Expression of Osteopontin in Non-small Cell Lung Cancer and Correlative Relation with Microvascular Density

Yu, Ting-Ting,Han, Zhi-Gang,Shan, Li,Tao, Jie,Zhang, Tao,Yuan, Shuai-Fei,Shen, Hong-Li Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1

Background and Objective: Lung cancer is one of the malignant diseases which most seriously threat humansurvival and development. This study aimed to assess osteopontin (OPN) expression in non-small cell lung cancer (NSCLC) and any relationship with clinicopathological features. Methods: Immunohistochemistry was used to determine OPN expression and microvascular density (MVD) in 120 cases of NSCLC also undergoing clinical assessment. Results: Moderately positive expression of OPN was found in 34.6% (41/120) and strong expression in 47.5% (57/120) of the NSCLCs; OPN expression in carcinomas was higher than in pericarcinoma tissues (P<0.05). While no obvious association was observed with NSCLC patient age, gender, maximum diameter of the tumor and pathological type, OPN expression was more commonly detected in poorly differentiated carcinoma tissue and lymph node metastasis as well as at advanced clinical stage (P<0.05); OPN expression in cancer tissue was positively correlated with MVD (r = 0.839, P = 0.000). Conclusion: OPN plays an important role in promoting tumor angiogenesis and progress of NSCLCs and has the possibility to become the new target for therapy.

Mitigating SYN flooding Attack and ARP Spoofing in SDN Data Plane

Ting-Yu Lin,Jhen-Ping Wu,Pei-Hsuan Hung,Ching-Hsuan Shao,Yu-Ting Wang,Yun-Zhan Cai,Meng-Hsun Tsai 한국통신학회 2020 한국통신학회 APNOMS Vol.2020 No.09

As the number of network devices increases rapidly, it becomes more and more difficult to defend network attacks. Large-scaled attacks, such as SYN flooding, may lead to heavy burden to the switches as well as the controller in a software defined network (SDN). In this paper, we investigate the SYN flooding and Address Resolution Protocol (ARP) spoofing attacks in SDN, and then propose mechanisms to address these two attacks. We also present a new scheme to detect SYN flooding by using only a few forwarding rules. Moreover, we utilize the Programming Protocol-independent Packet Processors (P4) technique to mitigate the burden of the controller.

Factors Related to Treatment Refusal in Taiwanese Cancer Patients

Chiang, Ting-Yu,Wang, Chao-Hui,Lin, Yu-Fen,Chou, Shu-Lan,Wang, Ching-Ting,Juang, Hsiao-Ting,Lin, Yung-Chang,Lin, Mei-Hsiang Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8

Background: Incidence and mortality rates for cancer have increased dramatically in the recent 30 years in Taiwan. However, not all patients receive treatment. Treatment refusal might impair patient survival and life quality. In order to improve this situation, we proposed this study to evaluate factors that are related to refusal of treatment in cancer patients via a cancer case manager system. Materials and Methods: This study analysed data from a case management system during the period from 2010 to 2012 at a medical center in Northern Taiwan. We enrolled a total of 14,974 patients who were diagnosed with cancer. Using the PRECEDE Model as a framework, we conducted logistic regression analysis to identify independent variables that are significantly associated with refusal of therapy in cancer patients. A multivariate logistic regression model was also applied to estimate adjusted the odds ratios (ORs) with 95% confidence intervals (95%CI). Results: A total of 253 patients (1.69%) refused treatment. The multivariate logistic regression result showed that the high risk factors for refusal of treatment in cancer patient included: concerns about adverse effects (p<0.001), poor performance(p<0.001), changes in medical condition (p<0.001), timing of case manager contact (p=.026), the methods by which case manager contact patients (p<0.001) and the frequency that case managers contact patients (${\geq}10times$) (p=0.016). Conclusions: Cancer patients who refuse treatment have poor survival. The present study provides evidence of factors that are related to refusal of therapy and might be helpful for further application and improvement of cancer care.

Imbalanced Data Classification Based on AdaBoost-SVM

Li Peng,Bi Ting-ting,Yu Xiao-yang,Li Si-ben 보안공학연구지원센터 2014 International Journal of Database Theory and Appli Vol.7 No.5

The classification of imbalanced data is one of the most challenging problems in data mining and machine learning research. Imbalanced dataset is a form that exists in reality area, which describes truly and objectively the essential characters of something. There will appear paucity of data and flooded in the classification of imbalanced dataset. Beside problems such as loss of information and data splitting phenomenon will also appear when using the traditional machine learning methods. So how to solve the classification problem of imbalanced data will be challenging. In this paper, aiming at the above problems, a classification algorithm based on AdaBoost-SVM is proposed. In the experiments with four typical forms of imbalanced data sets in UCI were validated the effectiveness of this strategy.

