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Phosphatidyl Inositol Metabolism and Initiation of DNA Synthesis
Lee, Myung Ae,Lee, Hyeong Ok,Jae, Cheol 한국유전학회 1988 Genes & Genomics Vol.10 No.4
Intracellular inositol lipid hydrolysis involved in the initiation of DNA synthesis was examined. NIH 3T3 cells metabolically labeled with ³H-inositol were growth-arrested by serum starvation for 14 hours followed by 3mM hydroxyurea treatment for 6 hours and were allowed to initiate DNA synthesis in the normal media. The increased breakdown of phosphatidyl inositides into inositol 1,4,5-triphosphate and diacylglycerol was observed with the maximal DNA synthesis rate which was measured by the ³H-thymidine incorporation for 30 minutes during the progression of cell cycle into S phase. The incorporation of ^3H into phosphatidyl inositol-4-phosphate and inositol-l,4-bisphosphate in ³H-myo-inositol labeled cells was markedly increased with the initiation of DNA synthesis. These data suggest that increased phosphatidyl inositol turnover is associated with the initiation of DNA synthesis, and this process is in close relationship with the phosphorylation of phosphatidyl inositol into phosphatidyl inositol-4-phosphate by phosphatidyl inositol kinase, which is also phosphorylated into phosphatidyl inositol-4,5-bisphosphate by phospholipase C, which is in turn hydrolyzed to form inositol-1,4,5-triphosphate.
In vivo anti-cancer activity of Korean Angelica gigas and its major pyranocoumarin decursin.
Lee, Hyo Jeong,Lee, Hyo Jung,Lee, Eun Ok,Lee, Jae Ho,Lee, Kuen Sung,Kim, Kwan Hyun,Kim, Sung-Hoon,L?, Junxuan Institute for Advanced Research in Asian Science a 2009 The American journal of Chinese medicine Vol.37 No.1
<P>We have reported that a 10-herbal traditional formula containing Korean Angelica gigas Nakai (AGN) exerts potent anti-cancer efficacy and identified decursin and decursinol angelate (DA) from AGN as novel anti-androgens. Here, we determined whether AGN would exert in vivo anti-cancer activity and whether decursin or DA could account for its efficacy. The AGN ethanol extract was tested against the growth of mouse Lewis lung cancer (LLC) allograft in syngenic mice or human PC-3 and DU145 prostate cancer xenograft in immunodeficient mice. The pharmacokinetics of decursin and DA were determined. The AGN extract significantly inhibited LLC allograft growth (30 mg/kg) and PC-3 and DU145 xenograft growth (100 mg/kg) without affecting the body weight of the host mice. Biomarker analyses revealed decreased cell proliferation (Ki67, PCNA), decreased angiogenesis (VEGF, microvessel density) and increased apoptosis (TUNEL, cPARP) in treated tumors. Decursin and DA injected intraperitoneally were rapidly hydrolyzed to decursinol. Decursinol and decursin at 50 mg/kg inhibited LLC allograft growth to the same extent, comparable to 30 mg AGN/kg. Therefore the AGN extract possessed significant in vivo anti-cancer activity, but decursin and DA only contributed moderately to that activity, most likely through decursinol.</P>
Production and Characterization of Kimchi with Enhanced Levels of γ-Aminobutyric Acid
Jae-Hwan Seok,Ki-Bum Park,Yo-Han Kim,Mi-Ok Bae,Myung-Ki Lee,Suk-Heung Oh 한국식품과학회 2008 Food Science and Biotechnology Vol.17 No.5
In the development of a nutrient enhanced functional food, kimchi was produced by using high γ-aminobutyric acid (GABA) producing lactic acid bacterium as a starter strain. The strain isolated from kimchi was identified by using an API kit and named Lactobacillus sp. OPK 2-59. Kimchi was produced by 3 methods 1) monosodium glutamate (MSG) added (M group); 2) starter added (S group); 3) MSG+starter added (M&S group). The produced kimchi was fermented for 24 hr in an incubator at a temperature of 15℃ and stored at 0-1℃ to examine its characteristics. The M&S group exhibited a sharper increase in acidity and a steeper fall in pH as well as a higher number of lactobacilli. The M&S group kimchi had 18 mg/100 g (fresh weight, f.w.) of GABA, whereas the M and S group each had 6 mg/100 g (f.w.) GABA. According to functional evaluation, the M&S group kimchi, which has higher GABA, was not significantly different in taste, color, texture, or smell, but the M&S group was generally superior. In summary, using Lactobacillus sp. OPK 2-59 and MSG, a high quality kimchi with increased GABA content can be produced as a functional food.
