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Kim Mi-Yeon,Kim Mi Jeong,Lee Changyeob,Lee Juwon,Kim Sang Seong,Hong Sungho,Kim Hyoung Tae,Seo Jinsoo,Yoon Ki-Jun,Han Sungho 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Enhancing adult neurogenesis in the brain has been suggested as a potential therapeutic strategy for AD. We developed a screening platform, ATRIVIEW®, for molecules that activate neuronal differentiation of adult mouse NSCs. The most potent hit from an FDA-approved drug library was SNR1611 (trametinib), a selective MEK1/2 inhibitor. We found that trametinib increases the levels of P15INK4b and Neurog2, suggesting a mechanism by which MEK1/2 inhibition induces neuronal differentiation. Oral administration of trametinib increased adult neurogenesis in the dentate gyrus and subventricular zone of the 5XFAD AD mouse model. Surprisingly, we also found that trametinib enhanced adult neurogenesis in the cortex. Consequently, trametinib rescued AD pathologies such as neuronal loss and cognitive impairment in 5XFAD mice. Finally, trametinib induced neurogenic differentiation of NSCs derived from AD patient iPSCs, which suggests its potential therapeutic application. Altogether, we suggest that restoration of endogenous adult neurogenesis by trametinib may be a promising therapeutic approach to AD.
Kim, Byung-Su,Bae, Eunkyung,Kim, Young-Ju,Ahn, Kwang-Sung,Park, Juwon,Rhee, Ji young,Lee, Young Yiul,Kim, Youngsoo,Lee, Dongsoon,Kim, Byoung Kook,Yoon, Sung-Soo RAPID COMMUNICATIONS OF OXFORD LTD 2007 ANTICANCER DRUGS Vol.18 No.6
Although STI571 still plays a key role in the treatment of chronic myeloid leukemia, emergence of resistance to STI571 is a major obstacle to successful outcome. Therefore, new agents that increase the sensitivity of chronic myeloid leukemia cells to STI571 are urgently required. SK-7041 is a novel hybrid synthetic histone deacetylase inhibitor derived from the hydroxamic acid of trichostatin A and pyridyl ring of MS-275. Its cytotoxic effects were examined both as a single agent and in combination with STI571 in acute and chronic myeloid leukemia. SK-7041 exhibited growth inhibition of leukemia cells by downregulation of CDK4, cyclin E and cyclin B1 expression, and by upregulation of p21 expression with subsequent activation of the mitochondria-mediated caspase pathway. SK-7041 showed synergism on growth inhibition, cell cycle arrest and induction of apoptosis in chronic myeloid leukemia (K562) when combined with STI571. The synergistic effect was mediated through the same mechanism as in SK-7041 alone, involving reduction of cyclin D1 and induction of p21. Taken together, our findings suggest that SK-7041 is active against leukemia and offers new prospects for overcoming STI571 resistance in chronic myeloid leukemia.
라이다-카메라 캘리브레이션을 통한 동적 장애물 회피를 위한 자율주행 인지시스템에 대한 연구
김현우(Hyunwoo Kim),최윤중(YunJung Choi),김상준(SangJun Kim),길현준(HyunJun Gil),서주원(JuWon Seo),박선영(SunYoung Park),김재일(Jaell Kim),임효진(HyoJin Lim),김정하(JungHa Kim) 한국자동차공학회 2022 한국자동차공학회 학술대회 및 전시회 Vol.2022 No.11
Sensor fusion area are known to great solution for the edge cases of perception system of automated car. This system uses camera and LiDAR on front side of the vehicle and integrated on a coordinate system for the projection. Each point data on image pixel integrated point cloud gets its class by semantic segmentation. This paper suggests a perception system of autonomous vehicle for moving objects by deep learning based image semantic segmentation and lidar points projection to camera pixel image.
