Potent Influence of Exogenous Melatonin on In Vitro Oocyte Maturation in the Longchin Goby, Chaenogobius annularis

김대근,황인준,백혜자 한국발생생물학회 2023 발생과 생식 Vol.27 No.3

Effects of changes in photoperiod on the reproductive events in fish are suggested to be mediated mainly via the action of melatonin (MEL). Changing levels of plasma MEL throughout the day and year are suggested to influence the hypothalamus–pituitary–gonadal axis in fish. Therefore, in this study, we aimed to investigate the effects of MEL on oocyte maturation and germinal vesicle breakdown (GVBD) in the marine fish, Chaenogobius annularis, in vitro. Oocytes at three different stages (pre-, mid-, and late-vitellogenesis) were incubated with (a) only MEL (5, 10, 50, 100, 500, and 1,000 pg/mL) and (b) 50 pg/mL of 17α,20β-dihydroxy-4-pregnen-3-one (17α20βP), maturation-inducing hormone (MIH) of this species, and MEL (4-h incubation before addition of MIH). Any single MEL treatment did not significantly induce GVBD. However, treatment with 50 pg/mL MEL or MIH significantly induced GVBD. These results suggest that preincubation with MEL accelerates the effect of MIH on longchin goby oocyte maturation.

카페리여객선 퇴선 시 여객 안전 향상을 위한 MES 장비에 대한 고찰

김대근,이은수 해양환경안전학회 2020 해양환경안전학회 학술발표대회 논문집 Vol.2020 No.06

An exploratory study for an evidence of electroencephalographic changes in isolated subjects for distant mental intention

김대근 한국감성과학회 2014 감성과학 Vol.17 No.4

This double-blind study, as a human experiment of nonlocality, investigated the effects of senders' intention onthe central nervous system of a distant human receiver and it explored the roles that motivation might have inmodulating these effects. Whole brain activity was measured in the receiver whom was asked to relax in a distantroom for 16 minutes; the sending person directed intention of oneness toward the receiver during repeatedvariable-second epochs separated by variable-second non-intention epochs. The total length of intention epochs andthat of nonintention epochs were balanced. Eighteen sessions were conducted. In 9 of those sessions, the senderwas the receiver's lover. In another 9 of those sessions, the sender was just acquainted with the receiver before thesession. The receiver's whole brain activity recorded during the intention epochs were compared with the samemeasures recorded during the nonintention epochs used as controls. The statistical difference between the intentionsversus controls across 18 sessions was examined by paired-t test. In addition, subgroup analysis for the 9 couplesessions and 9 non-couple sessions were additionally examined by the same test. The effect of distant intentionalitydecreased slow waves or increased EEG fast waves mainly in frontal regions, and increased EEG coherence duringthe intention epochs. The effects was not statistically significant after Bonferroni correction, but the couple sessionscombined showed the largest effect followed by all sessions combined. Non-couple sessions combined showed thesmallest effect. The changes in EEG power mean that receiver participants became more alert during the intentionepochs and the change in EEG coherence might be evidence of coherent heart influence on EEG activity. Plannedcomparison with specific hypothesis testing for the suggested changes in this study have to be followed for anevidence of electroencephalographic changes in isolated subjects for the distant mental intention.

