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심연근(Shen, Yan-Qin),장정(Zhang Zheng),모조설(Mao, Zhao-Xue),조연주(Cho, Youn-Joo) 한국실내디자인학회 2017 한국실내디자인학회 학술대회논문집 Vol.2017 No.10
This study analyzed for the present situation and characteristics of the community space of overseas cohousing. Based on this, this study aims to inquire into the necessary fundamental needed when designing a community space of future cohousing. As a result, this study could learn that cohousing is an intentional community of private homes clustered around shared space. Households have independent incomes and private lives, but neighbors collaboratively plan and manage community activities and shared spaces. In addition to personal space, the community has shared space, including children"s paly space, rest space, green space, sports space,learning space and public living space. Residents can hold various activities in the community. So these spaces give residents more opportunities to communicate and enrich their community life.
Han-Qin Shen,Xiangcong Liu,Pengfei Zhang,Lei Wang,Yan-ling Liu,Le-yi Zhang,Peng-shuai Liang,Chang-xu Song 대한수의학회 2018 Journal of Veterinary Science Vol.19 No.3
Recently, a novel atypical porcine pestivirus (APPV) in pig was reported. In this study, two APPV strains, APPV-China/GZ01/2016 (GZ01) and APPV-China/GD-SD/2016 (GD-SD), were identified in two newborn piglet herds with congenital tremor from China. The open reading frame of the two strains shared an 83.5% nucleotide identity. Phylogenetically, the APPV strains were placed into two groups: GZ01 belonged to group I and GD-SD belonged to group II. A high viral load was detected in the cerebellum (quantification cycles < 26). Further studies should be carried out to thoroughly elucidate the development of congenital tremors caused by APPV.
심연근(Shen, Yan-Qin),모조설(Mao, Zhao-Xue),남경숙(Nam, Kyung-Sook) 한국실내디자인학회 2018 한국실내디자인학회 학술대회논문집 Vol.20 No.1
The space environment of kindergarten is an important space for children to learn, play, live, grow and develop. It is the external condition of children`s spiritual growth and plays a potential education function. With the development of society and culture, the space design of kindergarten should also strive to meet the emotional and ideological needs of children. The purpose of this dissertation is to solve the problem of backward teaching environment in most Chinese kindergartens in China, to create a suitable space for children to grow, to meet the needs of children`s emotional and ideological needs. Research on the performance characteristics of emotional design and other content and the existing national kindergarten spatial design case analysis for the future design of kindergartens in China to bring help. The case study of this thesis is about three new public demonstration kindergartens in Shanghai. Analyze the performance characteristics of perceptual design in the study space and the activity space and make a qestrionnaire survey and analysis of the emotional design of kindergarten.
Han-Qin Shen,Zhuan-Qiang Yan,Fan-Gui Zeng,Chang-Tao Liao,Qing-Feng Zhou,Jian-Ping Qin,Qingmei Xie,Yingzuo Bi,Feng Chen 대한수의학회 2015 Journal of Veterinary Science Vol.16 No.3
As part of our ongoing influenza surveillance program in South China, 19 field strains of H9N2 subtype avian influenza viruses (AIVs) wereisolated from dead or diseased chicken flocks in Guangdong province, South China, between 2012 and 2013. Hemagglutinin (HA) genes ofthese strains were sequenced and analyzed and phylogenic analysis showed that 12 of the 19 isolates belonged to the lineage h9.4.2.5, whilethe other seven belonged to h9.4.2.6. Specifically, we found that all of the viruses isolated in 2013 belonged to lineage h9.4.2.5. The lineageh9.4.2.5 viruses contained a PSRSSR↓GLF motif at HA cleavage site, while the lineage h9.4.2.6 viruses contained a PARSSR↓GLF at thesame position. Most of the isolates in lineage h9.4.2.5 lost one potential glycosylation site at residues 200–202, and had an additional oneat residues 295–297 in HA1. Notably, 19 isolates had an amino acid exchange (Q226L) in the receptor binding site, which indicated that theviruses had potential affinity of binding to human like receptor. The present study shows the importance of continuing surveillance of newH9N2 strains to better prepare for the next epidemic or pandemic outbreak of H9N2 AIV infections in chicken flocks.
