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망가포디피르 트리소디움 조영증강 기능적 간 영상법을 이용한 생존간세포분율의 평가: 동물 모델에서의 예비보고
조순구,전용선,이경희,송장호,박인서,한승백,서창해 대한영상의학회 2007 대한영상의학회지 Vol.56 No.2
Purpose: We designed this study to evaluate the feasibility of using mangafodipir trisodium enhanced functional liver imaging (MT-FLI) for assessing the viable fraction of hepatocytes (VFH) in the liver. Materials and Methods: We evaluated the change of VFH with using MT-FLI before and after inducing acute hepatic necrosis (AHN) with CCl4 in the liver of 15 beagle dogs. The MR imaging was performed on a 1.5T MRI unit with using the EFGRE-3D sequence (TR/TE=4.7/1.1 msec; flip angle: 20.0°). We evaluated the linear dependence of the density of viable hepatocytes in AHN on the MR images as compared to that in the corresponding normal livers (DAHN/DN) on the VFH in their pathologic specimens, and the change of the VFH from the MT-FLI on that of the laboratory findings (AST, ALT, albumin, bilirubin, PT, ICG-R15) before and after AHN induction. Results: The mean±SD of the VFH from the MT-FLI in AHN was 61.2±10.7% of that of the normal ones. The DAHN/DN showed strong positive linear dependence on the VFH in their pathologic specimens (β=.769, p<.05). The change of the VFH from MT-FLI showed high linear dependence on that of all the above-mentioned laboratory findings (β<-.933 or >.938, p<.05). Conclusion: The MT-FLI seems to be a feasible method for measuring VFH in the liver. 목적: 저자들은 간 내 생존 간세포분율 평가에서 망가포디피르 트리소디움 조영증강 기능적 간영상법(이하 기능적 간영상법)의 이용 가능성을 알아보고자 본 연구를 시행하였다. 대상과 방법: 저자들은 15예의 개 간에서 CCl4를 이용하여 유발한 급성 간괴사 전후의 생존 간세포분율 변화를 기능적 간영상법을 이용하여 알아보았다. 자기공명영상은 1.5T MRI기기에서 EFGRE-3D 기법(TR/TE = 4.7/1.1 msec; flip angle, 20.0°)을 이용하여 시행하였다. 급성간괴사가 있는 간의 자기공명영상소견에서 정상과 비교한 생존 간세포의 비교밀도(DAHN/DN)와 조직 병리표본에서 생존 간세포분율의 상관관계 및 급성 간 괴사 유발 전후의 간기능검사소견(AST, ALT, albumin, bilirubin, PT, ICG-R15) 변화와 기능적 간영상소견에서 생존 간세포분율 변화간의 상관관계를 알아보았다. 결과: 급성 간 괴사가 유발된 간의 기능적 간영상소견에서 생존 간세포분율의 평균값은 정상상태의 61.2±10.7% 였다. DAHN/DN은 조직 병리표본에서의 생존 간세포분율과 높은 상관관계를 보였다(β= .769, p < .05). 기능적 간영상소견에서 생존 간세포분율의 변화는 간 괴사 유발 전후의 간기능검사소견 변화와 높은 상관관계를 보였다(β<-.933 or > .938, p < .05). 결론: 기능적 간영상법은 간 내 생존 간세포분율의 측정에 유용한 방법으로 생각한다.
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위 유문동벽 비후 : 가성 병변인가, 종양인가\ulcorner
조순구 대한영상의학회 1999 대한영상의학회지 Vol.40 No.2
Purpose : To demonstrate the two-phase spiral CT features of pseudo-wall thickening and tumor in the gastricantrum, and to evaluate the possibility of differential diagnosis by analyzing two-phase spiral CT scans.Materials and Methods : We retrospectively reviewed 120 cases in which two-phase spiral CT scans showed focal wallthickening in the prepyloric antrum of the stomach. Our series included 60 cases of gastric cancer (includingseven of early gastric cancer) and 60 cases of normal prepyloric antrum. All patients underwent two-phase spiralCT and upper gastrointestinal series (n=83) and/or gastric endoscopy (n=80). All cancer cases were confirmed bybiopsy (n=60). We evaluated the differential points between gastric cancer and pseudo-wall thickening of thegastric antrum. Results : The mean thickness of the antral wall was 19.0mm in the cancer group and 12.5mm in thenormal group. Thirty-one cases (51.7%) in the cancer group and 51 (85.0%) in the normal group showed concentricwall thickening, while in each group, the remainder showed eccentric wall thickening. The common enhancementpatterns of thickened wall in the cancer group were 1) a thick enhanced mucosal layer during the arterial phase,with diffusely enhanced whole wall thickness during the venous phase (n=21); 2) a thick enhanced mucosal layerduring the arterial phase, with thicker and more intense enhancement of the same area during the venous phase(n=18). In the normal group, the common enhancement pattern was a thin enhanced mucosal layer during both thearterial and venous phase (n=34). In the cancer group, the common associated findings were regionallymphadenopathy (n=43) and food remnants in the stomach (n=15), and in the normal group, intraluminal normalmucosal folds in the thickened segment (n=50). The findings of food remnants despite overnight fasting andintraluminal normal folds occurred only in the cancer and normal group, respectively. Conclusion : Pseudo-wallthickening frequently showed thin enhancement of the mucosal layer on both the arterial and venous phases oftwo-phase spiral CT scan; a tumor frequently showed a thick enhanced mucosal layer during the arterial phase, withdiffusely enhanced whole-wall thickness during the venous phase or a thick enhanced mucosal layer during thearterial phase, with thicker and more intense enhancement of the same area during the venous phase. The finding ofthin and homogeneously enhanced intraluminal normal mucosal folds in the thickened segment strongly suggested thatthe lesion was a pseudo-lesion.
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조순구,박상덕,이훈갑,주정화 대한신경외과학회 1983 Journal of Korean neurosurgical society Vol.12 No.2
A study of local hypothermia upon the brain was performed in cats. Extravascular local cooling of brain was designed for the experiment using a head exchanger with a cuff. The cuff was circulated by a cold liquid, saline, at a temperature of 0°±1.1℃ and rested on brain surface. The thermocouples were inserted and placed at different depths of each 0.5㎝ in the brain, and then temperatures were measured at each depth before and during cooling every 10 minutes. The mean precooling temperatures were 32.0℃ at brain surface and 37.7℃ at 1.5㎝ depth in brain. During cooling, temperature lowering was the most marked and evident at extent of 1.0㎝ thickness in the subcortical tissue. The lowest mean temperature at each depth throughout the cooling were 18.9℃ at surface, 20.0℃ at 0.5㎝ depth, 22.9℃ at 1.0㎝ depth and 32.8℃ at 1.5㎝ depth in the brain. Temperature lowering in the area of brain injured by contusion was more marked and evident in its degree than that in the normal brain, especially within 10 minutes of cooling. Another design of this experiment was an evaluation of the effect of local hypothermia on cerebral edema induced by impaction injury of the brain. Immediately after the intravenous administration of fluorescein, impaction injuries were made on the area of suprasylvian gyri, and then the left part of hemisphere received local hypothermia while the counter part of same brain was untreated. These injuried brains were removed as specimens at various time intervals after trauma and their coronal sections were examined macroscopically under the ultraviolet illumination. In cooled hemisphere, there were lesser extent of spread and brightness of fluorescein than those in the untreated. Local cerebral cooling in this experimental condition was safe and beneficial in the treatment of trauma-induced vasogenic edema.
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