전리수에서의 STS304의 부식

이종권,박소연,김범식 순천향대학교 산업기술연구소 2006 순천향 산업기술연구소논문집 Vol.12 No.1

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분비촉진물질 투여 후 흰쥐 턱밑샘에서 상피성장인자 수용체와 신경성장인자 수용체의변화양상

김은경,김정기,조의식 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.5

턱밑샘절제후 흰쥐 대구치와 절치에서 상피성장인자 수용체와 신경성장인자 수용체의변화 양상

최현규,김정기,조의식 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.5

3상 유도전동기 구동을 위한 전압원 인버터의 새로운 과변조 PWM 기법

신흥교,박종규,김봉식,신휘범 慶尙大學校 工科大學 自動化및컴퓨터應用技術硏究所 1997 自動化 및 컴퓨터應用技術 Vol.4 No.1

The novel PWM(pulsewidth modulation) strategy of three-phase voltage source inverter in the overmodulation range is proposed. Generally, the space vector PWM strategy in the overmodulation range is widely utilized due to its simple and effective digital implementation and increased voltage transfer ratio. A unique algorithm manages the transition form the onset of overmodulation to six-step operation. This proposed technique maximizes the utilization of the dc-link voltage and maintain the voltage linearity between the reference and output voltages, and it decreases the necessary memory quantity for the look-up table of the angle.

Idiopathic acquired punctate palmoplantar keratoderma: A report of four cases

( Jong Sic Kim ),( Hwa Young Jung ),( Yuri Woo ),( Miri Kim ),( Hyun Jeong Park ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Palmoplantar keratodermas(PPKs) refer to a thickening of skin of the palms and soles caused by excessive keratin. Four forms can be seen: diffuse, focal, punctate, and palmoplantar ectodermal dysplasias. Acquired punctate palmoplantar keratodermas(PPPKs) occur in later life, without family history, and tend to be attributable to an underlying etiology. Idiopathic, acquired PPPKs should be reserved as a diagnosis of exclusion, when all the other etiologies have been investigated and ruled out. Four patients were referred to our clinic, presenting with multiple 0.2cm-sized, round papules on the both palms for several months. The lesions were scattered but discretely distributed. None of the patients had past history and laboratory findings were normal. Histopathological findings were nonspecific, with marked hyperkeratosis of the stratum corneum. HPV stain was negative. One of the patients was treated with topical tretinoin and after two weeks, the lesions were slightly improved. The others had not received any treatment. As in these cases, PPPKs resemble verruca plana or lichen nitidus in clinical findings. Therefore, dermatologists should consider PPPKs as possible diagnosis to avoid unnecessary treatment.

Ingenol mebutate: A possible treatment option for superficial basal cell carcinoma as neoadjuvant therapy?

( Jong Sic Kim ),( Ji Won Yun ),( Sewon Hwang ),( Yuri Woo ),( Miri Kim ),( Hyun Jeong Park ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Basal cell carcinoma (BCC) is usually effectively managed with surgical removal. Ingenol mebutate gel (Picato, Leo Pharma, Inc.) is a new topical drug extracted from the latex sap of a plant Euphorbia peplus approved by Food and Drug Administration (FDA) for field therapy of actinic keratosis in 2012 for its chemoablative and immune-stimulatory properties. We describe a case of a 87-year-old Korean woman presenting with 1.5 x 1.5 cm-sized blackish crusted plaque and erosion on her scalp for a year. Histopathologically, the lesion showed peripherally palisading basaloid tumor cells budding from the epidermis and limited to upper dermis with partial retraction of stroma from the tumor nest. The patient was diagnosed as superficial BCC. We applied topical ingenol mebutate gel (Picato®) 0.05% for 2 consecutive days. The patient complained of pain, erythema and erosion on the application site on the second day. After 2 weeks of application, blackish plaque disappeared, but 4 weeks later, two blackish papules reappeared. Biopsy specimen of one of the papules showed remnant tumor cells. We conducted cryotherapy on the remaining lesion. Although ingenol mebutate gel (Picato®) monotherapy is insufficient for complete elimination of superficial BCC, we suggest that application of ingenol mebutate gel (Picato®) combined with other modalities such as punch biopsy and cryotherapy may be a useful treatment option for reducing tumor burden.

Cutaneous mastocytosis in Korean patients : a clinical features of 77 cases

( Jong Sic Kim ),( Ji Hong Lim ),( Sewon Hwang ),( Yuri Woo ),( Miri Kim ),( Hyun Jeong Park ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: Mastocytosis represents a group of rare disorders characterized by a neoplastic proliferation of abnormal mast cells in one or more tissues, involving mainly skin, bone marrow, gastrointestinal tract, and liver. Cutaneous mastocytosis is classified according to clinical presentation and is further defined by onset of disease. Objectives: To analyze clinical characteristics of cutaneous mastocytosis in Korean patients. Methods: We performed a retrospective review in 77 patients diagnosed as cutaneous mastocytosis. Patients were evaluated for onset of disease, sex, distribution, associated symptoms and distribution of lesions. Results: There were 16 (20.7%) cases of telangiectasia macularis eruptive perstans cases, 25 (32.5%) cases of urticaria pigmentosa, 22 (28.6%) cases of mastocytoma, and 14 (18.2%) cases of diffuse cutaneous mastocytosis. In 30% of cases disease onset was in the first year of life. There was a male predominance 2.1 : 1. The most common presentation was involvement of trunk together with both extremities. Conclusion: The most frequent clinical form of mastocytosis was urticarial pigmentosa followed by mastocytoma, telangiectasia macularis eruptiva perstans and diffuse cutaneous mastocytosis. Cutaneous mastocytosis is a benign disease in children without systemic involvement.

