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Transvascular delivery of small interfering RNA to the central nervous system
Kumar, Priti,Wu, Haoquan,McBride, Jodi L.,Jung, Kyeong-Eun,Hee Kim, Moon,Davidson, Beverly L.,Kyung Lee, Sang,Shankar, Premlata,Manjunath, N. Nature Publishing Group 2007 Nature Vol.448 No.7149
A major impediment in the treatment of neurological diseases is the presence of the blood–brain barrier, which precludes the entry of therapeutic molecules from blood to brain. Here we show that a short peptide derived from rabies virus glycoprotein (RVG) enables the transvascular delivery of small interfering RNA (siRNA) to the brain. This 29-amino-acid peptide specifically binds to the acetylcholine receptor expressed by neuronal cells. To enable siRNA binding, a chimaeric peptide was synthesized by adding nonamer arginine residues at the carboxy terminus of RVG. This RVG-9R peptide was able to bind and transduce siRNA to neuronal cells in vitro, resulting in efficient gene silencing. After intravenous injection into mice, RVG-9R delivered siRNA to the neuronal cells, resulting in specific gene silencing within the brain. Furthermore, intravenous treatment with RVG-9R-bound antiviral siRNA afforded robust protection against fatal viral encephalitis in mice. Repeated administration of RVG-9R-bound siRNA did not induce inflammatory cytokines or anti-peptide antibodies. Thus, RVG-9R provides a safe and noninvasive approach for the delivery of siRNA and potentially other therapeutic molecules across the blood–brain barrier.
Pulak Priti Patra,Sourabh Kumar Dubey,Raman Kumar Trivedi,Sanjeev Kumar Sahu,Sangram Keshari Rout 대한공간정보학회 2017 Spatial Information Research Vol.25 No.1
Landsat operational land imager (OLI) data and consequent laboratory measurements were used to predict chlorophyll-a (Chl-a) concentration and the trophic states for an inland lake within the East Kolkata Wetland, India (a Ramsar site). The most suitable band ratio was identified by performing Pearson correlation analysis between Chla concentrations and possible OLI band and band ratios from the study points. The results showed highest correlation coefficient from the band ratio OLI5/OLI4 with an R value of 0.85. The prediction model was then developed by applying regression analysis between the band ratio OLI5/OLI4 and Chl-a concentration of the study points. The reflectance ratios of the validation points were given as input on the prediction model and the model output was considered as predicted Chl-a values of the validation points to check the efficiency of the prediction model. The regression model between laboratory-derived Chl-a value and model-fitted Chl-a value of the validation points revealed a high correlation with an R2 value of 0.78. Trophic State Index (TSI) of the lake was also calculated from laboratory-derived Chl-a value and model-fitted Chla value of the validation points. The study presented a high correlation of TSI determined from predicted data with TSI from laboratory reference data (R = 0.88). The TSI values of the lake ranged from 65 to 75 which indicate that the lake is appeared to be eutrophic to hypereutrophic conditions. This empirical study showed that Landsat 8 OLI imagery can be effectively applied to estimate Chla levels and trophic states for inland lakes.
Vikas Kumar Singh,Priti Upadhyay,Pallavi Sinha,Ashish Kumar Mall,Ranjith K. Ellur,Atul Singh,Sanjay K.Jaiswal,Sunil Biradar,S. Ramakrishna,R.M. Sundaram,Ilyas Ahmed,B. C. Viraktamath,C. Kole,Sukhpal S 한국작물학회 2011 Journal of crop science and biotechnology Vol.14 No.1
A total of six TGMS (thermosensitive genic male sterile lines) and nine pollinator lines were subjected to molecular characterization using 48 genome-wide SSR (simple sequence repeat) markers. Cluster analysis revealed clear differentiation among the TGMS lines according to their source of origin. The SSR-based genetic distance between the hybrids of the parental lines ranged from 0.36to 0.79 suggesting a high degree of genetic divergence. Among a set of 54 hybrids generated using parental lines, 32 showed better parent heterosis (+21.7%) while 19 showed mid-parent heterosis (+15.0%). For the trait yield per plant genetic distance (GD) was negatively correlated with F1 performance (r = -0.202), mid-parent heterosis (r = -0.325*; P < 0.05), and better parent heterosis (r = -0.261), while it was positively correlated with specific combining ability (r = 0.042). Based on the grouped genetic distance (GGD),the hybrid combinations were divided into four groups. The GGD showed linear correlation with hybrid performance within the group (GGD = 40 - 50: r = -0.07; GGD = 70 - 80: r = 0.32). This information can be utilized in the development of higher yielding,two-line rice hybrids through selection of intermediately diverse parental lines using GGD.
