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- 저자 : ( Yuh-fen Pung ) (검색결과 4 건)
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Rhodomine B dye removal and inhibitory effect on B. subtilis and S. aureus by WOx nanoparticles
Yuet Lee Ying,Swee-Yong Pung,Ming Thong Ong,Yuh-Fen Pung 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.67 No.-
Visible-light-driven wide bandgap semiconductor photocatalysts were commonly developed via doping or coupling with another narrow bandgap metal oxide. However, these approaches required extra processing. The aim of study was to evaluate the photocatalytic performance of narrow bandgap WOx nanoparticles. A mixture of WO2 and WO3 nanoparticles were synthesized using solution precipitation technique. The photodegradation of RhB by these nanoparticles more effective in UV light than in visible light. In antibacterial susceptibility assay, WOx nanoparticles demonstrated good antibacterial against Gram-positive bacteria. The cell wall of bacterial was the main determinant in antibacterial effect other than W4+/W6+ ions and ROS.
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Highly UV light driven WOx@ZnO nanocomposites synthesized by liquid impregnation method
Myo Thuya Thein,Jia Ern Chim,Swee-Yong Pung,Yuh-Fen Pung 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.46 No.-
Highly UV driven WOx@ZnO nanocomposites were synthesized by liquid impregnation (LI) method. Thepresence of WOx particles on the surface of ZnO nanorods were verified by TEM and EDX mapping. Inaddition, the XPS analysis shows that the WOx nanoparticles were a mixture of WO2 and WO3nanoparticles. The photocatalytic enhancement of WOx@ZnO nanocomposites in degrading RhB dyeunder UV light suggests that deposition of WOx could have pro-longed the separation of electrons(in WOx) from the holes. More holes were able to diffuse to the surface of photocatalyst and directlyoxidized the RhB dye molecules into less harmful by-products.
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( Yi-wen Ting ),( Amanda Shen-yee Kong ),( Shamsul Mohd Zain ),( Wah-kheong Chan ),( Hwa-li Tan ),( Zahurin Mohamed ),( Yuh-fen Pung ),( Rosmawati Mohamed ) 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.3
Background/ Aims: 17β-hydroxysteroid dehydrogenase 13 (HSD17B13) variants were recently reported to have significantly lower odds of non-alcoholic fatty liver disease (NAFLD). This is a two-part study that aimed to evaluate the association of HSD17B13 variants with NAFLD and its histological severity, and to identify the association of the variants with clinical outcomes in a cohort of biopsy-proven NAFLD patients. Methods: Consecutive biopsy-proven NAFLD patients and controls without fatty liver were recruited for this study between 2009 and 2014. Genotyping for HSD17B13 variants was performed using rhAmp assays. A total of 165 patients with NAFLD were monitored up until August 2019. Clinical outcomes were recorded. Results: HSD17B13 rs72613567 TA allele and rs6834314 G allele were associated with lower odds of non-alcoholic steatohepatitis (NASH) in the overall cohort and among ethnic Chinese, but not among ethnic Malays or Indians (P<0.05). During a mean follow-up of 89 months, 32 patients (19.4%) experienced at least one clinical outcome (cardiovascular events, n=22; liver-related complications, n=6; extra-hepatic malignancy, n=5; and mortality, n=6). The rs72613567 homozygous TA allele and the rs6834314 homozygous G allele were independently associated with a lower incidence of liver-related complications (hazard ratio [HR], 0.004; 95% confidence interval [CI], 0.00-0.64; P=0.033 and HR, 0.01; 95% CI, 0.00-0.97; P=0.048, respectively) and were associated with lower grade of hepatocyte ballooning among the ethnic Chinese. Conclusion: HSD17B13 rs72613567 and rs6834314 variants were inversely associated with NAFLD and NASH, and were associated with lower incidence of adverse liver outcomes in a cohort of multi-ethnic Asian patients with NAFLD. (Clin Mol Hepatol 2021;27:486-498)
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Soh Fanny Chiat Orou,Kee Jeik Hang,Myo Thuya Thien,Ying Yuet Lee,Le Cheng Foh,Nguyen Duong Ngoc Diem,Goh Boon Hee,Pung Swee Yong,Pung Yuh Fen 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.62 No.-
Many studies suggested that waste water treatment using metal oxide nanoparticles, in particular the zinc oxide nanoparticles, appears to be an economical and efficient solution. However, antibacterial activities reported from various research groups were often confusing and contradicting. The present study aimed to evaluate the antibacterial effects and the underlying mechanisms on the custom-engineered Zinc oxice (ZnO) nanorods and ZnO nanodisks. Firstly, antibacterial activities of ZnO nanorods and ZnO nanodisks were studied on both Gram positive and Gram negative bacteria. The antibacterial performance of these ZnO nanoparticles were bench marked with titanium dioxide nanoparticles (TiO2). In antibacterial susceptibility assay, both types of ZnO nanoparticles showed potent inhibition on Bacillus subtilis (B. subtilis) and Staphylococcus aureus (S. aureus) with minimal inhibitory concentration (MIC) at 128 and 256 ug/ml, respectively. Nevertheless, no inhibition was found against Gram negative bacteria. Interestingly, no inhibition was found against both Gram positive and Gram negative bacteria for TiO2 nanoparticles, and thus TiO2 nanoparticles were omitted in the subsequent study. In the time-kill kinetics assay, the inhibitory effect of both types of ZnO nanoparticles on B. subtilis was significant as early as 90 min after treatment at 128 μg/ml. Besides different types of bacteria, generation of reactive oxygen species (ROS), surface area, surface charges, polarity were also examined. Our study suggested that the antibacterial effects of ZnO nanorods and ZnO nanodisks were mediated through not one but multiple chemical and physical properties of nanoparticles. This is the first report introducing a new concept on ‘Nanotoxicity Threshold’, i.e. the maximal tolerance level in bacteria before any damage manifested. Our study warrants that a more holistic view on the mechanistic insights of nanoparticles is required to minimize adverse health effect on human.
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