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Jeongmin Song,Hua Zheng,Hyo Jeong Seo,지근억 한국응용생명화학회 2012 Applied Biological Chemistry (Appl Biol Chem) Vol.55 No.2
Effect of oral administration of methanolic extract from Scutellaria baicalensis root (SB) on the development of oxazolone-induced atomic dermatitis (AD)-like skin lesions in hairless mice was investigated. Mice were orally administered SB 250, 500 mg/kg/day, or dexamethasone 1 mg/kg/day for 33 days. Oral administration of SB inhibited the development of clinical symptoms, and reduced dermal mast cell infiltration, but did not show definite suppressive effect on elevation of serum total IgE level under experimental condition. Interleukin (IL)-6 level in serum and the mRNA expressions of IL-4, IL-13, IL-12, interfereon-γ, transforming growth factor-β, and fork head box P3 in draining lymph nodes were not significantly affected by SB administration,indicating SB could alleviate AD via the inhibition of mast cell infiltration.
Jeongmin Song,Hwa Sung Chae,Jeong Won Shin,Joohon Sung,Yun-Mi Song,Seung-Hak Baek,Young Ho Kim 대한치과교정학회 2019 대한치과교정학회지 Vol.49 No.1
Objective: The purpose of this study was to investigate the influence of heritability on the craniofacial soft tissue cephalometric characteristics of monozygotic (MZ) twins, dizygotic (DZ) twins, and their siblings (SIB). Methods: The samples comprised Korean adult twins and their siblings (mean age, 39.8 years; MZ group, n = 36 pairs; DZ group, n = 13 pairs of the same gender; and SIB group, n = 26 pairs of the same gender). Thirty cephalometric variables were measured to characterize facial profile, facial height, soft-tissue thickness, and projection of nose and lip. Falconer’s method was used to calculate heritability (low heritability, h2 < 0.2; high heritability, h2 > 0.9). After principal components analysis (PCA) was performed to extract the models, we calculated the intraclass correlation coefficient (ICC) value and heritability of each component. Results: The MZ group exhibited higher ICC values for all cephalometric variables than DZ and SIB groups. Among cephalometric variables, the highest h2 (MZ-DZ) and h2 (MZ-SIB) values were observed for the nasolabial angle (NLA, 1.544 and 2.036), chin angle (1.342 and 1.112), soft tissue chin thickness (2.872 and 1.226), and upper lip thickness ratio (1.592 and 1.026). PCA derived eight components with 84.5% of a cumulative explanation. The components that exhibited higher values of h2 (MZ-DZ) and h2 (MZ-SIB) were PCA2, which includes facial convexity, NLA, and nose projection (1.026 and 0.972), and PCA7, which includes chin angle and soft tissue chin thickness (2.107 and 1.169). Conclusions: The nose and soft tissue chin were more influenced by genetic factors than other soft tissues.
Update on Current Treatment Options for Posttraumatic Stress Disorder
JeongMin Song,JeongHo Chae 대한신경정신의학회 2005 PSYCHIATRY INVESTIGATION Vol.2 No.2
This article reviews the various current treatment options of posttraumatic stress disorder (PTSD), a prevalent and disabling condition. The primary-source literature was reviewed using PubMed search, and secondary-source review articles and chapters were also used. Evidence from several studies suggests that both psychopharmacologic and psychotherapeutic therapies can be effective in PTSD. Selective serotonin reuptake inhibitors are generally the most appropriate choice of first-line medication for PTSD, and effective pharmacotherapy should be continued for at least 12 months. Psychotherapy, especially cognitive behavior therapy, is found to be effective in the treatment of PTSD. In addition to those therapies, eye movement desensitization and reprocessing therapy, and transcranial magnetic stimulation would be relatively new treatment options for PTSD.