ARE THE FAINT STRUCTURES AHEAD OF SOLAR CORONAL MASS EJECTIONS REAL SIGNATURES OF DRIVEN SHOCKS?
Lee, Jae-Ok,Moon, Y.-J.,Lee, Jin-Yi,Lee, Kyoung-Sun,Kim, Sujin,Lee, Kangjin IOP Publishing 2014 ASTROPHYSICAL JOURNAL LETTERS - Vol.796 No.1
<P>Recently, several studies have assumed that the faint structures ahead of coronal mass ejections (CMEs) are caused by CME-driven shocks. In this study, we have conducted a statistical investigation to determine whether or not the appearance of such faint structures depends on CME speeds. For this purpose, we use 127 Solar and Heliospheric Observatory/Large Angle Spectroscopic COronagraph (LASCO) front-side halo (partial and full) CMEs near the limb from 1997 to 2011. We classify these CMEs into two groups by visual inspection of CMEs in the LASCO-C2 field of view: Group 1 has the faint structure ahead of a CME and Group 2 does not have such a structure. We find the following results. (1) Eighty-seven CMEs belong to Group 1 and 40 CMEs belong to Group 2. (2) Group 1 events have much higher speeds (average = 1230 km s(-1) and median = 1199 km s(-1)) than Group 2 events (average = 598 km s(-1) and median = 518 km s(-1)). (3) The fraction of CMEs with faint structures strongly depends on CME speeds (V): 0.93 (50/54) for fast CMEs with V >= 1000 km s(-1), 0.65 (34/52) for intermediate CMEs with 500 km s(-1) <= V < 1000 km s(-1), and 0.14 (3/21) for slow CMEs with V < 500 km s(-1). We also find that the fraction of CMEs with deca-hecto metric type II radio bursts is consistent with the above tendency. Our results indicate that the observed faint structures ahead of fast CMEs are most likely an enhanced density manifestation of CME-driven shocks.</P>
Lee, Sun-Ryung,Park, Jae-Han,Park, Eui Kyun,Chung, Chin Ha,Kang, Shin-Sung,Bang, Ok-Sun Wiley Subscription Services, Inc., A Wiley Company 2005 Journal of Cellular Physiology Vol.205 No.2
<P>Akt is a key downstream effector of the PI3K signaling pathway and plays a role in cell growth and survival. Expression of a myristoylated constitutively active form of Akt (myr-Akt) in PC12 cells could override cell-growth arrest at G<SUB>2</SUB>/M phase and apoptosis that were induced by etoposide treatment. On the other hand, inactivation of Akt by expression of its dominant negative mutant form (km-Akt) inhibited cell proliferation by arresting the cells at G<SUB>2</SUB>/M phase. Expression of myr-Akt also led to an increase in the protein and mRNA levels of CDK1 and cyclin B1. Furthermore, EMSA data revealed that expression of myr-Akt promoted the binding of NF-Y to the consensus CCAAT promoter sequence, whereas expression of km-Akt almost completely abolished it. Moreover, the Akt activity was minimal in the cells that were arrested at G<SUB>2</SUB>/M phase by nocodazole treatment, but reached to a maximal level as the cells progressed to mitosis and G<SUB>1</SUB> phase upon removal of the drug. Treatment with Akt inhibitors, but not with those of MEK or p70S6K, blocked the release of the cells from the nocodazole-induced G<SUB>2</SUB>/M arrest, further revealing that the Akt activity is required for G<SUB>2</SUB>/M phase transition. These results suggest that Akt facilitate cell-cycle progression at G<SUB>2</SUB>/M phase in PC12 cells and this Akt activity is correlated with upregulation of NF-Y DNA-binding activity and cyclin B1/CDK1 gene expression. © 2005 Wiley-Liss, Inc.</P>
Jae-Hoon Shin,Nan-Hee An,Sang-Min Lee,Jung-Hun Ok,Byun-Woo Lee 한국토양비료학회 2016 한국토양비료학회지 Vol.49 No.6