코스닥등록법인의 조세혜택에 관한 연구

김대근,이귀선 숭실대학교 사회과학연구원 2002 사회과학논총 Vol.5 No.-

엘리트 무도선수의 인권의식에 따른 성취목표성향 및 운동몰입에 미치는 영향

김대근,정성배,성낙훈 한국국가안보·국민안전학회 2020 한국국가안보·국민안전학회지 Vol.11 No.-

The purpose of this study is to investigate the human rights consciousness of college sports athletes and the exercise commitment to athletes' achievement goals. In other words, this study aims to identify the perceptions, judgments, and behavioral awareness of the human rights awareness of college athletes, and to identify the propensity among goals, perceptions, and dispositions in relation to each athlete's achievement goals. Furthermore, on the impact of interactivity between sports immersion and behavioral immersion, which is closely related to the performance improvement of athletes, 267 students were surveyed using the Survey Monkey mobile program for university sports athletes. As a result of the analysis, it was found that it affects human rights awareness and achievement goal orientation. Also, the higher the achievement goal, the more immersive exercise and tighter athletic performance will be developed. The above results suggest that it is time to respond to the social perspectives of university athletes and to be free from future social-oriented anti-social behavior. 이 연구는 엘리트 무도선수에 대한 인권의식을 알아보고 선수가 인식하는 성취목표와 운동에 대한 몰입도 관계를 알아보는데 있다. 즉, 인권의식이 이슈화 되면서 선수에 관한 인권보호와 보장에 대한 가이드라인을 제시하고, 이탈방지 뿐만 아니라 자신에 대하는 태도와 동료와의 관계, 운동몰입 간의 성향을 파악 합에 있다. 또한 엘리트 무도선수의 정기적인 인권의식 교육프로그램 개발과 현장에서 적용 가능한 지도자들의 인권교육에 관한 기초 자료를 제공함에 있다. 엘리트 무도선수는 중등교육과 다른 환경에서 자신이 설정한 목표에 책임이 따르게 된다. 이는 일탈행동과 성공적인목표성향 두 관점에서 경기력에 영향을 미치기 때문에 성공적인 목표설정과 몰입간의 관계를 규명하고자 한다, 따라서 이 연구는 대학스포츠선수를 대상으로 편의표준추출법으로 267명을 대상으로 이루어졌으며, 자료처리는 SPSS 21.0/Amos 21.0 Version 통계프로그램을 이용하여 기술통계분석, 요인분석, 신뢰도분석, 상관분석 및 구조방정식(SEM)을 실시하였다. 분석결과 인권의식, 성취목표성향에 영향이 미치는 것으로 나타났다. 성취목표가 높게 측정될수록 운동몰입과 밀첩한 경기력이 계속하여 발전해 나갈 것으로 사료된다. 이상의 결과는 대학운동선수의 사회적 관점에서 어떻게 대응하고 차후 목표지향적인 관계형성 반사회적 행동에서 자유로질 것이며, 선수를 바라보는 폐쇄적인 관점에서 현재 대학선수에 관한 새로운 관점의 전환이 필요한 시점이라 사료된다.

Assessment of Noncontiguous Posterior Malleolar Fractures in Distal One-Third Tibia Shaft Fractures with Proximal Fibula Fractures

김대근,곽병훈 대한골절학회 2022 대한골절학회지 Vol.35 No.3

Purpose: Posterior malleolar fractures after intramedullary nail surgery rarely occur in distal tibia shaft fractures. The importance of preoperative ankle evaluation in preventing these fractures is also common knowledge. There are no studies in the literature on posterior malleolar fractures in distal onethird tibia shaft fractures except for distal metaphyseal tibia fractures to the best of our knowledge. The purpose of this study was to evaluate the incidence and radiological features of posterior malleolar fractures in distal one-third tibia shaft fractures with proximal fibula fractures. Materials and Methods: Thirty-one patients diagnosed with distal one-third tibia shaft fractures with proximal fibula fractures from January 2016 to May 2021 were retrospectively reviewed. With the aid of plain radiographs and computed tomography (CT) scans, the fracture patterns of the tibia and fibula were classified according to the AO Foundation /Orthopedic Trauma Association (AO/OTA) classification, and posterior malleolar fractures were identified. The fracture pattern was classified according to the Haraguchi classification, and the angle between the bimalleolar axis and the posterior malleolar fracture line was measured when there was a posterior malleolar fracture. Results: Out of the 31 distal one-third tibia shaft fractures with proximal fibula fractures, 16 cases (51.6%) had noncontiguous posterior malleolar fractures that were confirmed on a CT scan, while 3 cases (18.8%) were visible on initial plain radiographs. There was no statistically significant variation seen in the presence of a posterior malleolar fracture in the tibia (p=0.15) and fibula (p=0.87) fractures. According to the Haraguchi classification, there were 15 posterolateral-oblique fractures (Type I) and 1 medial-extension fracture (Type II), and the mean angle was 24.5°. Conclusion: Noncontiguous posterior malleolar fractures occurred in approximately half of the distal one-third tibia shaft fractures with proximal fibula fractures, and a CT scan was considered necessary to diagnose posterior malleolar fractures before surgery.

