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      • 空中 眞菌叢에 관한 硏究

        宋俊榮 계명대학교 醫科大學 皮膚科學 1993 仁耕 宋俊榮 敎授 華甲紀念 論文集 Vol.S No.-

        Eventhough there are many known and unknown micro-organisms in the atmosphere,. many disputable problems of the relationship between these and human beings still remain. According to the reports of aerial fungi being c10sely related with asthma, eczema and dermatitis, the dermatitis showing allergens and seasonal recurrence, ‘ aerial fungi began to be applied in the therapeutic field inc1uding skin tests. Therefore, aerial fungi formerly thought to be non-pathogenic were found to be possibly pathogenic. And also opportunisic infection of fungi is increasing after the popular use of various recently developed antibiotics, steroids and anticancerous agents. Before understanding the relationship between aerial fungi and various diseases, the flora and seasonal variations of all species of aerial fungi of each country should be investigated first. In countries where mycology -has been highly developed, many workers have already reported their own flora of aerial fungi annually, and it became known that . the commo-nest colonies were hormodendrum, penicillium, aspergillus and altemaria with slight differences. However investigation of the flora of aerial fungi in Korea has not been reported yet. For the purposes of determining the aerial fungi and seasonal variation of all species in various situations, the author has investigated Taegu city and some selected areas in Korea from February 1963 through July 1964 by the sampling method ' of gravity sedi-mentation by 5 and 10 minutes' exposure of Sabouraud’s dextrose agar plate and identified the fungi macroscopically and microscopically with the following results. 1. From 6 sites of Taegu city, 19 genera from 8, 536 total colonies -were sampled and the commonest fungi in the air were hormodendrum (25.08%), penicillium(13.6&%), alternaria (10.68%), aspergillus (7.08%) in order of frequency. 2. The highest frequency of the commonest genus was different each month. 3. The most suitable exposure time for sampling was 5 to 10 minutes. 4. The total number of colonies . began to increase from March through May with the peak in June, decreased in July, increased again from August through September,. and then decreased again from September. 5. The total number of colonies was colonies related to weather temperature, and with temperatures above 20˚C and below 5˚C, the number of colonies decrease markedly. 6. The relationship between the total number of colonies to humidity and windspeed was obscure. 7. The total number of colonies outdoors was twice as high as indoors. 8. Each month the total number of colonies of the commonest genera was a1most pararelled indoors and outdoors, except April through June and October through November. 9. The genera and tota1 number of colonies showed diurnal periodicity indoors and outdoors, increasing in the day-time and deα'easing in the night-time; concurrently. 10. of various situations, exposure in crowded 1ocations showed the highest number of colonies. 11. on a rainy day and a day after snowing the tota1 number of co10nies was increased, whilst on a severely cold day and an excessive1y hot day the total number of co1onies decreased. 12. Month1y. variations of each of the commonest genera including the effect of wea-ther were: 1) Hormodendrum: increased from March through June, decreased from July through August and then increased from September through October again, 50 that this genus was closely related -to the effect of weather. 2) Penicillium: incresed in April and May and seemed unrelated to the effect of weather. 3) Altelllelria: increased from Fe through June and was re1ated to the effect of weather. 4) Aspergillus: increased from June through September and was related to the effect of weather. 13. Except for penicillium and aspergillus, the number the commonest colories was higher outdoors than indoors. 14. The flora of aerial fungi at 1, 000 Ft. interva1s up to 6, 000 Ft. altitude were: 1) The total number of co10nies decreased with increase in a1titude and at a level of 5, 000 Ft. number of co10nies was marked1y decreased. 2) The commonest isolated genera were hormodendrum alternaria, penicillium, in that order, and compared with that of the ground, generally. hormodendrum and alternaria were increased whi1st penicillium and aspergillus co1onies were decreased. 3) Hormodendrum and alternaria colonies were isolated from each interval up to 6, 000Ft. a1titude but aspergillus and penicillium were isolated from each interva1 up to 5, 000 Ft. a1titude only.

