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도라지 추출물 연양갱이 β-amyloid에 의한 세포독성 및 Scopolamine에 의해 유도된 인지능 저하 동물 모델의 개선효과
오홍근,김정훈,신은혜,강영례,이봉근,박상훈,문대인,권이성,김영필,최민휴,김옥진,박광현,이학용 한국자원식물학회 2013 한국자원식물학회지 Vol.26 No.4
The aim of this study was to examine improving effect of Platycodon extracts (PE) and/or Platycodon extracts jelly (PEJ) on cognitive impairment in vitro and in vivo. PC12 (Pheochromocytoma) cells were pretreated with PE for 1hr and than incubated with 50 μM amyloid β (Aβ)25-35 for additional 48hr. Cell viability was assessed by WST-1. Animals for Morris water test and passive avoidance test were divided into normal, control and two Platycodon extracts treated groups that were named Normal (n=7), Control (0 mg/kg, n=7), PE (300 mg/kg, n=7), PEJ (10 g/kg, n=7). Cognitive impairment was induced by scopolamine (1 mg/kg/body weight, i.p.) in the three experimental groups but not the normal group. Pretretment of PE (0.01-1 mg/mL) were not induced cytotoxicity but observed in high dose-treated group (5 and 10 mg/mL)in PC12 cells. Protective effects of PE against Aβ-induced cytotoxicity were increased in dose dependent manner in PC12cells. Administration of PE and PEJ were significantly reduced escape latency time on Morris water maze test and passive avoidance test in copolamine-induced cognitive impairment animal model. These results suggest that Platycodon extracts and its related product available to ameliorative purpose for cognitive ability impairments. 본 연구에서는 도라지 추출물에 대한 세포 독성을 확인하였으며, Aβ에 의한 PC12 세포 독성에 대한 보호효과를관찰하였다. 또한 도라지 추출물과 도라지 추출물 연양갱을 4주간 강제 경구 투여하여 Morris 수중미로시험에서 도달지점까지의 도달시간이 도라지 추출물 및 도라지 추출물연양갱 투여에 의해서 모두에서 유의하게 감소하였다. 이와 유사하게 수동회피시험에서도 자극이 있는 어두운 방을나오는 시간이 도라지 추출물 및 도라지 추출물 연양갱 투여에 의해서 현저하게 감소하였다. 따라서 도라지 추출물및 도라지 추출물 연양갱은 인지능 개선에 도움을 줄 것으로 생각된다.
야콘 추출물이 Streptozotocin으로 유도된 당뇨 동물모델에서 혈당강하에 미치는 효과
오홍근(Hong-Geun Oh),강영례(Young-Rye Kang),김정훈(Jung-Hoon Kim),문대인(Dea-In Moon),서민영(Min-Young Seo),박상훈(Sang-Hoon Park),최광호(Kwang-Ho Choi),김창용(Chang-Ryong Kim),김상현(Sang-Hyun Kim),오지현(Ji-Hyun Oh),김선영(Sun-Youn 한국식품영양과학회 2012 한국식품영양과학회지 Vol.41 No.6
This study was performed to investigate improvements in diabetes mellitus by extracts of yacon in streptozotocin (STZ)-induced diabetic rats. Fifty rats were divided into a normal group and four experimental groups. STZ (45 ㎎/㎏) was injected intraperitoneally to induce type I diabetes in the four experimental groups. Yacon extracts were administered for 5 weeks. Forty-five ICR mice were also divided into one positive control group and four experimental groups for the oral glucose tolerance test (OGTT) after fed yacon extract. The control group did not eat any yacon extracts, while Group 1 (GI) was fed 125 ㎎/㎏ of yacon extracts, Group 2 (GII) was fed 250 ㎎/㎏ of yacon extracts, and Group 3 (GIII) was fed 500 ㎎/㎏ of yacon extracts. After treatment for 5 weeks, blood glucose in GIII group showed decreased tendency at the 5 week. In OGTT by glucose, the glucose level of yacon treatment group in diabetic rats was significantly decreased compared to the glucose level of the control group, but there was no difference in OGTT by maltose. In ICR mice, the glucose level of the experimental group in OGTT by maltose was significantly decreased compared to the control group. The area of the islets of Langerhans was increased by yacon treatment in a dose-dependent manner on diabetic rats. Insulin concentration of the GIII group was also decreased compared to the control group, while the concentration of fructosamine, total cholesterol, and triglycerides in serum showed no difference. OGTT by glucose or maltose in ICR mice or diabetic rats, area of the Islets of Langerhans, and insulin concentration improved. Yacon treatment may be a useful therapeutic and preventive strategy for diabetes mellitus.
