of Animal Medicine at the D university Animal Center. Among the CGE, MGE, and LGE groups, the MGE had the greatest increase in physical performance time. In the FFA levels, there was significant differences(p<.05) in CG, MG and LG groups, and also there was major difference of FFA levels in the MG and LG. In the lipase levels, there was signifi.ant differences (p<.05) in CG, MG and LG groups. MG was the greatest than the other groups. In the insulin hormone levels, there was the great differences (p<.05) in LG compare to CG groups, whereas there was no significant difference in the CG and MG. In conclusion, these results suggest that regular prolonged physical training with MCT supplementation, improves exercise performance time through the increase of energy substrate utilization, lipase activity and FFA levels, irrespective of insulin hormone responses.

대사증후군에 대한 운동의 과학적인 효과

곽이섭(Kwak, Yi Sub) 계명대학교 생활과학연구소 2016 科學論集 Vol.42 No.-

Metabolic syndrome is reported to be closely related to insulin resistance and increase the prevalence of cardiovascular disease. In addition, the prevalence of metabolic syndrome increased with increasing prevalence of obesity and the resulting mortality rate is also higher. Diagnostic criteria for the metabolic syndrome vary, but up to now is difficult to present a clear diagnostic criteria there are differences of race and gender in the process of determining the number of the metabolic basis. Recently, studies examine the relationship of various metabolic diseases and metabolic syndrome have been associated with the exercise proceeds. Regular exercise it is possible to improve the body composition and weight loss. In addition, to improve the cardiovascular disease and metabolic conditions. However, research on a method for the purpose of accurate exercise prevention and treatment of metabolic syndrome is lacking. The purpose of this study was to evaluate the effects of exercise interventions on the basis of scientific analysis of the metabolic syndrome.

서로 다른 운동활동이 뇌기능에 미치는 영향

곽이섭 ( Yi-sub Kwak ) 한국체육대학교 체육과학연구소 2017 스포츠사이언스 Vol.34 No.2

Regular physical activity has beneficial effects on brain function such as memory, long-term memory, cognition (MMSE), mood state and neuroplasticity. It is well reported that biological, psychological, social and physiological improvement were identified after regular exercise and exercise training. This was caused by neuromodulation by physical exercise such as neuroendocrine responses (cortisol), brain-derived neurotrophic factor (BDNF), myokine (IGF-1), and even more serotonin, dopamine levels. In this research, through the many recent papers analysis, we evaluated and focused that physical exercise on brain function in animals and several kinds of subjects and athletes include patients. And also we analyzed different type of exercise on brain function in terms of BDNF and IGF-1 related with cortisol level. From the results, regular exercise has beneficial effects on people with children and aged, and especially on the SCI, and dementia patients. Further study, especially on the mechanism of energy exhaustion by exercise or food restriction is needed in this area.

태극권 운동이 중년비만여성의 혈액성분과 체력변인에 미치는 영향

곽이섭(Yi-Sub Kwak),김이순(Yi-Soon Kim),김경철(Kyung-Chul Kim) 한국생명과학회 2009 생명과학회지 Vol.19 No.11

