아급성 피부형 홍반성 루푸스

강승주(Seung Joo Kang),조광현(Kwang Hyun Cho),이유신(Yoo Shin Lee),이창우(Chang Woo Lee) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.6

Subacute cutaneous lupus erythematosus is a recently recognized distinct subset of lupus erythematosus, having characteristics of clinical, pathologic, serologic, irnrnunologic features. We present a case of subacute cutaneous lupus erythematosus in a 29-year-old woman with symmetric, superficial, nonscarring papulosquamous lesion on the face, scalp, and the extensor surface of the upper extremities. She has a mild systemic illness of musculoskeletal complaints. Serologic abnormalities of the patients are positive rheumatoid factor and anti-Ro antibody test, but fluorescent antinuclear antibody test is negative, which is done by the conventional methods uaing rodent tissue for the substrate. The histopathologic finding of the lesion show the sarne general pattern of the cutaneous lupus erythematosus, and lupus band test is positive.

크론병 환자와 그 친척들에서 장내 세균 조성의 이상

강승주 ( Seung Joo Kang ),임종필 ( Jong Pil Im ) 대한장연구학회 2011 Intestinal Research Vol.9 No.2

크론병의 병인에서 장내 세균이 중요한 역할을 함은 이미 잘 알려져 있다. 이 연구는 크론병 환자들의 대변에서 세균 조성을 살펴보고 정상인과 어떻게 다른지, 또 환자들의 가까운 친척들에서도 정상인과는 다른 microbiota의 이상 소견이 있는지를 알아보기 위해 시행되었다. 대상이 된 환자군은 벨기에의 세 명이상의 크론병 환자가 포함되어 있는 가계(family)를 중심으로 하였다. 3명 이상의 크론병 환자를 포함한 21개의 가계와 1명의 환자만을 포함한 4개의 가계에서 68명의 크론병 환자와 84명의 정상인 크론병 환자의 친척, 그리고 환자군 가계와 연령, 성별이 matching 된 크론병 환자들이 포함되지 않은 정상 가계 10개에서 55명의 정상 성인이 분석 대상이었다. 각 대상의 장내세균 분석을 위해서 16S rRNA의 유전자의 증폭 후 denaturing gradient gel electrophoresis (DGGE) analysis를 이용하였다. 이는 군집 중합효소 연쇄반응(polymerase chain reaction, PCR)을 위해서 미생물에서 공통적으로 가지고 있는 16S rRNA 유전자의 hypervariable V3 region을 대상으로 증폭을 시행한 후 DGGE gel에 영동시켜 각 개인의 주요한 분변 장내세균을 프로파일링하는 방법이다. 각 밴드의 강도를 분석하여 환자군, 환자의 친척군, 일반인군에서 유의한 차이를 보이는 밴드를 잘라내어 그 안의 DNA를 추출해 RT-PCR로 sequencing을 시행하고 그 결과를 clustering analysis를 통해 미생물 종을 알아내는 방법을 이용하였다. 크론병 환자군과 정상군(정상 친척들 및 대조군)을 비교하였을 때 양군의 DGGE profiling 중에 207개의 밴드 중 차이를 보인 75개의 밴드에 대해 Bonferroni 보정을 시행한 후 유의한 6개의 밴드를 분리해서 RT-PCR을 통해 정량적 염기 서열 분석을 시행하였다. 각 밴드의 염기서열 분석 결과를 BLAST analysis에서 얻어진 GenBank 염기서열과 그 일치도를 바탕으로 각각의 종을 분석한 결과 Faecalibacterium prausnitzii (F. prausnitzii), unknown species of Clostridium cluster XIVa, Ruminococcus gnavus (R. gnavus), Dialister invisus (D. invisus), Bifidobacterium adolescentis (B. adolescentis)와 일치되었다. 정량적인 PCR 결과를 보면 D. invisus (P=0.04), unknown species of Clostridium cluster XIV1 (P=0.03), F. prausnitzii (P<1.3×10(-5))로 나타났으며, B. adolescentis (P=5.4×10(-6))의 경우에는 크론병 환자군에서 정상군에 비해 감소되었고 R. gnavus (P=2.1×10(-7))의 경우에는 증가되었다. 이 논문에서는 특징적으로 크론병 환자의 정상인 친척들과 정상인의 장내 세균 조성을 비교하였다. 그 결과 세 개의 세균의 조성이 틀렸는데 R. torque (P=0.02)는 정상인에 비해 크론병 환자의 친척에서 많았고 unspecified member of the Escherichia coli-Shigella group (P=0.01)과 Coprococcus aerofaciens (P=0.004)는 정상인에 비해 크론병 환자의 친척에서 적었다.

