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- 검색키워드
- 저자 : Kyong-Suk Hong (검색결과 123 건)
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이상일,서석훈,홍경민,신용섭,장상희,신부영 영남대학교 공업기술연구소 2001 工業技術硏究所論文集 Vol.29 No.1
Bio-and-photodegradable polymer composites were prepared by blending biodegradable aliphatic polyester and photodegradable master batch(M/B). Photodegradability, biodegradability, thermal properties and mechanical properties were investigated. The biodegradability of EnPol(G4600) composites decreased wish increasing the amount of M/B, while that of EnPol(G8000) composites increased. Tensile strength and elongation decreased with increasing the time of outdoor exposure and the amount of M/B but modulus comparatively maintained. The mechenical properties decreased as the content of M/B increased, while the melting temperature unchanged.
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Central nervous system blast crisis of chronic myeloid leukemia and treatment with dasatinib
( Hong Suk Park ),( Jinny Park ),( Young Saeng Kim ),( In Geun Park ),( Jun Sik Hong ),( Hee Kyong Ahn ),( Sun Jin Sim ),( Eun Kyoung Joe ),( Dong Bok Shin ),( Jae Hoon Lee ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Chronic myeloid leukemia (CML) is a myeloproliferative disorder driven by the BCR-ABL1. Owing to the high efficacy of imatinib mesylate for CML in chronic phase, the frequency of the blast crisis is greatly reduced. Some CML cases develop extramedullary disease caused by infiltration of blast cells. However, the central nervous system (CNS) as an isolated site of extramedullary blast crisis is rare. Herein, we report case of dasatinib-based maintenance therapy for lymphoid blast crisis of the CNS in a patient with CML who was receiving imatinib mesylate therapy. In July 2012, a 55 years old man was diagnosed with Philadelphia chromosome positive CML in the chronic phase. Immediately, imatinib mesylate administration was initiated. Four months after the diagnosis, he complained of headache. On cerebrospinal fluid (CSF) examination, the CSF had increased number of WBCs (6289/iL); almost all WBCs were lymphoid cells. Brain MRI revealed abnormal leptomeningeal enhancement of the frontal lobes. In addition to a complete hematological, cytogenetic response and evidence of the absence of malignant lymphoblasts in the peripheral blood and bone marrow samples, these findings led to the diagnosis of isolated lymphoid blast crisis in CNS. Immediately, the patient was treated with scheduled intrathecal methotrexate, cerebrospinal radiotherapy and TKI dasatinib. Major molecular response was achieved after 4 months after treatment change, followed by matched related allogeneic peripheral blood SCT. During the course of dasatinib maintenance therapy, several follow-up tests were performed and persistently yielded results indicating complete hematologic, molecular, and cytogenetic responses. The patient was neurological symptom-free for 2 years. In addition, the abnormal enhancement of the frontal lobe observed on the initial brain MRI had disappeared. This report is meaningful of significance as because we used a minimal treatment of intrathecal chemotherapy, radiotherapy, allogeneic peripheral blood SCT and an oral TKI without using cytotoxic chemotherapy such as hyper-CyVAD.
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( Hong Jun Kim ),( In Keun Choi ),( Se Ryeon Lee ),( Seung Tae Kim ),( Hwa Jung Sung ),( Kyong Hwa Park,),( Sang Cheul Oh ),( Jae Hong Seo ),( Sang Won Shin ),( Yeul Hong Kim ),( Jun Suk Kim ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1
Introduction: Recent study reported that 38 percent of new patients with soft tissue sarcoma were aged more than 65 years. However, few studies reported clinical outcomes after chemotherapy in elderly patients with recurrent or advanced soft tissue sarcoma. Elderly patients hesitate to receive chemotherapy. But, an equal response to chemotherapy is expected in elderly patients as in young patients. Hence, we aimed to study the clinical results of chemotherapy in elderly patients with recurrent or advanced soft tissue sarcoma. Patients and Methods: 97 patients were admitted for chemotherapy at the Korea University Anam, Guro, and Ansan Hospital s between 2003.3 and 2012.4. Patients were treated with an appropriate chemotherapy regimen. Results: The median age of the patients in the entire group was 52 years. Patients received a median of 4 cycles of chemotherapy. The median overall survival for the entire group was 61 months (95% CI: 29.3-92.7 months). 33 patients were identified as elderly patients aged 60 years or older. In the elderly group, the most common type of soft tissue sarcoma was leiomyosarcoma (21.2%). The median number of chemotherapy cycles was three and median survival was 15 months in the elderly group. In the elderly group, one patient had a complete response. There were four partial responses. 14 patients had progressive disease. In the subgroup analysis, 51 of 64 patients (79.75%) in the non-elderly group were responders, while 19 of 33 patients (57.6%) in elderly group responders were responders (Chi-square test p=0.03). However, there was no statistically significant difference in survival between the elderly and non-elderly groups (p=0.11, log-rank test). Disease burden and response to chemotherapy were predictive of survival in elderly patients with recurrent or advanced soft tissue sarcoma. Conclusions: Taking only an age-based decision for systemic chemotherapy seems not to be reasonable in elderly patients with recurrent or advanced soft tissue sarcoma. A judicious decision needs to be taken for selecting the candidate for chemotherapy in elderly patients with recurrent or advanced soft tissue sarcoma after considering the benefit and toxicity of chemotherapy.