본 연구는 12주 규칙적인 태극권 운동이 중년비만 여성의 혈액성분과 체력요인에 미치는 영향을 분석하여 다음과 같은 결과를 얻었다. 1. 태극권 운동 전, 후 신체적 특성 중 양식(YS) 그룹이 12 건식(12KS) 그룹에 비해 체중, 체지방률, 수축기 및 이완기 혈압이 높았지만 유의한 차이는 나타내지 못했다. 2. 태극권 운동 전, 후, 혈액변인 중 양식 그룹(YS)의 중성지방(TG)을 제외하고 모두 감소함을 나타냈지만 통계적 차이는 나타내지 못했다. 또한 12건식(12KS) 그룹은 혈액변인 모두 감소하였지만 통계적으로 유의하지는 못했다. 두 그룹 모두 감소함을 나타냈지만 유의한 차이를 나타내지 못해 결과적으로 혈액변인의 개선은 나타내지 못했다. 3. 태극권 운동 전, 후 체력요인은 두 그룹 모두에서 유의하게(p<0.05) 증가함을 나타냈으나 양식 그룹(YS)의 평형성 (Balance)은 유의한 차이를 나타내지 못했고 12 건식(12KS) 그룹에서는 민첩성과 평형성이 유의한 차이를 나타내지 못했다. 따라서 본 연구는 대상으로 12주 태극권 운동이 비만여성의 혈액성분 개선에는 크게 영향을 미치지 못한데 반해 체력요인에 긍정적인 영향을 미치는 것으로 나타났다. Tai Chi is a slow and gentle exercise which is suitable for obese women with chronic diseases. Tai Chi can improve the health of a senior without exacerbating existing impairments, including obese patients. The purpose of this study was to evaluate the effects of different types of Tai Chi exercise on blood variables (glucose, cholesterol, TG, HDL, LDL, cortisol) and physical fitness (muscle strength, flexibility, muscle endurance, agility, balance). Thirty obese women were recruited from a public health center. They were divided into Yang style (YS: n=15) and 12 (12KS: n=15). The Tai Chi exercise group participated in a training program for 12 weeks (3times/week). There was significant improvement in muscle strength, flexibility, and muscle endurance in both groups. Agility was significantly increased in YS, more than in 12KS. However, there was no improvement in balance in both groups. There was significant improvement in cholesterol, HDL, LDL, and cortisol in both groups. However there was no improvement in blood glucose levels in either group. From the results, there was no significant difference in either Tai Chi exercises. The Tai Chi exercise program was effective in improving cholesterol related variables and physical fitness, except balance, in both groups. Further study is needed in this area.

규칙적인 운동참여가 여성 치매환자의 일상생활도 및 빈혈치료에 미치는 영향

곽이섭 ( Yi Sub Kwak ),엄상용 ( Sang Yong Um ) 한국스포츠정책과학원(구 한국스포츠개발원) 2004 체육과학연구 Vol.15 No.2

본 연구는 여성 치매환자 30명을 대상으로 하여 12개월간의 규칙적인 운동을 실시하여 일상생활도와 빈혈치료(RBC, Hb, Hct, MCV, MCH, MCHC)에 미치는 영향을 과학적으로 규명하는데 목적이 있다. 치매환자를 각각 15명씩 운동군과 통제군으로 분류한 후, 운동군에서는 12개월간 주 2∼3회, 30∼60분 동안 그룹 운동을 실시하였으며, 운동군과 통제군 모두 전(사전), 중(6개월후), 후(12개월후) 총 3회에 걸쳐 일상생활도(ADL: activities of daily living)와 혈액학적 변인(RBC, Hb, Hct, MCV, MCH, MCHC)을 측정·분석하였다. 본 연구를 위하여 그룹별 시기 간 (사전 & 6개월 후, 사전 & 12개월 후)에 따른 종속변인의 차이를 알아보기 위해 paired samples t-test를 사용하였으며, 유의수준은 α≤.05로 설정하였고, 연구결과는 다음과 같다. 일상생활도는 운동군의 경우 시간이 경과함에 따라 통계적으로 유의하게 증가하였고 통제군은 감소하는 경향을 보였지만 통계적인 유의성은 나타나지 않았다. 혈액학적 변인의 경우 운동군은 운동 전에 비해 6개월 후는 크게 증가하지 않았지만 12 개월 후에는 크게 증가하여 RBC, Hb, MCHC 수치가 통계학적으로 유의하게 증가하였으나 나머지는 유의하게 증가하지 않았으며, 반면에 통제군은 시간이 경과함에 따라 거의 모든 수치가 감소하여 운동 전에 비해 12개월 후에는 MCV를 제외한 모든 변인이 통계적으로 유의하게 감소하였다. 결론적으로 규칙적인 운동은 여성 치매환자의 일상생활도 향상에 매우 효과적임을 알 수 있었으며, 이는 6개월만의 운동으로도 효과가 있음을 알 수 있었고 12개월 후에는 더 큰 증가를 나타내었다. 반면에 통제군은 통계적으로 유의한 변화가 나타나지 않았다. 한편, 혈액학적 분석결과 운동이 치매환자의 빈혈증상을 개선하는데 도움을 주는 것으로 나타났으며, 이는 적어도 12개월간의 꾸준한 운동을 통해 얻을 수 있다는 사실을 알 수 있었고, 운동을 하지 않는 경우 상당 히 빈혈증세가 악화됨을 알 수 있었다. 이러한 연구결과를 바탕으로 추후 많은 피험자들에게 보다 다양한 운동기간과 운동프로그램을 적용하여 심도 있는 연구가 이루어져야 할 것이다. The present study was designed to examine the effects of regular exercise on activities of daily living and hematological variables in patient with senile dementia. Thirty female patients with senile dementia were volunteered to participate in the study and were divided into two groups : the exercise group (n=15) and the control group (n=15). The exercise group participated in regular exercise program, and their ADL (activities of daily living), hematological variables (RBC, Hb, Hct, MCV, MCH, and MCHC) were evaluated at baseline, after 6 months, after 12 months. The subjects carried on exercising, 30-60 minute a day, 2-3 times per week for 12 months. Statistical techniques for data analysis was paired samples t-test. The level of statistical significance was ≤.05. The results of this study were summarized as follows: In the case of exercise group, mid and post ADL values significantly higher than pre value, whereas there was no significant difference in the control group. In the hematological variables, however there were significantly higher in the exercise group. there was significantly lower in the control group except MCV. Consequently, these results suggest that regular exercise have an effect on activities of daily living and anemia in patient with senile dementia. In addition, regular exercise program may be helpful to reduce the incidence of hypoxia and behavioral complications. Therefore, this study involving more subjects and shorter and longer period of exercise program should be well-grounded to detect the statistical significance in the future study.