Singh, Vikas Kumar,Upadhyay, Priti,Sinha, Pallavi,Mall, Ashish Kumar,Ellur, Ranjith K.,Singh, Atul,Jaiswal, Sanjay K.,Biradar, Sunil,Ramakrishna, S.,Sundaram, R.M.,Ahmed, Ilyas,Viraktamath, B.C.,Kole, 한국작물학회 2011 Journal of crop science and biotechnology Vol.14 No.1
A total of six TGMS (thermosensitive genic male sterile lines) and nine pollinator lines were subjected to molecular characterization using 48 genome-wide SSR (simple sequence repeat) markers. Cluster analysis revealed clear differentiation among the TGMS lines according to their source of origin. The SSR-based genetic distance between the hybrids of the parental lines ranged from 0.36 to 0.79 suggesting a high degree of genetic divergence. Among a set of 54 hybrids generated using parental lines, 32 showed better parent heterosis (+21.7%) while 19 showed mid-parent heterosis (+15.0%). For the trait yield per plant genetic distance (GD) was negatively correlated with $F_1$ performance (r = -0.202), mid-parent heterosis (r = $-0.325^*$; P < 0.05), and better parent heterosis (r = -0.261), while it was positively correlated with specific combining ability (r = 0.042). Based on the grouped genetic distance (GGD), the hybrid combinations were divided into four groups. The GGD showed linear correlation with hybrid performance within the group (GGD = 40 - 50: r = -0.07; GGD = 70 - 80: r = 0.32). This information can be utilized in the development of higher yielding, two-line rice hybrids through selection of intermediately diverse parental lines using GGD.
Seismic Performance of Footings on Stone Columns Treated Dry Sand Beds
Priti Maheshwari,Nitish Kumar Yadav,Jagdish Prasad Sahoo 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.11
An extensive experimental study has been carried out to study the seismic performance of footings on stone columns treated dry sand beds. Physical models have been prepared in a laminar shear box of size 1 m3 on the shaking table which has a single degree of freedom motion for representing horizontal shaking action under seismic vibrations. Effect of the configuration of stone columns, aspect ratio of footing, relative density of sand bed, frequency and peak ground acceleration (PGA) of cyclic input motion on vertical settlement of footing has been studied. Optimum length of stone columns has been found to lie between 13 − 16 times the diameter. Direction of shaking perpendicular to length of footing has been found to be more critical. Effect of aspect ratio has been found to be more pronounced at larger PGA. Influence of the frequency on response of footings has also been quantified.
