Multidimensional Differential-Linear Cryptanalysis of ARIA Block Cipher

Wen-Tan Yi,Jiongjiong Ren,Shao-Zhen Chen 한국전자통신연구원 2017 ETRI Journal Vol.39 No.1

ARIA is a 128-bit block cipher that has been selected as a Korean encryption standard. Similar to AES, it is robust against differential cryptanalysis and linear cryptanalysis. In this study, we analyze the security of ARIA against differential-linear cryptanalysis. We present five rounds of differential-linear distinguishers for ARIA, which can distinguish five rounds of ARIA from random permutations using only 284.8 chosen plaintexts. Moreover, we develop differential-linear attacks based on six rounds of ARIA-128 and seven rounds of ARIA-256. This is the first multidimensional differential-linear cryptanalysis of ARIA and it has lower data complexity than all previous results. This is a preliminary study and further research may obtain better results in the future.

Zero-Correlation Linear Cryptanalysis of Reduced Round ARIA with Partial-sum and FFT

( Wen-tan Yi ),( Shao-zhen Chen ),( Kuan-yang Wei ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.1

Block cipher ARIA was first proposed by some South Korean experts in 2003, and later, it was established as a Korean Standard block cipher algorithm by Korean Agency for Technology and Standards. In this paper, we focus on the security evaluation of ARIA block cipher against the recent zero-correlation linear cryptanalysis. In addition, Partial-sum technique and FFT (Fast Fourier Transform) technique are used to speed up the cryptanalysis, respectively. We first introduce some 4-round linear approximations of ARIA with zero-correlation, and then present some key-recovery attacks on 6/7-round ARIA-128/256 with the Partial-sum technique and FFT technique. The key-recovery attack with Partial-sum technique on 6-round ARIA-128 needs 2^123.6 known plaintexts (KPs), 2¹²¹encryptions and 2^90.3 bytes memory, and the attack with FFT technique requires 2^124.1KPs, 2^121.5 encryptions and 2^90.3 bytes memory. Moreover, applying Partial-sum technique, we can attack 7-round ARIA-256 with 2^124.6KPs, 2^203.5 encryptions and 2¹⁵² bytes memory and 7-round ARIA-256 employing FFT technique, requires 2^124.7KPs, 2^209.5 encryptions and 2¹⁵² bytes memory . Our results are the first zero-correlation linear cryptanalysis results on ARIA.

Loss-of-function HSD17B13 variants, non-alcoholic steatohepatitis and adverse liver outcomes: Results from a multi-ethnic Asian cohort

( Yi-wen Ting ),( Amanda Shen-yee Kong ),( Shamsul Mohd Zain ),( Wah-kheong Chan ),( Hwa-li Tan ),( Zahurin Mohamed ),( Yuh-fen Pung ),( Rosmawati Mohamed ) 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.3

Background/ Aims: 17β-hydroxysteroid dehydrogenase 13 (HSD17B13) variants were recently reported to have significantly lower odds of non-alcoholic fatty liver disease (NAFLD). This is a two-part study that aimed to evaluate the association of HSD17B13 variants with NAFLD and its histological severity, and to identify the association of the variants with clinical outcomes in a cohort of biopsy-proven NAFLD patients. Methods: Consecutive biopsy-proven NAFLD patients and controls without fatty liver were recruited for this study between 2009 and 2014. Genotyping for HSD17B13 variants was performed using rhAmp assays. A total of 165 patients with NAFLD were monitored up until August 2019. Clinical outcomes were recorded. Results: HSD17B13 rs72613567 TA allele and rs6834314 G allele were associated with lower odds of non-alcoholic steatohepatitis (NASH) in the overall cohort and among ethnic Chinese, but not among ethnic Malays or Indians (P<0.05). During a mean follow-up of 89 months, 32 patients (19.4%) experienced at least one clinical outcome (cardiovascular events, n=22; liver-related complications, n=6; extra-hepatic malignancy, n=5; and mortality, n=6). The rs72613567 homozygous TA allele and the rs6834314 homozygous G allele were independently associated with a lower incidence of liver-related complications (hazard ratio [HR], 0.004; 95% confidence interval [CI], 0.00-0.64; P=0.033 and HR, 0.01; 95% CI, 0.00-0.97; P=0.048, respectively) and were associated with lower grade of hepatocyte ballooning among the ethnic Chinese. Conclusion: HSD17B13 rs72613567 and rs6834314 variants were inversely associated with NAFLD and NASH, and were associated with lower incidence of adverse liver outcomes in a cohort of multi-ethnic Asian patients with NAFLD. (Clin Mol Hepatol 2021;27:486-498)

