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Baek, Jong Chul,Jo, Jae Yoon,Lee, Seon Mi,Cho, In Ae,Shin, Jeong Kyu,Lee, Soon Ae,Lee, Jong Hak,Cho, Min-Chul,Choi, Won Jun The Korean Society for Reproductive Medicine 2019 Clinical and Experimental Reproductive Medicine Vol.46 No.3
Objective: To investigate serum 25-hydroxyl vitamin D (25(OH)D) and vitamin D-binding protein (VDBP) concentrations in women with endometriosis according to the severity of disease. Methods: Women with mild endometriosis (n = 9) and advanced endometriosis (n = 7), as well as healthy controls (n = 16), were enrolled in this observational study. Serum total 25(OH)D concentrations were analyzed using the Elecsys vitamin D total kit with the Cobas e602 module. Concentrations of bioavailable and free 25(OH)D were calculated. Concentrations of VDBP were measured using the Human Vitamin D BP Quantikine ELISA kit. Variables were tested for normality and homoscedasticity using the Shapiro-Wilk test and Leven F test, respectively. Correlation analysis was used to identify the variables related to total 25(OH)D and VDBP levels. To assess the effects of total 25(OH)D and VDBP levels in the three groups, multivariate generalized additive modeling (GAM) was performed. Results: Gravidity and parity were significantly different across the three groups. Erythrocyte sedimentation rate (ESR) and CA-125 levels increased as a function of endometriosis severity, respectively (p= 0.051, p= 0.004). The correlation analysis showed that total 25(OH)D levels were positively correlated with gravidity (r = 0.59, p< 0.001) and parity (r = 0.51, p< 0.003). Multivariate GAM showed no significant relationship of total 25(OH)D levels with EMT severity after adjusting for gravidity and ESR. However, the coefficient of total 25(OH)D levels with gravidity was significant (1.87; 95% confidence interval, 0.12-3.63; p= 0.040). Conclusion: These results indicate that vitamin D and VDBP levels were not associated with the severity of endometriosis.
Vitamin D and endometriosis: Is there a correlation with disease severity?
Baek, Jong Chul,Jo, Jae Yoon,Lee, Seon Mi,Cho, In Ae,Shin, Jeong Kyu,Lee, Soon Ae,Lee, Jong Hak,Cho, Min-Chul,Choi, Won Jun The Korean Society for Reproductive Medicine 2020 Clinical and Experimental Reproductive Medicine Vol.47 No.3
백종선(Jong Seon Baek),김진수(Jin Su Kim),김원경(Won Kyung Kim),김다윗(David Kim),송정은(Jeong Eun Song),강길선(Gilson Khang) 한국고분자학회 2019 폴리머 Vol.43 No.3
제 2형 당뇨병 혈당 강하제 메트포르민 염산염은 물에 대한 높은 용해도로 초기 방출이 급격하게 일어나고, 이로 인한 부작용들이 발생한다. 따라서 서방화로 부작용을 줄이고 복용편리성을 증가시킬 필요가 있다. 메트포르민 염산염에 PEO 8000k와 pH가 낮은 환경에서 졸(sol), pH가 높은 환경에서 젤(gel)로 존재하고 정제의 부식을 막아주는 Carbomer 940을 혼합하여, 습식과립 형태의 서방정제로 설계하였다. 습식과립의 공정에서 일어나는 화학적 변화를 FTIR을 이용하여 평가하였고, 정상적으로 과립이 형성되었는지 확인하기 위하여 DSC와 XRD를 실행하였다. 그리고 주사전자현미경을 이용하여 형태학적 특성을 관찰하였다. 이후 제형이 제대로 설계되었는지 확인하기 위하여 생체외 용출거동을 통해 변화된 용출률을 확인하였다. 이러한 결과를 통해 메트포르민과 적절한 고분자들을 이용한 서방정으로의 가능성을 확인할 수 있다. Metformin hydrochloride, a type 2 diabetes hypoglycemic agent, shows high solubility in water, resulting in rapid initial release and side effects. Therefore, it is necessary to reduce the side effects and to increase the convenience using sustained release. The metformin hydrochloride was designed as a sustained release tablet agent through the wet granulation of PEO 8000k and Carbomer 940 which is a sol at low pH and is a gel at high pH and prevents the corrosion of tablets. FTIR was used for the chemical changes in the process of wet granulation, and DSC and XRD were performed to confirm whether the granules were formed. Morphological characteristics were observed using a scanning electron microscope. In order to confirm that the formulation was properly designed, the dissolution rate was confirmed through in vitro dissolution behavior. These results confirm the possibility of using metformin and appropriate polymers as a sustained- release formulation.
