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공수득,구본식,김병천,이규석 ( Soo Deuk Kong,Bon Sik Koo,Byung Chun Kim,Kyu Suk Lee ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.3
Vesiculobullous eruptions are a rare cutaneous manifestation of systemic lupus erythematosus (SLE). They are related to intense inflammation within the cutaneous lesions and subsequent blister formation. We report a case of vesiculobullous eruption of SLE in a 23-year-old male. The bullous eruptions were present ori the lip, forehead, both feet and hands. He met ARA(American Rheumatism Association) is criteria for a diagnosis of SLE and the eruptions developed during a systemic attack of the disease. Routine histology of the lesion showed subepidermal blisters with intact epidermis and dense neutrophilic infiltration in the upper dermis. Direct immunofluorescence of lesional skin showed a linear-granular pattern of immune deposits at the dermoepidermal junction. Electronmicroscopy of the lesional skin showing subepidermal bullae are located beneath the lamina densa. Combination therapy of prednisolone and hydrochloroquine showed complete clearing of the lesions within several weeks. We observed a good response without evidence of recurrence. (Kor J Dermatol 1997;35(3): 588-592)
彈力素 遺傳子 發現에 interleukin-1ß와 interleukin-10이 미치는 影響
孔壽得,宋俊榮 계명대학교 醫科大學 皮膚科學 1999 논문집 Vol.S No.-
The elastic fibers are a major fibrillar component of the extracellular matrix of several organs. and their presence provides elastic properties to these tissues. Recent molecular biological studies also have revealed that accumulation of elastotic material in the skin reflects enhanced synthesis of not only elastin but also a fibrillin, an integral component of the elastic fibers, and steady-state levels of the elastin mRNA increased in photo damaged skin. Furthermore a variety of cytokines. Growth factors, and hormones have been shown to modulate elastin gene expression including transforming growth factor-ß, tumor necrosis factor^(-a), insulin-like growth factor-I, glucocorticoids, cyclic AMP, and vitamin D3. Recently, interleukin-1ß(ⅠL-1ß) and interleukin-10 (ⅠL-1 0)have been shown to up-regulatory function in elastin gene expression. In this study, the effects of IL-1ß and IL-10 were examined on elastin gene expression by Northern blot analysis. chloramphenicol acetyltransferase(CAT) assay, and laser confocal microscopy in cultured human fibroblasts. In Northern blot analysis. IL-1β showed an up-regulatory effect on elastin mRNA steady-state levels 2.09 and 2.54-fold compared with control cultured and incubated without IL-1ß and IL-10 showed an up-regulatory effect on elastin mRNA steady-state levels 1.09, 3.18 and 3.45-fold compared with control cultured and incubated without IL-10. In CAT assay, the percentage of acetylation were 8.6% in untreated control and 13.2% in 1U/ml of IL-1,8 and18.9% in 10U/ml of IL-1ß and 19.2% in 1ng/ml of IL-10 and 19% in 10ng/ml of IL10 in cultured fibroblasts. The promoter activities were increased 1.5 and 2. 2-fold in IL- 1β (1U/ml. 10U/ml) and 2.23 and 2.21-fold in IL-10 (lng/ml. 10ng/ml) treated fibroblasts compared to control groups. It means that IL-1, 8 and IL-10 enhanced elastin gene promoter activity. In laser confocal microscopy, the results indicated significant increase in the elastin epitopes associated with the cells cultured with IL-1ß and IL-10. These results show that IL-1ß and IL-10 increase elastin gene expression on transcriptional and protein levels by cultured fibroblasts. It suggests that they may effect on elastin synthesis by a stage up-regulator in human skin.
彈力素 遺傳子 發現에 interleukin-1ß와 interleukin-10이 미치는 影響
孔壽得,宋俊榮 계명대학교 의과대학 1999 仁耕 宋俊榮 敎授 定年紀念 論文集 Vol.S No.-
The elastic fibers are a major fibrillar component of the extracellular matrix of several organs. and their presence provides elastic properties to these tissues. Recent molecular biological studies also have revealed that accumulation of elastotic material in the skin reflects enhanced synthesis of not only elastin but also a fibrillin, an integral component of the elastic fibers, and steady-state levels of the elastin mRNA increased in photo damaged skin. Furthermore a variety of cytokines. Growth factors, and hormones have been shown to modulate elastin gene expression including transforming growth factor-ß, tumor necrosis factor^(-a), insulin-like growth factor-I, glucocorticoids, cyclic AMP, and vitamin D3. Recently, interleukin-1ß(ⅠL-1ß) and interleukin-10 (ⅠL-1 0)have been shown to up-regulatory function in elastin gene expression. In this study, the effects of IL-1ß and IL-10 were examined on elastin gene expression by Northern blot analysis. chloramphenicol acetyltransferase(CAT) assay, and laser confocal microscopy in cultured human fibroblasts. In Northern blot analysis. IL-1β showed an up-regulatory effect on elastin mRNA steady-state levels 2.09 and 2.54-fold compared with control cultured and incubated without IL-1ß and IL-10 showed an up-regulatory effect on elastin mRNA steady-state levels 1.09, 3.18 and 3.45-fold compared with control cultured and incubated without IL-10. In CAT assay, the percentage of acetylation were 8.6% in untreated control and 13.2% in 1U/ml of IL-1,8 and18.9% in 10U/ml of IL-1ß and 19.2% in 1ng/ml of IL-10 and 19% in 10ng/ml of IL10 in cultured fibroblasts. The promoter activities were increased 1.5 and 2. 2-fold in IL- 1β (1U/ml. 10U/ml) and 2.23 and 2.21-fold in IL-10 (lng/ml. 10ng/ml) treated fibroblasts compared to control groups. It means that IL-1, 8 and IL-10 enhanced elastin gene promoter activity. In laser confocal microscopy, the results indicated significant increase in the elastin epitopes associated with the cells cultured with IL-1ß and IL-10. These results show that IL-1ß and IL-10 increase elastin gene expression on transcriptional and protein levels by cultured fibroblasts. It suggests that they may effect on elastin synthesis by a stage up-regulator in human skin.