아토피 피부염 환자의 말초혈액 T림프구 아형과 혈청내 IgE 치에 관한 연구

강승주(Seung Joo Kang),김선훈(Seon Hoon Kim),이유신(Yoo Shin Lee) 대한피부과학회 1987 大韓皮膚科學會誌 Vol.25 No.2

This study was undertaken to elucidate any quantitative abnormalities of Tlymphocyte subsets (helper/inducer T cell; T cell and suppressor/cytotoxic T cell: T cell) and IgE levels in the peripheraI blood in atopic dermatitis patients by using monoclonal antibodies and enzyme immunoassay, respectively. In addition we have tried to ascertain whether there are any correlations betveen such immuiiologic abnormalities and the severity of the disease. The results showed that there were significant decrease in the mean percentage of T Cells and increase in the mean value of T/T cell ratios in patients with atopic dermatitis. These changes seem to relate to the severity of the disease when evaluated as groups. A significant increase in the mean value of serum IgE was found in atopic dermatitis patients and the change was related to the severity of the disease. But increase of serum IgE level did not correlated closely with the T cell abnormalities in each patients.

소화기 내시경 시술 전후 항혈전제 사용 임상진료지침: 2023 IDEN 합의

강승주 ( Seung Joo Kang ),태정현 ( Chung Hyun Tae ),방창석 ( Chang Seok Bang ),신철민 ( Cheol Min Shin ),정영훈 ( Young-hoon Jeong ),최미영 ( Miyoung Choi ),황주하 ( Joo Ha Hwang ),( Yutaka Saito ),( Philip Wai Yan Chiu ) 대한소화기학회 2024 대한소화기학회지 Vol.83 No.6

Antithrombotic agents, including antiplatelet agent and anticoagulants are widely used in Korea due to increasing incidence of cardio-cerebrovascular disease and aging population. The management of patients using antithrombotic agents during endoscopic procedures is an important clinical challenge. Clinical practice guideline regarding this issue which was developed by the Korean Society of Gastrointestinal Endoscopy was published in 2020. However, since then, new evidence has emerged for the use of dual antiplatelet therapy and direct anticoagulant management, and revised guidelines were issued in the US and Europe. Accordingly, the previous guidelines were revised, cardiologists also participated in the development group, and the recommendations went through a consensus process among international experts. This guideline presents 14 recommendations made according to the Grading of Recommendations, Assessment, Development, and Evaluation methodology, and was reviewed by multidisciplinary experts. This guideline provides useful information that can assist endoscopists in the management of patients on antithrombotic agents who require diagnostic and elective therapeutic endoscopy. It will be revised as necessary to cover changes in technology, evidence, or other aspects of clinical practice. (Korean J Gastroenterol 2024;83:217-232)

아토피 피부염 환자에서 집먼지 진드기 항원에 대한 제1형 알레르기 반응에 관한 연구

강승주(Seung Joo Kang),김규한(Kyu Han Kim),김선훈(Seon Hoon Kim) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.3

The authors investigated the radioallergosorbent test (RAST) for the specific IgE and the prick test with hose dust mite in 129 patients with atopic dermatitis(AD) wit4 four or more family numbers. RAST and prick test results were described according to family background of respiratory atopy(RA) and severity of AD. The results are summarized as follows : l. A comparison between the prick test results and RAST reactions gave a concordance of 88%. The prick test was more sensitive than the RAST. 2. The level of specific IgE in patients with personal history(PH) or family history(FH) of RA was significantly increased compared to those in patients with only AD. 3. In patients without PH and FH of RA, the level of specific IgE in patients with FH of AD was significantly increased compared to those in patients without FH of AD. 4. The level of specific IgE did not reflect the severity of AD. From the above results, it could be concluded that type I allergy to house dust mite is not directly related to AD and it occurs predominantly in those patients with AD wha have a predisposition to RA. (Kor J Dermatol 20(3): 285 201,1091)

방사선 치료시 사용한 피부 표기 용액에 포함된 Resorcin에 의한 알레르기성 접촉 피부염

강승주(Seung Joo Kang),은희철(Hee Chul Eun),이유신(Yoo Shin Lee) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.5

Resorcin is widely being used in the fields of the therapeutics, cosmetics, industry, but allergic contact dermatitis is an infrequent adverse reaction. We have experienced a case of allergic contact dermatitis to resorcin. A 59-year- old male with Kaposi's sarcoma on the right foot developed linear erythematous vesicular eruption along the marking areas 4 days after application of Castellanis paint, used as a skin marking solution for radiation therapy. He showed patch test positive reaction to Castellani's paint as well as its individual components, resorcin and phenol.

