韓國産 산형과 植物에 關한 本草學的 硏究

李尙建,辛民敎,宋昊埈 圓光大學校 韓醫學硏究所 1992 원광한의학 Vol.2 No.1

For the purpose of developing Korean Herbaolgy with the plants of Umbelliferae which grow wild and is planted in Korea, the these and writings on herbalogy, from literature of successive generations, have been thoroughly investigative and the results obtained were as follows : 1. There were totaled to 34 genera and 95 species in Korea and among them medicinal plants are 23 genera, 49 species, some 52 % in total but, the number of species may be added because of the similiar plants. 2. According to the oriental names which can be used for medical purpose, the medicinal plants are belonging to the Umbelliferae family were classified as Radix 20, Fructus 8, Herba 7, Rhizoma 3, Foilum and Flos 2. Thus it was noticed that Radix was the main kind. 3. According to sum of 95 species in Umbelliferae family, they were classified into Angelica genera 23, Bupleurum genera 8, Piucedanum genera 7, Hydrocotyle genera 6. Thus it was noticed that Angelica genera was the main kind, some 24% in total. 4. According to the number of species of the origin plants about each chinese materia midicals, they were classified into RADIX BUPLEURI 6, HERBA HYDROCOTYLEI 4, and RADIX ANGELICAE GLGANTIS·RADIX LIGUSTICI TENUISSIMAE·RADIX ANGELICAE DAHURICAE·FRUCTUS TORILIS 3 each. Thus the origin plants was not complexed reletively. 5. According to nature and flavour of medicinal plants, they were classified into warmth, heat: 19 each, cold, cool : 9 each, balance 1 and unidentified 8. Thus it was noticed that warmth and heat is the main in nature and flavour of medicinal plants. 6. According to the Properties and Principal curative action, they were classified into Drugs for diaphoretics or drugs for treating exterior symptom-complex 7. Drugs for relieving pain 6, Antirheumatics, Drugs which have tonifying actions for the treatment of deficiencies of Yin, Yang, Qi and blood and therefore can be classified into four groups 4, Febrifugal and detoxicant drugs 3, Diuretics and hydragogues, Antitussives 2 each. Thus it was noticed that Drugs for diaphoretics or drugs for treating exterior symptom-complex was the main kind. 7. Comparing to whole medicinal plants 49 kinds, toxic durgs include minor toxin were 2 kinds, 4% of the whole. Thus toxic durgs were rare. From this result, It was revealed that the plants for medical purpose in Umbelliferae was 52% of the whole, in which RADIX was mostly abundunt and toxic plants was so rare that it will be used for clinical treatments more easily. It is considered that many experiements and clinical approaches must be continued to use Umbelliferae plants widely.

工業系 敎師의 再敎育을 위한 硏修 프로그램의 開發에 관한 硏究

李來然,劉承坤,羅聲雄,禹鎬吉 충남대학교 공업교육연구소 1983 論文集 Vol.6 No.2(A)

This study is intended to provide a more effective curriculum for the In- Service Training Program of industrial technical teachers. The curricula which have been used during last five years were carefully analyzed and the main conclusions are suggested as follows; 1) It must be given to the teachers to take optional subjects. 2) Experiments should be reinforced make up for the understanding of theory. 3) Practical studies and factory investigations have to be provided to the teachers during the In-Service Training Program. In case of needs, the expert engineer of industries become a instructor to the teachers for explaining the up-to-date industrial techniques and theories. 4) The teachers who attending the In- Service Training Program should take an active interest in the program for getting a remarkable results.

Pichia pastoris로부터 Toll-like Receptor 9의 세포 내 도메인 단백질의 발현과 순수분리 정제

이균영,이곤호 Plant molecular biology and biotechnology research 2005 Plant molecular biology and biotechnology research Vol.2005 No.

Toll-like receptors (TLR) are important components of innate immunity in the defense against pathogens. TLRs recognize pathogen-associated common molecular patterns. TLRs are similar to the receptors involved in defense responses in plants. TLR protein is a type 1 membrane protein, consisting of an extracellular domain containing leucine-rich repeats and a cytoplasmic domain. The cytoplasmic domain delivers ligand recognition signals that result in production of anti-microbial agents. The cytoplasmic domain (amino acid 858-1032) of toll-like receptor 9 has been expressed using methylotrophic yeast Pichia pastoris. The protein expression was confirmed by Western-blot, N-terminal sequencing and MALDI-TOF mass spectrometry. The proteins have been purified by nickel affinity, cation exchange and gel-filtration chromatography.