Whole Cell-mediated Biocatalytic Synthesis of Helicid Cinnamylate and Its Biological Evaluation as a Novel Tyrosinase Inhibitor

Rong-ling Yang,Xi Chen,Yu-ye Song,Qian-lin Zhu,Muhammad Bilal,Yu Wang,Zheng Tong,Ting-ting Wu,Zhao-Yu Wang,Hong-zhen Luo,Xiang-jie Zhao,Ting-ting He 한국생물공학회 2022 Biotechnology and Bioprocess Engineering Vol.27 No.3

Tyrosinase inhibitors are clinically effective for treating some dermatological disorders related to melanin hyperpigmentation. Accordingly, the discovery and development of tyrosinase inhibitors have great value in the pharmaceutical and cosmetic industry. Here, a novel tyrosinase inhibitor, 6′-O-cinnamoyl-helicid (helicid cinnamylate) was successfully synthesized by a simple and effective biocatalytic approach with Aspergillus oryzae cells. Investigation of the effects of several key variables on helicid cinnamylate synthesis found that the reaction conversion, reaction rate and regioselectivity reached 99%, 9.40 mM/h and > 99%, respectively, at the optimal conditions with anhydrous acetone as the solvent, whole-cell concentration of 40 mg/mL, and the molar ratio of vinyl cinnamate to helicid of 10 at 45°C. The whole-cells retained 68.87% of its initial activity after reusing for seven batches, indicating a potent application potential in non-aqueous biocatalytic systems. It was worth noting that helicid cinnamylate demonstrated a more potent tyrosinase inhibitory activity with an IC50 value of 3.55 mM than helicid (IC50 = 4.48 mM) and arbutin (IC50 = 5.48 mM), which suggest that helicid cinnamylate could be developed as a more potential tyrosinase inhibitor. In conclusion, this study provides a novel whole-cell catalytic approach for the synthesis of helicid cinnamylate and insight into its application as a tyrosinase inhibitor.

BUILDING A SUSTAINABLE BUSINESS MODEL FOR PROFESSIONAL CLUBS IN THE CHINA NATIONAL BASKETBALL LEAGUE (NBL): A STAKEHOLDER PERSPECTIVE

Yu-Ting Chen,Jeeyeon Kim 글로벌지식마케팅경영학회 2020 Global Marketing Conference Vol.2020 No.11

Professional sport leagues are both commercial products and public products. As China’s sports leagues transition from state-governed properties to a more commercial model, professional sports are facing a crucial turning point on balancing stakeholders pertaining to its commercial/market value and social value. How to develop a sustainable business and management model of professional sports teams, fitting Chinese culture and the calls on free economy, has become a major challenge to scholars, practitioners and entrepreneurs in China’s sport industry. Every organisation has its relationships with many groups (stakeholders) that affect and are affected by its decisions, which are dynamic in a constantly changing world. Stakeholder theory was developed through concerns regarding the nature of these relationships in terms of both processes and outcomes for both organisation and stakeholders, and the changing nature of the environment.

THE EFFECT OF INFLUENCERS AND USER GENERATED CONTENT ON HIGH-END PRODUCT PURCHASE INTENTION

Yu-Ting Chen,Jeeyeon Kim 글로벌지식마케팅경영학회 2020 Global Marketing Conference Vol.2020 No.11

Marketing communication has undergone significant transformation in recent years. Influencers, who generate content on social networking sites (SNSs), have had a dramatic impact on consumers’ purchase decisions. Brands and marketers are therefore the most effective and powerful marketing tools. Social media influencers, so-called “YouTubers,” have become online opinion leaders by creating and posting content on social media, in contrast to celebrities who are well-known via traditional media in general. Previous studies regarding influencers have focused on the factors that contribute to the effectiveness of influencer marketing across various contexts or person-related factors. However, previous studies have not only elicited mixed findings concerning the effects of influencer marketing, but also reveal a lack of basic understanding of the mechanisms by which video content and influencers themselves impact consumer, particularly in the high-end product industry. Present-day social media influencers are not only information providers but also friendly communicators rather than inaccessible celebrities. Favorable attitudes towards influencers may play a crucial role in consumer behavior when purchasing high-end products in which have high prices and uncertainties. While some studies include the construct of the perception of influencers in their models, there is a lack of research on the effect of influencers and video content. Thus, we expect our empirical research to provide a comprehensive understanding of the nature of social contagion, which is highlighted by social media influencers.