Antiviral activity of gemcitabine against human rhinovirus in vitro and in vivo
Song, Jae-Hyoung,Kim, Seong-Ryeol,Heo, Eun-Young,Lee, Jae-Young,Kim, Dong-eun,Cho, Sungchan,Chang, Sun-Young,Yoon, Byung-Il,Seong, Jeongmin,Ko, Hyun-Jeong ELSEVIER 2017 ANTIVIRAL RESEARCH Vol.145 No.-
<P>Rhinovirus, a major causative agent of the common cold, is associated with exacerbation of asthma and chronic obstructive pulmonary disease. Currently, there is no antiviral treatment or vaccine for human rhinovirus (HRV). Gemcitabine (2',2'-difluorodeoxycytidine, dFdC) is a deoxycytidine analog with antiviral activity against rhinovirus, as well as enterovirus 71, in vitro. However, the antiviral effects of gemcitabine in vivo have not been investigated. In the current study, we assessed whether gemcitabine mediated antiviral effects in the murine HRV infection model. Intranasal administration of gemcitabine significantly lowered pulmonary viral load and inflammation by decreasing proinflammatory cytokines, including TNE-alpha and IL-1 beta, and reduction in the number of lung-infiltrating lymphocytes. Interestingly, we found that the addition of UTP and CTP significantly attenuated the antiviral activity of gemcitabine. Thus the limitation of UTP and CTP by the addition of gemcitabine may inhibit the viral RNA synthesis. These results suggest that gemcitabine, an antineoplastic drug, can be repositioned as an antiviral drug to inhibit HRV infection. (C) 2017 Elsevier B.V. All rights reserved.</P>
( Song Young-ok ),( Kim Haeyoung ),( Nam Yunyoung ),( Choe Kwisoon ),( Ha Jeongmin ) 한국정신간호학회 2022 정신간호학회지 Vol.31 No.1
Purpose: This study aimed to develop a competency-based educational program for strengthening the competency of psychiatric nurses and evaluate its effects. Methods: The study used a quasi-experimental design. Participants included 64 psychiatric nurses in South Korea: 33 nurses (32 females, 1 male) in the experimental group and 31 nurses (26 females, 5 males) in the control group. A competency-based education program for psychiatric nurses was developed through a literature review and discussion with 12 experts. The program addressed eight topics and provided 24 hours of education over 4 days, for 6 hours each day. The collected data via questionnaires were analyzed statistically. Results: The education program enhanced overall clinical nursing competence and strengthened professional self-growth competence. The management and teaching competencies of both the experimental and the control groups also increased significantly. Conclusion: The findings of this study presented an educational program to strengthen the clinical competency of psychiatric nurses and it was proven that the education had a capacity-building effect.
이기종 프로세서 사용수명을 고려한 신경망 가속 스케쥴링
황정민(Jeongmin Hwang),정수안(Suan Jung),김보길(Bogil Kim),송진호(William J. Song) 대한전자공학회 2022 대한전자공학회 학술대회 Vol.2022 No.11
In this paper, we analyze the impact on the lifetime reliability of heterogeneous processors while accelerating neural network execution. Most edge devices are designed with heterogeneous processors that integrate CPUs and accelerators to process vast amounts of data quickly. Although performance has been improved due to device expansion, energy efficiency has been reduced due to increased power and energy consumption. Therefore, lifetime reliability management has become more difficult due to complex processor design structures. As neural networks become more common in various industries, performance, energy efficiency and lifetime reliability management become more important. This paper presents parallel scheduling of CPUs and accelerators in neural networks acceleration, named cooperative scheduling. We propose a method to improve performance while satisfying the required lifetime reliability through adopting a combination of improved scheduling and lifetime reliability management methods during neural network acceleration.
장애인의 웹 접근성 향상을 위한 한의학술논문검색(OASIS) 시스템 분석
한정민(JeongMin Han),김철(Chul Kim),김하영( HaYoung Kim),송미영(MiYoung Song) 한국정보과학회 2009 한국정보과학회 학술발표논문집 Vol.36 No.1
새로운 웹 콘텐츠 개발방법이 발전하면서 웹사이트는 더욱 화려해지고 다양화 되었다. 하지만 이러한 새로운 기술들은 웹 사용을 위해서는 보조기구를 이용해야 하는 장애인 및 고령자들에게는 웹 접근에 대한 제약을 가중시키고 있다. 이러한 애로사항을 개선하기 위해 정부에서는 장애인, 고령자 등을 포함한 모든 사람들이 웹에서 원하는 정보들을 자유롭게 접근하고 이용할 수 있도록 하는 「장애인차별금지 및 권리구제 등에 관한 법률」을 시행하게 되었으며, 각 기관에서 제공하는 웹사이트들은 새로운 정비가 필요하게 되었다. 그리하여 본 논문에서는 한의학연구원에서 제공하고 있는 한의학술논문 통합검색시스템(이하:오아시스)에 대하여 국가에서 권고하고 있는 국가표준의 준수여부를 평가하고 웹 접근성을 높일 수 있는 개선방안을 제시하여 다양한 계층의 사용자들에게 사용의 편리성을 제공하고자 한다.