Differential Responses to Short-term Salinity Stress of Heat-tolerant Cherry Tomato Cultivars Grown at High Temperatures

Fang-Yi Liu,Kuo-Tan Li,Wen-Ju Yang 한국원예학회 2014 Horticulture, Environment, and Biotechnology Vol.55 No.2

Although many new tomato cultivars with various degrees of heat-tolerance have been released, year-roundtomato production in subtropical lowlands is still challenged by summer heat and an increasing risk from salinity stress. Little information about the simultaneous effects of heat and salinity on growth and fruiting in tomatoes is available. It was hypothesized that cultivars which perform better in high temperatures are also more tolerant to salinity stress. Two highly heat-tolerant cultivars, ‘Tainan ASVEG No. 19’ (TA19) and ‘Taiwan Seed ASVEG No. 22’ (TSA22), andone moderately heat-tolerant cultivar, ‘Hualien ASVEG No. 21’ (HA21), were grown under high temperature conditionsand were irrigated with a 0, 50, 150, or 200 mM NaCl solution for 20 days. Vegetative growth, fruiting behavior,and fruit quality were monitored. Number of leaves, leaf area, shoot fresh and dry weights, and root fresh weightwere generally decreased with increasing level of salinity stress, but root dry weight was not affected, resulting in anincrease in root to shoot ratio in all three cultivars. Yield was also decreased by salinity treatments in all threecultivars due to reduced number of flowers, fruit set, and fruit size. The highly heat-tolerant ‘TA19’ had the lowestvegetative growth and the highest yield under the high temperature condition, but the yield was strongly suppressedby the short-term mild salinity treatment. On the other hand, vegetative growth was little affected and the degree ofyield reduction was less intense with the short-term mild salinity treatment in the moderately heat-tolerant ‘HA21’. The result indicated that effects of heat stress and salinity stress are not additive and differential responses to salinityunder high temperatures exist among cultivars with various degrees of heat-tolerance.

IRS-2 Partially Compensates for the Insulin Signal Defects in IRS-1−/−Mice Mediated by miR-33

Chen-Yi Tang,Xiao-Fei Man,Yue Guo,Hao-Neng Tang,Jun Tang,Ci-La Zhou,Shu-Wen Tan,Min Wang,Hou-De Zhou 한국분자세포생물학회 2017 Molecules and cells Vol.40 No.2

Insulin signaling is coordinated by insulin receptor substrates (IRSs). Many insulin responses, especially for blood glucose metabolism, are mediated primarily through Irs-1 and Irs-2. Irs-1 knockout mice show growth retardation and insulin signaling defects, which can be compensated by other IRSs in vivo; however, the underlying mechanism is not clear. Here, we presented an Irs-1 truncated mutated mouse (Irs-1−/−) with growth retardation and subcutaneous adipocyte atrophy. Irs-1−/− mice exhibited mild insulin resistance, as demonstrat-ed by the insulin tolerance test. Phosphatidylino-sitol 3-kinase (PI3K) activity and phosphorylated Protein Kinase B (PKB/AKT) expression were elevated in liver, skeletal muscle, and subcu-taneous adipocytes in Irs-1 deficiency. In addition, the expression of IRS-2 and its phosphorylated version were clearly elevated in liver and skeletal muscle. With miRNA microarray analysis, we found miR-33 was down-regulated in bone marrow stromal cells (BMSCs) of Irs-1−/− mice, while its target gene Irs-2 was up-regulated in vitro studies. In addition, miR-33 was down-regulated in the presence of Irs-1 and which was up-regulated in fasting status. What’s more, miR-33 restored its expression in re-feeding status. Meanwhile, miR-33 levels decreased and Irs-2 levels increased in liver, skeletal muscle, and subcutaneous adipocytes of Irs-1−/− mice. In primary cultured liver cells transfected with an miR-33 inhibitor, the expression of IRS-2, PI3K, and phosphorylated-AKT (p-AKT) increased while the opposite results were observed in the presence of an miR-33 mimic. Therefore, decreased miR-33 levels can up-regulate IRS-2 expression, which appears to compensate for the defects of the insulin signaling pathway in Irs-1 deficient mice.