퉁퉁마디로부터 염에 의하여 유도되는 Aldolase 유전자의 분리 및 발현분석

차준영,네티 엘마와티,김순길,이증주,임채오,정우식,이곤호,손대영 Plant molecular biology and biotechnology research 2003 Plant molecular biology and biotechnology research Vol.2003 No.-

Soil salinity is one of the most serious abiotic stresses limiting the productivity of agricultural crops. To cope with salt stress, plants respond with physiological, developmental and biochemical changes, including the synthesis of a number of proteins and the induction of gene expression. Salicornia herbacea is a halophytic plant that grows in salt marches and on muddy seashores. In order to understand the biochemical and molecular mechanisms of salt tolerance in S. herbacea, we isolated several genes that involved in the salt tolerance by mRNA differential display.Here we report the cloning of a cDNA encoding fructose-1, 6-bisphosphate aldolase, named ShADL, which is 1293 bp long and contains an open reading frame consisted of 359 amino acids with calculated molecular mass of 39 kDa. ShADL protein showed 86% identity with Arabidopsis and 78% with aldolase of common ice plant. Northern blot analysis revealed that the transcript of ShADL gene was increased dramatically depending on the NaCI concentrations.

퉁퉁마디로부터 색소체 외막 단백질 유전자의 분리 및 발현분석

네티 엘마와티,차준영,양영실,정민희,신동진,이병현,이곤호,손대영 Plant molecular biology and biotechnology research 2004 Plant molecular biology and biotechnology research Vol.2004 No.-

Complementary DNA encoding chloroplast outer envelope membrane protein (OEP) from the halophyte Salicornia herbacea has been cloned and sequenced. The full length cDNA is 596 bp and encodes a polypeptide of 91 amino acid residues with a molecular mass of 8.9 kDa. The expression level of ShOEP increased by salt, drought and ABA treatments. ShOEP expression was largely induced in roots and shoots by high salts. The biological function of ShOEP was examined by yeast complementation. ShOEP can suppress Na+ sensitivity of yeast mutant (cnbΔ) in the presence of salt. These results suggest that ShOEP is a salt inducible gene and may have functions in the regulation of plant salt stress.

A User-Oriented Interactive Model for the Conceptual Design of Bulk Cargo Ships

Lee, Dong-Kon,Lee, Kyung-Ho,Han, Soon-Hung,Lee, Soon-Sub,Lee, Kyu-Yeul,Shin, Soo-Chol,Shin, Dong-Won,Lee, Jong-Chol,Kwon, Sung-Chil The Society of Naval Architects of Korea 1994 Selected papers of the society of naval architects Vol.2 No.1

This paper describes a design model for the conceptual design of ships. Existing design models have problems such that their operating mode of batch versions cannot reflect the design procedures in reality. Reliability of the results is low because the performance estimations are based mainly on empirical formulas. To improve the problems of existing design models, a new design model has been developed. The new model consists of an interactive user interface, a database of main engines, a database of particulars of existing ships, and ten modules for performance estimations. To develop such a user-oriented system, the concept of graphical user interface (GUI) is adopted.

Clinical significance of metabolic tumor volume by PET/CT in stages II and III of diffuse large B cell lymphoma without extranodal site involvement

Song, Moo-Kon,Chung, Joo-Seop,Shin, Ho-Jin,Lee, Sang-Min,Lee, Su-Ee,Lee, Ho-Sup,Lee, Gyeong-Won,Kim, Seong-Jang,Lee, Seok-Mo,Chung, Dong-Seop Springer-Verlag 2012 Annals of hematology Vol.91 No.5

<P>The objective of this study was to investigate whether metabolic tumor volume (MTV) by positron emission tomography (PET) can be a potential prognostic tool when compared with Ann Arbor stage, in stages II and III nodal diffuse large B cell lymphoma (DLBCL). We evaluated 169 patients with nodal stages II and III DLBCL who underwent measurements with PET prior to rituximab combined with cyclophosphamide, adriamycin, vincristine, and prednisone (R-CHOP). Cutoff point of MTV was measured using the receiver operating characteristic (ROC) curve. During a median period of 36 months, stage II was 59.2% and III was 40.8%. Using the ROC curve, the MTV of 220 cm<SUP>3</SUP> was the cutoff value. The low MTV group (<220 cm<SUP>3</SUP>) had longer progression-free survival (PFS) and overall survival (OS), compared with the high MTV group (≥220 cm<SUP>3</SUP>) (<I>p</I> < 0.001, <I>p</I> < 0.001). Stage II patients had longer survival than those in stage III (PFS, <I>p</I> = 0.011; OS, <I>p</I> = 0.001). The high MTV group had lower PFS and OS patterns, regardless of stage, compared with the low MTV group (<I>p</I> < 0.001, <I>p</I> < 0.001). Multivariate analysis revealed an association of the high MTV group with lower PFS and OS (PFS, hazard ratio (HR) = 5.300, <I>p</I> < 0.001; OS, HR = 7.009, <I>p</I> < 0.001), but not stage III (PFS, <I>p</I> = 0.187; OS, <I>p</I> = 0.054). Assessment of MTV by PET had more potential predictive power than Ann Arbor stage in the patients that received R-CHOP.</P>

Prognostic value of metabolic tumor volume on PET?/?CT in primary gastrointestinal diffuse large B cell lymphoma.

