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Jayoung Lee,Ju Hye Lee,Hanbin Yoon,Ho Jeong Lee,Hosang Jeon,Jiho Nam 대한방사선종양학회 2017 Radiation Oncology Journal Vol.35 No.2
Primary liver tumor, especially hepatocellular carcinoma (HCC), is a common cause of cancer death worldwide. The incidence is generally higher in Asian countries than in western countries. Carcinogenesis of HCC is often associated with hepatitis viral infections. Current standard treatment of HCC is surgical resection or transplantation in patients with early stage disease. However, the patient with advanced stage disease, surgical resection is often limited. Sorafenib or other treatment modalities are not so effective as well. We report a case of unusual radiation super-sensitivity in advanced stage HCC, and review the literature.
Lee, Jayoung,Lee, Ju Hye,Yoon, Hanbin,Lee, Ho Jeong,Jeon, Hosang,Nam, Jiho The Korean Society for Radiation Oncology 2017 Radiation Oncology Journal Vol.35 No.2
Primary liver tumor, especially hepatocellular carcinoma (HCC), is a common cause of cancer death worldwide. The incidence is generally higher in Asian countries than in western countries. Carcinogenesis of HCC is often associated with hepatitis viral infections. Current standard treatment of HCC is surgical resection or transplantation in patients with early stage disease. However, the patient with advanced stage disease, surgical resection is often limited. Sorafenib or other treatment modalities are not so effective as well. We report a case of unusual radiation super-sensitivity in advanced stage HCC, and review the literature.
( Chanwon Lee ),( Junouk Ha ),( Jayoung Park ),( Seongho Choi ),( Heeseung Park ),( Jaeseung Lee ),( Seungheon Lee ),( Younghwan Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: To investigate the relationship between markers of overall glucose exposure, postprandial glucose excursions and glycemic variability in patients with type 2 diabetes mellitus (T2DM). Methods: Sixty three patients with T2DM (mean age of 56 years) were enrolled, and all wore a continuous glucose monitoring system (CGMS) for 72 hours. We investigated the interrelationships between markers of overall glucose exposure, markers of postprandial glucose excursions and glycemic variability parameters from a CGMS. Results: Spearman`s correlation analysis revealed a signifi cant correlation between all markers of overall glucose exposure and various parameters related to glucose excursion. Percent coeffi cient of variation (CV) showed the strongest correlation with the GA (r = 0.470, p < 0.01). In participants with HbA1c levels < 7.5% (n = 33), almost all of glycemic markers and glycemic variability parameters were signifi cantly correlated with each other. All postprandial glucose excursion parameters also showed signifi cant correlation with other glycemic markers. In participants with HbA1c levels < 7.5% (n = 33), all markers of overall glucose exposure showed signifi cant interrelationships with mean glucose, postprandial glucose excursion and glycemic variability parameters (except CV). However, in participants with HbA1c levels = 7.5% (n = 30), postprandial glucose excursion and glycemic variability parameters were not related with any chronic glycemic marker. Conclusions: The postprandial glucose excursions may explain the glycemic variability and the total glucose exposures in well-controlled diabetic participants.
교훈: 목표지향 제어봉제어계통 독립 소프트웨어 확인 및 검증
이자영 ( Jayoung Lee ),손광영 ( Kwangyoung Sohn ),이상석 ( Sangseok Lee ),이준구 ( Junku Lee ),박근옥 ( Geunok Park ) 한국정보처리학회 2013 한국정보처리학회 학술대회논문집 Vol.20 No.1
단순 부품부터 계통까지 기존의 아날로그 제품들이 최근 들어 펌 웨어(Firmware)와 고수준의 컴퓨터 언어로 구현된 응용 소프트웨어를 포함하는 디지털 설비로 바뀌고 있다. 따라서 어느 때 보다 소프트웨어의 확인 및 검증의 중요성이 대두되고 있으며, 이를 위해 학계뿐만 아니라 국제표준 기관에서 확인 및 검증을 위한 지침을 제시하고 있는 실정이다. 본 논문은 원자력발전소 출력을 제어하는 제어봉제어계통의 업그레이드와 관련하여 IEEE 1012 에 따라 수행된 독립 확인 및 검증 업무를 요약하고, 이를 통해 얻은 교훈을 기술한다.