( Avnish Kumar Seth ),( Priti Jain ) 대한장연구학회 2022 Intestinal Research Vol.20 No.2
Background/Aims: To study role of fecal microbiota transplantation (FMT) in induction, maintenance, and rescue in patients with corticosteroid-dependent ulcerative colitis (CDUC). Methods: Patients with active CDUC received 3 fortnightly sessions of colonoscopic induction FMT (iFMT) in addition to standard of care. In patients who achieved clinical remission (CR) or response, prednisolone was tapered from week 4 and azathioprine from week 12. Responders were advised maintenance FMT (mFMT) every 6 months. Those with relapse were offered rescue FMT (rFMT), and low dose prednisolone was added if there was no improvement in 2 weeks. Results: All 27 patients enrolled completed iFMT and were followed up for 39 months (range, 9-71 months). The mean Mayo score decreased from 6.4±2.5 at baseline to 2.6±3.7 at week 4, 2.6±3.4 at week 12, and 2.8±3.8 at week 24 (P<0.05). Corticosteroid-free CR and clinical response at week 12 were seen in 13 patients (48%) and 1 patient (3.7%), respectively. Corticosteroid and azathioprine-free CR at week 24 was seen in 13 patients (48%) and in them histological response was seen in 2 patients (15.2%) at week 4, 5 patients (38.4%) at week 12, and 10 patients (76.9%) at week 24. First relapse was seen in 10 of 13 responders (76.9%) at a median of 14.8 months (range, 6-34 months) after iFMT and was less frequent in patients on mFMT. Relapse was treated successfully with rFMT alone in 4 patients (40%) and rFMT with low dose steroids in 5 patients (50%). Conclusions: iFMT, mFMT, and rFMT may have a role in treatment of selected patients with CDUC. (Intest Res 2022;20:251-259)
Cyclic codes from the first class two-prime Whiteman's generalized cyclotomic sequence with order 6
Pramod Kumar Kewat,Priti Kumari 대한수학회 2019 대한수학회보 Vol.56 No.2
Let $p_1$ and $p_2$ be two distinct odd primes with $\mathrm{gcd}(p_1-1,p_2-1)=6$. In this paper, we compute the linear complexity of the first class two-prime Whiteman's generalized cyclotomic sequence (WGCS-I) of order $d=6$. Our results show that their linear complexity is quite good. So, the sequence can be used in many domains such as cryptography and coding theory. This article enrich a method to construct several classes of cyclic codes over $\mathrm{GF}(q)$ with length $n=p_1p_2$ using the two-prime WGCS-I of order 6. We also obtain the lower bounds on the minimum distance of these cyclic codes.
CYCLIC CODES FROM THE FIRST CLASS TWO-PRIME WHITEMAN'S GENERALIZED CYCLOTOMIC SEQUENCE WITH ORDER 6
Kewat, Pramod Kumar,Kumari, Priti Korean Mathematical Society 2019 대한수학회보 Vol.56 No.2
Let $p_1$ and $p_2$ be two distinct odd primes with gcd($p_1-1$, $p_2-1$) = 6. In this paper, we compute the linear complexity of the first class two-prime Whiteman's generalized cyclotomic sequence (WGCS-I) of order d = 6. Our results show that their linear complexity is quite good. So, the sequence can be used in many domains such as cryptography and coding theory. This article enrich a method to construct several classes of cyclic codes over GF(q) with length $n=p_1p_2$ using the two-prime WGCS-I of order 6. We also obtain the lower bounds on the minimum distance of these cyclic codes.
Stochastic Analysis of Strip Footings on Elastic Layered Soil
P. Pradeep Kumar,Priti Maheshwari 대한토목학회 2013 KSCE Journal of Civil Engineering Vol.17 No.7
In the present work, Monte Carlo simulation assisted analysis of strip footings resting on elastic layered soil has been carried out. The elastic modulii of soil layers have been treated as a stationary stochastic field characterized by mean, variance, Autocorrelation Function (ACF) and the Autocorrelation Distance (ACD). Realizations of elastic modulii (E), generated by solving a stochastic differential equation, have been fed to a deterministic distributed parameter model to generate realizations of dependent stochastic fields viz. settlement of footing and interfacial vertical stresses. Subsequently these realizations have been analyzed to evolve probability distribution functions, variance and ACF of the dependent stochastic fields. It is revealed that ACF of these fields are independent of the ACF of E. The variance of settlement has been found to increase as the ACD of E increases, implying requirement of a larger factor of safety when random soils display low frequency (macro level) variations. On the other hand variance of the vertical stress is larger at smaller ACD of E, indicating that for vertical stress, larger factor of safety is required when the random soils display high frequency (micro level) variations.