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김두화,박정환,한도수,허선아,김성현,조성동 조선대학교 기초과학연구소 1992 自然科學硏究 Vol.15 No.1
The reaction of Asymmetrical organotins with acid chlorides in the presence of Benzylbis (triphenylphosphine) palladium(Ⅱ) chloride gave good yields of ketones in chloroform.
임신 중 환경오염물질 2-Bromopropane에 노출된 마우스의 모독성 평가
허정두(Jeong-Doo Heo),김충용(Chung-Yong Kim),강성철(Chen-Zhe Ziang),서정은(Jeong-Eun Suh),정문구(Moon-Koo Chung),김무강(Moo-Kang Kim),신동호(Dong-Ho Shin),김종춘(Jong-Choon Kim) 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.1
2-Bromopropane (2-BP), a halogenated propane analogue, is a substitute for chlorofluorocarbones (CFCs). The present study was carried out to investigate the potential adverse effects of 2-BP on pregnant dams after maternal exposure during the gestational days (GD) 6 through 17 in ICR mice. The test chemical was administered subcutaneously to pregnant mice at dose levels of 0, 500, 1000, and 1500 ㎎/㎏/day. All pregnant females were subjected to autopsy on GD 18. Treatment-related clinical signs, as evidenced by dose-dependent increases in the incidence and severity of rough fur, swelling, induration, crust formation, and ulceration at the injection sites, were observed at dose levels of above 1000 ㎎/㎏/day. Maternal body weight on GD 18 and maternal body weight gain for the intervals GD 6-17 (treatment period) were suppressed at a dose level of 1500 ㎎/㎏ in a dose-dependent manner, but not statistically significant. Hematological investigations revealed a dose-dependent decrease in the number of platelet at a dose level of 1500 ㎎/㎏. Fetal body weights of both sexes in the 1500 ㎎/㎏ group were also decreased in a dose-dependent manner. There were no adverse effects on mortality, food consumption, organ weights, and reproductive findings except for decreased fetal body weight in any treatment group. Based on these results, it was concluded that the 12-day repeated subcutaneous dose of 2-BP resulted in an increased incidence of clinical signs, suppressed maternal body weight, reduced platelet count and decreased fetal body weight at a dose level of 1500 ㎎/㎏/day in pregnant mice. In the present experimental conditions, the no-observed-adverse-effect level of 2-BP was considered to be 500 ㎎/㎏ for dams.
Jeong-Ah Song,Hyo-Seon Yang,Jinsoo Lee,Soonjin Kwon,Kyung Jin Jung,Jeong-Doo Heo,Kyu-Hyuk Cho,Chang Woo Song,Kyuhong Lee 한국독성학회 2010 Toxicological Research Vol.26 No.3
Bronchoalveolar lavage (BAL) is a useful tool in researches and in clinical medicine of lung diseases because the BAL fluid contains biochemical and cytological indicators of the cellular response to infection, drugs, or toxicants. However, the variability among laboratories regarding the technique and the processing of the BAL material limits clinical research. The aim of this study was to determine the suction frequency and lavage fraction number necessary to reduce the variability in lavage using male Sprague-Dawley rats. We compared the total cell number and protein level of each lavage fraction and concluded that more cells and protein can be obtained by repetitive lavage with a suction frequency of 2 or 3 than by lavage with a single suction. On the basis of total cell recovery, approximately 70% of cells were obtained from fractions 1~3. The first lavage fraction should be used for evaluation of protein concentration because fractions 2~5 of lavage fluid were diluted in manifolds. These observations were confirmed in bleomycin-induced inflamed lungs of rats. We further compared the BAL data from the whole lobes with data from the right lobes and concluded that BAL data of the right lobes represented data of the whole lobes. However, this conclusion can only be applied to general lung diseases. At the end, this study provides an insight into the technical or analytical problems of lavage study in vivo.
허천(Heo Cheon),정우진(Jeong Woo-Jin),염두승(Yeom Doo-Seoung) 한국체육과학회 2001 한국체육과학회지 Vol.10 No.2
Based on the above research, the conclusion is as follows regarding the improvements of the park athletic facilities. 1. The public athletic facilities should always be open to the local self-governing bodies. They should expand the insufficient facilities considering regional circumstances for the public to utilize them efficiently. 2. Each region should make financial contributions to enlarge the athletic facilities through a fixed budget The main source of income will be provided through the leasing of the athletic facilities. 3. Every region should meet the necessities of the local citizens. Each facility should take into account the organization, program, and use for the public. Most importantly, each facility should educate the general public on exercise and the benefits of good health. 4. Most of the people have a lot of spare time and are apt to take part in social athletics. So each region should plan and develop a variety of programs democratically according to the properties of the participants.
