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( Ja Kyung Koo ),( Jeong Han Kim ),( Yun Jung Choi ),( Cho I Lee ),( Jae Hoon Yang ),( Hyeon Young Yoon ),( Hye Jin Choi ),( Soon Young Ko ),( Won Hyeok Choe ),( So Young Kwon ),( Chang Hong Lee ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: The Model for end-stage liver disease (MELD) has been widely used for predicting short term mortality in cirrhotic patients and employed for deceased donor liver allocation in the U.S. In year 2011, modification of MELD score was published (Gastroenterology 2011;140:1952-1960). We aimed to validate this for Korean cirrhotic patients. Methods: We retrospectively reviewed medical records of cirrhotic patients who admitted at konkuk university hospital from 2006 to 2010. Predictive value for 3 months mortality was compared between Refit MELD, Refit MELD-Na, current MELD, current MELD-Na, Child-Pugh score. Comparison was done by calculating area under receiver operating curve (AUROC). Results: Total 882 patients were enrolled and there were 77 deaths (8.7%) within 3 month. The most common etiology was alcohol (n=400, 45.4%) and the next was hepatitis B (n=302, 34.2%). 666 patients were male (75.5%), and Child-Pugh class A, B and C were 256 (29.0%), 379 (43.0%) and 247 (28.0%). AUROC of Refit MELD, Refit MELD-Na, MELD, MELD-Na and Child-Pugh score were 0.842, 0.817, 0.844, 0.848 and 0.831 respectively. There was no significant difference between scores except between Refit MELD-Na and MELD (p=0.0447), andu between Refit MELD-Na and MELD-Na (p=0.0008). After exclude Child-Pugh class A patients, AUROC of Refit MELD, Refit MELD-Na, MELD, MELD-Na and Child-Pugh score were 0.793, 0.751, 0.795, 0.798 and 0.765 respectively. The Refit MELD-Na showed lower value than MELD-Na (p=0.0005), MELD (p=0.0190) and Refit MELD (p=0.0174). Conclusions: Improvement of predictive value for 3 months mortality was not definite. Especially Refit MELD-Na showed the lowest value. This result may be due to difference of underlying etiology of cirrhosis between Korea and U.S. More large prospective study is warranted.
( Ja-won Cho ),( Su-hyun Shim ) 조선대학교 구강생물학연구소 2018 Oral Biology Research (Oral Biol Res) Vol.42 No.2
This study was designed to investigate the perception of public posts between students enrolled in dental college and in graduate school of dentistry and to propose the new curriculum and public policy to be more appropriate for the future. Study participants were 397 students in dental college and 160 students in graduate school of dentistry. A self-reported questionnaire to ask about socio-demographic characteristics, career plan and the perception of public posts was conducted for 557 students. The data were analyzed using a chi-square test, frequency analysis, and Pearson’s correlation coefficient. There were significant differences in socio-demographic characteristics, major satisfaction, and career plans between the two groups. Although these two groups have different backgrounds, both groups of students were motivated by opportunities to get a specialized job and wanted to contribute to public welfare as healthcare professionals in public posts. Most students (96.2%) agreed that government should set up public posts for dentists. Significantly, students in graduate school of dentistry were more likely to quit their jobs if they had opportunities to fill public posts (48.1%) and most of them (38.5%) ranked administrative positions higher than other types of public posts as a desired job. Additionally, students living in the Korean metropolitan area showed the tendency to work in the Korean metropolitan area after graduation, while those living in other areas wanted to work in areas outside the metropolitan area (P<0.001). Though a more well-designed longitudinal study is needed, this study can be valuable for curriculum development and health policymaking.
effect of Sodium Lauryl Sulfate Non-containing Dentifrice on Salivary Flow and Oral Malodor
Cho, Ja-Won Shin, Seung-Chul Jee, Yun-Jeong Jung, Ho-Young Park, Ji-Hyon, Kang Si-Yeoun 대한임상예방치과학회 2006 International Journal of Clinical Preventive Denti Vol.2 No.1
Objectives: The purpose of this study was to evaluate effects of salivary flow and oral malodor between dentifrice with and without sodium lauryl sulfate(SLS). Methods: Among 98 volunteers, 39 of normal adults who had lower than average 3.7 cc of unstimulated salivary flow were examined. They were offered first experimental dentifrice(Biotenedentifrice, Laclede co., U.S.A) and second experimental dentifrice(TheraBreath dentifrice, California Breath Clinics, U.S.A.) that did not contained SLS, and control dentifrice which contained SLS. After toothbrushing, they were checked oral malodor by B/B checker(mBA-21, Taiyo, Japan) and unstimulated salivary flowtest. Results: Before the experiment, 98 of voluteer's unstimulated salivary flow was 4.71 cc for 5 minutes of average time. Normal adult 39 volunteers were chosen which they had lower than 3.7 cc of average unstimulated salivary flow for 5 minutes. By the B/B checker measurement, it showed 32.82 B/B value by using control dentifrice was statistically higher than 25.49 B/B value of first experimental dentifrice and 24.51 B/B value of second experimental dentifrice and that of second experimental dentifrice(p>0.05). Unstimulated salivary flow for 5 minutes showed that 2.556 cc before experiment, 2.779 cc when they used first experimental dentifrice, 2.654 cc when they used second experimental dentifrice, and 2.351 cc when they used control dentifrice. Conclusion: Precautions for oral malodor patient who has low salivary flow, avoiding dentkfrice containing sodium lauryl sulfate, should be taken.
