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Wu, Bing-Li,Luo, Lie-Wei,Li, Chun-Quan,Xie, Jian-Jun,Du, Ze-Peng,Wu, Jian-Yi,Zhang, Pi-Xian,Xu, Li-Yan,Li, En-Min Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
Background: Fascin, an actin-bundling protein forming actin bundles including filopodia and stress fibers, is overexpressed in multiple human epithelial cancers including esophageal squamous cell carcinoma (ESCC). Previously we conducted a microarray experiment to analyze fascin knockdown by RNAi in ESCC. Method: In this study, the differentially expressed genes from mRNA expression profilomg of fascin knockdown were analyzed by multiple bioinformatics methods for a comprehensive understanding of the role of fascin. Results: Gene Ontology enrichment found terms associated with cytoskeleton organization, including cell adhesion, actin filament binding and actin cytoskeleton, which might be related to fascin function. Except GO categories, the differentially expressed genes were annotated by 45 functional categories from the Functional Annotation Chart of DAVID. Subpathway analysis showed thirty-nine pathways were disturbed by the differentially expressed genes, providing more detailed information than traditional pathway enrichment analysis. Two subpathways derivated from regulation of the actin cytoskeleton were shown. Promoter analysis results indicated distinguishing sequence patterns and transcription factors in response to the co-expression of downregulated or upregulated differentially expressed genes. MNB1A, c-ETS, GATA2 and Prrx2 potentially regulate the transcription of the downregulated gene set, while Arnt-Ahr, ZNF42, Ubx and TCF11-MafG might co-regulate the upregulated genes. Conclusions: This multiple bioinformatic analysis helps provide a comprehensive understanding of the roles of fascin after its knockdown in ESCC.
Xiao-Quan Xu,Chen-Jiang Wu,Shan-Shan Lu,Qian-Qian Gao,Qing-Quan Zu,Xing-Long Liu,Hai-Bin Shi,Sheng Liu 대한영상의학회 2017 Korean Journal of Radiology Vol.18 No.5
Objective: To determine the relationship between intravoxel incoherent motion (IVIM) imaging derived quantitative metrics and serum soluble CD40 ligand (sCD40L) level in an embolic canine stroke model. Materials and Methods: A middle cerebral artery occlusion model was established in 24 beagle dogs. Experimental dogs were divided into low- and high-sCD40L group according to serum sCD40L level at 4.5 hours after establishing the model. IVIM imaging was scanned at 4.5 hours after model establishment using 10 b values ranging from 0 to 900 s/mm2. Quantitative metrics diffusion coefficient (D), pseudodiffusion coefficient (D*), and perfusion fraction (f) of ischemic lesions were calculated. Quantitative metrics of ischemic lesions were normalized by contralateral hemisphere using the following formula: normalized D = Dstroke / Dcontralateral. Differences in IVIM metrics between the low- and high-sCD40L groups were compared using t test. Pearson’s correlation analyses were performed to determine the relationship between IVIM metrics and serum sCD40L level. Results: The high-sCD40L group showed significantly lower f and normalized f values than the low-sCD40L group (f, p < 0.001; normalized f, p < 0.001). There was no significant difference in D*, normalized D*, D, or normalized D value between the two groups (All p > 0.05). Both f and normalized f values were negatively correlated with serum sCD40L level (f, r = -0.789, p < 0.001; normalized f, r = -0.823, p < 0.001). However, serum sCD40L level had no significant correlation with D*, normalized D*, D, or normalized D (All p > 0.05). Conclusion: The f value derived from IVIM imaging was negatively correlated with serum sCD40L level. f value might serve as a potential imaging biomarker to assess the formation of microvascular thrombosis in hyperacute period of ischemic stroke.
Yaopeng Wu,Nan Zheng,Yaohuan Wu,Quan Yang 국제구조공학회 2024 Structural Engineering and Mechanics, An Int'l Jou Vol.89 No.6
The bistable thin cylindrical shell is developable structure with the ability to transition between its two stable configurations. This structure offers significant potential applications due to its excellent deformability. In this paper, the composite thin cylindrical shell consisting of the composite layer and the piezoelectric layer was investigated. The material and geometric parameters of the shell were found to influence its stable characteristics. The analysis model of the composite thin cylindrical shell incorporating the piezoelectric layer was developed, and the expressions for its strain energy were derived. By applying the minimum energy principle, the impact of the electric field intensity on the bi-stable behaviors of the cylindrical shell was analyzed. The results showed that the shell exhibited the bistability only under the appropriate electric field strength. And the accuracy of the theoretical prediction was verified by simulation experiments. This study provides an important reference for the application of deployable structures.
Design, analyses, and evaluation of a spiral TDR sensor with high spatial resolution
Quan Gao,Guangxi Wu,Xiong Yu 국제구조공학회 2015 Smart Structures and Systems, An International Jou Vol.16 No.4
Time Domain Reflectometry (TDR) has been extensively applied for various laboratory and field studies. Numerous different TDR probes are currently available for measuring soil moisture content and detecting interfaces (i.e., due to landslides or structural failure). This paper describes the development of an innovative spiral-shaped TDR probe that features much higher sensitivity and resolution in detecting interfaces than existing ones. Finite element method (FEM) simulations were conducted to assist the optimization of sensor design. The influence of factors such as wire interval spacing and wire diameter on the sensitivity of the spiral TDR probe were analyzed. A spiral TDR probe was fabricated based on the results of computer-assisted design. A laboratory experimental program was implemented to evaluate its performance. The results show that the spiral TDR sensor featured excellent performance in accurately detecting thin water level variations with high resolution, to the thickness as small as 0.06 cm. Compared with conventional straight TDR probe, the spiral TDR probe has 8 times the resolution in detecting the water level changes. It also achieved 3 times the sensitivity of straight TDR probe.
