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( Yi-shan Ding ),( Won-suk Kim ),( Sun Joo Park ),( Se-kwon Kim ) 한국수산과학회(구 한국수산학회) 2018 Fisheries and Aquatic Sciences Vol.21 No.3
Background: Apoptosis is a process of programmed cell death, and apoptosis defect results in serious diseases such as cancer. Apoptosis induction is one of the key mechanisms of anti-cancer agents. This study was aimed to find anti-prostate cancer compounds from marine-derived fungus Microsporum sp. Results: We found that physcion isolated from the fermentation broth extract of the marine fungus Microsporum sp. strain MFS-YL decreases the cell proliferation of PC3 human prostate cancer cells. Physcion induced cell apoptosis as determined by Annexin V/propidium iodide double staining. Physcion downregulated the anti-apopotoic proteins such as Ras, Bcl-xL, and Bcl-2, whereas upregulated the pro-apoptotic Bax. Physcion also activated caspase-3, caspase-8, and caspase-9. Conclusion: These results suggest that physcion from Microsporum sp. inhibits the proliferation of PC3 human prostate cancer cells via the pathway leading to apoptotic cell death. Physcion may be a potential candidate in the field of anticancer drug discovery against human prostate cancer.
Ding, Yi-Shan,Kim, Won-Suk,Park, Sun Joo,Kim, Se-Kwon The Korean Society of Fisheries and Aquatic Scienc 2018 Fisheries and Aquatic Sciences Vol.21 No.8
Background: Apoptosis is a process of programmed cell death, and apoptosis defect results in serious diseases such as cancer. Apoptosis induction is one of the key mechanisms of anti-cancer agents. This study was aimed to find anti-prostate cancer compounds from marine-derived fungus Microsporum sp. Results: We found that physcion isolated from the fermentation broth extract of the marine fungus Microsporum sp. strain MFS-YL decreases the cell proliferation of PC3 human prostate cancer cells. Physcion induced cell apoptosis as determined by Annexin V/propidium iodide double staining. Physcion downregulated the anti-apopotoic proteins such as Ras, Bcl-xL, and Bcl-2, whereas upregulated the pro-apoptotic Bax. Physcion also activated caspase-3, caspase-8, and caspase-9. Conclusion: These results suggest that physcion from Microsporum sp. inhibits the proliferation of PC3 human prostate cancer cells via the pathway leading to apoptotic cell death. Physcion may be a potential candidate in the field of anticancer drug discovery against human prostate cancer.
기술시대 지역정신을 존중하는 현대경관설계 : 북경사계스키장 경관계획 사례
丁山,이기철,박승범,남정칠,김승환,강영조 東亞大學校 建設技術硏究所 2007 硏究論文集 Vol.30 No.2
The Four-Season ski resort which is prepared for 2008 Beijing Olympic project is the biggest indoor ski-dome. The fundamental concept for landscape design is to harmonize the development of Beijing city via the construction of modern building, the culture of China and Olympic spirit. Thus, the concept is evolved from the satisfaction of public, the realization of ecology and the site-of-art technique. The project requires the value of regional spirit when carrying out the planning of landscape. Thus, the starting point of design is evolved from the respect for nature, humanism, culture, sustainable development of city and ecosystem.