오홍근(Hong-Geun Oh),문대인(Dae-In Moon),김정훈(Jung-Hoon Kim),강영례(Young-Rye Kang),박정우(Jung-Woo Park),서민영(Min-Young Seo),박상훈(Sang-Hoon Park),강양규(Yang-Gyu Kang),최충현(Chung-Hyeon Choe),박인선(In-Sun Park),김주(Ju Kim) 한국식품영양과학회 2012 한국식품영양과학회지 Vol.41 No.5
이 연구에서는 SD rat과 Mongolian gerbil에서 실험적으로 HCl-ethanol(150 mM HCl+60% ethanol)을 투여하여 급성 위염을 유발하고, H. pylori 감염시켜 만성 위염, 위궤양을 유발한 후, 건해삼을 투여하여 건해삼에 의한 항위염, 항위궤양 효과 및 H. pylori 감염 경향성 및 치료율을 검토하였던바 다음과 같은 결과를 얻었다. 7주령 SD rats와 H. pylori에 감염시킨 7주령 Mogolian gerbils를 정상군(Nor, n=6)과 대조군(Con, 60% HCl-ethanol+증류수(vehicle), n=6)에 비하여 실험군 Ⅰ(DSD Ⅰ, 60% HCl-ethanol+건해삼 30 ㎎/㎏, n=6), 실험군 Ⅱ(DSD Ⅱ, 60% HCl-ethanol+건해삼 100 ㎎/㎏, n=6), 실험군 Ⅲ(DSD Ⅲ, 60% HCl-ethanol+건해삼 300 ㎎/㎏, n=6)에서는 건해삼 투여 용량에 따른 항위염, 항위궤양 및 항헬리코박터 효과를 육안적 소견, CLO test 및 병리조직학적 검사를 통해 확인할 수 있었다. 이상의 결과를 종합해볼 때 건해삼이 새로운 위염 및 위손상 치료제와 기능성식품의 개발에 활용할 수 있음을 확인하였다. Sea cucumber, Stichopus japonicus, is used not only as an outstanding tonic food but also as a traditional medicine for the treatment of asthma, hypertension, rheumatism, anemia, and sinus congestion. The purpose of this study was to examine sea cucumber as an anti-gastritis and anti-gastric ulcer in HCl-ethanol-induced gastric and H. pylori-infected animal models. Thirty 7-week-old SD rats and Mongolian gerbils were divided into normal (Nor, n=6), control (Con, 60% HCl-ethanol+water, n=6), groupⅠ (DSCⅠ, 60% HCl-ethanol+sea cucumber 30 ㎎/㎏, n=6), groupⅡ (DSCⅡ, 60% HCl-ethanol+sea cucumber 100 ㎎/㎏, n=6), and group Ⅲ (DSCⅢ, 60% HCl-ethanol+sea cucumber 300 ㎎/㎏, n=6). Sea cucumber significantly suppressed gastric lesions and ulcers in the 60% HCl-ethanol-induced gastric model. Especially, 100 ㎎/kg of sea cucumber showed significantly inhibitory effects. In histopathological analysis of the H. pylori model, we found that sea cucumber augmented the eradication rates of H. pylori and attenuated gastric ulcer formation. Our results suggest that sea cucumber has inhibitory effects on gastritis and gastric ulcers. In addition, sea cucumber can be applied for the treatment of H. pylori.
