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Park, Kwang-Il,Kang, Sang-Rim,Park, Hyeon-Soo,Lee, Do Hoon,Nagappan, Arulkumar,Kim, Jin A,Shin, Sung Chul,Kim, Eun Hee,Lee, Won Sup,Chung, Hyon-Jong,An, Su Jin,Kim, Gon Sup Hindawi Publishing Corporation 2012 Evidence-based Complementary and Alternative Medic Vol.2012 No.-
<P><I>Lonicera japonica THUNB.</I>, which abundantly contains polyphenols, has been used as a traditional medicine for thousands of years in East Asian countries because of the anti-inflammation properties. This study aimed to investigate the anti-inflammatory mechanism of polyphenol components isolated from Korea <I>L. japonica T.</I> by nuclear factor-kappaB (NF-<I><I>κ</I></I>B) and mitogen-activated protein kinases (MAPKs) pathway. Polyphenols significantly decreased lipopolysaccharide- (LPS-) induced mRNA and protein expression of inducible nitric oxide synthase and cyclooxygenase-2, as well as mRNA expression of tumor necrosis factor-alpha, interleukin- (IL-) 1<I><I>β</I></I>, and IL-6. Moreover, polyphenols inhibited nuclear translocation of NF-<I><I>κ</I></I>B p65, phosphorylation/degradation of the inhibitor of <I><I>κ</I></I>B, and phosphorylation of p38 MAPK, whereas the extracellular signal-regulated kinase and Janus N-terminal kinase were not affected. These results indicate that polyphenol components isolated from Korea <I>L. japonica T.</I> should have anti-inflammatory effect on LPS-stimulated RAW 264.7 cells through the decrease of proinflammatory mediators expression by suppressing NF-<I><I>κ</I></I>B and p38 MAPK activity.</P>
임사비나,임형택,박히준,장지련,최일환,이석찬,김대수,신희섭 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-
Objective : Acupuncture has been used for treatment of numerous disorders, especially for pain control in Oriental Medicine. However, the mechanism of pain control by acupuncture was not clear until now. This study was performed to prove analgesic mechanism of acupuncture treatment at acupoint ST_(36) by observing the changes of abdominal pain and c-Fos expression in the thalamus. Methods : Abdominal pain was induced by acetic acid, and the changes of writhing reflex after acupuncture treatment an ST_(36) and non-acupoints were measured. c-Fos immunohistochemistry was also performed to study the changes of the neuronal activity in the thalamus. Results : The writhing reflex decrease significantly after acupuncturing at ST_(36) compared with control group(p<0.05). The changes of the writhing reflex by non-acupoint acupuncture treatment also showed significant decrease compared with control group(p<0.05). c-Fos expression in the thalamus, especially periventricular part was significantly decreased after acupuncturing at ST_(36) compared with control groups(p<0.05). Conclusion : This study shows that the acupuncture has the analgesic effect in the abdominal pain induced by acetic acid and the thalamus might be a important area for this mechanism.
Song, In Ho,Jeong, Mun Sik,Hong, Hyo Jeong,Shin, Jong Il,Park, Yong Serk,Woo, Sang-Keun,Moon, Byung Seok,Kim, Kwang Il,Lee, Yong Jin,Kang, Joo Hyun,Lee, Tae Sup American Association for Cancer Research 2019 Clinical Cancer Research Vol.25 No.20
<P><B>Purpose:</B></P><P>Cholangiocarcinoma is a malignancy of bile duct with a poor prognosis. Conventional chemotherapy and radiotherapy are generally ineffective, and surgical resection is the only curative treatment for cholangiocarcinoma. L1-cell adhesion molecule (L1CAM) has been known as a novel prognostic marker and therapeutic target for cholangiocarcinoma. This study aimed to evaluate the feasibility of immuno-PET imaging–based radioimmunotherapy using radiolabeled anti-L1CAM antibody in cholangiocarcinoma xenograft model.</P><P><B>Experimental Design:</B></P><P>We prepared a theranostic convergence bioradiopharmaceutical using chimeric anti-L1CAM antibody (cA10-A3) conjugated with 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) chelator and labeled with <SUP>64</SUP>Cu or <SUP>177</SUP>Lu and evaluated the immuno-PET or SPECT/CT imaging and biodistribution with <SUP>64</SUP>Cu-/<SUP>177</SUP>Lu-cA10-A3 in various cholangiocarcinoma xenograft models. Therapeutic efficacy and response monitoring were performed by <SUP>177</SUP>Lu-cA10-A3 and <SUP>18</SUP>F-FDG-PET, respectively, and immunohistochemistry was done by TUNEL and Ki-67.</P><P><B>Results:</B></P><P>Radiolabeled cA10-A3 antibodies specifically recognized L1CAM <I>in vitro</I>, clearly visualized cholangiocarcinoma tumors in immuno-PET and SPECT/CT imaging, and differentiated the L1CAM expression level in cholangiocarcinoma xenograft models. <SUP>177</SUP>Lu-cA10-A3 (12.95 MBq/100 μg) showed statistically significant reduction in tumor volumes (<I>P</I> < 0.05) and decreased glucose metabolism (<I>P</I> < 0.01). IHC analysis revealed <SUP>177</SUP>Lu-cA10-A3 treatment increased TUNEL-positive and decreased Ki-67-positive cells, compared with saline, cA10-A3, or <SUP>177</SUP>Lu-isotype.</P><P><B>Conclusions:</B></P><P>Anti-L1CAM immuno-PET imaging using <SUP>64</SUP>Cu-cA10-A3 could be translated into the clinic for characterizing the pharmacokinetics and selecting appropriate patients for radioimmunotherapy. Radioimmunotherapy using <SUP>177</SUP>Lu-cA10-A3 may provide survival benefit in L1CAM-expressing cholangiocarcinoma tumor. Theranostic convergence bioradiopharmaceutical strategy would be applied as imaging biomarker-based personalized medicine in L1CAM-expressing patients with cholangiocarcinoma.</P>