복수로 발현한 원발성 전신형 비정형 거대세포 림프종

박진명 ( Jin Myung Park ),강승주 ( Seung Joo Kang ),김미나 ( Mi Na Kim ),김수현 ( Su Hyun Kim ),조현진 ( Hyun Jin Jo ),최문선 ( Mun Sun Choi ),김지원 ( Ji Won Kim ) 대한내과학회 2009 대한내과학회지 Vol.76 No.8

시뮬레이션 교육이 간호대학생의 자아탄력성, 자기효능감, 전공만족도에 미치는 효과

김은주(Kim, Eun-Joo),강승주(Kang, Seung-Ju) 한국산학기술학회 2016 한국산학기술학회논문지 Vol.17 No.1

본 연구는 간호교육(기본간호학이론 및 실습) 1년을 마친 간호대학생을 대상으로 임상실습 전 시뮬레이션 교육이 자아탄력성, 자기효능감, 전공만족도에 미치는 효과를 알아보는 데 목적이 있다. 연구대상은 J도 J시에 소재한 대학의 간호학 과 1학년 학생 28명이며, 단일군 사전사후 설계의 원시실험연구이다. 시뮬레이션 교육의 효과를 분석하기 위해 실험군의 일 반적인 특성과 자아탄력성, 자기효능감, 전공만족도를 측정하였다. 연구결과, 자아탄력성(t=-7.38, p<.001)과 자기효능감 (t=-4.93, p<.001), 전공만족도(t=-5.28, p<.001)가 모두 통계적으로 유의미하게 향상되었다. 그러므로, 시뮬레이션교육이 간호 대학생의 자아탄력성, 자기효능감, 전공만족도에 미치는 긍정적인 효과를 확인하였다. 이에 본연구자는 시뮬레이션교육의 시작시기로 간호대학생의 시뮬레이션 교육은 임상실습 전에 실시함이 효과적이었음을 제시하는데 의의가 있다. This study examined the effects of simulation training for nursing students who completed one year of basic nursing education. The study focused on effects of simulation training exercises on areas including self-resilience, self-efficacy, and satisfaction during the course of study. The raw experimental study of a single group was a pre-post design. The general characteristics and ego resilience were measured to analyze the effects of simulated training, self-efficacy, a major pre-acquisition and satisfaction. The improvements of the self-resilience (t=-7.38,p<.001) and self-efficacy (t=-4.93,p<.001), Major satisfaction (t=-5.28,p<.001) were statistically significant. Therefore, the simulation training has a positive effect on nursing students in terms of the self-efficacy, major satisfaction. The purpose of this research is significant in that it is presented before the nursing college students begin clinical practice as the starting time of simulation training.

자기효능증진 자조관리 프로그램이 뇌졸중 환자의 자기효능과 일상생활동작 수행능력에 미치는 효과

김인숙(Kim In Sook),강승주(Kang Seung Joo),김계하(Kim Kye Ha) 한국성인간호학회 2008 성인간호학회지 Vol.20 No.4

한국인 헬리코박터 파일로리 감염 치료 근거 기반 임상 진료 지침 개정안 2020

정혜경 ( Hye-kyung Jung ),강승주 ( Seung Joo Kang ),이용찬 ( Yong Chan Lee ),양효준 ( Hyo-joon Yang ),박선영 ( Seon-young Park ),신철민 ( Cheol Min Shin ),김성은 ( Sung Eun Kim ),임현철 ( Hyun Chul Lim ),김지현 ( Jie-hyun Kim ) 대한내과학회 2021 대한내과학회지 Vol.96 No.3

Helicobacter pylori (H. pylori) infection is one of the most common infectious diseases worldwide. Although its incidence is gradually decreasing, about half of the world's population still get infected. H. pylori infection is responsible for substantial gastrointestinal morbidity worldwide. It is the most common cause of gastric and duodenal ulcers as well as gastric cancer. Since the revision of the H. pylori Clinical Practice Guidelines in 2013, the eradication rate of H. pylori has gradually decreased with the use of classical triple therapy, wherein amoxicillin, clarithromycin, and proton pump inhibitors are administered, for 7 days. According to a nationwide randomized controlled study conducted by the Korean College of Helicobacter and Upper Gastrointestinal Research released in 2018, the intention-to-treat eradication rate was only 63.9%, which was due to increased antimicrobial resistance induced by the use of antibiotics, especially clarithromycin. The update of clinical practice guideline for treatment of H. pylori was developed based on evidence-based medicine by conducting a meta-analysis. The draft recommendations were finalized after expert consensus on three recommendations regarding the indication for treatment and eight recommendations on the treatment itself. These guidelines are designed to provide patients, nurses, medical school students, policymakers, and clinicians with clinical evidence to guide primary care and treatment of H. pylori infection. These may differ from current medical insurance standards and will be revised further, if necessary, based on research-based evidence. (Korean J Med 2021;96:160-189)