Song, Moo-Kon,Chung, Joo-Seop,Shin, Ho-Jin,Moon, Joon-Ho,Lee, Jeong-Ok,Lee, Ho-Sup,Lee, Sang-Min,Lee, Gyeong-Won,Lee, Su-Ee,Kim, Seong-Jang Japanese Cancer Association 2012 Cancer Science Vol.103 No.3

<P>Primary gastrointestinal (PGI) diffuse large B cell lymphoma (DLBCL) is a relatively common disease. Recent studies indicate that measurement of maximum standardized uptake value (SUV(max)) on pretreatment for (18)F-fluorodeoxyglucose PET is an important prognostic factor in PGI DLBCL. However, there is still an association between initial tumor burden and prognosis. Thus, in the present study, we investigated whether tumor volume by PET could have a potential prognostic value to predict the outcome. From 2006 to 2009, 165 Stage I E/II E PGI DLBCL patients were enrolled in the study. One hundred and five patients received cyclophosphamide, doxorubicin, vincristine, prednisone, and rituximab (R-CHOP) only, whereas 60 patients underwent surgery plus R-CHOP. Metabolic tumor volume (MTV) was defined initial tumor burden as target GI lesion above SUV, 2.5 by PET as a contouring border. Over a median follow-up period of 36.6 months, receiver operating characteristic (ROC) analysis indicated that the best cut-off values for MTV and SUV(max) were 160.1 cm(3) and 12.0, respectively. The estimated area under the ROC curve was higher for MTV than SUV(max). Thus, MTV was a better predictor for survival than SUV(max). In patients with a low MTV (<160.1 cm(3)), there were no significant differences in survival between patients undergoing R-CHOP alone and surgery plus R-CHOP (P = 0.347 for progression-free survival [PFS]; P = 0.148 for overall survival [OS]). Conversely, in patients with a high MTV (>160.1 cm(3)), survival was longer in those who underwent surgery plus R-CHOP than in those treated with R-CHOP alone (P < 0.001 for PFS; P < 0.001 for OS). Multivariate analysis revealed that high MTV is an independent factor for predicting survival. Even in the era of rituximab, treatment of PGI DLBCL is not easy in patients with a high MTV.</P>

Status of Conservation, Research and Use of Medicinal Plants in Peninsular Malaysia

Sok-Young Lee,Ho-Cheol Ko,Young-Yi Lee,Na-Young Ro,Jung-Sook Sung,Jung-Ro Lee,Kyung-Ho Ma,Yoon-Chan Huh,Chung-Kon Kim,Mun-Sup Yoon 한국국제농업개발학회 2010 韓國國際農業開發學會誌 Vol.22 No.4

Incidence and clinical characteristics of clonal cytogenetic abnormalities of acquired aplastic anemia in adults

Lee, Ji Hyun,Kwon, Kyung A,Lee, Suee,Oh, Sung Yong,Kim, Sung-Hyun,Kwon, Hyuk-Chan,Han, Jin-Yeong,Song, Moo-Kon,Chung, Joo-Seop,Lee, Ho Sup,Kim, Yang Soo,Lee, Sang-Min,Joo, Young-Don,Kim, Hyo-Jin Korean Society of Hematology; Korean Society of Bl 2010 Blood Research Vol.45 No.4

<P><B>Background</B></P><P>Cytogenetic abnormalities (CAs) have been reported frequently in patients with otherwise typical aplastic anemia (AA), but their implications in the prognosis and in the evolution to hematologic malignancies are controversial.</P><P><B>Methods</B></P><P>We retrospectively analyzed 127 adult AA patients who had successful cytogenetic analysis at initial diagnosis.</P><P><B>Results</B></P><P>The patients were classified into 3 groups according to the initial and follow-up results of cytogenetic profiles. Group 1 included patients who had persistent AA with normal cytogenetic profiles (N=117); Group 2, those who had a normal cytogenetic profile at initial diagnosis but later acquired CA (N=4, 3.1%); and Group 3, those who had CA at the initial diagnosis, regardless of follow-up cytogenetic status (N=6,4.7%). In Group 2, 2 patients later developed CA without progression to acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS); the other 2 patients later progressed to AML. None of the patients in Group 3 progressed to AML or MDS. There was no significant difference in overall survival between Groups 1 and 3.</P><P><B>Conclusion</B></P><P>AA patients with CA at initial diagnosis or follow-up may not be at greater risk for evolution to AML or MDS, or show shorter survival periods. Prospective studies and a larger patient samples are needed to establish the clinical relevance of CA.</P>