The effects of codon usage on the formation of secondary structures of nucleocapsid protein of peste des petits ruminants virus

Xiao‑xia Ma,Yi‑ning Wang,Xiao‑an Cao,Xue‑rui Li,Yong‑sheng Liu,Jian‑hua Zhou,Xue‑peng Cai 한국유전학회 2018 Genes & Genomics Vol.40 No.9

The nucleocapsid (N) protein of peste des petits ruminants virus (PPRV) with a conserved amino acid usage pattern plays an important role in viral replication. The primary objective of this study was to estimate roles of synonymous codon usages of PPRV N gene and tRNA abundances of host in the formation of secondary structure of N protein. The potential effects of synonymous codon usages of N gene and tRNA abundances of host on shaping different folding units (α-helix, β-strand and the coil) in N protein were estimated, based on the information about the modeling secondary structure of PPRV N protein. The synonymous codon usage bias was found in different folding units in PPRV N protein. To better understand the role of translation speed caused by variant tRNA abundances in shaping the specific folding unit in N protein, we modeled the changing trends of tRNA abundance at the transition boundaries from one folding unit to another folding unit (β-strand → coil, coil → β-strand, α-helix → coil, coil → α-helix). The obvious fluctuations of tRNA abundance were identified at the two transition boundaries (β-strand → coil and coil → β-strand) in PPRV N protein. Our findings suggested that viral synonymous codon usage bias and cellular tRNA abundance variation might have potential effects on the formation of secondary structure of PPRV N protein.

Treatment of fever with traditional Chinese medicine according to Zheng on cancer patients (based on case reports)

Peng Cao,Lan-Ying Liu,Xue-Ting Cai,Xiao-Ning Wang,Jie-Ge Huo,Zhong-Ying Zhou 셀메드 세포교정의약학회 2012 셀메드 (CellMed) Vol.2 No.2

Fever in cancer patients is often due to the following causes: evil qi and toxity stagnancy, disorders of qi and blood, deficiencies of zang and fu organs, and the disorder of yin and yang. The treatments given to cancer patients with a fever are according to five: (a) Excessive inner heat and toxicants: remove heat and the toxicant, induce purgation. We use Cheng-Qi-Tang plus Qing-Wen-Bai-Du-Yin. (b) Tangle of damp and heat, and qi stagnancy: remove damp and heat, smooth the qi channel. We use Gan-Lu-Xiao-Du-Dan or San-Ren-Tang. (c) Obvious blood and heat stagnancy: remove heat and blood stasis. We use Xue-Fu-Zhu-Yu-Tang. (d) Deficiency of spleen qi, inner heat caused by a yin deficiency: nourish spleen qi and yin to remove the inner heat. We use Bu-Zhong-Yi-Qi-Tang or Xiao-Jian-Zhong-Tang. (e) Prominent yin deficiency and hectic fever: replenish yin and remove inner heat. We use Qing-Hao-Bie-Jia-Tang or Chai-Qian-Mei-Lian-San. The pathogenesis of fever in cancer patients is complicated. We can see both deficiency and excess in one differentiation. Therefore, we must make sure of it, then we can get the most effective treatment.

Interval-valued Analytic Network Process and its Application in Risk Assessment of Dynamic Alliance

Xiao-Guang Zhou,Yan-Hui Zhou,Xiao-Xiao Cui 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.9

Analytic Network Process (ANP) has been widely used in solving many complicated decision making problems. An approach to acquire the comprehensive weights of interval-valued Analytic Network Process (IV-ANP) is proposed. Firstly, the independent local interval-valued weights are obtained by solving the goal programming for interval-valued pairwise comparison matrices. Based on the interaction and feedback relationships among criteria and/or indices, an unweighted interval-valued supermatrix is formed. To avoid loss of information, an extreme value method is developed for acquiring the global weights of IV-ANP. Secondly, the alternatives are ranked on the basis of interval-valued preference order. Finally, with the interaction and feedback relationships between criteria and/or indices being considered, an index system for assessing the risk of dynamic alliance is presented. With the uncertain and inaccurate information during the evaluation process being considered, the proposed IV-ANP method is applied for risk assessment of dynamic alliance, and sensitivity analyses for some key risk factors are performed to show their impacts on the risk levels of alliance enterprises.

