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RPSA Gene Mutants Associated with Risk of Colorectal Cancer among the Chinese Population
Zhang, Shan-Chun,Jin, Wen,Liu, Hui,Jin, Ming-Juan,Chen, Ze-Xin,Ding, Zhe-Yuan,Zheng, Shuang-Shuang,Wang, Li-Juan,Yu, Yun-Xian,Chen, Kun Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
The primary aim of this study was to evaluate the relationship of single nucleotide polymorphisms (SNPs) in ribosomal protein SA (RPSA) gene with colorectal cancer (CRC). A case-control study including 388 controls and 387 patients with CRC was conducted in a Chinese population. Information about socio-demography and living behavior factors was collected by a structured questionnaire. Three SNPs (rs2133579, rs2269349, rs7641291) in RPSA gene were genotyped by Illumina SnapShot method. Multiple logistic regression models were used for assessing the joint effects between tea consumption and SNPs on CRC. The subjects with rs2269349 CC genotype had a decreased risk for CRC (OR=0.60; 95%CI = 0.37-0.99), compared with TT/CT genotype after adjustment for covariates. A similar association of rs2269349 with rectal cancer was observed (OR=0.49; 95%CI=0.24-1.00). Further analyses indicated that this SNP could modify the protective effect of tea drinking on CRC. Among the subjects with rs2269349 TT/CT or rs2133579 AA/GA, there was a marginal significantly lower risk of CRC (OR and 95%CI: 0.63 and 0.39-1.01 for rs2269349; 0.64 and 0.40-1.02 for rs2133579) in tea-drinking subjects in comparison to non-tea-drinking subjects. Mutants in the RPSA gene might be associated with genetic susceptibility to CRC and influence the protective effect of tea consumption in the Chinese population.
Overtopping Failure Process and Core Wall Fracture Mechanism of a New Concrete Core Wall Dam
You-ming Zuo,Jia-wen Zhou,Hai-bo Li,Jie-yuan Zhang,Chang Tan,Xiaodong Wang,Yu-shan Wang,Yue Zhou 대한토목학회 2024 KSCE Journal of Civil Engineering Vol.28 No.5
Concrete core wall dams have emerged as a cost-effective alternative to the reconstruction of old dams. However, the flooding mechanism and flood line of these dams differ significantly from traditional earth and rockfill dams due to the concrete core wall functioning as reinforcement. This study presents model tests that simulate the overtopping failure of earth and rockfill dams with concrete core walls of various thicknesses. The hydrologic curve and two-dimensional evolution of the breach are analyzed, and mechanical analysis examines the relationship between core wall thickness and free face during core wall failure. Results indicate that the presence of the concrete core wall shifts the overtopping failure mode to the scour pit failure mode. The scour pit failure mode occurs when upstream water scours the downstream core wall to form scour holes and free faces. Continuous scouring increases the depth of the free face, ultimately causing the moment between the two sides of the core wall to exceed the bending moment of the core wall, resulting in fracture. The study provides a theoretical basis for the design of core walls for this new type of dam.
RESEARCH ARTICLE : (一)-Catechin glycosides from Ulmus davidiana
( Mohammed Hosny ),( Ming Shan Zhang ),( Haiyan Zhang ),( Hyun Wook Chang ),( Mi Hee Woo ),( Jong Keun Son ),( Sunny Kyung Seon Lee ) 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0
Extensive chromatographic separation of the n-BuOH soluble fraction obtained from the stem and root barks of U. davidiana resulted in five hitherto unknown compounds together with a known one (-)-catechin 1. Structures of the five compounds were elucidated by chemical and spectroscopic analyses, to be (-)-catechin-7-O-gallate-5-O-(5″″-trans-caffeoyl)-β-D-apiofuranoside-3-O-β-D-apiofuranosyl-(1 → 2)-β-D-glucopyranoside 2, (-)-catechin-7-O-gallate-5-O-(5″″-trans-caffeoyl)-β-D-apiofuranoside-3-O-β-D-glucopyranoside 3, (-)-catechin-7-O-gallate-5-O-β-D-apiofuranoside-3-O-(2″-O-galloyl)-β-D-glucopyranoside 4, (-)-catechin-7-O-gallate-5-O-(5″″-trans-caffeoyl)-β-D-apiofuranoside 5, and (-)-catechin-7-O-gallate-5-O-(5″″-trans-feruloyl)-β-D-apiofuranoside 6.