A study on the spray characteristics of a piezo pintle-type injector for DI asoline engines
Quan Dong,Tsuneaki Ishima,Hisanobu Kawashima,Wu-qiang Long 대한기계학회 2013 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.27 No.7
We studied the spray flow initiated from a piezo pintle-type injector for DI gasoline engines in an environment supplied by a constant volume vessel by means of laser diagnostics. To fully grasp the effects of the characteristic parameters, including designed spray angle,needle lift, injection pressure (Pinj) and ambient pressure (Pb), on the spray atomization and mixture preparation, particle image velocimetry (PIV) and phase Doppler anemometry (PDA) are used in the experiment, respectively. The gas perpendicularly enters into the outer periphery of the conical spray injected through the pintle-type injector activated by piezo, which creates two large-scale vortices:the vortex A and vortex B. The velocity standard deviation of the spray field is introduced to analyze the gas flow motion in the vicinity of nozzle. The droplet information of spray field is also recorded by PDA in variable boundary conditions. The time dividing method is used to study the droplet characteristics in four parts of spray. The injector with 98° designed spray angle has smaller droplet mean diameter (D10 and D32), due to a larger spray distribution. When the droplet velocity of the spray field is close to 0 m/s, the D10 and D32hold at around 10 μm and 20 μm, respectively, in atmospheric pressure condition, which are about 20 μm and 40 μm, respectively, at ambient pressure of 1.1 MPa.
Wu, Xiang-Mei,Liu, Xing,Jiao, Qing-Fang,Fu, Shao-Yue,Bu, You-Quan,Song, Fang-Zhou,Yi, Fa-Ping Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6
Human papillomavirus (HPV) is the primary etiologic agent of cervical cancer. Consideration of safety and non human leukocyte antigen restriction, protein vaccine has become the most likely form of HPV therapeutic vaccine, although none have so far been reported as effective. Since tumor cells consistently express the two proteins E6 and E7, most therapeutic vaccines target one or both of them. In this study, we fabricated DC vaccines by transducing replication-defective recombinant adenoviruses expressing E6/E7 fusion gene of HPV-16, to investigate the lethal effects of specific cytotoxic T lymphocytes (CTL) against CaSki cells in vitro. Mouse immature dendritic cells (DC) were generated from bone marrow, and transfected with pAd-E6/E7 to prepare a DC vaccine and to induce specific CTL. The surface expression of CD40, CD68, MHC II and CD11c was assessed by flow cytometry (FCM), and the lethal effects of CTL against CaSki cells were determined by DAPI, FCM and CCK-8 methods. Immature mouse DC was successfully transfected by pAd-E6/E7 in vitro, and the transfecting efficiency was 40%-50%. A DC vaccine was successfully prepared and was used to induce specific CTL. Experimental results showed that the percentage of apoptosis and killing rate of CaSki cells were significantly increased by coculturing with the specific CTL (p <0.05). These results illustrated that a DC vaccine modified by HPV-16 E6/E7 gene can induce apoptosis of CaSki cells by inducing CTL, which may be used as a new strategy for biological treatment of cervical cancer.
Quan, Jianping,Ding, Rongrong,Wang, Xingwang,Yang, Ming,Yang, Yang,Zheng, Enqin,Gu, Ting,Cai, Gengyuan,Wu, Zhenfang,Liu, Dewu,Yang, Jie Asian Australasian Association of Animal Productio 2018 Animal Bioscience Vol.31 No.4
Objective: Average daily gain (ADG) is an important target trait of pig breeding programs. We aimed to identify single nucleotide polymorphisms (SNPs) and genomic regions that are associated with ADG in the Duroc pig population. Methods: We performed a genome-wide association study involving 390 Duroc boars and by using the PorcineSNP60K Beadchip and two linear models. Results: After quality control, we detected 3,5971 SNPs, which included seven SNPs that are significantly associated with the ADG of pigs. We identified six quantitative trait loci (QTL) regions for ADG. These QTLs included four previously reported QTLs on Sus scrofa chromosome (SSC) 1, SSC5, SSC9, and SSC13, as well as two novel QTLs on SSC6 and SSC16. In addition, we selected six candidate genes (general transcription factor 3C polypeptide 5, high mobility group AT-hook 2, nicotinamide phosphoribosyltransferase, oligodendrocyte transcription factor 1, pleckstrin homology and RhoGEF domain containing G4B, and ENSSSCG00000031548) associated with ADG on the basis of their physiological roles and positional information. These candidate genes are involved in skeletal muscle cell differentiation, diet-induced obesity, and nervous system development. Conclusion: This study contributes to the identification of the casual mutation that underlies QTLs associated with ADG and to future pig breeding programs based on marker-assisted selection. Further studies are needed to elucidate the role of the identified candidate genes in the physiological processes involved in ADG regulation.