http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Sol Yi ),( Jihee Kim ),( Soo Young Lee ) 생화학분자생물학회 2020 BMB Reports Vol.53 No.12
Bone resorption is linked to bone formation via temporal and spatial coupling within the remodeling cycle. Several lines of evidence point to the critical role of coupling factors derived from pre-osteoclasts (POCs) during the regulation of bone marrowderived mesenchymal stem cells (BMMSCs). However, the role of glial cell-derived neurotrophic factor (GDNF) in BMMSCs is not completely understood. Herein, we demonstrate the role of POC-derived GDNF in regulating the migration and osteogenic differentiation of BMMSCs. RNA sequencing revealed GDNF upregulation in POCs compared with monocytes/macrophages. Specifically, BMMSC migration was inhibited by a neutralizing antibody against GDNF in pre-osteoclast-conditioned medium (POC-CM), whereas treatment with a recombinant GDNF enhanced migration and osteogenic differentiation. In addition, POC-CM derived from GDNF knock-downed bone marrow macrophages suppressed BMMSC migration and osteogenic differentiation. SPP86, a small molecule inhibitor, inhibits BMMSC migration and osteogenic differentiation by targeting the receptor tyrosine kinase RET, which is recruited by GDNF into the GFRa1 complex. Overall, this study highlights the role of POC-derived GDNF in BMMSC migration and osteogenic differentiation, suggesting that GDNF regulates bone metabolism. [BMB Reports 2020; 53(12): 646-651]
김솔이 ( Kim Sol-yi ),차수정 ( Cha Su-jung ) 한국무용교육학회 2021 韓國舞踊敎育學會誌 Vol.32 No.2
The study aims to comparatively analyze the works of convergence dance using technology. In this study, among the converged dance works using technology, two domestic cases and three overseas cases, which are permitted to disclose the data, were selected to carry out a comparative analysis of the characteristics of convergence technology using technology, and conducted interviews with the choreographers of organizations in Korea. The results of this study are as follows: 《Beyond Black, 2020》 by the Korea National Contemporary Dance Company shows a new choreography method using AI. HOWHYOU’s 《GODOT, 2018》 is aims to automate dance performances, using technologies that were not used in the existing dance performances such as Black 2.0 and Gyrosens AΦE’s 《0AR, 2018》 used AR to allow the audience to focus more, and showed various aspects by changing the graphic appearance of the dancer 《Celestial Motion II, 2019》 by Alexander Whitley Dance Company uses VR and AR motion capture to increase immersion in the work by giving the audience the feeling of being involved in the work together. 《Celestial Motion: Virtual Dance Experience, 2019》 recorded 《Celestial Motion II, 2019》 on a 360-degree camera, complementing the shortcomings of seeing only the flat surface of the work in conventional video. This result will be an important approach to planning dance performances by expanding the changes in time and society ahead of the advent of the 4th Industrial Revolution and expanding the field of view of the audience with higher standards.
Apoptotic Effects of Resveratrol via mTOR and COX-2 Signal Pathways in MCF-7 Breast Cancer Cells
Sol Hwa Lee(이솔화),Hye yeon Lee(이혜연),Song Yi Park(박송이),Ock Jin Park(박옥진),Young Min Kim(김영민) 한국생명과학회 2011 생명과학회지 Vol.21 No.9
식물에서 추출한 파이토케미컬은 암세포의 여러 신호전달 기작에 관여함으로써 apoptosis를 유도한다. 본 연구에서는 파이토케미컬의 한 종류인 레스베라트롤을 MCF-7 세포에 처리함으로써 암세포의 증식 억제와 apoptosis 유도 효과를 알아보았고, 이러한 효과가 암세포의 성장과 증식에 관여하는 단백질인 mTOR와 COX-2의 발현 양상에 어떠한 영향을 미치는지 알아보고자 하였다. 그 결과 MCF-7 세포에 레스베라트롤을 처리했을 때 농도가 증가함에 따라 암세포의 생존률이 감소하였고, Hoechst 33342를 이용한 chromatin 염색과 Annexin V-propodium iodide staning을 통하여 암세포의 세포증식 효과 apoptosis에 의해 유도된 것임을 알 수 있었다. MCF-7 세포에 레스베라트롤을 처리했을 때 mTOR 및 COX-2의 발현 양상을 확인하기 위해 Western blotting을 실시한 결과, 레스베라트롤의 농도가 높아짐에 따라 mTOR 및 COX-2의 발현이 감소함을 확인 하였다. 이와 같은 결과는 MCF-7 유방암 세포에서 레스베라트롤에 의한 암세포의 증식 억제 및 apoptosis 유도가 mTOR 신호경로 저해를 통한 COX-2의 발현을 감소시킴으로써 나타나는 것으로 보인다. Resveratrol, a kind of phytochemical, is presented in grape skins. Resveratorl exerts antiproliferative, anti-cancer and pro-apoptotic activities in cancer cells. Mammalian target of rapamycin (mTOR) is a critical regulator of cellular growth and proliferation, and it is known to be a strategic target for anti-cancer therapeutic uses. mTOR is a major downstream of the PI3K/Akt pathway, which is activated in various cancer cells. It also plays an important role in the survival, proliferation and angiogenesis of cells. Cyclooxygenase-2 (COX-2) is an important protein that mediates inflammatory processes. It plays an important role in various tumors by affecting cell proliferation, mitosis, apoptosis and angiogenesis. In this study, we have investigated the effects of resveratrol on apoptosis through mTOR and COX-2 expression in MCF-7 breast cancer cells. The treatment of resveratrol with different concentrations inhibited proliferation of MCF-7. The data showed that resveratrol induced apoptotic cell death of cancer cells and decreased mTOR and COX-2 expression. These results suggest that resveratrol induces apoptosis of MCF-7 breast cancer cells by inhibiting mTOR and COX-2 expression.
Yi Lee,Moon Kyo Kim,Mi Sun Lee,Juhyeok Kim,Enkhtsetseg Yeruult,Suk-Yoon Kwon,Sol Ji Noh,Seong Won Park 한국원예학회 2021 한국원예학회 학술발표요지 Vol.2021 No.10
Watermelon (Citrullus lanatus) is an important fruit that grows in temperate tropical climates around the world. In this study, quantitative trait loci (QTL) analysis was performed using the genotypes and phenotypes of 87 F2 populations derived from CBARES1 and CBARES2 from the Korean watermelon resources. A total of 37 quantitative traits related to leaves, stems, flowers, and fruits were investigated. The single nucleotide polymorphism (SNP) locus and the insertion or deletion (InDel) locus were found by comparing the nucleotide sequences of the parent generation, CBARES1 and CBARES2. SNP markers were genotyped through resequencing and InDel markers genotyped through PCR and electrophoresis. A linkage map with a total length of 3036.90 cM was constructed consisting of 1,539 SNP markers and 80 InDel markers. InDel data from the actual experimental results were compared with SNP data to confirm the linkage distance and location on the chromosome. As a result, from the 80 InDel markers, 56 were matched to the SNP location and 24 slightly deviated. QTL analysis with the inclusive composite interval mapping (ICIM) method revealed that 37 traits showed significant QTL results in 73 regions of the chromosome. The epistasis QTL analysis was performed to supplement the part that did not show a clear logarithm of the odds ratio (LOD) value due to the additive effect. The linkage map and QTL created in this study are important resources for gene discovery and improvement of watermelon quality.