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Phenolic glycosides from the rhizomes of Cyperus rotundus and their antidepressant activity
Lin, San-qing,Zhou, Zhong-liu,Zhang, Hua-lin,Yin, Wen-qing 한국응용생명화학회 2015 Applied Biological Chemistry (Appl Biol Chem) Vol.58 No.5
Depression is the most common psychiatric comorbidity in patients. Searching for antidepressant drugs from natural products is very important for the treatment of this disease. The ethanol extract and its fractions of Cyperus rotundus were evaluated for antidepressant activities in mice by our group. The aim of this study was to investigate the potential active components of C. rotundus. The extraction and solvent partition of the rhizomes of C. rotundus, and repeated column chromatography for n-BuOH fraction yielded three new phenolic glycosides, rotunduside D (1), rotunduside E (2), and rotunduside F (3). Their chemical structures were identified on the basis of spectroscopic data analyses including NMR, MS, UV, and IR. The potential antidepressant activity of all the isolated compounds was evaluated. In the despair mice models, rotunduside F (3) showed significant antidepressant activity at the dosage of 50 mg/kg, which was close to the positive control fluoxetine (20 mg/kg).
Phenolic glycosides from the rhizomes of Cyperus rotundus and their antidepressant activity
San-Qing Lin,Zhong-Liu Zhou,Hua-lin Zhang,Wen-Qing Yin 한국응용생명화학회 2015 Applied Biological Chemistry (Appl Biol Chem) Vol.58 No.5
Depression is the most common psychiatric comorbidity in patients. Searching for antidepressant drugs from natural products is very important for the treatment of this disease. The ethanol extract and its fractions of Cyperus rotundus were evaluated for antidepressant activities in mice by our group. The aim of this study was to investigate the potential active components of C. rotundus. The extraction and solvent partition of the rhizomes of C. rotundus, and repeated column chromatography for n-BuOH fraction yielded three new phenolic glycosides, rotunduside D (1), rotunduside E (2), and rotunduside F (3). Their chemical structures were identified on the basis of spectroscopic data analyses including NMR, MS, UV, and IR. The potential antidepressant activity of all the isolated compounds was evaluated. In the despair mice models, rotunduside F (3) showed significant antidepressant activity at the dosage of 50 mg/kg, which was close to the positive control fluoxetine (20 mg/kg).
Qingli Lin,Yi-Yan Lu,Ling Hu,Xiaobo Zhao 한국강구조학회 2022 International Journal of Steel Structures Vol.22 No.2
To achieve a rapid and great enhancement in the fl exural performance of reinforced concrete beams, this study proposes a new strengthening method using U-shaped steel casing and focuses on studying the fatigue performance of strengthened beams. In this paper, ten specimens were tested under fatigue loads. Testing results demonstrated that no obvious damage was observed from the strengthened beam after 2 million fatigue cycles compared with the reference beam which failed at 58.97 × 10 4 fatigue cycles, indicating the good joint performance of the U-shaped steel casing and the RC beam. The strengthened beams generally failed by the sudden rupture of the bottom steel plate accompanied by concrete crushing. The mid-span defl ection and material strains all increased rapidly at the beginning, then steadily developed during nearly 80% of the fatigue life, and grew rapidly again after the weld toe cracking until the strengthened beam failed. The fatigue life was signifi cantly extended with the increase of either the height of the steel box or the thickness of the bottom plate, while it was dramatically shortened with the increase in the fatigue load amplitude. To facilitate the use of the outcomes, a simplifi ed formula for predicting the concrete residual strain of strengthened beams was derived. The predicted results matched the experimental ones well. The derived formula is theoretically only applicable to strengthened beams with dimensions same as the specimens in the experimental tests under similar loading conditions. Reasonably good agreements were found between the fi nite element analyses and experimental results. The developed fi nite element model can well simulate the failure mode under static load and the damage evolution under fatigue load. Based on the stress analysis results, the fatigue lives of the strengthened beams were predicted relatively accurately using the Fe-safe software, with the deviations mostly less than 15%.
Improved Multi-target Tracking Algorithm Based on Gaussian Mixture Particle PHD Filter
Qing Lin,Pei Cao,Dingan Liao,Yongzhao Zhan,Yaping Yang 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.2
The paper proposes Gaussian mixture particle probability hypothesis density filter(PHD) algorithm ,which can effectively solve the problem that the object number is changing or unknown, based on particle PHD filter. This algorithm calculates the object number and state by recursive procedure, avoiding the uncertainty of target state estimation caused by particle sampling and clustering. Gaussian mixture particle is introduced to effectively maintain the multi-modal distribution of each target,reducing the complexity of calculation.