운동 강도의 차이가 제2형 당뇨병 환자와 비만인의 초과산소 섭취량, 안정 시 대사량 및 생화학적 변인에 미치는 영향

곽이섭(Yi-Sub Kwak),구우영(Woo-Young Ku),유병인(Byung-In Yoo),진영완(Young-Wan Jin),최경석(Kyung-Suk Choi),조준용(Joon-Yong Cho),우진희(Jin-Hee Woo),황혜진(Hye-Jin Hwang) 한국생명과학회 2008 생명과학회지 Vol.18 No.10

The purpose of this study was to evaluate the effect of various exercise intensity on Excess post exercise energy expenditure (EPEE), Resting Metabolic Rate (RMR),thyroid hormonal changes and biochemical variables in obese and NIDDM patients. The subject of the present study were divided into four groups and four periods: trained (T; n=10), control (C; n=10), obese (O; n=10) and NIDDM (N; n=10) group. And the periods were divided as follows; Resting (RE), Maximal (MA), High intensity (HI), and Low intensity (LI). There was significant difference in RMR among different intensity of exercise. in the T (p<0.05) not in the C, O, and N groups. however, there was no significant different percent body fat among all groups. In the energy expenditure, there was significant different among C, O, N groups compare to T in HIEE (high intensity exercise energy expenditure), LIEE (low intensity exercise energy expenditure), HIEEPE (high intensity exercise energy expenditure post exercise) and LIEEPE (low intensity exercise expenditure post exercise). In the hormonal level, there was significant different in T4 level in the T group at LI period and there was also significant difference in T4, Free T3, & Free T4 levels in T group at LI period, however there was no significant different in the O and N groups except LI period. In the fatigue variables, there was significant different in lactate and ammonia levels in the N group in the period of HI compare to C. The present cross-sectional study was design to investigate the relationship between exercise intensity and RMR in four groups. The focus of this investigation was to compare RMR in aerobically trained (T), control (C), obese (O) and NIDDM (N) group. The relationship among RMR, exercise intensity and percent body fat would best be investigated using Meta Lyzer 3B, MMX3B and body composition analyzer. Each subject completed measurement of percent body fat, RMR, hormone in the period of maximal oxygen uptake exercise (MA), high intensity exercise (HI), and low intensity exercise (LI). From the results, High and Low intensity of exercise, there was a trend for an increased RMR (kcal/day) in the trained groups and control group (in case of LI) not for the obese and N groups. This is best explained not by the reduced percent body fat but by the highly induced energy expenditure (during exercise and post exercise energy expenditure) and increased T4, Free T3, and Free T4 hormonal levels in the low intensity exercise for the T group and sometimes C group.