A Sb2Se3/Palygorskite Nanocomposite Catalyst for p-Nitrophenol Reduction

Lin Tan,Aidong Tang,Muen He,Xin Wen,Laifu Zhong,Peng Yan,Jing Chenc,Yi Zhang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.9

A nanocomposite consisting of rod-like Sb2Se3 and fiberous palygorskite (Pal) was prepared using cetyltrimethyl ammonium bromide (CTAB) as a pillaring agent to change Pal microstructure. CTAB optimal dosage was 0.2 g (versus 0.388 g of Pal). Sb2Se3/Pal has a high catalytic activity towards the catalytic reduction of p-nitrophenol to p-aminophenol while in the presence of NaBH4 at room temperature. The excellent performance is attributed to dispersion of rod-like Sb2Se3 in fiberous Pal which promoted more active sites exposure. The results provide new ideas for preparing new catalysts.

IRS-2 Partially Compensates for the Insulin Signal Defects in IRS-1^-/- Mice Mediated by miR-33

Tang, Chen-Yi,Man, Xiao-Fei,Guo, Yue,Tang, Hao-Neng,Tang, Jun,Zhou, Ci-La,Tan, Shu-Wen,Wang, Min,Zhou, Hou-De Korean Society for Molecular and Cellular Biology 2017 Molecules and cells Vol.40 No.2

Insulin signaling is coordinated by insulin receptor substrates (IRSs). Many insulin responses, especially for blood glucose metabolism, are mediated primarily through Irs-1 and Irs-2. Irs-1 knockout mice show growth retardation and insulin signaling defects, which can be compensated by other IRSs in vivo; however, the underlying mechanism is not clear. Here, we presented an Irs-1 truncated mutated mouse ($Irs-1^{-/-}$) with growth retardation and subcutaneous adipocyte atrophy. $Irs-1^{-/-}$ mice exhibited mild insulin resistance, as demonstrated by the insulin tolerance test. Phosphatidylinositol 3-kinase (PI3K) activity and phosphorylated Protein Kinase B (PKB/AKT) expression were elevated in liver, skeletal muscle, and subcutaneous adipocytes in Irs-1 deficiency. In addition, the expression of IRS-2 and its phosphorylated version were clearly elevated in liver and skeletal muscle. With miRNA microarray analysis, we found miR-33 was down-regulated in bone marrow stromal cells (BMSCs) of $Irs-1^{-/-}$ mice, while its target gene Irs-2 was up-regulated in vitro studies. In addition, miR-33 was down-regulated in the presence of Irs-1 and which was up-regulated in fasting status. What's more, miR-33 restored its expression in re-feeding status. Meanwhile, miR-33 levels decreased and Irs-2 levels increased in liver, skeletal muscle, and subcutaneous adipocytes of $Irs-1^{-/-}$ mice. In primary cultured liver cells transfected with an miR-33 inhibitor, the expression of IRS-2, PI3K, and phosphorylated-AKT (p-AKT) increased while the opposite results were observed in the presence of an miR-33 mimic. Therefore, decreased miR-33 levels can up-regulate IRS-2 expression, which appears to compensate for the defects of the insulin signaling pathway in Irs-1 deficient mice.

Cohort profile: Singapore’s nationally representative Retirement and Health Study with 5 waves over 10 years

Ng Reuben,Tan Yi Wen,Tan Kelvin Bryan 한국역학회 2022 Epidemiology and Health Vol.44 No.-