Inhibition of DNA Topoisomerases I and II of Compounds from Reynoutria japonica
( Kyoung Hwangbo ),( Ming Shan Zhang ),( Young Jin Kim ),( Jong Yeop Im ),( Chong Soon Lee ),( Mi Hee Woo ),( Yurngong Jahng ),( Hyun Wook Chang ),( Jong Keun Son ) 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0
Three anthraquinones (1, 2 and 4), three stilbenes (5, 6 and 7) and 3,5-dihydroxybenzyl alcohol (3) were isolated from Reynoutria japonica. Their structures were identified as emodin (1), emodin-8-O-β-D-glucoside (2), 3,5-dihydroxybenzyl alcohol (3), citreorosein (4), cis-resveratrol (5), trans-resveratrol (6) and trans-resveratrol-5-O-β-D-glucopyranoside (7) by comparing their physicochemical and spectral data with published data. Compound 3 was isolated for the first time from the Polygonaceae family. Among the purified compounds, 3 showed more potent inhibitory activity against topoisomerase I (IC: 4 μM) than camptothecin, as the positive control (IC: 18 μM). Compounds 3, 4, 5, 6 and 7 showed stronger inhibitory activities toward DNA topoisomerase II (IC: 0.54, 14, 15, 0.77 and 3 μM, respectively) than the positive control, etoposide (IC: 44 μM). Compounds 1 and 4 displayed weak cytotoxicities against human lung cancer (A549), ovarian cancer (SK-OV-3), human liver hepatoblastoma (HepG2) and colon adenocarcinoma (HT-29) cell lines.
Cytotoxic anthraquinone dimers from Melandrium firmum
Chang Hao Zhang,Da Lei Yao,Cheng-Shen Li,Jie Luo,Mei Jin,Ming-Shan Zheng,Zhen-Hua Lin,Tie-Feng Jin,Gao Li 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.6
Two new anthraquinone dimers, melrubiellin A(1) and melrubiellin B (2), were isolated from the aerialpart of Melandrium firmum Rohrbach, along with sevenknown compounds (3–9). The structures of these compoundswere elucidated by spectral analyses, including 1Dand 2D NMR (COSY, HMQC, HMBC and NOESY)experiments. Compound 1 and 2 exhibited significantcytotoxicity towards HeLa, NCI-H460, Hep G2, Hep 3Band MKN-28 cell lines with IC50 values ranging from 5.26to 81.16 lM.
Compaction techniques and construction parameters of loess as filling material
Hu, Chang-Ming,Wang, Xue-Yan,Mei, Yuan,Yuan, Yi-Li,Zhang, Shan-Shan Techno-Press 2018 Geomechanics & engineering Vol.15 No.6
Loess often causes problems when used as a filling material in the construction of foundations. Therefore, the compaction technique, shear behavior, and bearing capacity of a filled foundation should be carefully considered. A series of tests was performed in this study to obtain effective compaction techniques and construction parameters. The results indicated that loess is strongly sensitive to water. Thus, the soil moisture content should be kept within 12%-14% when it is used as a filling material. The vibrating-dynamic combination compaction technique is effective and has fewer limitations than other methods. In addition, the shear strength of the compacted loess was found to increase linearly with the degree of compaction, and the soil's compressibility decreased rapidly with an increase in the degree of compaction when the degree of compaction was less than 95%. Finally, the characteristic value of the bearing capacity increased with an increase in the degree of compaction in a ladder-type way when the degree of compaction was within 92%-95%. Based on the test data, this paper could be used as a reference in the selection of construction designs in similar engineering projects.