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The Regulation of Alpha-Amylase Synthesis in Bacillus subtilis
WON, MISUN,CHAMBLISS, GLENN H.,SONG, KYUNG BIN 한국미생물 · 생명공학회 1991 Journal of microbiology and biotechnology Vol.1 No.4
In B, subtilis, α-amylase synthesis is regulated by amyR located directly on the upstream of amyE. Three different amyR alleles have been reported, amyRl, amyR2 and amyR3. Strains bearing the gra-10 mutation which confers derepression for catabolite repression has G→A transition mutation at +5 of amyR1. S1 nuclease mapping demonstrated that transcription initiated at 8 bases downstream from the -10 region of putative Eσ^A promoter P1 in amyR1 and gra-10. In amyR2, the major transcription initiatd at the same place and the minor, 10 bases downstream from -10 of P2. The transcript from P2 contributed approximately 15-20% of total amyE mRNA. S1 nuclease protection experiment indicated that amyE mRNA levels corresponded to the rate of synthesis assumed by specific activities of α-amylase in culture supernatants, suggesting that α-amylase synthesis is regulated at the level of transcription.
WON, MISUN,KIM, SOYOUN,LEE, SEUNGHWAN,KIM, CHULJUNG,KIM, HYUNSU,JUN, MOOHYUNG,SONG, KYUNG BIN 한국미생물 · 생명공학회 2001 Journal of microbiology and biotechnology Vol.11 No.1
To examine the characteristics of the recombinant thin aggregative fimbriae of Salmonella, the AgfA subunit gene was amplified from Salmonella enteritidis using a PCR. The maltose binding protein (MBP)-AgfA fusion protein was overproduced in E. coli and purified. The secondary structure of AgfA was then elucidated from the difference CD spectra. An estimation of the secondary structure of AgfA using the self-consistent method revealed a mostly β-sheet structure.
( Misun Yang ),( Jin Wha Choi ),( Ji Sook Kim ),( So Yoon Ahn ),( Se In Sung ),( Yun Sil Chang ),( Won Soon Park ) 대한주산의학회 2018 Perinatology Vol.29 No.3
Objective: The purpose of this study is to compare the clinical characteristics of newborn hearing test results between infants in well-baby nursery (WBN) versus neonatal intensive care unit (NICU) and to determine the optimal strategies of hearing screening for each group. Methods: A total of 2,161 newborns admitted to WBN and NICU were enrolled in this retrospective cohort study. Automated audio brainstem response was used for hearing screening test. The screening rates, referral rates, prevalence rates, false positive rates and predictive positive value (PPV) were analyzed for infants in WBN and NICU. Results: The referral rates of the screening test were 2.2% and 5.0% in WBN and NICU groups (P<0.01); the prevalence rate of congenital hearing loss (HL) were 0.5% and 4.6% in the WBN and NICU groups (P<0.01). The false positive rates and PPV of screening test were 0.9% and 36.8% in WBN; 0.8% and 80% in NICU. Infants with bilateral refer results in both WBN and NICU were at the higher risk of congenital HL, compared with infants with unilateral refer results in WBN who were mostly confirmed to have false positive. Conclusion: The infants in WBN showed high unilateral referral rate with low prevalence rate of HL. However, the infants with bilateral refer results in WBN and uni- or bi-lateral refer results in NICU had higher prevalence rate of HL, compared with those with unilateral refer results in WBN. Different strategies for hearing screening might be considered in infants in WBN and NICU.
대두부산물의 지방세포분화 유도유전자의 발현저해 및 전지방세포 분화 억제 효과
Misun Choi(최미선),Jee-In Kim(김지인),Jin-Boo Jeong(정진부),Subok Lee(이수복),Jae-Nam Jeong(정재남),Hyung-Jin Jeong(정형진),Eul-Won Seo(서을원),Taek-Yoon Kim(김택윤),Oh-Jun Kwon(권오준),Jae-Hwan Lim(임재환) 한국생명과학회 2011 생명과학회지 Vol.21 No.3
대두는 여러 종류의 파이토케미컬을 함유하고 있으며 이에 의한 항산화, 항염증, 항비만 효능 등이 있음이 잘 알려져 있다. 대두 부산물 성분의 비만억제효능을 확인하기 위하여 Oil-Red O 염색법과 정량 PCR을 통하여 지방세포분화억제 및 지방생성억제 효능을 분석하였다. 분화유도물질인 isobutylmethylanthine (IBMX), dexamathasone 및 insulin 처리에 따른 지방세포 분화유도와 함께 대두부산물-침지수, 순물, 두유-의 처리는 세포손상 없이 지방세포분화 연관 유전자-PPARγ, Fabp4, Scd1, adipsin, apolipoprotein (APOE), adiponectin (ADIPOQ)-의 발현을 감소시키는 효능을 보였다. 또한 대두에서 잘 알려진 isoflavone -daidzein과 genistein- 분석을 통하여 대두 부산물에 포함된 두 종류의 isoflavone의 함량을 확인하였다. 결과적으로 대두부산물에는 지방세포분화유도 유전자의 발현억제를 통한 전지방세포의 분화 및 지방세포의 지방생성을 억제하고 있음을 확인하였다. 따라서 두부생산 시 발생하는 대두부산물은 지방세포분화 억제 효능을 바탕으로 이를 이용하는 건강기능식품제조에 활용될 수 있을 것으로 판단된다. Soybean is known to contain various phytochemicals that are related to anti-oxidant, anti-inflammatory and anti-obesity effects in mice and humans. The anti-obesity effect of by-product extracts from soybean on the differentiation of 3T3-L1 pre-adipocytes to adipocytes was investigated by suppressing adipocyte differentiation and lipid accumulation with Oil Red-O assay and quantitative PCR. In inducing differentiation of 3T3-L1 pre-adipocytes in the presence of an adipogenic cocktail, isobutylmethylanthine (IBMX), dexamathasone, and insulin, treatment with filtrated soybean soaked water, soybean milk, and soycurd residue from soybean curd processing significantly decreased mRNA expression of obesity-related gene such as PPARγ, Fabp4, and Scd1, adipsin, apolipoprotein (APOE) and adiponectin (ADIPOQ) without any significant cytotoxicity. We also determined the well-known isoflavones in soybean, such as daidzein and genistein, in the by-product extracts. Taken together, we suggest that soybean by-product extract showed anti-obesity effect by suppressing adipocyte related gene expression, and that by-products collected during soybean curd processing may be a good candidate as an ingredient in health care products.