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( Hyeun Bum Kim ),( Chul Young Lee ),( Sung Jae Kim ),( Jeong Hee Han ),( Keum Hwa Choi ) 한국동물자원과학회(구 한국축산학회) 2015 한국축산학회지 Vol.57 No.33
The objective of this study was to evaluate effects of a combined use of extracts of medicinal herbs Taraxaumi mongolicum, Viola yedoensis Makino, Rhizoma coptidis, and Radix isatidis (MYCI) on porcine epidemic diarrhea (PED). Twenty-two 3-day-old piglets received an oral challenge with 3 × 103.5 TCID50 of the virulent PED virus (PEDV) in PBS or PBS only and daily oral administration of 60 mg of the MYCI mixture suspended in milk replacer or the vehicle for 7 days in a 2 × 2 factorial arrangement of treatments. Average daily gain (ADG) increased (p < 0.05) in response to the MYCI treatment in the PEDV-challenged piglets (.18 vs. 7 g for the vehicle- vs. MYCI-administered group), but not in unchallenged animals (27 vs. 28 g). Diarrhea score and fecal PEDV shedding, however, were not influenced by the MYCI treatment. The PEDV challenge caused severe intestinal villus atrophy and crypt hyperplasia, both of which were alleviated by administration of the MYCI mixture as indicated by an increase in the villus height and a decrease in the crypt depth due to the treatment. Overall, medicinal herb extracts used in this study ameliorated impaired growth performance and intestinal lesion of newborn piglets challenged with the virulent PEDV. Therefore, our results suggest that the MYCI mixture could be used as a prophylactic or therapeutic agent against PED.
( Hyeun Bum Kim ),( Yuankai Wang ),( Xingmin Sun ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.3
We investigated the increased risk of Clostridium difficile infection (CDI) caused by the combined use of antibiotics and an immunosuppressive drug in a mouse model. Our data showed that an approximate return to pretreatment conditions of gut microbiota occurred within days after cessation of the antibiotic treatment, whereas the recovery of gut microbiota was delayed with the combined treatment of antibiotics and dexamethasone, leading to an increased severity of CDI. An alteration of gut microbiota is a key player in CDI. Therefore, our data implied that immunosuppressive drugs can increase the risk of CDI through the delayed recovery of altered gut microbiota.
Kim, Hyeun Bum,Lee, Chul Young,Kim, Sung Jae,Han, Jeong Hee,Choi, Keum Hwa Korean Society of Animal Science and Technology 2015 한국축산학회지 Vol.57 No.10
The objective of this study was to evaluate effects of a combined use of extracts of medicinal herbs Taraxaumi mongolicum, Viola yedoensis Makino, Rhizoma coptidis, and Radix isatidis (MYCI) on porcine epidemic diarrhea (PED). Twenty-two 3-day-old piglets received an oral challenge with $3{\times}10^{3.5}$ $TCID_{50}$ of the virulent PED virus (PEDV) in PBS or PBS only and daily oral administration of 60 mg of the MYCI mixture suspended in milk replacer or the vehicle for 7 days in a $2{\times}2$ factorial arrangement of treatments. Average daily gain (ADG) increased (p < 0.05) in response to the MYCI treatment in the PEDV-challenged piglets (-18 vs. 7 g for the vehicle- vs. MYCI-administered group), but not in unchallenged animals (27 vs. 28 g). Diarrhea score and fecal PEDV shedding, however, were not influenced by the MYCI treatment. The PEDV challenge caused severe intestinal villus atrophy and crypt hyperplasia, both of which were alleviated by administration of the MYCI mixture as indicated by an increase in the villus height and a decrease in the crypt depth due to the treatment. Overall, medicinal herb extracts used in this study ameliorated impaired growth performance and intestinal lesion of newborn piglets challenged with the virulent PEDV. Therefore, our results suggest that the MYCI mixture could be used as a prophylactic or therapeutic agent against PED.