Song, Jeong-Ah,Yang, Hyo-Seon,Lee, Jin-Soo,Kwon, Soon-Jin,Jung, Kyung-Jin,Heo, Jeong-Doo,Cho, Kyu-Hyuk,Song, Chang-Woo,Lee, Kyu-Hong Korean Society of ToxicologyKorea Environmental Mu 2010 Toxicological Research Vol.27 No.3
Bronchoalveolar lavage (BAL) is a useful tool in researches and in clinical medicine of lung diseases because the BAL fluid contains biochemical and cytological indicators of the cellular response to infection, drugs, or toxicants. However, the variability among laboratories regarding the technique and the processing of the BAL material limits clinical research. The aim of this study was to determine the suction frequency and lavage fraction number necessary to reduce the variability in lavage using male Sprague-Dawley rats. We compared the total cell number and protein level of each lavage fraction and concluded that more cells and protein can be obtained by repetitive lavage with a suction frequency of 2 or 3 than by lavage with a single suction. On the basis of total cell recovery, approximately 70% of cells were obtained from fractions 1~3. The first lavage fraction should be used for evaluation of protein concentration because fractions 2~5 of lavage fluid were diluted in manifolds. These observations were confirmed in bleomycin-induced inflamed lungs of rats. We further compared the BAL data from the whole lobes with data from the right lobes and concluded that BAL data of the right lobes represented data of the whole lobes. However, this conclusion can only be applied to general lung diseases. At the end, this study provides an insight into the technical or analytical problems of lavage study in vivo.
Park, Doo-Sang,Oh, Hyun-Woo,Heo, Sun-Yeon,Jeong, Won-Jin,Shin, Dong-Ha,Bae, Kyung-Sook,Park, Ho-Yong The Microbiological Society of Korea 2007 The journal of microbiology Vol.45 No.5
Burkholderia sp. HY-10 isolated from the digestive tracts of the longicorn beetle, Prionus insularis, produced an extracellular lipase with a molecular weight of 33.5 kDa estimated by SDS-PAGE. The lipase was purified from the culture supernatant to near electrophoretic homogenity by a one-step adsorption-desorption procedure using a polypropylene matrix followed by a concentration step. The purified lipase exhibited highest activities at pH 8.5 and $60^{\circ}C$. A broad range of lipase substrates, from $C_4\;to\;C_{18}$ p-nitrophenyl esters, were hydrolyzed efficiently by the lipase. The most efficient substrate was p-nitrophenyl caproate ($C_6$). A 2485 bp DNA fragment was isolated by PCR amplification and chromosomal walking which encoded two polypeptides of 364 and 346 amino acids, identified as a lipase and a lipase foldase, respectively. The N-terminal amino acid sequence of the purified lipase and nucleotide sequence analysis predicted that the precursor lipase was proteolytically modified through the secretion step and produced a catalytically active 33.5 kDa protein. The deduced amino acid sequence for the lipase shared extensive similarity with those of the lipase family 1.2 of lipases from other bacteria. The deduced amino acid sequence contained two Cystein residues forming a disulfide bond in the molecule and three, well-conserved amino acid residues, $Ser^{131},\;His^{330},\;and\;Asp^{308}$, which composed the catalytic triad of the enzyme.
Pectolinarigenin suppresses the tumor growth in gastric cancer
Ho Jeong Lee,Ju Hong Lee,Je-Hein Kim,Jeong Doo Heo 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Gastric cancer (GC) is identified as the second leading cause of death as one of the common recorded cancer cases in the world. Even though the mortality rate of gastric cancer remains the second leading cause of death worldwide and it is still the most prevalent cancer in Eastern Asis. It is known the natural flavonoid, pectolinarigenin (PEC) contains in Cirsium chanroenicum and citrus fruits. In a previous study, we investigated the mechanism of PEC-induced cellular response such as apoptosis and autophagy in gastric cancer cells. In the present study, we conducted the anti-cancer effect of PEC by xenograft mouse model. AGS human gastric cancer cells were cultured and subcutaneous to Balb/c nude mice to make a xenograft mouse model was established to evaluate the anti-tumor effect of PEC in vivo. After finished in vivo experiment, mice were sacrificed and tear off the tumor for comparative proteomic analysis was performed to identify proteins associated with PEC-suppressed tumor. We observed their tumor volume and tumor weight reduced in the PEC treatment group than the control group, that treatment of PEC suppressed tumor in the xenograft mice model dose-dependent manner. In addition, body weight and hematological analysis showed that PEC was not toxic in the xenograft mice model. We identified 616 proteins related to cellular response such as tumorigenesis and cell death signal in the tumor of xenograft mice model by LC-MS analysis. Thus, PEC treatment might suppress the tumor growth of GC and the proteomic analysis provides basic information about target proteins that are important for novel GC therapeutic agent. In a further study, we will find out which proteins play a role in GC suppression.