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Kim, Young-Suk,Pi, Sung-Hee,Lee, Young-Man,Lee, Sang-Im,Kim, Eun-Cheol Wiley (John WileySons) 2009 Journal of periodontology Vol.80 No.12
<P>BACKGROUND: Although heme oxygenase-1 (HO-1) is involved in anti-inflammation, the mechanisms of its activity in regulating periodontal inflammation are largely unclear. Therefore, the aim of this study is to investigate the anti-inflammatory properties of HO-1 in lipopolysaccharide (LPS)- and proinflammatory cytokine-stimulated inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production in human periodontal ligament (PDL) cells. METHODS: PDL cells were treated with LPS plus a combination of tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta in serum-free media for 1 day. The production of NO was evaluated using a Griess reagent kit. The expression of iNOS and HO-1 proteins and mRNAs was evaluated using Western blotting and reverse transcriptase-polymerase chain reaction, respectively. RESULTS: Proinflammatory cytokines and LPS triggered iNOS and HO-1 expression and NO production in PDL cells. HO-1 inhibitor and HO-1 small interfering RNA (siRNA) attenuated the LPS- and cytokine-stimulated NO release and iNOS and HO-1 expression. Specific inhibitors of p38, extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinases phosphatidylinositol 3-kinase (PI3K), nuclear factor-kappa B (NF-kappaB), and protein kinase C delta (PKC-delta) greatly reduced the levels of iNOS and HO-1 expression induced by LPS plus cytokines. CONCLUSIONS: Collectively, these data suggested that HO-1 inhibition blocked LPS- and proinflammatory cytokine-stimulated iNOS expression and NO production in PDL cells via a mechanism that involves p38, ERK, PI3K, NF-kappaB, and PKC-delta. Thus, the regulation of HO-1 activity may be a therapeutic strategy for periodontal disease.</P>
Hwa-Jeong Lee,Kyung San Min,Sung-Hee Pi,Hoon-Sang Chang,Kyung-Hwa Kang,Hyung-Ryong Kim,Hong-In Shin,Suk-Keun Lee,Eun-Cheol Kim 대한구강악안면병리학회 2007 대한구강악안면병리학회지 Vol.31 No.5
Previous in vi tro studies demonstrated that H202 or carbamide peroxide cou ld penetrate i nto pul p chambers through enamel and dentin (Benetti et a l., 2004; G okay et a l. , 2004‘ Suli eman et al .. 2005) ‘ Recently. Lee et al.(2006) demonstrated that H20Z enhanced the diffe rentiation of odontoblast like cell line, whereas it inhibited osteogenic diffe rentiation in pre 。steobl astic cell line, as seen by its efl"ecLs on an early difï"erentiation marker. ALP activity. I-lowever. the effects of HZ02 have not been well elucidated in primary cultured human pulp cells ln th is study‘ we investigated whether HO- 1 is involved in H20 2-induced cytotoxicity and examined the production 0 1" dent in sia lophosphoprotein (DSPP) and other minera li zation markers, in human pulp cells H20Z dec1'eased cell viabili ty. but increased HO-l and DSPP expression in a concentra t ion and time dependent manner. Inhibitors of guanylate cyclase, PI3K. ERK, and p38 MAP kinase blocked J-!?,0 2- induced cytot oxicity and the expression of HO-1 and DSPP mRNAs in pulp cells. These data suggest that t he induction of HO-l by H202 in pu lp cells plays a protective role against the cytotoxic effects of H202 and stimulates DSPP expression. resulting in prematu re oclontoblast differentiation th rough pathways t hat involve cGMP. p38. ancl ERK
Hwa Jeong Lee,Kyung San Min,Sung Hee Pi,Hoon Sang Chang,Kyung Hwa Kang,Hyung Ryong Kim,Hong In Shin,Suk Keun Lee,Eun Cheol Kim 대한구강악안면병리학회 2007 대한구강악안면병리학회지 Vol.31 No.2
Al though the changes in tooth morphology and hardness by hydrogen peroxide(H20 z) have been r‘epor‘.ted .‘ the pαr。o야t뻐ec야tive role of heme oxygenase-l(HO-l) against the cytotoxic effects of H202 has not been clarifïed i n human pulp cells ln this st udy. we investigated whether HO-l is involved in Hz0 2-induced cytoLox icity a nd examined the production 0 1' dentin sia lophosphoprotein(DSPP) and other mineralization markers‘ in hllman pu lp cells H202 decreased cell viabi lity, but increased HO-l and DSPP expression in a concentra tion and time dependent manner . Inhibitors of gllanylate cyclase. PI3K, ERK. and p38 MAP kinase blocked H202-indllced cytotoxicity and the expression of HO-l and DSPP mRNAs in pulp cells. These data suggest that the induction of HO-l by H202 in plllp cells plays a protective role against the cytotoxic effects 0 1' HzOz and stimulates DSPP expression‘ reslllting in prematllre odontoblast dilTerentiation throllgh pathways that involve cGMP‘ p38. and ERK.