Yong-Il Shin,Yeo-Kyoung Won,Kyung-Sup Shin,조영준,김정열 대한안과학회 2019 Korean Journal of Ophthalmology Vol.33 No.1
Purpose: To evaluate the changes of axial length (AXL) in eyes with unilateral idiopathic central serous chorioretinopathy(CSC) after resolution of serous retinal detachment. Methods: A total of 31 patients diagnosed with idiopathic unilateral CSC were included in this study. Thechanges of AXL according to serous retinal detachment were examined. The keratometric value and AXLwere measured using partial coherence interferometry. Serous retinal detachment and central macular thickness(CMT) were measured by spectral domain optical coherence tomography. Results: The mean age of the 31 CSC patients, including 19 males, was 42.7 years. The AXL was significantlyincreased from 23.41 to 23.58 mm after resolution of serous retinal detachment (p < 0.001). The CMT wassignificantly decreased from 413.4 to 226.8 μm after resolution of serous retinal detachment (p < 0.001). Thedifferences in AXL correlated with CMT differences and subretinal fluid height (r = -0.616, p < 0.001 and r =-0.637, p < 0.001, respectively), and the best-corrected visual acuity was significantly different after resolutionof serous retinal detachment (p < 0.001). Conclusions: In unilateral idiopathic CSC with serous retinal detachment, a shortened AXL in the acute phasewas restored after resolution of serous retinal detachment.
( Na Il Shin ),( Hye Jin Hong ),( Young Il Kim ),( Il Sup Kim ),( Jae Hoon Sung ),( Sang Won Lee ),( Seung Ho Yang ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2024 Brain Tumor Research and Treatment Vol.12 No.1
Background This study aimed to retrospectively assess results of intracranial meningioma surgery with or without intraoperative neuromonitoring (IONM) in a single institution. Methods Two cohorts (a historical cohort and a monitoring cohort) were collected for the analysis. Before IONM was introduced, a total of 107 patients underwent intracranial meningioma operation without IONM from January 2000 to December 2008 by one neurosurgeon (historical cohort). After IONM was introduced, a total of 99 patients with intracranial meningioma were operated under IONM between November 2018 and February 2023 by two neurosurgeons (monitoring cohort). A retrospective comparison was made on the complications from meningioma surgery between the two groups. Results In the monitoring cohort, warning signals of motor evoked potential (MEPs) or somatosensory evoked potential (SSEPs) were alarmed in 10 patients. Two of these 10 patients aborted the operation and eight of these 10 patients with warning signals underwent tumor resection. Of these eight patients, five showed postoperative morbidity. Five of 89 patients without warning signals developed neurological deficits. In the historical cohort, 14 of 107 patients showed postoperative morbidity or mortality. Conclusion Even after successful resection of intracranial meningiomas prior to the advent of IONM, integration of MEPs and SSEPs monitoring yielded valuable insights for surgical teams during operative procedures.
Kyung-Do Lee,Sang-Il Na,Shin-Chul Baek,Ki-Do Park,Jong-Seo Choi,Suk-Jin Kim,Hak-Jin Kim,Hee-Sup Yun,Suk-Young Hong 한국토양비료학회 2015 한국토양비료학회지 Vol.48 No.5
Remote sensing can be used to provide information about the monitoring of crop situation. This study was conducted to estimate the amount of nitrogen present in paddy fields by measuring the amount of nitrogen in hairy vetch using an UAV (Unmaned Aerial Vehicle). NDVIs (Normalized Difference Vegetation Index) were calculated using UAV images obtained from paddy fields in Seocheon on May 14<SUP>th</SUP> 2015. There was strong relationship between UAV NDVI and the amount of nitrogen in hairy vetch (R<SUP>2</SUP>=0.79). Spatial distribution maps of green manure nitrogen were generated on each paddy field using the nitrogen-vegetation index relations to help farmers determine the amount of N fertilizers added to their rice fields after the application of green manure such as hairy vetch.
Expression of Yeast Cyclophilin A (Cprl) Provides Improved Stress Tolerance in Escherichia coli
( Il Sup Kim ),( Sun Young Shin ),( Young Saeng Kim ),( Hyun Young Kim ),( Dong Hee Lee ),( Kyung Moc Park ),( Ing Nyol Jin ),( Ho Sung Yoon ) 한국미생물 · 생명공학회 2010 Journal of microbiology and biotechnology Vol.20 No.6