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( Hyunil Jang ),( Young-joo Jin ),( Cheol-woo Kim ),( Lucia Kim ),( Jin-woo Lee ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Bullous pemphigoid is a type of acute or chronic autoimmune disease that involves subepidermal skin lesions with bulla formation. Although viral infections, such as, human herpes virus (HHV), human immunodeficiency virus, cytomegalovirus, Epstein-Barr virus, HHV-6, hepatitis B virus (HBV), and hepatitis C virus (HCV) are known factors of bullous pemphigoid, HCV infection has only been rarely associated factor, especially in HBV endemic area. Methods: A case report Results: A 78-year-old man was admitted to our hospital due to erythematous bulla of onset 3 months prior to presentation affecting his entire body. Pathologic findings, that is, subepidermal bullae containing eosinophils and neutrophils with superficial perivascular lymphocytic and eosinophilic infiltration, were consistent with bullous pemphigoid. Anti-HCV was positive and HCV quantitative real-time PCR was 1.25x105 IU/Ml. HCV genotype was 2a. After a diagnosis of bullous pemphigoid associated with chronic HCV infection was reached, he was treated with oral methylprednisolone for bullous pemphigoid, and his skin lesions improved. Oral direct acting antiviral agents (sofosbuvir plus ribavirin) were prescribed for chronic hepatitis C, and sustained viral response was achieved. Conclusions: In conclusion, the authors report a rare case of bullous pemphigoid associated with chronic HCV infection in a HBV endemic area, and advise that HCV should be considered in the differential diagnosis of factors precipitating bullous pemphigoid, even in HBV endemic areas.
Analgesic Effect of Grape Seed Proanthocyanidin Extract in Fibromyalgia Animal Model
Hyunil Mun(문현일),Seong-Ho Kim(김성호),Tae Jung Jang(장태정),Il Soo Moon(문일수) 한국생명과학회 2010 생명과학회지 Vol.20 No.4
산성 식염수 쥐모델은 사람의 섬유근통에 근접한 모델로 제시되고 있다. 포도씨에서 얻은 oligomeric proanthocyanidin complexes (OPC)는 항산화제로 알려져 있다. 저자들은 산성 식염수 모델에서 통증 역치에 대한 OPC의 효과를 연구했다. 좌측 장딴지 근육에 pH 4.0의 산성 식염수 100 μl를 0일과 5일에 주사했다. 대조군은 pH 7.2의 생리 식염수를 같은 스케줄로 주사했다. 산성 식염수 그룹 10마리를 다시 두 그룹으로 나누어 한 그룹은 멸균 식염수, 다른 한 그룹은 OPC 300 ㎎/㎏를 복강 내 주사했다. 복강 내 주사 한시간 후 다시 통각에 대한 역치를 조사했다. 0일에 비해 7일에서 산성 식염수 모델은 기계적 과통각을 나타냈다(p<0.05). OPC 300 ㎎/㎏ 를 복강내 주사한 그룹에서 강력한 항통각 효과를 나타냈다(주사측 발바닥, p=0.001; 반대측 발바닥, p=0.002). 면역조직화학 염색상 복강내 식염수를 처치한 대조군에 비해 OPC 처치군에서 대뇌의 M1 및 M2 영역에서 산-감지 이온 통로3의 발현이 감소되었다(p<0.05). 사람의 섬유근통에서 OPC 치료의 효과를 보기 위한 연구가 향후 필요할 것으로 생각된다. The acidic saline animal model of pain has been suggested to mimic fibromyalgia (PM). Oligomeric proanthocyanidin complexes (OPC) from grape seeds are known to act as an antioxidant. We studied the effects of OPC on the pain threshold in the acidic saline animal model of pain. The left gastrocnemius muscle was injected with 100 μl of saline at pH 4.0 under brief isoflurane anesthesia on days o and 5. Control rats (n=5) received identical injections of physiological saline (pH 7.2) on the same schedule. Rats (n=10) with acidic saline injection were separated into two study subgroups. After measurement of pre-drug pain thresholds, rats were injected intraperitoneally with either saline or OPC 300 ㎎/㎏. Paw withdrawal thresholds to pressure were again measured 60 min after intra-peritoneal injection. Nociceptive thresholds were measured with a Dynamic Plantar Aesthesiometer by applying an increasing pressure to right or left hind paw until the rat withdrew the paw. Compared to baseline (day 0), acid injections produced mechanical hyper-responsiveness on day 7 (pre-drug) in these rats [p<0.05]. A potent antihyperalgesic effect was observed when rats were injected intra-peritoneally with OPC 300 ㎎/㎏ [injected paw, p=0.001; contralateral paw, p=0.002]. OPC treatment decreased the expression of acid sensing ion channel 3 in the brain motor cortex area on immunohistochemical staining when OPC 300 ㎎/㎏ was administered intraperitoneally in the animal model of FM pain [p<0.05]. Further research is required to determine the efficacy of OPC treatments in FM pain in humans.