A new reconfigurable liquid-metal-antenna-based sensor

Xiao-Ping Zhou,Yihui Fu,Hantao Zhu,Zihao Yu,Shanyong Wang 국제구조공학회 2022 Smart Structures and Systems, An International Jou Vol.30 No.4

In this paper, a new sensor chip with frequency reconstruction range of 2.252 GHz ~ 2.450 GHz is designed and fabricated. On this basis, a self-designed "T-shaped" shell is added to overcome the disadvantage of uneven deformation of the traditional steel shell, and the range of the sensor chip is expanded to 0 kN ~ 96 kN. The liquid metal antenna is used to carry out a step-by-step loading test, and the relationship between the antenna resonance frequency and the pressure load is analyzed. The results show that there is a good linear relationship between the pressure load and the resonant frequency. Therefore, the liquid metal antenna can be regarded as a pressure sensor. The cyclic loading and unloading experiments of the sensor are carried out, and different loading rates are used to explore the influence on the performance of the sensor. The loading and unloading characteristic curves and the influence characteristic curves of loading rate are plotted. The experimental results show that the sensor has no residual deformation during the cycle of loading and unloading. Moreover, the influence of temperature on the performance of the sensor is studied, and the temperature correction formula is derived.

Characterization of Microstructure and Mechanical Properties of Mg–8Li–3Al–1Y Alloy Subjected to Different Rolling Processes

Xiao Zhou,Qiang Liu,Ruirui Liu,Haitao Zhou 대한금속·재료학회 2018 METALS AND MATERIALS International Vol.24 No.6

The mechanical properties and microstructure evolution of Mg–8Li–3Al–1Y alloy undergoing different rolling processeswere systematically investigated. X-ray diffraction, optical microscope, scanning electron microscopy, transmission electronmicroscopy as well as electron backscattered diffraction were used for tracking the microstructure evolution. Tensile testingwas employed to characterize the mechanical properties. After hot rolling, the MgLi2Alprecipitated in β-Li matrix due to thetransformation reaction: β-Li → β-Li + MgLi2Al + α-Mg. As for the alloy subjected to annealed hot rolling, β-Li phase wasclearly recrystallized while recrystallization rarely occurred in α-Mg phase. With regard to the microstructure undergoing coldrolling, plenty of dislocations and dislocation walls were easily observed. In addition, the microstructure of alloys subjectedto annealed cold rolling revealed the formation of new fresh α-Mg grains in β-Li phase due to the precipitation reaction. Themechanical properties and fracture modes of Mg–8Li–3Al–1Y alloys can be effectively tuned by different rolling processes.

Synthesis and Characteristic of Novel Soluble Triazoleimide Oligomers with Terminated Arylacetylene

Zhou, Xiao'an,Du, Lei,Wan, Liqiang,Wang, Xiaofei,E, Yanpeng,Huang, Farong Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.9

Novel soluble triazoleimide oligomers terminated with arylacetylene terminated were synthesized by the Cu(I)-catalysed 1,3-dipolar cycloaddition polymerization of diazides and imide-containing dialkyne. Several molecular weight triazoleimide oligomers were prepared from diazide and dialkyne monomers with different stoichiometric combinations. The curing behaviors of the oligomers were tested by differential scanning calorimetry (DSC). The thermal properties of the cured products were evaluated by DSC and thermogravimetric analysis (TGA). These cured oligomers showed the glass transition temperature of about $225-235^{\circ}C$ and the decomposition temperature (at 5% weight loss) of about $385-393^{\circ}C$ in nitrogen.