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군의관 미승조 함정 해군 보건의료인력의 건강임무수행도, 중요도, 난이도 차이 분석
홍경숙 ( Kyong Suk Hong ),김선희 ( Seon Hee Kim ),노은미 ( Young Hee Park ) 한국노인의료복지학회 2014 노인의료복지연구 Vol.6 No.2
The purpose of this study was to investigate the general characteristics of naval medical petty officers in warships without naval surgeons and analyze tile performance, significance and difficulty of Health duty by rank and warship size. The results of this study are as follows. First, the analysis of general characteristics shows that the number of chief petty officers was 35 (43.8%), the number of those aged 30 and over and under 40 were 30 (37.5%), and the number of those who attending or graduated from high school and junior college was 48 (60%). Second, the difference in Health performance, Health significance and difficulty of Health duty by rank was not all statistically significant. Third, the difference in Health performance of Health duty by warship size was found to be significant only in the Health duty of ‘prevention responsibility.’ The Health performance of ‘prevention responsibility` was significantly low in third class warships as opposed to first class warships, second class warships and other support warships.
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홍경숙 ( Kyong Suk Hong ),최윤경 ( Yun Kyoung Choi ) 국군간호사관학교 군진간호연구소 2014 군진간호연구 Vol.32 No.2
Purpose: The purpose of this study was to conduct a job analysis of naval medical petty officer without naval surgeons on the warship by using the DACUM(developing a curriculum) technique. Methods: A DACUM workshop was held in October 3, 2013 and November 23, 2013, a job analysis (draft) consisting of duties and tasks was conducted, and then content validity was evaluated through hands-on experts. Based on the evaluation results, research tools were decided, and then a survey was performed from March 11, 2014 to April 11, 2014. Results: The definition of ‘naval medical petty officer without naval surgeons in the warship’ turned out to be ‘primary care providers who try to prevent loss of combat force in case of emergency by maintaining and promoting soldiers’ health, staying close to the warship crew, and by performing related duties such as preventive medical practice activities, supply path management, educational training, and administration management’. As a result of the analysis, their job was classified into 5 duties and 31 tasks. Conclusion: In order to improve work efficiency and maximize work results of naval medical petty officers without naval surgeons on the warship, standardization of works through a systematic job analysis is necessary.
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전찬홍(Hong Jeon Chan),김형진(Hyung Jin Kim),김응호(Eung Ho Kim),안중경(Joong Kyong Ahn),고재현(Jay Hyun Koh),차훈석(Hoon Suk Cha),고은미(Eun Mi Koh) 대한내과학회 2002 대한내과학회지 Vol.62 No.6
통풍 환자의 남녀비는 32.8:1이었으며 연령별로는 40대가 가장 많은 부분을 차지하고 유병기간은 평균 6.2년이었다. 만성 신기능 저하의 소견이 20.4%에서 관찰되었고, 고혈압 (41.4%), 허혈성 심질환 (14.7%), 뇌혈관 질환 (8.6%) 등 순환기계 질환과 고지혈증 (13.7%)의 빈도가 높았으며 환자 중 60.7%가 과체중 또는 비만에 해당하였다. 24시간 요중 요산치는 83.8%가 800 mg/day 이하인 저배설에 해당하였다. 관절염의 최초 발현 양상은 제1중족지절관절을 침범하는 단관절염의 형태가 62.2%로 가장 많았으며 족근관절, 슬관절, 족관절의 순이었다. 방사선학적 골미란은 관찰 환자 중 35%에서 발견되었고 토푸스는 전체 환자 중 20.4%에서 관찰되었으며, 골미란, 토푸스의 발현과 유병기간 간에는 통계적으로 유의한 상관관계가 있었다. 알로퓨리놀의 부작용 중 간기능 이상은 37.6%에서 관찰되었고, 중등도 또는 고도 이상을 보인 환자는 12.6%였다. 이상을 보인 환자에서도 주의 깊게 추적하면서 약물을 지속하거나, 일시적으로 투약을 중단 한 후 간기능이 회복되면 재사용하는 방법으로 재발이나 심각한 부작용 없이 대부분의 환자가 알로퓨리놀을 계속 투여할 수 있었다. 본 연구의 결과는 통풍의 발현양상을 관찰한 기존의 국내외의 보고와 큰 차이를 보이지는 않았다. 심혈관계 질환 및 신장 기능 저하, 과체중 등 대사성 이상의 빈도가 높게 나타났으며 진단 기술의 발달과 환경요인 변화에 의해 통풍의 유병률이 증가하고 있으므로, 임상에서도 이러한 점들을 고려한 치료적 접근이 필요하리라 생각된다. 알로퓨리놀에 의한 간기능 이상은 빈도가 매우 높은 부작용이나 급히 약물을 중단하기 보다는 조심스러운 추적하 사용이나 재사용 등의 방법을 우선 고려해 볼 수 있을 것으로 생각된다. Background : The prevalence of gout in Korea seems to be increasing but previous studies were outdated and small in number of cases. We enrolled relatively large number of patients and compared our data with previous studies to provide a better understanding of clinical manifestations of gout in Korean. Methods : From 1994 to 2000, 372 patients, visited Samsung medical center for gout, were reviewed retrospectively. Age, sex, duration of disease, body mass index, 24 hour urine uric acid level, involved joints, frequency of tophi, bone changes on simple X-ray, associated diseases and complications of treatments were investigated. Results : In 372 patients reviewed, 361 patients were male (97%) and only 11 patients (3%) were female. Age of onset was 46.4±13.3 years. Most frequently affected joint in first attack was 1st metatarsophalangeal joint (62.2%). Tophi were observed in 20.4% and bony erosions were detected in 34.6% of patients. The most commonly accompanied disease was hypertension (41.1%) and overweight and obesity were noted in 60.7% of patients. Liver function abnormalities associated with allopurinol were noted in 37.7% of patients and after cessation of drug, most of them showed complete recovery. Conclusion : Clinical features were similar to those of western countries. It may be due to changes in life style and usage of drugs that affect serum level of uric acid. So more emphasis on life style modification and control of chronic illness will be needed.(Korean J Med 62:648-656, 2002)
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