심연근(Shen, Yan-Qin),남경숙(Nam, Geong-Sook) 한국실내디자인학회 2017 한국실내디자인학회 학술대회논문집 Vol.2017 No.10
(Background and Purpose) The development of modern human society always depends on the new generation. Modern preschool education is actually environmental education, The impact of the environment on survival and development is generally inversely proportional to age. This is determined by the physical and mental development of children and the educational value of the environment in two aspects. Therefore, adults should provide a suitable environment for children"s development, a caring and free environment. Montessori"s educational philosophy advocates creating a ready environment for children to enable children to develop freely in a "prepared environment". This article carries on the related proposal to this argument. (Conclusions) Now the kindergarten in the design of the building space is more inclined to open space environment. However, the division of space is relatively traditional. The kindergarten has less activity space and can"t meet the daily needs of the children.
Qin Chen,Wen-Wen Yang,Pan Shen,Qing-Ri Cao,Beom-Jin Lee,Jing-Hao Cui 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.6
The present study aimed to evaluate the gastrointestinalmucosa irritation of three platycodin formulations. Platycodin-loaded core pellets were prepared viaextrusion–spheronization method and coated withEudragit L100-55 (L100) or Eudragit S100 (S100) forpH-dependent release. The release of platycodin D fromcoated pellets exhibited pH dependent release profiles. Thepharmacokinetic study in rats showed that Tmax of thecoated pellets were prolonged as compared to that of uncoatedpellets. The S100-coated pellets possess a lowerCmax and decreased AUC0–24h as compared to the L100-coated and uncoated pellets. Hematoxylin-eosin stainingand nuclear factor Kappa B (NF-jB) measurement werecarried out to observe the gastrointestinal mucosa irritations. The results revealed that the irritations of platycodinon the upper gastrointestinal mucosa are dose-dependent. However, no obvious irritation effect on the gastrointestinaltissues of rats was detected after oral administration ofthe coated pellets. In addition, the amount of NF-jB in thestomach of rats treated with the uncoated pellets was aboutfivefold higher as compared to that of the coated pellets. Insummary, the L100-coated platycodin pellets exhibitedhigher oral bioavailability and less gastrointestinal mucosairritations as compared to the other two formulations.
Shen, Fang,Wu, Chun-Xiao,Yao, Yu,Peng, Peng,Qin, Zhi-Yong,Wang, Yin,Zheng, Ying,Zhou, Liang-Fu Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
Background: Only few epidemiological data on primary central nervous system (CNS) tumors in Shanghai have been reported. Methods: All cases of primary CNS tumors that were registered at Center for Disease Control and Prevention (CDC) were collected (1973-2007: urban Shanghai; 2003-2007: whole Shanghai city). Trends were analyzed using joinpoint analysis and rates were stratified by age, gender and region. Histological data were collected from both CDC and Huashan Hospital. Results: From 1973 to 2007, the five-year average incidence rate in urban Shanghai increased in both genders, especially in the elderly population. Joinpoint analysis showed the age-adjusted incidence rate for males increased first but then plateaued, whilst rates for females continued increasing over the 35 years. For the five-year status quo (2003-2007), rural had a higher age-adjusted incidence rate than urban populations, and females higher than males, especially those with advanced age. According to CDC (2003-2007) and Huashan Hospital (1951-2011), the two most common histological subtypes were neuroepithelial tumors (with male predominance) and meningiomas (with female predominance). Conclusions: In Shanghai, a steadily increased incidence rate of primary CNS tumors was observed in general, and in the elderly and female population in particular.
Qin, Hua,Gu, Qiang,Kuppu, Sundaram,Sun, Li,Zhu, Xunlu,Mishra, Neelam,Hu, Rongbin,Shen, Guoxin,Zhang, Junling,Zhang, Yizheng,Zhu, Longfu,Zhang, Xianlong,Burow, Mark,Payton, Paxton,Zhang, Hong 한국식물생명공학회 2013 Plant biotechnology reports Vol.7 No.3
The Arabidopsis gene AVP1 encodes an $H^+$-pyrophosphatase that functions as a proton pump at the vacuolar membranes, generating a proton gradient across vacuolar membranes, which serves as the driving force for many secondary transporters on vacuolar membranes such as $Na^+/H^+$-antiporters. Overexpression of AVP1 could improve drought tolerance and salt tolerance in transgenic plants, suggesting a possible way in improving drought and salt tolerance in crops. The AVP1 was therefore introduced into peanut by Agrobacterium-mediated transformation. Analysis of AVP1-expressing peanut indicated that AVP1-overexpression in peanut could improve both drought and salt tolerance in greenhouse and growth chamber conditions, as AVP1-overexpressing peanuts produced more biomass and maintained higher photosynthetic rates under both drought and salt conditions. In the field, AVP1-overexpressing peanuts also outperformed wild-type plants by having higher photosynthetic rates and producing higher yields under low irrigation conditions.