알긴산 나트륨에 포접된 란소프라졸 장용성 경질캡슐의 특성분석
백종선(Jong Seon Baek),김진수(Jin Su Kim),김원경(Won Kyung Kim),김다윗(David Kim),송정은(Jeong Eun Song),강길선(Gilson Khang) 한국고분자학회 2019 폴리머 Vol.43 No.3
소화성 궤양 및 역류성 식도염을 치료하는 효과적인 약물 치료제로는 양성자펌프 억제제(proton pump inhibitor, PPI)가 있다. 란소프라졸은 PPI계열 약물로 복용 후 낮은 pH에 노출되면 용출률이 저해되어 재석출이 일어난다. 따라서 본 연구에서는 란소프라졸의 약물방출을 제어하기 위하여, 알긴산 나트륨과 습식과립 공정을 이용한 장용성 용질캡슐을 제조하였다. 이 제형은 위액의 산성조건에서 방출이 억제되고, 장액의 중성이나 약 알칼리 조건에서 급속한 약물방출이 일어나는 것을 목표로 하였다. 제조된 경질캡슐의 특성분석을 위해 DSC, XRD, FTIR, SEM을 실행하였다. 이 후 제형이 제대로 설계되었는지 확인하기 위하여 생체 외 용출거동을 통해 변화된 용출률을 확인하였다. 이러한 결과를 토대로 알긴산나트륨이 포접된 란소프라졸 장용성 캡슐은 소화성 궤양 및 역류성 식도염 치료제로 사용 가능함을 확인할 수 있다. An effective drug treatment for peptic ulcer and reflux esophagitis is the proton pump inhibitor (PPI) such as lansoprazole. However when the lansoprazole is exposed to low pH, its dissolution rate becomes low and thus re-precipitation occurs. Therefore an enteric solute capsule was prepared using sodium alginate and wet granulation process. This formulation aimed to inhibit release in acidic conditions of stomach fluid and to cause rapid drug release under conditions of intense, neutral or weakly alkaline conditions. DSC, XRD, FTIR, and SEM were performed to characterize the manufactured hard capsules. In order to confirm that the formulation was properly designed, the dissolution rate was confirmed through in vitro dissolution behavior. Based on these results, it can be confirmed that lansoprazole enteric capsules containing sodium alginate can be used as a treatment for peptic ulcer and reflux esophagitis.
( Jong Ryeal Hahm ),( Jin Sook Ahn ),( Hae Sook Noh ),( Seon Mi Baek ),( Ji Hye Ha ),( Tae Sik Jung ),( Yong Jun An ),( Duk Kyu Kim ),( Deok Ryong Kim ) 생화학분자생물학회 2010 BMB Reports Vol.43 No.5
Fenofibrate, an agonist of PPARα, plays an important role in activating many proteins catalyzing lipid metabolism, and it also has a considerable effect on improvement of insulin sensitivity in the diabetic condition. To investigate fenofibrate- dependent expression of peripheral tissue proteins in diabetes, we analyzed whole muscle or fat proteins of fenofibrate-fed OLETF rats, an animal model of type II diabetes, using 2-dimensional gel electrophoresis. We found that many proteins were specifically expressed in a fenofibrate-dependent manner in these diabetic rats. In particular, a functionally unknown C11orf59 protein was differentially expressed in the muscle tissues (about 5-fold increase) in fenofibrate-fed OLETF rats as compared to control rats. Additionally, the signal proteins phosphatidylethanolamine binding protein and IkB interacting protein were differentially regulated in the fenofibrate-treated adipose tissues. We suggest here that these proteins might be involved in controlling lipid or carbohydrate metabolism in diabetes via PPARα activation. [BMB reports 2010; 43(5): 337-343]
Ginsenoside $Rs_3$, A genuine Dammarane-Glycoside from Korean Red Ginseng
Baek, Nam-In,Kim, Jong-Moon,Park, Jeong-Hill,Ryu, Jae-Ha,Kim, Dong-Seon,Lee, You-Hui,Park, Jong-Dae,Kim, Shin-Il The Pharmaceutical Society of Korea 1997 Archives of Pharmacal Research Vol.20 No.3
A genuine dammarane-glycoside, named as ginsenoside $ Rs_3$, was isolated from the MeOH extracts of Korean red ginseng (Panax ginseng C.A. Meyer) through repeated silica gel column chromatographies and its chemical structure was determined as (20S)-protopanaxadiol $3-O-[6^{11}-O-acetyl-{\beta}-D-glucopyranosyl (1{\rightarrow2)-{\beta}-D-$glucopyranoside on the basis of several spectral and physical evidences including HMBC and FAB-MS.