TAZ as a novel regulator of oxidative damage in decidualization via Nrf2/ARE/Foxo1 pathway

Yu Hai-Fan,Zheng Lian-Wen,Yang Zhan-Qing,Wang Yu-Si,Wang Ting-Ting,Yue Zhan-Peng,Guo Bin 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

TAZ, as a crucial effector of Hippo pathway, is required for spermatogenesis and fertilization, but little is known regarding its physiological function in uterine decidualization. In this study, we showed that TAZ was localized in the decidua, where it promoted stromal cell proliferation followed by accelerated G1/S phase transition via Ccnd3 and Cdk4 and induced the expression or activity of stromal differentiation markers Prl8a2, Prl3c1 and ALP, indicating the importance of TAZ in decidualization. Knockdown of TAZ impeded HB-EGF induction of stromal cell proliferation and differentiation. Under oxidative stress, TAZ protected stromal differentiation against oxidative damage by reducing intracellular ROS and enhancing cellular antioxidant capacity dependent on the Nrf2/ARE/Foxo1 pathway. TAZ strengthened the transcriptional activity of Nrf2 which directly bound to the antioxidant response element (ARE) of Foxo1 promoter region. Additionally, silencing TAZ caused accumulation of intracellular ROS through heightening NOX activity whose blockade by APO reversed the disruption in stromal differentiation. Further analysis revealed that TAZ might restore mitochondrial function, as indicated by the increase in ATP level, mtDNA copy number and mitochondrial membrane potential with the reduction in mitochondrial superoxide. Additionally, TAZ modulated the activities of mitochondrial respiratory chain complexes I and III whose suppression by ROT and AA resulted in the inability of TAZ to defend against oxidative damage to stromal differentiation. Moreover, TAZ prevented stromal cell apoptosis by upregulating Bcl2 expression and inhibiting Casp3 activity and Bax expression. In summary, TAZ might mediate HB-EGF function in uterine decidualization through Ccnd3 and ameliorate oxidative damage to stromal cell differentiation via Nrf2/ARE/Foxo1 pathway.

Collaborative Action Research on the Implementation of a Preschool Aesthetic Thematic Curriculum

Yu-Ting Chen 환태평양유아교육연구학회 2017 Asia-Pacific journal of research in early childhoo Vol.11 No.2

Using collaborative action research, this study aimed to investigate the practice of implementing an aesthetic thematic curriculum in a preschool in Taiwan. The author served as a curriculum consultant and co-teacher with two early childhood teachers in a mixed-age preschool class. The participants were 22 young children aged 3 to 5. Data sources included classroom observations, interviews, teaching reflection notes, aesthetic ability assessment, and other documentation. The major findings are as follows. (1) Based on young children’s life experiences, the co-teachers applied a thematic approach to integrating the aesthetic domain and other learning domains in the aesthetic thematic curriculum, focusing on the topic of “Beautiful Restaurants.” (2) The young children’s aesthetic abilities were developed in terms of exploring and perceiving, performing and creating, and responding and appreciating. Moreover, there was a significant difference in the children’s aesthetic abilities. (3) The co-teachers promoted their professional development in aesthetic curriculum design and aesthetic teaching skills. Recommendations for early childhood aesthetic education and teacher education are discussed.

Numerical Investigation of Flow Characteristics in a Viscous Damping System with Symmetrical Hydraulic Cylinders

Yu-Ting Wu,Zhen Qin,Amre Eizad,Sung-Ki Lyu,Choon-Man Lee 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.22 No.4

Hydraulic dampers are widely applied due to their characteristics of absorbing huge impact energy, stable and reliable working performance, and easy on-demand design. The hydraulic cylinder is an important part of the hydraulic damping system and the flow conditions inside the cylinder significantly affect its performance. However, only a few researches related to the flow field inside the hydraulic cylinder have been reported. In this study, a novel viscous damping system with opposing symmetrical hydraulic cylinders that can guarantee the smoothness of vibration absorption in a single degree of freedom is proposed. The advantage of this design is that the damping characteristic can be regulated using the external flow valve provided in the external hydraulic loop. The hydraulic damping system is simulated using the commercial software ANSYS Fluent software environment, different strokes and frequencies are applied to observe the internal flow characteristics. As can be seen from the results of numerical investigation, when the piston on one side moves, the piston on the other side also moves, and the pressure change in the cylinder is caused by the collective effect of the cavity volume change and the flow change of the hydraulic oil. In addition, by comparing the streamline and velocity distribution in the cavity under different strokes and frequencies, the relationship between vortex and velocity and compression distance is summarized. These results provide valuable information to facilitate the design of viscous damping system with symmetrical hydraulic cylinders