The Retirement and Health Study (RHS) is Singapore’s largest nationally representative cohort with over 15,000 participants (aged 45-85 years) followed across five timepoints in 10 years (2014-2024). Accounting for sample weights, the sample represents 1.2 million Singaporeans and permanent residents of a total population of 5.5 million. The RHS sought consent to link survey responses to relevant administrative data, enabling the cross-validation of self-reports with national databases. There are 10 sections in the RHS with over 400 questions, 50% of which are on respondents’ physical and mental health, healthcare utilization and insurance; the remaining 50% are about employment history, retirement adequacy, wealth, and household expenditure. The RHS was set up to provide microdata to compliment administrative data for whole-of-government policy making given that Singapore will reach super-aged status by 2026. Sample findings include a need for older adults to balance between immediate financial needs and investments regarding their pension funds. Also, 86% of older adults preferred to transit into partial retirement by reducing workloads. On the health front, existing studies utilising the RHS have revealed latent classes of disabilities, and that intentions to seek employment can mitigate disability developments. Another study reported that physical disability and social isolation was projected to increase, with ethnic disparities in social functioning. Overall, the RHS will be used for evidenced-informed policy agenda setting and evaluation across domains of health, finance, retirement adequacy, social and family development.

Induction of Indoleamine 2,3-dioxygenase (IDO) Enzymatic Activity Contributes to Interferon-Gamma Induced Apoptosis and Death Receptor 5 Expression in Human Non-small Cell Lung Cancer Cells

Chung, Ting Wen,Tan, Kok-Tong,Chan, Hong-Lin,Lai, Ming-Derg,Yen, Meng-Chi,Li, Yi-Ron,Lin, Sheng Hao,Lin, Chi-Chen Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.18

Interferon-gamma (IFN-${\gamma}$) has been used to treat various malignant tumors. However, the molecular mechanisms underlying the direct anti-proliferative activity of IFN-${\gamma}$ are poorly understood. In the present study, we examined the in vitro antitumor activity of IFN-${\gamma}$ on two human non-small-cell lung carcinoma (NSCLC) cell lines, H322M and H226. Our findings indicated that IFN-${\gamma}$ treatment caused a time-dependent reduction in cell viability and induced apoptosis through a FADD-mediated caspase-8/tBid/mitochondria-dependent pathway in both cell lines. Notably, we also postulated that IFN-${\gamma}$ increased indoleamine 2,3-dioxygenase (IDO) expression and enzymatic activity in H322M and H226 cells. In addition, inhibition of IDO activity by the IDO inhibitor 1-MT or tryptophan significantly reduced IFN-${\gamma}$-induced apoptosis and death receptor 5 (DR5) expression, which suggests that IDO enzymatic activity plays an important role in the anti-NSCLC cancer effect of IFN-${\gamma}$. These results provide new mechanistic insights into interferon-${\gamma}$ antitumor activity and further support IFN-${\gamma}$ as a potential therapeutic adjuvant for the treatment of NCSLC.

Parecoxib: an Enhancer of Radiation Therapy for Colorectal Cancer

Xiong, Wei,Li, Wen-Hui,Jiang, Yong-Xin,Liu, Shan,Ai, Yi-Qin,Liu, Rong,Chang, Li,Zhang, Ming,Wang, Xiao-Li,Bai, Han,Wang, Hong,Zheng, Rui,Tan, Jing Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2

Background: To study the effect of parecoxib, a novel cyclooxygenase-2 selective inhibitor, on the radiation response of colorectal cancer (CRC) cells and its underlying mechanisms. Materials and Methods: Both in vitro colony formation and apoptosis assays as well as in vivo mouse xenograft experiments were used to explore the radiosensitizing effects of parecoxib in human HCT116 and HT29 CRC cells. Results: Parecoxib sensitized CRC cells to radiation in vitro with a sensitivity enhancement ratio of 1.32 for HCT116 cells and 1.15 for HT29 cells at a surviving fraction of 0.37. This effect was partially attributable to enhanced apoptosis induction by parecoxib combined with radiation, as illustrated using an in vitro apoptosis assays. Parecoxib augmented the tumor response of HCT116 xenografts to radiation, achieving growth delay more than 20 days and an enhancement factor of 1.53. In accordance with the in vitro results, parecoxib combined with radiation resulted in less proliferation and more apoptosis in tumors than radiation alone. Radiation monotherapy decreased microvessel density (MVD) and microvessel intensity (MVI), but increased the hypoxia level in xenografts. Parecoxib did not affect MVD, but it increased MVI and attenuated hypoxia. Conclusions: Parecoxib can effectively enhance radiation sensitivity in CRC cells through direct effects on tumor cells and indirect effects on tumor vasculature.