[P152] Pigmented contact dermatitis from henna: A report of 11 cases

( Jong Sic Kim ),( Yu Ri Woo ),( Miri Kim ),( Hyun Jeong Park ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

The henna is a vegetable hair dyes that can be recommended to the patients who are sensitized to oxidative dyes due to their low allergenicity. In recent years, there have been an increasing number of reports on the pigmented contact dermatitis after henna. Herein, we report 11 cases of pigmented contact dermatitis due to henna. Eleven female patients aged 50-64 visited our clinic, presenting with hyperpigmentation in the lateral side of face and neck. They all had dyed their hair with pure henna powder for 1-9 times and the pigmented lesion was developed within 2-10 months after hair coloring. Histopathology revealed liquefaction degeneration of the epidermis with pigmentary incontinence in the papillary dermis in all patients. Epidermal atrophy with rete ridge flattening was also observed in 3 cases. A diagnosis of pigmented contact dermatitis from henna was made. They were treated with vitamine C iontophoresis and low-pulse energy 1,064-nm Q-switched (QS) Nd:YAG laser once a week but the lesion remained with little improvement. Hair dyeing with henna is associated with pigmented contact dermatitis in middle-aged women and it is difficult to treat. Because it occurs mostly in middle-aged women and requires long-term treatment, careful attention should be paid when hair dyeing in this age group with henna.

Primary diffuse large B cell lymphoma occurring in a young adult

( Jong Sic Kim ),( Hwa Young Jung ),( Yuri Woo ),( Miri Kim ),( Hyun Jeong Park ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT) occurs in elderly patients and has been considered as a lymphoma with a poor prognosis, with estimated 5-year specific survival rates of approximately 50%. A 23-year-old man presented with a 3-year history of several erythematous nodules and patches on his both arms and trunk. There was no specific past history. Histological examination of the specimen revealed multifocal and nodular infiltrates of atypical medium to large-sized mononuclear cells with enlarged nuclei showing one or more prominent nucleoli. Immunohistochemical examination revealed that the tumor cells were positive for CD20, bcl-2, bcl-6, multiple myeloma oncogene 1 (MUM 1), but negative for CD10 and CD30. In situ hybridization for EBV was negative. The patient had no fever, weight loss or night sweats. Whole body imaging studies and bone marrow histopathology did not detect metastatic or disseminated disease. Based on these results, we diagnosed the patient with PCDLBCL-LT, which was stage II according to the WHO-EORTC classification. Treatment with combination chemotherapy (R-CHOP) was started at hematooncology department. So far, four cases of PCDLBCL-LT are reported in the Korean literature. All of the cases in the literature were elderly patients over the age of 50. To our knowledge, this is the first report of a PCDLBCL-LT occurring in a patient with the age of third decade.

Localization of Broca's Area Using Functional MR Imaging: Quantitative Evaluation of Paradigms

Kim, Chi-Heon,Kim, Jae-Hun,Chung, Chun-Kee,Kim, June-Sic,Lee, Jong-Min,Lee, Sang-Kun The Korean Neurosurgical Society 2009 Journal of Korean neurosurgical society Vol.45 No.4

Objective : Functional magnetic resonance imaging (fMRI) is frequently used to localize language areas in a non-invasive manner. Various paradigms for presurgical localization of language areas have been developed, but a systematic quantitative evaluation of the efficiency of those paradigms has not been performed. In the present study, the authors analyzed different language paradigms to see which paradigm is most efficient in localizing frontal language areas. Methods : Five men and five women with no neurological deficits participated (mean age, 24 years) in this study. All volunteers were right-handed. Each subject performed 4 tasks, including fixation (Fix), sentence reading (SRI. pseudoword reading (PR), and word generation (WG). Fixation and pseudoword reading were used as contrasts. The functional area was defined as the area(s) with a t-value of more than 3.92 in fMRI with different tasks. To apply an anatomical constraint, we used a brain atlas mapping system, which is available in AFNI, to define the anatomical frontal language area. The numbers of voxels in overlapped area between anatomical and functional area were individually counted in the frontal expressive language area. Results : Of the various combinations, the word generation task was most effective in delineating the frontal expressive language area when fixation was used as a contrast (p<0.05). The sensitivity of this test for localizing Broca's area was 81 % and specificity was 70%. Conclusion : Word generation versus fixation could effectively and reliably delineate the frontal language area. A customized effective paradigm should be analyzed in order to evaluate various language functions.