Graph SLAM을 통한 산악형 도심지역의 고정밀지도 작성 및 위치 인식 시스템에 대한 연구
김현우(Hyunwoo Kim),최윤중(YunJung Choi),강동완(DongWan Kang),김상준(SangJun Kim),길현준(HyunJun Gil),서주원(JuWon Seo),박선영(SunYoung Park),김재일(JaeIl Kim),임효진(HyoJin Lim),김정하(JungHa Kim) 한국자동차공학회 2022 한국자동차공학회 학술대회 및 전시회 Vol.2022 No.11
This paper suggests a localization system architecture of unmanned vehicle for autonomous driving. In this system, Graph SLAM algorithm is used for correction of accumulated errors acquired from scan matching algorithm. On this paper, the experiments are proceeded in environment of mountainous city which have continuous elevations. The acceleration and magnetic data from IMU, RTK corrected GNSS are used for graph optimization and loop closure on mapping. NDT scan matching algorithm is used for localization.
김대식(Daesik Kim),김주원(Juwon Kim),소진섭(JinSub So),김진우(Jinwoo Kim),정형일(Hyeongil Jeong),이성준(Seoungjun Lee),김용한(Yonghan Kim) 한국철도학회 2014 한국철도학회 학술발표대회논문집 Vol.2014 No.5
철도운영의 효율화와 최적의 유지보수를 위해서는 KTK, KTX-산천, 전동차와 같이 고정 편성으로 동일한 차종으로 구성하여 운행하는 것이 가장 효율적이며, 이런 이유로 국내는 물론 세계적으로 동종의 차량으로 열차 운행 다이아를 설정하고 있으며, 화물열차도 최대한 동일 사양으로 묶어 운행을 하고 있다. 본 연구는 국가R&D 사업으로 개발하고 있는 2층 고속열차, 고속화물열차 및 여객/화물 복합열차의 종합편성시험을 위한 안전 및 인터페이스 측면에서 고려되어야 할 사항에 대하여 연구하고 분석하였다. In light of operational efficiency and maintenance effectiveness, it is the most effective way that a train is composed of same cars such as KTX, KTX-Sancheon and Electric Multiple Unit. Therefore, world trend of a train formation is toward the same kind of cars’ and even a freight train often run with the same kind of cars. This study is aimed at analysis of essential elements about safety and interface of a developing high speed train which is composed of duplex passenger cars and passenger/freight complex cars.
자율주행 시스템의 Pure-pursuit 알고리즘을 이용한 Path Management 시스템 개발
최윤중(YunJung Choi),김현우(Hyunwoo Kim),신희석(HeeSeok Shin),김명준(MyeongJun Kim),김상준(SangJun Kim),길현준(HyunJun Gil),서주원(JuWon Seo),박선영(SunYoung Park),김재일(Jaell Kim),임효진(HyoJin Lim),김정하(JungHa Kim) 한국자동차공학회 2022 한국자동차공학회 학술대회 및 전시회 Vol.2022 No.11
Research on autonomous vehicles consists of perception, judgement, and control. This paper is about the Ld method of the Pure-pursuit algorithm among the control algorithms based on the kinematic method in the control field. In the process of finding the correct L<SUB>d</SUB> for actual control, an error occurred between the detected L<SUB>d</SUB> value and the correct L<SUB>d</SUB>, and only a part of the path was detected L<SUB>d</SUB>. In order to store only the coordinates to be detected by LD in the path reference, the interval between paths was set very small, and the average interval and error of the detected LD values were calculated. The average interval and error of the detected LD value was proportional to the distance the sensor moved during the period of receiving a new signal, and accordingly, the path interval and path error were set appropriately. In the existing algorithm, the optimal interval and error are determined using the experimental data of the vehicle. The algorithm in this study may be less accurate than the existing algorithm. However, using only the target speed, the period of the sensor, and the minimum turning radius of the vehicle, it is possible to set the distance and the error of the path with high accuracy. Finally, the verification was carried out by directly controlling the autonomous vehicle.