제주항 카페리여객선 계류시스템 개선에 관한 연구

김대근,조익순,이형탁 해양환경안전학회 2020 해양환경안전학회 학술발표대회 논문집 Vol.2020 No.11

補助部門의 原價配賦와 意思決定에 관한 考察

金大根 건국대학교 1986 論文集 Vol.22 No.1

The Purpose of this paper is to survey mathematical model of overhead cost allocation and to examine their economic meaning and implications. We lave traced historically two approaches to this problems : the matrix model approach and the LP model approach. Capettini and Salamon (1977) presented an example of the decision making necessary to determine whether to continue generating a service internally versus acquiring the service externally. The example demonstrates that the basic data required for a correct solution to this decision problem can be obtained from the information normally presumed to be available when service department costs are allocated to producing departments by the algebraic (simultaneous equations) method. Baker and Taylor (1979) Proposed a LP approach to the external aquisition problems, and demonstrated how to use LP results to compute cost allocation. The mathematical duality in the LP model shows that the problems of optimal allocation and of valuation are inseparable. The problem of allocation is that of finding optimal quanties of service department output (minimize the sum of service department costs), and the problem of evaluation is that of determining the service values (determine allocating cost). The two problems are mathematically identical and are two aspects of the same problem. This would be expected on the basis of usual economic reasoning, but we shall gain important insight in accounting theory, especially in the problem of cost determination. The problem of cost determination is not separable from that of the relevant decision model for optimal resource allocation. This is an illustration of the way in which mathematical reasoning can lead to the discovery of new accounting facts.

참소리쟁이의 세포독성 성분

김대근,최상운,류시용,이강노,지옥표 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

Activity-guided fractionation and repeated column chromatography afforded two cytotoxic compounds R-3 and R-4 from the root of Rumex japonicus HOUTT. Compounds were identified as musizin and emodin, respectively, by the physicochemical and spectral data. Besides R-3 and R-4, two compounds R-1 and R-2, chrysophanol and physcion, respectively, were also isolated. The compound R-3 and R-4 exhibited cytotoxicity against cultured human tumor cell lines. A-549, SK-OV-3, SK-MEL-2, XF498 and HCT15 with ED_50 values ranging from 2.68 to 10.06㎍/㎖.

감사인의 양적 중요성 판단 기준의 적용에 관한 연구

金大根,趙徹衍 韓日經商學會 2001 韓日經商論集 Vol.21 No.-

This thesis studied if, under the varied audit environment, there is any significant difference on the degree of strictness (rigidity) of an auditor's quantitative materiality judgement when an auditor formulates audit opinion regarding to the exception out of gathered evidence. This study defined the degree of strictness as : the lower the average of threshold between unqualified and qualified opinion, the stronger the degree of strictness of an auditor's quantitative materiality judgment. This research found the followings: First, there is no statistically significant difference in the degree of strictness of an auditor's quantitative materiality judgment affected by the scale of the auditor. Second, the scale of the client affects an auditor in the degree of strictness of an auditor's quantitative materiality judgment. Third, there is a significant difference in the degree of strictness of an auditor's quantitative materiality judgment for listed vs. non-listed corporation. Fourth, the higher the debt ratio of the client, the stronger the degree of strictness of an auditor's quantitative materiality judgment. Fifth, an auditor applied quantitative materiality judgment more strictly for the client corporation with any turnover between net profit and net loss.