      • 癩腫樣型癩의 血淸脂蛋白의 分劃

        宋俊榮,鄭泰浩 계명대학교 醫科大學 皮膚科學 1993 仁耕 宋俊榮 敎授 華甲紀念 論文集 Vol.S No.-

        Presently, four general procedures have introduced for separating different classes of plasma. lipoprotein, ultracentrifugation, electrophoresis, immunological precipitation, and polyanion precipitation with dextran sulfate. Very recently Sakurabayashi and . Kawai introduced the convenient technique separating for fractional quantitation of serum very .low density and low density lipoprotein by precipitation with heparin in calcium chloride solution. This report was planned to determine the fructuation of serum very low density and low density lipoprotein in lepromatous leprosy patients- 2O leprornato11s patients and 2O normal subjects were selected from the Aeluck Leprosy Hospital. Serum lipoprotein was analized by the method of Sakurabayashi and Kawai, serum transaminase by Sigma method and bilirubin was determined by Van Den Bergh’ s coloration technic with following results; Serum very low density lipoprotein . and low density lipoprotein of leprosy patients were 77.6 7.9mg% and 107.7 17.9mg%, these values were slightly lower than normal subject’s but not significant. Through cellulose acetate.electrophoresis of serum lipoprotein in normal and lepromatous patients no significant differences were noticed. The values of serum transaminase and bilirubin bf lepromatous patients also showed within normal limit

      • 나환자의 혈정 Angiotensin converting enzyme치

        송준영,박의수 계명대학교 醫科大學 皮膚科學 1993 仁耕 宋俊榮 敎授 華甲紀念 論文集 Vol.S No.-

        Angiotensin-converting enzyme(ACE) is a dipeptidyl carboxypeptidase that is a membrane bound mainly on the luminal surface of pulmonary endothelial capillary cells. It functions to inactivate brady kinin, and also converts angiotensin 1 to angiotensin n. Activity of ACE was first identified in plasma by Skeggs and co-workers in 1956. In 1974 Lieberman discovered that elevated levels of serum ACE were associated with active sarcoidosis and that this assay would be used to assist a diagnosis of sarcoidosis. The association of sarcoidosis and enhanced ACE activity was su뼈equently supported by data from other investigators. Increased serum ACE levels have also been observed in patients with nongranulomatous diseases and granulomatous diseases including leprosy. The author studied the serum ACE levels in leprosy patients(fourty-three with tuberculoid type and eighty-nine with lepromatous type) and twenty nOrIl1al healthy controls by the spectrophotometric method described by Lieberman. Comparative studies of ACE levels in these two types of leprosy with nOrInal healthy controls and relationship among the duration of treatment, age, and sex were also conducted. The results were summarized as follows: Ages of the selected patients were between 30 to 77 years in tuberculoid leprosy (average 54. 1), 23 to 75 years in lepromatous leprosy(average 53.8) and 14 to 49years in the control group(average 28.4). The duration of treatment in tuberculoid leprosy was between 1 and 39 years and average was 20.7 years. Of lepromatous leprosy, duration of treatment was between 2 and 50 years and the average was25.4 years. The mean serum ACE level in normal healthy control group was 6. 39+2. 33 μ/ml,which was significantly lower than that of all leprosy patients, 9. 77+4. 31 μ/ml (p <0.001), and that of both the tuberculoid leprosy, 11. 33+5. 61 μIml(p <0.001) , and the lepromatous leprosy, 9.01±3.25μ/ml(p<O.Ol). There were no significant differences of serum ACE levels between the tuberculoid leprosy group and the lepromatous leprosy group and also no meaningful sex differences of serum ACE levels in leprosy and control group. There was no correlation between age and serum ACE levels in the tuberculoid leprosy, lepromatous leprosy and control groups. There was no relationship between the duration of dapsone treatment and serum ACE level in both the tuberculoid and lepromatous leprosy groups.

      • 鬱陵島 白癬에 관하여

        宋俊榮 계명대학교 醫科大學 皮膚科學 1993 仁耕 宋俊榮 敎授 華甲紀念 論文集 Vol.S No.-

        There have been no extensive studies on the distribution of dermatophytosis in Korea except a few reports covering the limited areas by several investigators. During the period 1954 to 1958,Dr. Suh carried out the investigations on the distributional stauts of dermatophytosis in more wider areas of Korea and on the recent varieties a) There was 4.61% in male children whereas there was 0.79% in female(The ratio between the male and female sex was 7: 1). b) The morbidity found in each grade is listed in the decreasing order: 2nd grade. 3rd grade, 4th below grade. 5th , grade, ' 1st grade and 6th grade. c) The morbidity was also different geographically and it was the highest in Joudong school (9. 73%) and the the Jowest in Woosan school. 3. On1y55 strains (80.9%) of Trichophyton , fer-rugineum were cultued among the , total cases of 68 and noother causative organisms were found. 4. The positivity of culture was parallel with the degree of fluorescence of affected hairs under wood lamp and the size of lesion.

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