Understanding N mineralization dynamics in soil is essential for efficient nutrient management. An anaerobic incubation experiment was conducted to examine N mineralization potential and N mineralization rate of the organic amendments with different C:N ratio in paddy soil. Inorganic N in the soil sample was measured periodically under three temperature conditions (20°C, 25°C, 30°C) for 90 days. N mineralization was accelerated as the temperature rises by approximately 10% °C<SUP>-1</SUP> in average. Negative correlation (R<SUP>2</SUP> = 0.707) was observed between soil inorganic N and C:N ratio, while total organic carbon extract (R<SUP>2</SUP> = 0.947) and microbial biomass C (R<SUP>2</SUP> = 0.824) in the soil were positively related to C:N ratio. Single exponential model was applied for quantitative evaluation of N mineralization process. Model parameter for N mineralization rate, k, increased in proportion to temperature. N mineralization potential, Np, was very different depending on C:N ratio of organic input. Np value decreased as C:N ratio increased, ranged from 74.3 mg kg<SUP>-1</SUP> in a low C:N ratio (12.0 in hairy vetch) to 15.1 mg kg<SUP>-1</SUP> in a high C:N ratio (78.2 in rice straw). This result indicated that the amount of inorganic N available for crop uptake can be predicted by temperature and C:N ratio of organic amendment. Consequently, it is suggested that the amount of organic fertilizer application in paddy soil would be determined based on temperature observations and C:N ratio, which represent the decomposition characteristics of organic amendments.
Granular cell tumor of the esophagus in an adolescent
Lee, Ji Sun,Ko, Kyung Ok,Lim, Jae Woo,Cheon, Eun Jeong,Kim, Young Jin,Son, Jang Sin,Yoon, Jung Min The Korean Pediatric Society 2016 Clinical and Experimental Pediatrics (CEP) Vol.59 No.no.sup1
Esophageal granular cell tumor (GCT) is a rare neoplasm originating from the Schwann cells of the submucosal neuronal plexus. Histology is the gold standard for its diagnosis. Endoscopic resection or surgical excision should be considered, depending on the potential for malignancy. Here, we report a case of an esophageal GCT in an adolescent. A 12-year-old boy presented with a 1-year history of dysphagia and vomiting. Upper gastrointestinal endoscopic examination and esophagography showed narrowing of the midesophagus, and computed tomography angiography of the thoracic aorta revealed an esophageal or periesophageal mass posterior to the paratracheal segment of the esophagus. The tumor was surgically excised, and based on the pathological findings, esophageal GCT was diagnosed.
Hashimoto thyroiditis with an unusual presentation of cardiac tamponade in Noonan syndrome
Lee, Mi Ji,Kim, Byung Young,Ma, Jae Sook,Choi, Young Earl,Kim, Young Ok,Cho, Hwa Jin,Kim, Chan Jong The Korean Pediatric Society 2016 Clinical and Experimental Pediatrics (CEP) Vol.59 No.no.sup1
Noonan syndrome is an autosomal dominant, multisystem disorder. Autoimmune thyroiditis with hypothyroidism is an infrequent feature in patients with Noonan syndrome. A 16-year-old boy was admitted because of chest discomfort and dyspnea; an echocardiogram revealed pericardial effusion. Additional investigations led to a diagnosis of severe hypothyroidism due to Hashimoto thyroiditis. The patient was treated with L-thyroxine at 0.15 mg daily. However, during admission, he developed symptoms of cardiac tamponade. Closed pericardiostomy was performed, after which the patient's chest discomfort improved, and his vital signs stabilized. Herein, we report a case of an adolescent with Noonan syndrome, who was diagnosed with Hashimoto thyroiditis with an unusual presentation of cardiac tamponade.