이현아 ( Hyun A Lee ),홍선화 ( Sun Hwa Hong ),강영례 ( Yong Rae Kang ),김민선 ( Min Sun Kim ),복난희 ( Na Hee Bok ),김옥진 ( Ok Jin Kim ) 원광대학교 생명자원과학연구소 2009 생명자원과학연구 Vol.31 No.1
Porcine epidemic diarrhea (PED) is acute viral enteric disease of swine of all ages by a coronavirus, PEDV. Recently, it has been reported that reliable diagnosis is accomplished successfully by vius isolation, RT-PCR, monoclonal antibody-based immunohistochemistry (IHC) and in situ Hybrydization (ISH). The major objective of this study was to compare the diagnostic methods for the detection of PEDV. The techniques were tested on the intestinal tissues and the formalin-fixed paraffin-embedded intestinal tissues from 28 piglets naturally infected with PEDV. As its results, 100% among tested animals were diagnosed by RT-PCR. PEDV antigens were demonstrated in 43% piglets by IHC. PEDV isolation were demonstrated in 4% by cell culture. Positive enterocytes were distributed over the tip and along the sides of atrophied or fused villi in the jejunum and ileum. However, PEDV RNAs were detected in 68% cases. Positive cells typically had dark brown reaction products in the cytoplasms of enterocytes. Therefore, ISH was more sensitive than IHC for the detection of PEDV. Furthermore, the reaction of ISH was more strong than that of IHC as a result of its testing. These results of this study indicate that RT-PCR and ISH could be used as a effective tool for the detection of PEDV.
오홍근(Hong-Geun Oh),박정우(Jung-Woo Park),강영례(Young-Rye Kang),김정훈(Jung-Hoon Kim),서민영(Min-Young Seo),김민걸(Min-Gul Kim),두재균(Jae-Kyun Doo),신동화(Dong-Hwa Shin),정은수(Eun-Soo Jung),채수완(Soo-Wan Chae),김옥진(Ok-Jin Kim) 한국식품영양과학회 2011 한국식품영양과학회지 Vol.40 No.12
본 연구에서는 4주간 혼합곡 식이를 공급하여 treadmill을 통한 운동시간과 glycogen 저장능력 변화를 관찰함으로써 지구력 개선에 대한 평가를 하였다. 7주령 SD rats은 정상군 (Nor, 정상식이, n=6), 대조군(Con, 20% 정상식이+80% milled rice, n=6), GⅠ(혼합곡 식이 Ⅰ, n=6), GⅡ(혼합곡 식이 Ⅱ, n=6), GⅢ(혼합곡 Ⅲ, n=6)와 GⅣ(혼합곡 식이 Ⅳ, n=6) 으로 임의 군배정을 하였다. 지구력 시험은 24일간의 적응 훈련과 혼합곡식이 공급을 한 후 실시하였다. 운동 지속 시간과 glycogen 저장능력은 혼합곡식이 공급에 의해서 증가하였다. 더욱이 25 min 운동 그리고/또는 탈진 시까지의 운동 후에서 혈액 내 무기질인, CPK와 lactate의 농도는 혼합곡 투여에 의하여 감소하였으나, GOP, GTP, lactate LDH의 농도는 군간 차이는 보이지 않았다. 본 연구에서는 4주간의 혼합곡 식이가 운동 지속 시간과 glycogen 장 능력이 증가되었으며, 피로물질인 무기질인, CPK와 lactate의 농도가 감소시킴으로써 지구력 개선에 도움을 줄 것으로 생각된다. This study evaluated the effect of multigrain supplementation on exercise-related changes in running time and glycogen storage capacity of male SD rats engaged in treadmill exercise. Thirty-six 6-week-old rats were divided into six groups: normal (Nor) fed normal feed, control (Con) fed with 20% normal feed and 80% milled rice, test group one (GI) fed with multigrain feed I, test group two (GII) fed with multigrain feed II, test group three (GIII) fed with multigrain feed III, and test group four (GIV) fed with multigrain feed IV. Endurance tests by treadmill machine were administered after 24 days of multigrain feed supplementation and adaptive training. Running time was extended and glycogen storage capacity increased in the multigrain-treated group compared to the non-treated group. Also, the fatigue indicators of inorganic phosphorous, CPK, and lactate concentration were all reduced in the multigrain feed group compared to the control group after 25 min and/or exhausted exercise. But there was no difference in GOP, GTP, lactate, or LDH concentrations between the groups. Our results demonstrated that endurance improved with multigrain feed in rats. Specifically, running time, glycogen storage capacity, inorganic phosphorous, CPK, and lactate serum concentration increased. Importantly, the improvements in endurance brought about in the GII group fed with waxy barley was the greatest among the experimental groups.