Ja Kyung Lee,Eu Jeong Ku,Su-jin Kim,Woochul Kim,Jae Won Cho,Kyong Yeun Jung,Hyeong Won Yu,Yea Eun Kang,Mijin Kim,Hee Kyung Kim,Junsun Ryu,June Young Choi 대한외과학회 2024 Annals of Surgical Treatment and Research(ASRT) Vol.106 No.1
Purpose: Current clinical practices favor less or no thyroid-stimulating hormone (TSH) suppression for low- to intermediate-risk thyroid cancer patients who receive thyroid lobectomy. The association of TSH suppression on healthrelated quality of life (HR-QoL) in patients after thyroid lobectomy is not well studied. This study aimed to evaluate the effect of TSH suppression on patient HR-QoL after thyroid lobectomy. Methods: This study included patients enrolled in an ongoing, multicenter, randomized controlled study investigating the effects of TSH suppression. Patients were randomized to either the low-TSH group (TSH target range, 0.3–1.99 μIU/mL) or the high-TSH group (TSH target range, 2.0–7.99 μIU/mL). The HR-QoL, hyperthyroidism symptom, and depression symptom questionnaires performed preoperatively and 2 weeks and 3 months postoperatively were evaluated. Results: Total of 669 patients (low-TSH group, 340; high-TSH group, 329) were included. Although total HR-QoL score changes were not different between the 2 groups, the high-TSH group had a significantly higher score in the physical domain at postoperative 3 months (P = 0.046). The 2 groups did not have significant differences in hyperthyroidism and depression scores. Conclusion: In the short-term postoperative period, the physical HR-QoL scores in thyroid lobectomy patients were better when they did not receive TSH suppression. This study suggests the importance of considering HR-QoL when setting TSH suppression targets in thyroid lobectomy patients.
( Won-ju Kima ),( Ja-hyun Koo ),( Hyun-jung Cho ),( Jae-ung Lee ),( Ji Yun Kim ),( Sohee Lee ),( Jong Hoon Kim ),( Mi Seon Ohe Minah Suh ),( Eui-cheol Shin ),( Joo Yeon Ko ),( Myung Hyun Sohn ),최제민 ( 한국피부장벽학회 2018 한국피부장벽학회지 Vol.20 No.2
Background: Atopic dermatitis and psoriasis are the most common chronic inflammatory skin diseases. However, there are high unmet medical needs with limitations for transcutaneous drug development due to the skin barrier. Objective: We aimed to identify a novel transdermal delivery peptide and develop a transcutaneously applicable immune modulatory protein by targeting cytokine signaling in atopic dermatitis and psoriasis. Methods: We generated reporter proteins conjugated with a human-originated transdermal delivery peptide, AP and analyzed intracellular delivery efficiency in mouse or human skin cells and tissues. Especially, we utilized multi-photon confocal microscopy for visualizing the localized proteins. We also generated a recombinant therapeutic protein, AP-rPTP, which is conjugated with AP and phosphatase domain of TC-PTP targeting multiple STATs. Immune modulatory function of AP-rPTP was confirmed in splenocytes upon cytokine stimulation and TcR stimulation. Finally, we confirmed in vivo efficacy of AP-rPTP in OXA-induced acute dermatitis, OVA-induced chronic dermatitis, and imiquimod-induced psoriasis models. Results: AP-conjugated reporter proteins exhibited significant intracellular transduction efficacy in keratinocytes, fibroblasts, and immune cells. In addition, transcutaneous administration of AP-dTomato showed significant localization into the dermis and epidermis in mouse skin. AP-rPTP could inhibit pSTAT1, pSTAT3, and pSTAT6 in splenocytes and also regulate T cell activation and proliferation. Transcutaneous paper-patch of AP-rPTP protein significantly ameliorated ear thickness, tissue inflammation, and cytokine expression in allergy- as well as psoriasis-like dermatitis models. Conclusion: We identified a 9 amino acid-long novel transdermal delivery peptide and suggest the feasibility of utilizing AP for transcutaneous biologic drug development such as AP-rPTP as a novel immune modulatory drug candidate for dermatitis.