Triterpenoids and Sterones from the Stem Bark of Ailanthus altissima

Xiao-Jiang Zhou,Min Xu,Xue-Song Li,Yue-Hu Wang,Ye Gao,Rui Cai,Yong-Xian Cheng 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.1

One new tirucallane-type triterpenoid, alianthusaltinin A (1), one new C29 sterone, alianthaltone A (2), and 12 known compounds have been isolated from the stem bark of Ailanthus altissima. The structures of new compounds were identified by means of spectroscopic methods. Compound 3 was isolated from natural sources for the first time, and compounds 4, 5, and 9 were isolated from this plant for the first time.

Structural deformation monitoring and service reliability analysis for slab track in plateau areas

Xiao-Zhou Liu,Zai-Wei Li,Hong-Yao Lu,Yue-Lei He 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.9

How to effectively monitor the structural condition of slab track and determine its service reliability is a key problem to be solved in the development of high-speed rail (HSR) lines in plateau areas, due to the influence of extreme climate, such as low air pressure, dryness and large temperature difference. To this end, this paper first develops an online displacement monitoring system for double-block slab track. Considering the actual operation condition of the HSR line, this system uses the non-contact vision sensing technique to measure the slab displacement. The slab temperature is also measured synchronously by the system. Then, the relationship between atmospheric temperature and the displacement of the slab track is discussed. The monitoring data are grouped according to three temperature states when being collected: stable temperature, rapid temperature rise, and rapid temperature drop. Finally, the serviceability limit state (SLS) equation of slab track is established and the service reliability of slab track under three temperature conditions is calculated using Monte Carlo method. The results show that track slab deformation is highly sensitive to temperature change and can significantly affect the service reliability of the slab track; compared with the period of “stable temperature”, when the temperature rises rapidly, the reliability index of the slab track decreases from 4.48 to 3.92 and the corresponding failure possibility increases around 12 times. This research can provide data support and theoretical basis for intelligent health management of the HSR slab track in the plateau area.

Synthesis and Characteristic of Novel Soluble Triazoleimide Oligomers with Terminated Arylacetylene

Xiao’an Zhou,Lei Du,Liqiang Wan,Xiaofei Wang,Yanpeng E,Farong Huang 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.9

Novel soluble triazoleimide oligomers terminated with arylacetylene terminated were synthesized by the Cu(I)-catalysed 1,3-dipolar cycloaddition polymerization of diazides and imide-containing dialkyne. Several molecular weight triazoleimide oligomers were prepared from diazide and dialkyne monomers with different stoichiometric combinations. The curing behaviors of the oligomers were tested by differential scanning calorimetry (DSC). The thermal properties of the cured products were evaluated by DSC and thermogravimetric analysis (TGA). These cured oligomers showed the glass transition temperature of about 225 - 235 oC and the decomposition temperature (at 5% weight loss) of about 385 - 393 oC in nitrogen.

Allium Vegetables and Risk of Prostate Cancer: Evidence from 132,192 Subjects

Zhou, Xiao-Feng,Ding, Zhen-Shan,Liu, Nai-Bo Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7

Objective: To evaluate the relationship between allium vegetable intake and risk of prostate cancer. Methods: A systematic literature search up to May 2013 was carried out in PubMed, EMBASE, Scopus, Web of Science, Cochrane register, and Chinese National Knowledge Infrastructure (CNKI) databases, and the references of retrieved articles were also screened. The summary relative risks with 95% confidence interval for the highest versus the lowest intake of allium vegetables were calculated. Heterogeneity and publication bias were also evaluated. Results: A total of nine epidemiological studies consisting of six case-control and three prospective cohort studies were included. We found a significantly decreased risk of prostate cancer for intake of allium vegetables (OR=0.82, 95% CI 0.70, 0.97). Moreover, in the subgroup analysis stratified by allium vegetable types, significant associations were observed for garlic (OR=0.77, 95% CI 0.64-0.91) but not onions (OR=0.84, 95% CI 0.62-1.13). Conclusions: Allium vegetables, especially garlic intake, are related to decreased risk of prostate cancer. Because of the limited number of studies, further well-designed prospective studies are warranted to confirm the findings of our study.