한우에서의 Rotavirus의 분리와 Serotype 결정 및 염기서열 분석
유제현(Jae Hyeun Yu),차광종(Kwang Jong Cha),김응률(Eung Ryool Kim),김유성(You Seong Kim),이영건(Young Kun Lee),송진욱(Jin Ook Song),조홍찬(Hong Chan Cho),주지선(Ji Sun Ju),박범석(Bum Suk Park),유대환(Dea Hwan Yoo),김세민(Se Min Kim) 대한바이러스학회 2000 Journal of Bacteriology and Virology Vol.30 No.3
이정현(Jung-Hyeun Lee),박봉석(Bong Seok Park),구근범(Geun Bum Koo),현창호(Chang-Ho Hyun) 한국지능시스템학회 2021 한국지능시스템학회논문지 Vol.31 No.5
본 논문에서는 인공지능 자세 진단 디지털 테라퓨틱스 시스템을 제안 및 구현한다. 구현한 시스템은 육안으로 사람의 자세를 확인하고 진단하는 진단자의 경험과 지식 기반 진단을 대신할 수 있도록 퍼지 추론 엔진을 적용한다. 비전센서를 이용하여 피진단자의 영상을 획득하고 획득한 영상을 퍼지 추론 엔진을 통해 진단함수를 만든다. 또한, 퍼지 추론 엔진 설계를 위해서 척추측만증과 골반 틀어짐 진단에 대해 공개되어 있는 의학정보를 활용하고 설계한 퍼지추론을 통해 진단 기준을 시스템화 한다. 그리고, 자세에 대한 진단 결과를 메시지로 출력하여 피측정자의 자세 정보를 제공할 수 있는 그래픽 사용자 환경을 구현한다. 제안한 시스템은 자세정보 획득을 위한 보조기구의 착용없이 영상 정보를 이용하여 자세를 인식한다. 마지막으로 시나리오 기반 성능 실험을 통해 시스템의 성능을 검증한다. In this paper, the intelligent digital therapeutic system for posture diagnosis is proposed and implemented. A large amount of information is digitally stored and AI technologies such as machine learning and artificial intelligence provides good potential for the automated classification of medical conditions. The proposed system adopts fuzzy inference engine to make the diagnosis of ones posture with the way that human doctors (experts) do based on their knowledge and experience. The proposed system acquires the image of examinee using vision sensor and diagnoses whether the posture is corrected or not through the fuzzy system. In order to design the fuzzy reasoning engine, open medical information about scliosis and pelvic misalignment is used as input-output data. Then, the diagnostic criteria is functionalized with fuzzy mathematics. A graphic user interface is designed to provide the current condition of ones posture and the guide for the posture diagnosis that is generated by the proposed system. The proposed system recognizes ones posture with only image information. Any auxiliary device is not required to recognize ones posture. In conclusion, the performance of the proposed system is verified with four scenario based experiments; correct posture, tilt posture (scoliosis), incorrect vertical-line posture, and out of the measurement range.
황신범 ( Shin-bum Hwang ),김준규 ( Jun-kyu Kim ),원대희 ( Dae-hui Won ),김양우 ( Yang-woo Kim ),손영달 ( Young-dal Son ),이현태 ( Hyeun-tae Lee ) 한국정보처리학회 2009 한국정보처리학회 학술대회논문집 Vol.16 No.1
현대인들의 감정 불안정 상태로 인한 질병과 사회문제, 범죄 등이 많은 이슈로 나타나고 있다. 본 논문은 사람의 감정에 따른 생리적인 변화를 생체신호를 측정하여 분석하고 이를 이용하여 사람의 감정을 조절할 수 있는 음악을 선택하여 조절한다. 사람의 심박수를 측정하고 그 데이터를 HRV(심장박동 변화율)로 변환하면 그 사람의 현재 기분을 추정해 낼 수 있다는 연구 결과를 적용하여 기분에 따라 알맞은 음악을 자동으로 선택 하여 들려줄 수 있는 시스템을 설계하고 구현한다.
최현범(Hyun Bum Choir),이상헌(Sang Hyeun Lee),최강훈(Kang Hun Choi),윤영석(Young Suck Yoon) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.11
Recently, the problem of battery weight in electric vehicles has emerged. In order to to achieve weight reduction of the vehicle body, it is necessary to replace the material and optimize the design accordingly, and the actual situation is that an efficient product manufacturing method is required to change the lightweight material. In this study, Car body parts were developed using die casting.