Chronic Kidney Disease and Associated Cardiovascular Risk Factors in Chinese with Type 2 Diabetes
Qing-Lin Lou,Xiao-Jun Ouyang,Liu-Bao Gu,Yong-Zhen Mo,Ronald Ma,Jennifer Nan,Alice Kong,Wing-Yee So,Gary Ko,Juliana Chan,Chun-Chung Chow,Rong-Wen Bian 대한당뇨병학회 2012 Diabetes and Metabolism Journal Vol.36 No.6
Background: To determine the frequency of chronic kidney disease (CKD) and its associated risk factors in Chinese type 2 diabetic patients, we conducted a cross-sectional study in Nanjing, China, in the period between January 2008 and December 2009. Methods: Patients with type 2 diabetes under the care by Jiangsu Province Official Hospital, Nanjing, China were invited for assessment. CKD was defined as the presence of albuminuria or estimated glomerular filtration rate <60 mL/min/1.73 m2. Albuminuria was defined as urinary albumin-to-creatinine ratio ≥30 mg/g. Results: We recruited 1,521 urban Chinese patients with type 2 diabetes (mean age, 63.9±12.0 years). The frequency of CKD and albuminuria was 31.0% and 28.9%, respectively. After adjusted by age and sex, hypertension, anemia and duration of diabetes were significantly associated with CKD with odds ratio (95% confidence interval) being 1.93 (1.28 to 2.93), 1.70 (1.09 to 2.64), and 1.03 (1.00 to 1.06), respectively. Conclusion: In conclusion, CKD was common in the urban Nanjing Chinese with type 2 diabetes. Strategies to prevent or delay progression of kidney disease in diabetes should be carried out at the early disease course of type 2 diabetes.
Causal relationship between the loss of RUNX3 expression and gastric cancer
Qing-Lin Li,Chohei Sakakura,Kosei Ito,Xin-Zi Chi,Lee, Kwang-Youl,Lee, Chang-Woo,Han, Sang-Bae,Kim, Hwan-Mook,Kim, Wun-Jae,Atsushi Kaneda,Toshikazu Ushijima,Yoshiaki Ito,Bae, Suk-Chul 이화여자대학교 세포신호전달연구센터 2002 고사리 세포신호전달 심포지움 Vol. No.4
The human runt-related gene RUNX3/PEBP2αC, located on chromosome 1p36, is a major mediator of signals elicited by members of the transforming growth factor-β(TGF-β) superfamily. Here we show that 45-60% of gastric cancer cell lines and surgically resected specimens do not significantly express RUNX3 due to a combination of hemizygous deletion and hypermethylation of the RUNX3 promoter region. Tumorigenicity of gastric cancer cell lines in nude mice was inversely related to their level of RUNX3 expression, and one gastric tumor associated mutation(R122C), occurring within the conserved Runt domain completely abolished the tumor suppressive effect of RUNX3. The results suggest that a lack of RUNX3 function is causally related to the genesis and progression of human gastric cancer.
Qing-Lin Zhu,김시원 경성대학교 산업개발연구소 2012 산업혁신연구 Vol.28 No.4
본 연구에서는 우리나라 제조업에 속한 중소기업들을 대상으로 표준화 활동이 기술혁신활동에 미치는 영향을 실증적으로 분석하였다. 표준화 활동을 기업의 전사적 표준경영, 국내표준활동, 국제표준활동, 인증획득 등으로 구분하였으며, R&D집약도와 특허출원을 각각 기술혁신활동의 대용변수로 삼았다. 분석대상은 636개 중소제조기업으로, 정성적 분석방법인 로지스틱 회귀모형을 사용하였다. 분석결과 인증획득활동은 기술혁신활동변수를 R&D집약도로 놓았을 경우와 특허출원으로 놓았을 경우 공히 기술혁신에 정(+)의 영향을 미치는 것으로 나타났다. 전사적 표준경영과 국제표준활동은 기술혁신활동변수를 특허출원으로 놓았을 경우에만 각각 기술혁신에 정(+)의 영향을 미치는 것으로 나타났다. 그러나 KS(Korean Standards) 등 국내표준활동 요인은 R&D집약도와 특허출원에 대해서 모두 아무런 영향을 미치지 않는 것으로 분석되었다. 전반적으로 우리나라 제조업에 속한 중소기업들에 있어서 표준화 활동은 제품기획, R&D 등 기술혁신활동의 초기 단계에서는 어떠한 영향을 가지지 못하지만 특허출원 등 성과와 관련된 중기 이후 단계에서는 긍정적인 역할을 하는 것으로 볼 수 있다. 따라서 표준화 활동을 기술혁신의 전주기에 걸쳐서 연계시키는 정부와 기업의 노력이 요청된다고 하겠다.