Immunotoxicological Effects of Aripiprazole: In vivo and In vitro Studies
Baek, Kwang-Soo,Ahn, Shinbyoung,Lee, Jaehwi,Kim, Ji Hye,Kim, Han Gyung,Kim, Eunji,Kim, Jun Ho,Sung, Nak Yoon,Yang, Sungjae,Kim, Mi Seon,Hong, Sungyoul,Kim, Jong-Hoon,Cho, Jae Youl The Korean Society of Pharmacology 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.4
Aripiprazole (ARI) is a commonly prescribed medication used to treat schizophrenia and bipolar disorder. To date, there have been no studies regarding the molecular pathological and immunotoxicological profiling of aripiprazole. Thus, in the present study, we prepared two different formulas of aripiprazole [Free base crystal of aripiprazole (ARPGCB) and cocrystal of aripiprazole (GCB3004)], and explored their effects on the patterns of survival and apoptosis-regulatory proteins under acute toxicity and cytotoxicity test conditions. Furthermore, we also evaluated the modulatory activity of the different formulations on the immunological responses in macrophages primed by various stimulators such as lipopolysaccharide (LPS), pam3CSK, and poly(I:C) via toll-like receptor 4 (TLR4), TLR2, and TLR3 pathways, respectively. In liver, both ARPGCB and GCB3004 produced similar toxicity profiles. In particular, these two formulas exhibited similar phospho-protein profiling of p65/nuclear factor $(NF)-{\kappa}B$, c-Jun/activator protein (AP)-1, ERK, JNK, p38, caspase 3, and bcl-2 in brain. In contrast, the patterns of these phospho-proteins were variable in other tissues. Moreover, these two formulas did not exhibit any cytotoxicity in C6 glioma cells. Finally, the two formulations at available in vivo concentrations did not block nitric oxide (NO) production from activated macrophage-like RAW264.7 cells stimulated with LPS, pam3CSK, or poly(I:C), nor did they alter the morphological changes of the activated macrophages. Taken together, our present work, as a comparative study of two different formulas of aripiprazole, suggests that these two formulas can be used to achieve similar functional activation of brain proteins related to cell survival and apoptosis and immunotoxicological activities of macrophages.
( Jong Man Park ),( Seung Geun Lee ),( Eun Kyoung Park ),( Dae Sung Lee ),( Sung Min Baek ),( Kyung Lim Hwang ),( Joong Keun Kim ),( Ji Heh Park ),( Geun Tae Kim ),( Seon Yoon Choi ) 대한류마티스학회 2014 대한류마티스학회지 Vol.21 No.3
Objective. The present study determined if vitamin D deficiency is a potential risk factor for increased carotid intima- media thickness (CIMT) in patients with rheumatoid arthritis (RA). Methods. This cross-sectional study analyzed 50 consecutive female RA patients without cardiovascular disease history at the Pusan National University Hospital between September and December of 2013. CIMT was measured using a high-resolution ultrasonography. Serum 25-hydroxy vitamin D (25-OHD) levels were assessed by radioimmunoassay, and vitamin D deficiency was defined as serum 25-OHD levels <20 ng/mL. Stepwise multivariable linear regression analyses were performed to evaluate the association between vitamin D deficiency and increased CIMT. Results. The median 25-OHD level (inter-quartile range) was 14.0 (11.0∼20.7) ng/mL, and 74% of patients had vitamin D deficiency. The mean±standard deviation of CIMT was 0.58±0.08 mm. RA patients with vitamin D deficiency had significantly higher CIMT than those without this feature (0.59±0.07 vs 0.54±0.05, p=0.028). In univariable linear regression models, vitamin D deficiency (β(SE)=0.047 (0.021), p=0.028), older age (β(SE)=0.003 (7.2-4), p<0.001) and higher disease activity score 28-erythrocyte sedimentation rate (β(SE)=0.021 (0.010), p=0.034) and Korean version of health assessment questionnaire score (β(SE)=0.051 (0.015), p=0.002) were significantly associated with increased CIMT. Vitamin D deficiency remained statistically significant in multivariable regression models after adjusting for confounders. Conclusion. Vitamin D deficiency was associated with increased CIMT in female RA patients. Our finding suggests that hypovitaminosis D can be a risk factor for atherosclerosis in RA patients.