다구찌 방법을 이용한 하이브리드 차량의 SOC 유지전략 최적화
김현일(Hyunil Kim),전순일(Soonil Jeon),박영일(Yeong-il Park),이장무(Jang-moo Lee) 한국자동차공학회 2003 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
We present new structure of SOC sustaining strategy for a charge sustaining hybrid electric vehicle (HEY), which can reflect the strategies for a mild HEV(Honda Insight) and a normal HEV(Toyota Prius). The proposed SOC sustaining strategy is composed of two steps to prevent over-charging or depleting of electric energy storage device such as NiMH. For this purpose, six SOC limits characterizing the SOC sustaining strategy are optimized through analysis of means (ANOM) in Taguchi's method. Besides, their relative effects on fuel economy are evaluated based on analysis of variance (ANOVA)
다이나믹 프로그램밍을 이용한 HEV 의 최적 연비 비교
김현일(Hyunil Kim),공진형(Jin-hyung Kong),임원식(wonsic Lim),이장무(Jang-moo Lee) 한국자동차공학회 2003 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
Dynamic Programming is one of the global optimization techniques used to develop optimal control strategies for HEVs. In this paper, we applied dynamic programming in deriving the maximum possible fuel economies of three types of vehicles, a diesel HEV. Honda Insight and Toyota Prius. The results from the optimizations were validated with the histories of control variables and the operating points of the power sources. We compared fuel economies from the optimizations with those from other researches.<br/>
장명욱(Myungwook Jang),김태규(Taekyu Kim),정훈(Hoon Jung),손현일(Hyunil Son) 한국추진공학회 2018 한국추진공학회 학술대회논문집 Vol.2018 No.12
HNIW는 고에너지 물질로 4가지 결정상(α, β, γ, ε)을 가지고 있으며, 결정상에 따른 열적 특성이 변화하는 것으로 알려져 있다. 본 연구는 혼합형 고체 추진제의 한 종류인 나이트레이트 에스터 폴리이서(Nitrate Ester Polyester; NEPE)계열의 추진제에서 주로 사용되는 HNIW의 결정상에 따른 추진제 점도, 기계적 물성 및 연소특성 변화를 관찰하였다. HNIW의 결정상에 따라 경화 추진제의 기계적 물성은 큰 변화가 없으나, 연소 특성에는 큰 차이를 보는 것으로 확인할 수 있었다. 추진제의 높은 밀도와 안정된 연소특성을 동시에 고려할 때, HNIW의 결정상은 NEPE계 추진제의 주요 인자로 확인할 수 있다. The HNIW is a high energy material and has 4 crystalline phases, and it is known that the thermal propertises depend on the crystal phase. In this paper solid propellant with nitrate ester polyester(NEPE) system has been researched for the viscosity, mechanical properties and burning properties with crystal phases of HNIW. According to the crystal phase of HNIW, the mechanical properties of the cured propellant did not change much, but it was found that ther was a difference in burning properties. Considering both higher density and stable burning properties, the optimum crystal phase of HNIW can be identified as the main factors to the NEPE system propellant.
장명욱(Myungwook Jang),김태규(Taekyu Kim),한해지(Haeji Han),윤재호(Jaeho Yun),손현일(Hyunil Son) 한국추진공학회 2018 한국추진공학회지 Vol.22 No.3
The propellant tile and crack which account for the greatest proportion of solid rockets are profoundly affected by viscosity and mechanical properties of solid propellant. In this paper solid propellant with nitrate ester polyester(NEPE) system has been researched for the viscosity, mechanical properties and burning properties with size and mixing ratio of RDX. the viscosity of propellant was changed significantly depending on the size of RDX and mixing ratio, and mechanical properties of NEPE system propellant were also varied. Considering both lower viscosity and stable mechanical properties, the optimum size and mixing ratio of RDX can be identified as the main factors to the NEPE system propellant.