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Heo Yujin,Nayeon Choi,유건희,Chung Man Ki 대한후두음성언어의학회 2022 대한후두음성언어의학회지 Vol.33 No.1
Chronic invasive aspergillosis is a life-threatening disease, especially in immunocompromised patients. The diagnosis and treatment of tracheal aspergillosis (TA) are challenging because of its rarity and nonspecific clinical presentations. The treatment standard of TA has been medical treatment like other forms of invasive aspergillosis, but patients with medically resistant TA require surgical intervention. We demonstrated a successful surgical outcome of chronic invasive TA in a 16-year-old patient with immunocompromised status related to acute myelocytic leukemia.
Middle Cerebral Artery doppler in increased internal cranial pressure fetus
( Yujin Heo ),( Juyeon Kang ),( Hyun Mi Kim ),( Mi Ju Kim ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-
Doppler of the middle cerebral artery (MCA), along with doppler of the umbilical artery (UA), is one of the tools that provide information about the well-being in fetuses. In fetal hypoxemia, there is a central redistribution of blood flow with decreased impedance, allowing for increasing blood flow and preferential delivery of oxygen to the brain. When accompanied by high peak systolic velocity (PSV), it may indicate fetal anemia. Although rare, in some cases of normally grown fetuses, reverse end-diastolic flow in MCA may be indicative of increasing intracranial pressure (IICP), even when PSV is within normal range. A normally grown fetus at 35weeks 1day of gestational age was diagnosed with severe bilateral ventriculomegaly and suspicious intracranial hemorrhage (ICH). We found reverse diastole on MCA Doppler on the day of diagnosis, but with normal peak systolic velocity. On the next day, oligohydramnios developed and ventriculomegaly aggravated. We continuously found absent diastole and intermittent reverse diastole on MCA. With the above findings, the patient complained of decreased fetal movement so underwent emergency cesarean section. The delivered baby was a male weighing 2530g, adequate for gestational age, and APGAR score was 8 at 1min and 9 at 5min respectively. Hb was 13.4 g/dL and there was no serologic evidence of microbial infection. Postnatal brain ultrasonography showed intraventricular cystic change and univentricular thrombus. External ventricular drainage (EVD) was conducted in each ventricle. After removal of EVD, the neonate did not aggravate hydrocephalus. Neonate discharged after 40 days of hospitalization. This case demonstrates that sustained reverse end-diastolic flow alone without increased PSV may be a worrisome sign of AGA fetus under condition that is likely to cause IICP, such as ICH.
Mixed application of Bt products against three species of moths
Jeong Jun Kim,Hong Zhu,Heo Seon,Yujin Song,Sang Guei Lee 한국응용곤충학회 2010 한국응용곤충학회 학술대회논문집 Vol.2010 No.10
The first commercial bioinsecticide in Korea was registered in 2003 to control diamond back moth and beet armyworm in Chinese cabbage using Bacillus thuringiensis subsp. aizawai. Currently, fourteen microbial pesticides have registered in Korean market. The Korean government is aiming for 40% reduction (from the 2004 value) in the use of chemical pesticides by 2013. To increase the use of microbial pesticides as an alternative of chemicals, we conducted in vitro bioassay with Bt products. Bt products were treated alone and in combination against larvae of beet armyworm, diamond back moth and tobacco cutworm. Five Bt products shown high mortality against diamond back moth in recommended concentration, but had low control effects against beet armyworm and tobacco cutworm. Mixed Bt products had no synergic effects against the tested three moths. When Bt products were sprayed with higher concentration than recommended dose, those mortality was similar with lower concentration.
Therapeutic effects of ginsenosides on breast cancer growth and metastasis
Yujin Jin,Diem Thi Ngoc Huynh,Thuy Le Lam Nguyen,Hyesu Jeon,Kyung-Sun Heo 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.8
Breast cancer is the most common cause ofcancer-related deaths among women worldwide. Thus, thedevelopment of new and eff ective low-toxicity drugs is vital. The specifi c characteristics of breast cancer have allowed forthe development of targeted therapy towards each breast cancersubtype. Nevertheless, increasing drug resistance is displayedby the changing phenotype and microenvironmentsof the tumor through mutation or dysregulation of variousmechanisms. Recently, emerging data on the therapeuticpotential of biocompounds isolated from ginseng have beenreported. Therefore, in this review, various roles of ginsenosidesin the treatment of breast cancer, including apoptosis,autophagy, metastasis, epithelial-mesenchymal transition,epigenetic changes, combination therapy, and drug deliverysystem, have been discussed.
Yujin Jin,Diem Thi Ngoc Huynh,Kyung-Sun Heo 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.3
Ginsenoside-Rh1 (Rh1) is a ginseng-derivedcompound that has been reported to exert anticancer eff ectsby regulating cell cycle arrest and apoptosis according toreactive oxygen species (ROS) production. However, theeff ects of Rh1 on mitochondrial dysfunction are involved intriple negative breast cancer (TNBC) cell apoptosis, and therelated molecular mechanisms remain unknown. Rh1 treatmentinduced cell toxicity less than 50% at 50 μM. In addition,Rh1 induced apoptosis in TNBC cells through cleavedcaspase-3 activation and G1/S arrest. The Rh1-treatedTNBC cells showed a signifi cant increase in mitochondrialROS (mtROS), which in turn increased protein expressionof mitochondrial molecules, such as Bak and cytochromeC, and caused the loss of mitochondrial membrane potential. Pretreatment with mitochondria-targeted antioxidantMito-TEMPO alters the Rh1-reduced rate of mito- andglycol-ATP. Furthermore, Rh1 induces ER stress-mediatedcalcium accumulation via PERK/eIF2α/ATF4/CHOP pathway. Inhibition of ATF4 by siRNA transfection signifi cantlyinhibited Rh1-mediated apoptosis and calcium production. Interestingly, Mito-TEMPO treatment signifi cantly reducedapoptosis and ER stress induced by Rh1. Finally, Rh1 at5 mg/kg suppressed tumor growth through increased levelsof ROS production, cleaved caspase-3, and ATF4 more than5-fl uorouracil treated group. Overall, our results suggest thatRh1 has potential for use in TNBC treatment.
Experimental model and novel therapeutic targets for non-alcoholic fatty liver disease development
Yujin Jin,Kyung-Sun Heo The Korean Society of Pharmacology 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.4
Non-alcoholic fatty liver disease (NAFLD) is a complex disorder characterized by the accumulation of fat in the liver in the absence of excessive alcohol consumption. It is one of the most common liver diseases worldwide, affecting approximately 25% of the global population. It is closely associated with obesity, type 2 diabetes, and metabolic syndrome. Moreover, NAFLD can progress to non-alcoholic steatohepatitis, which can cause liver cirrhosis, liver failure, and hepatocellular carcinoma. Currently, there are no approved drugs for the treatment of NAFLD. Therefore, the development of effective drugs is essential for NAFLD treatment. In this article, we discuss the experimental models and novel therapeutic targets for NAFLD. Additionally, we propose new strategies for the development of drugs for NAFLD.