Cyclosporin A가 치은섬유아세포의 세포주기조절에 미치는 영향
피성희,신형식 원광대학교 치의학연구소 2001 圓光齒醫學 Vol.10 No.2
Cyclosporin A is a cyclic polypeptide produced by the metabolism of fungi. It is widely used at present as immunosuppressive treatment following organ transplants. It is also used to deal with autoimmune diseases such as rheumatoid arthritis or type Ⅱ diabetes. Gingival hyperplasia is one of the most frequent side-effects associated with the prescription of Cyclosporin A. The mechanisms involved in Cyclosporin A induced gingival hyperplasia are not yet clear. In vitro Cyclosporin A promotes proliferation of gingival fibroblasts, that Cyclosporin A act as a mitogen. Its action is based on mitosis of gingival fibroblasts regulated by cell cycle regulatory proteins. It was the purpose of the present study to examine the effects of Cyclosporin A on human gingival fibroblasts by means of biological and biochemical criteria. In this present study, we examined change of cell proliferation, cell activity, cell viability and cell cycle progression after application of Cyclosporin A. We also examined expression of cell cycle regulatory proteins by western blot analysis. Human gingival fibroblasts were cultured for 48 hours with application of Cyclosporin A at concentrations of 0.01, 0.1, 1, and 10ng/ml. Cyclosporin A(lng/ml) significantly increased the cell activity of gingival fibroblast. Proliferation and viability of gingival fibroblasts were also increased in group treated with 1ng/ml of Cyclosporin A compared to control group. In the cell cycle analysis, S phase was increased and G 1 phase was decreased in the group treated with 1 ng/ml of Cyclosporin A. Cyclosporin A increased the expression of cdk4 and inhibited the expression of pRB and p21. These results suggest that 1ng/ml of Cyclosporin A may increase the cell cycle progression of human gingival fibroblasts, and its mechanisms may increase the expression of cdk4 and decrease the expression of pRB and p21.
Clinical and radiographic analysis of the causes of tooth extraction
( Hee Yung Chang ),( Woo Hyuk Yun ),( Ha Na Hyun ),( Sung Hee Pi ),( Hyung Keun You ) 조선대학교 치의학연구원 2015 Oral Biology Research (Oral Biol Res) Vol.39 No.1
Purpose: In the present study, we present clinical and radiological grounds as well as principles of tooth extraction based on tooth extraction cases in the Department of Periodontology at Wonkwang University Dental Hospital. Materials and Methods: This study was conducted on 323 patients who visited the Department of Periodontology at Wonkwang University Dental Hospital and underwent tooth extraction. Their medical records and radiographs were surveyed, along with smoking habits, systemic diseases, medication/tooth mobility, and probing depth. Crossover analysis was performed to examine the interrelationship between smoking and its causes. Results: A total of 620 teeth was extracted. The proportion of smokers in patients who underwent tooth extraction due to periodontal problems was higher. However, there was no statistically significant difference (p>0.05) between periodontal problems and other problems. A total of 383 (61.77%) showed periodontal problems: “floating state” or loss of attachment in entire roots (radiolucent images with average width of about 2.65 mm surrounding roots), which was a typical example of extraction with periodontal problems (193, 50.39%). A total of 106 (17.10%) showed prosthodontic problems: 55 (51.89%) showed crown loss, and average length of retained roots was 9.98 mm as measured on radiographs. A total of 97 (15,65%) had conservative or endodontic problems: deep caries, shifted beyond cemento enamel junction (CEJ) to root area (boundary of root apex of caries were presented above the average of 3.92 mm from CEJ toward root apex). A total of 34 (5.48%) cases had orthodontic and other problems. Conclusion: For proper prognosis of individual teeth, generalized judgment based on collected patient information, and treatment philosophy of clinicians will be required.
급진성 치주염 환자에서 전신적 항생제 복용을 동반한 외과적 치주 치료 후 치주조직의 재생: 증례보고
임상진 ( Sang Jin Lim ),윤우혁 ( Woo Hyuk Yun ),피성희 ( Sung Hee Pi ),유형근 ( Hyung Keun You ) 조선대학교 구강생물학연구소 2011 Oral Biology Research (Oral Biol Res) Vol.35 No.2
The purpose of this study is to evaluate the feasibility of periodontal tissue regeneration in patients suffering from aggressive periodontitis who took systemic antibiotics as an adjunctive to periodontal treatment. Two patients with aggressive periodontitis were selected. Examination of clinical value and radiograph were performed. First, they took scaling and root-planing with systemic antibiotics. Appropriate surgical treatments were followed with selective alveolar bone graft. Patients visited regularly for postoperative clinical and radiographic evaluations. After periodontal treatment with an adjunctive antibiotics, improved clinical index such as increased clinical attachment level, decreased mobility and bleeding on probing were found in comparison with initial examination. Recovery of bone loss was observed in radiographic examination. This study suggests that periodontal treatment with systemic antibiotics is effective on prevention of disease and regeneration of periodontal tissue in patients with aggressive periodontitis.