90-day Repeated Dose Toxicity and Genotoxicity Tests of Coptis chinensis in F344 Rats
Yong-Hoon Lee,Duyeol Kim,Sun Hee Park,Hye-Yeong Lee,Mi-Young Lee,Beom Seok Han,Min Kwon,Woo Chan Sohn,Ji Hyeon Seok,Jong Kwon Lee,Jayoung Jeong,Jin Seok Kang,Jongkoo Kang 한국실험동물학회 2012 한국실험동물학회 학술발표대회 논문집 Vol.2012 No.8
배추에 살포된 몇 가지 농약제제에 따른 성분의 휘산과 비산
이서래,이장영,한일근,이상윤,여익현 한국환경농학회 1997 한국환경농학회지 Vol.16 No.4
배추 재배시 살포된 농약의 비산 휘산정도를 알아보기 위해 유기인계인 chlorpyrifos, EPN, pirimiphos-methyl, phenthoate, 유기염소계인 tetradifon, dicofol, 피레스로이드계인 bifenthrin 농약을 이용하여 포장실험을 수행하였다. 이들의 잔류량 분석은 다성분 분석법을 이용하였는데 농약성분에 따라 다르나 회수율은 78∼92%로 우수하였으며 표준편차도 ±0.68∼3.52%로서 재현성이 있었다. 농약의 살포량은 농약사용지침서에서 권하는 량으로 하였으며, 1차실험시에는 바람이 불어오는 첫 구간에 농약을 살포하였고, 2차 실험시에는 풍향에 관계없이 정중앙에 살포하고 방사형으로 시료를 채취하였다. 실험결가 살포농약 대부분이 비산이나 휘산으로 인해 인접 작물에 전이 잔류하는 것을 확인하였다. 살포 중 비산되는 양은 농약성분과 풍향, 거리에 따라 달리 나타났으며 살포구간의 농작물 중 농약잔류량에 비하여 비살포구에서의 농작물 중 농약잔류량 비율은 3m거리에서 평균 0.66%, 6m 거리에서 0.10%, 9m 거리에서 0.05%이었고 근접지역에서는 최고 1.83%에 이르렀다. In order to investigate the drift of pesticides sprayed on Chinese cabbage, 7 pesticides chlorpyrifos, EPN, pirimiphos-methyl, phenthoate, tetradifon, dicofol and bifenthrin were applied in two sets of field tests. The pesticide residues were quantified bar multiple-residue analysis, in which the recovery rate was 78-92% and standard deviation was ±0.68-3.52%. It was found that most of the tested pesticides were spread by drift to neighbouring area and brought about the contamination of the unsprayed crops. The extent of drift varied depending upon the pesticide, distance and wind direction. The mean residue levels on unsprayed crops were 0.66% at 3 meter distance, 0.10% at 6 m distance and 0.05% at 9 m distance from the applied area and the maximum level was 1.83% of the residue on sprayed crops.
Lee, Jeong-A,Kim, Mi-Kyung,Kim, Hyoung-Mi,Lee, Jong Kwon,Jeong, Jayoung,Kim, Young-Rok,Oh, Jae-Min,Choi, Soo-Jin Dove Medical Press 2015 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.10 No.-
<P><B>Background</B></P><P>Orally administered particles rapidly interact with biological fluids containing proteins, enzymes, electrolytes, and other biomolecules to eventually form particles covered by a corona, and this corona potentially affects particle uptake, fate, absorption, distribution, and elimination in vivo. This study explored relationships between the biological interactions of calcium carbonate particles and their biokinetics.</P><P><B>Methods</B></P><P>We examined the effects of food grade calcium carbonates of different particle size (nano [N-Cal] and bulk [B-Cal]: specific surface areas of 15.8 and 0.83 m<SUP>2</SUP>/g, respectively) on biological interactions in in vitro simulated physiological fluids, ex vivo biofluids, and in vivo in gastrointestinal fluid. Moreover, absorption and tissue distribution of calcium carbonates were evaluated following a single dose oral administration to rats.</P><P><B>Results</B></P><P>N-Cal interacted more with biomatrices than bulk materials in vitro and ex vivo, as evidenced by high fluorescence quenching ratios, but it did not interact more actively with biomatrices in vivo. Analysis of coronas revealed that immunoglobulin, apolipoprotein, thrombin, and fibrinogen, were the major corona proteins, regardless of particle size. A biokinetic study revealed that orally delivered N-Cal was more rapidly absorbed into the blood stream than B-Cal, but no significant differences were observed between the two in terms of absorption efficiencies or tissue distributions. Both calcium carbonates were primarily present as particulate forms in gastrointestinal fluids but enter the circulatory system in dissolved Ca<SUP>2+</SUP>, although both types showed partial phase transformation to dicalcium phosphate dihydrate. Relatively low dissolution (about 4%), no remarkable protein–particle interaction, and the major particulate fate of calcium carbonate in vivo gastrointestinal fluids can explain its low oral absorption (about 4%) regardless of particle size.</P><P><B>Conclusion</B></P><P>We conclude that calcium carbonate nanoparticles can act more actively with biological matrices in vitro and ex vivo, but that in vivo, their biological interactions and biokinetics are not affected by particle size.</P>
Jayoung Lee,Soojin Kim,Kyongje Woo,Hasuk Bae 대한재활의학회 2022 Annals of Rehabilitation Medicine Vol.46 No.4
Objective To analyze the effects of lymphovenous anastomosis (LVA) surgery after 1 year using the elastic index (EI) and volume.Methods This study was a retrospective study of 41 patients, with lymphedema, who underwent LVA surgery between July 2018 and June 2020. Limb circumference, used to determine the volume of the limb with lymphedema, and EI, which reflects tissue stiffness and measured using ultrasonography were measured for each patient before and 1 year after LVA surgery. To examine the effect of LVA, differences in the preoperative and 1-year postoperative volumes and EIs were analyzed using the Wilcoxon signed-rank test.Results The mean volume and EI of the dominant site in upper-extremity lymphedema were 2,309.4 cm3 and 1.4, respectively, preoperatively and 2,237.1 cm3 and 0.9, respectively, at 1 year postoperatively. The mean volume and EI difference of the dominant site 1 year after surgery was -16.6 cm3 (p=0.22) and -0.5 (p<0.001). The mean volume and EI of dominant site in lower-extremity lymphedema were 6,137.0 cm3 and 1.2, respectively, preoperatively, and 5,832.6 cm3 and 1.1, respectively, at 1 year postoperatively. The mean volume and EI difference of the dominant site 1 year postoperatively were -320.9 cm3 (p=0.04) and -0.2 (p=0.09), respectively.Conclusion LVA surgery is more effective in reducing pressure than in reducing volume, which may be helpful in preventing the progression of lymphedema.