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저선량 방사선에 의한 Ikaros-Autotaxin 상호작용 조절 효과
강한아,조성준,김성진,남선영,양광희 (사)한국방사선산업학회 2016 방사선산업학회지 Vol.10 No.1
Abstract - Ikaros, a transcription factor containing zinc-finger motif, has known as a criticalregulator of hematopoiesis in immune system. Ikaros protein modulates the transcription of targetgenes via binding to the regulatory elements of the genes promoters. However the regulatoryfunction of Ikaros in other organelle except nuclear remains to be determined. This study exploredradiation-induced modulatory function of Ikaros in cytoplasm. The results showed that Ikarosprotein lost its DNA binding ability after LDIR (low-dose ionizing radiation) exposure. Cell fractionationand Western blot analysis showed that Ikaros protein was translocated into cytoplasmfrom nuclear by LDIR. This was confirmed by immunofluorescence assay. We identified Autotaxinas a novel protein which potentially interacts with Ikaros through in vitro protein-binding screening. Co-immunoprecipitation assay revealed that Ikaros and Autotaxin are able to bind eachother. Autotaxin is a crucial enzyme generating lysophosphatidic acid (LPA), a phospholipidmediator, which has potential regulatory effects on immune cell growth and motility. Our resultsindicate that LDIR potentially regulates immune system via protein-protein interaction of Ikarosand Autotaxin. Ikaros, a transcription factor containing zinc-finger motif, has known as a criticalregulator of hematopoiesis in immune system. Ikaros protein modulates the transcription of targetgenes via binding to the regulatory elements of the genes promoters. However the regulatoryfunction of Ikaros in other organelle except nuclear remains to be determined. This study exploredradiation-induced modulatory function of Ikaros in cytoplasm. The results showed that Ikarosprotein lost its DNA binding ability after LDIR (low-dose ionizing radiation) exposure. Cell fractionationand Western blot analysis showed that Ikaros protein was translocated into cytoplasmfrom nuclear by LDIR. This was confirmed by immunofluorescence assay. We identified Autotaxinas a novel protein which potentially interacts with Ikaros through in vitro protein-binding screening. Co-immunoprecipitation assay revealed that Ikaros and Autotaxin are able to bind eachother. Autotaxin is a crucial enzyme generating lysophosphatidic acid (LPA), a phospholipidmediator, which has potential regulatory effects on immune cell growth and motility. Our resultsindicate that LDIR potentially regulates immune system via protein-protein interaction of Ikarosand Autotaxin.
사유는 저항인가? - 아도르노와 사유의 비판적 자기반성 -
강한 대한철학회 2019 哲學硏究 Vol.151 No.-
Thinking would be the love of wisdom as the etymology of philosophy, if today thinking begins with a question sparked by wonders of the world. But when thinking is already locked in coercion, thinking becomes not the love of wisdom but a resistance. In the asymmetric relationship between mind and power that cannot be separated by dichotomy today, Adorno argues that thinking is a resistance to coercion prior to particular content. This paper divides the coercive moments inherent in rationality into the non historicity of thinking, the degeneration of social progress, the facticity of Positivism, and the forgotten correlation between humans and nature. It also critically examines the nature of these moments in the contexts of epistemology, social philosophy and historical philosophy. In the critical self-reflection of aporia which is not separated by dichotomy, a model of resistive thinking is revealed. It has a contemporary significance to present a model of thinking to those who strive to find the driver of criticism and resistance. 만일 오늘날도 사유가 세계의 경이에서 촉발된 물음에서 시작한다면, 사유는 철학의 어원대로 지혜사랑의 활동일 것이다. 그러나 사유가 이미 강압 속에 놓여 있을 때, 사유는 애지적 활동이 아닌 저항적 활동이 된다. 오늘날 이분법으로 분리될 수 없는 정신과 권력의 비대칭적 관계 속에서, 아도르노는 사유가 특수한 내용에 앞서 자체로 부정이며 강압에 맞선 저항임을 주장한다. 본고는 합리성에 내재된 강압적 계기들을 사유의 비역사성‧사회적 진보의 퇴보성・실증주주의 사실성・망각된 자연연관성으로 구별한다. 그리고 이 계기들의 성격을 인식론적・사회철학적・역사철학적 맥락에서 비판적으로 검토한다. 정신과 권력, 자유와 지배, 의식과 사회가 뒤엉킨 합리성 그 자신의 비판적 자기반성 속에서, 저항으로서 사유의 모델은 드러난다. 이는 오늘날 비판과 저항의 동인을 찾는 이들에게 스스로 생각할 수 있는 사유의 모델을 제시한다는 점에서 의의가 있을 것으로 보인다.
폐광산으로부터 유출되는 산성광산배수 중화처리를 위한 반응조 실험 연구
강한,박성민,장윤득,김정진,Kang, Han,Park, Seong-Min,Jang, Yun-Deug,Kim, Jeong-Jin 대한자원환경지질학회 2008 자원환경지질 Vol.41 No.1
폐광산으로부터 유출되는 산성광산배수 중화처리를 위해 2가지 방법으로 반응조를 설계하여 실험을 실시하였다. 중화제로 사용한 물질은 방해석이 주 구성광물이여 소량의 돌로마이트를 포함한 석회암이다. 중화 효과는 중화제의 반응 위치와 양에 따라 다르게 나타난다. 반응조 상부에서 산성광산배수와 중화제를 반응 시킬 때 반응 효과가 더 좋으며 중화제의 양이 많을수록 중화되는 속도가 빠르다. 상부에서 중화제와 반응시킬 경우 산성광산배수로부터 침전되는 침전물의 영향을 거의 받지 않아 중화제가 전부 소모될 때까지 반응을 지속시킬 수 있다. Two types of reactor were designed to neutralize acid mine drainage flow from closed mine. Limestone used as a neutralizer, which composed mainly of calcite with small amount of dolomite. In general, the effect of neutralization depended upon both the position of reaction and the amount of supply of neutralizer. It was observed that the neutralization was enhanced as the reaction with acid mine drainage occurred at the upper part of reactor with sufficient supply of neutralizer. When the reaction was sustained in upper part of the reactor, the neutralizer was not affected by precipitates and the reaction could last until all of neutralizer was consumed.